Table 1 Phenotypes with causal relationships with knee OA
Phenotype | rG | GCP | P_GCP |
|---|---|---|---|
Certain infectious and parasitic diseases | 0.678 | 0.742 | 6.74E-05 |
Diagnoses - main ICD10: L72 Follicular cysts of skin and subcutaneous tissue | 0.434 | 0.739 | 3.47E-05 |
Non-cancer illness code, self-reported: type 2 diabetes | 0.320 | 0.713 | 3.11E-03 |
Hip circumference | 0.408 | -0.606 | 2.31E-05 |
Diagnoses - main ICD10: J45 Asthma | 0.429 | -0.615 | 5.56E-11 |
Weight | 0.397 | -0.641 | 1.52E-05 |
Treatment/medication code: atorvastatin | 0.252 | -0.647 | 8.07E-25 |
Non-cancer illness code, self-reported: high cholesterol | 0.207 | -0.649 | 4.46E-26 |
Diagnoses - main ICD10: I50 Heart failure | 0.301 | -0.672 | 1.47E-03 |
Heel bone mineral density (BMD) (left) | 0.190 | -0.684 | 6.38E-08 |
Work hours - lumped category: Over 40Â h | 0.278 | -0.701 | 2.26E-04 |
BMI | 0.400 | -0.708 | 4.03E-04 |
Chest pain or discomfort when walking uphill or hurrying | 0.364 | -0.727 | 6.02E-05 |
Meniscus derangement | 0.801 | -0.733 | 3.74E-04 |
IPF (EUR Biobanks) | 0.333 | -0.782 | 2.72E-07 |
Job SOC coding: Higher education teaching professionals | -0.315 | -0.799 | 8.43E-08 |
Current employment status: Unemployed | 0.342 | -0.847 | 7.97E-13 |
Workplace very dusty: Sometimes | 0.702 | -0.911 | 1.19E-28 |
Glucose | 0.138 | -0.930 | 3.55E-61 |
Treatment/medication code: beclometasone | 0.296 | -0.941 | 5.50E-09 |
Obesity | 0.526 | -0.943 | 2.22E-70 |