Table 3 Phenotypes with causal relationships with hip or knee OA

Diagnoses - main ICD10: L72 Follicular cysts of skin and subcutaneous tissue

0.358

0.924

2.66E-19

Diseases of the musculoskeletal system and connective tissue

0.840

0.615

9.33E-03

Work hours - lumped category: Over 40 h

0.298

-0.613

3.72E-03

Workplace had a lot of cigarette smoke from other people smoking: Often

0.255

-0.616

1.67E-03

Weight

0.392

-0.623

2.28E-05

Job SOC coding: Higher education teaching professionals

-0.264

-0.638

5.35E-03

Hallux valgus (acquired)

0.347

-0.639

2.59E-04

Heel bone mineral density (BMD)

0.226

-0.645

2.26E-07

FI10 : arithmetic sequence recognition

-0.342

-0.663

1.18E-03

Workplace very hot: Often

0.386

-0.670

8.46E-04

Workplace very dusty: Sometimes

0.596

-0.679

1.17E-05

Job SOC coding: Secondary education teaching professionals

-0.319

-0.686

7.05E-04

Diagnoses - main ICD10: M23 Internal derangement of knee

0.729

-0.697

1.10E-03

FI8 : chained arithmetic

-0.242

-0.726

2.49E-04

Glycated haemoglobin (HbA1c)

0.167

-0.761

2.85E-07

Non-cancer illness code, self-reported: back problem

0.325

-0.789

7.17E-08

Meniscus derangement

0.730

-0.791

1.19E-06

Current employment status: Unemployed

0.374

-0.862

5.69E-15

Obesity

0.406

-0.906

2.62E-33

Workplace had a lot of cigarette smoke from other people smoking: Sometimes

0.317

-0.923

1.76E-47

Non-cancer illness code, self-reported: chronic obstructive airways disease/copd

0.394

-0.932

2.03E-09