Table 5 Functional roles of 5 hub genes with degree ≥10
No. | Gene symbol | Full name | Function |
|---|---|---|---|
1 | AIF1 | Allograft inflammatory factor 1 | Actin-binding protein that enhances membrane ruffling and RAC activation. Plays a role in RAC signaling and phagocytosis. |
2 | IGFBP4 | Insulin-like growth factor binding protein 4 | IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth-promoting effects of the IGFs on cell culture. |
3 | ARHGDIB | Rho GDP dissociation inhibitor beta | Regulates the GDP/GTP exchange reaction of the Rho proteins; regulates reorganization of the actin cytoskeleton mediated by Rho family members |
4 | IGSF6 | Immunoglobulin superfamily member 6 | It is coded entirely within the intron of METTL9 which is transcribed in the opposite strand of the DNA. |