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Table 2 Phenotypes with causal relationships with hip OA

From: Phenome-wide causal associations between osteoarthritis and other complex traits through the latent causal variable analysis

Phenotype

rG

GCP

P_GCP

Pain type(s) experienced in last month: Hip pain

0.443

0.781

1.86E-07

Leg pain on walking

0.420

0.714

1.56E-04

Mineral and other dietary supplements: Glucosamine

0.297

0.628

6.88E-03

Chest pain or discomfort walking normally

0.251

0.627

6.27E-03

Weight

0.239

-0.616

7.05E-04

Arm predicted mass (right)

0.202

-0.625

7.66E-03

Whole body fat-free mass

0.182

-0.627

7.37E-03

Whole body water mass

0.183

-0.628

7.25E-03

Arm fat-free mass (right)

0.204

-0.631

6.55E-03

Arm fat-free mass (left)

0.207

-0.643

4.46E-03

Arm predicted mass (left)

0.203

-0.644

4.37E-03

Basal metabolic rate

0.201

-0.646

3.15E-03

Meniscus derangement

0.358

-0.662

5.42E-03

Weight change during worst episode of depression: Gained weight

0.346

-0.666

2.15E-03

Job SOC coding: Secondary education teaching professionals

-0.330

-0.674

2.34E-03

Neck/shoulder pain for 3 + months

0.451

-0.714

3.17E-04

Job coding: secondary school teacher or teaching professional (including head teacher)

-0.340

-0.718

1.80E-04

BMI

0.239

-0.732

4.18E-06

Other/unspecified dorsalgia

0.323

-0.749

5.21E-05

Blood clot, DVT, bronchitis, emphysema, asthma, rhinitis, eczema, allergy diagnosed by doctor: Blood clot in the leg (DVT)

0.316

-0.882

2.19E-26

Non-cancer illness code, self-reported: deep venous thrombosis (dvt)

0.336

-0.948

3.12E-84

  1. Phenotypes with FDR < 0.05 and |GCP| > 0.6. More detailed information of the phenotypes was provided in Additional file S5. OA osteoarthritis, rG genetic correlation, GCP genetic causality proportion, SE standard error, P p value