Lifestyle factors and subacromial impingement syndrome of the shoulder: potential associations in finnish participants

Lv, Zhengtao; Cui, Jiarui; Zhang, Jiaming; He, Li

doi:10.1186/s12891-024-07345-w

Table 2 Causal effects of modifiable lifestyle factors on impingement syndrome of shoulder using MR analyses

From: Lifestyle factors and subacromial impingement syndrome of the shoulder: potential associations in finnish participants

Exposure	MR method	OR (95%CI)	Beta (SE)	P	P_− het	P_− pleio
Smoking initiation	MR Egger	0.91 (0.50, 1.67)	-0.089 (0.31)	0.77	0.0068
	MR Egger intercept		0.0048 (0.0059)			0.41
	Weighted median	1.11 (0.90, 1.35)	0.10 (0.10)	0.33
	IVW	1.17 (1.01, 1.35)	0.16 (0.074)	0.035	0.0069
	MR-PRESSO distortion test			NA
Alcoholic drinks per week	MR Egger	3.59 (1.00, 12.86)	1.28 (0.65)	0.052	0.0023
	MR Egger intercept		-0.012 (0.0078)			0.13
	Weighted median	1.97 (0.96, 4.02)	0.68 (0.36)	0.065
	IVW	1.44 (0.85, 2.44)	0.37 (0.27)	0.17	0.0015
	MR-PRESSO distortion test			0.80
Coffee consumption	MR Egger	1.01 (1.00, 1.02)	0.0094 (0.0057)	0.12	0.95
	MR Egger intercept		-0.014 (0.014)			0.31
	Weighted median	1.01 (1.00, 1.01)	0.0061 (0.0038)	0.12
	IVW	1.00 (1.00, 1.01)	0.0042 (0.0030)	0.15	0.93
	MR-PRESSO distortion test			NA
Moderate-to-vigorous physical activity	MR Egger	21.76 (0.20, 2428.16)	1.08 (2.41)	0.22	0.18
	MR Egger intercept		-0.041 (0.035)			0.27
	Weighted median	1.04 (0.36, 2.95)	0.039 (0.53)	0.87
	IVW	1.42 (0.61, 3.28)	0.35 (0.43)	0.42	0.16
	MR-PRESSO distortion test			NA
Sedentary behavior	MR Egger	3.85 (0.093, 159.16)	1.34 (1.90)	0.55	0.79
	MR Egger intercept		-0.063 (0.060)			0.40
	Weighted median	0.54 (0.22, 1.35)	-0.61 (0.46)	0.20
	IVW	0.55 (0.25, 1.19)	-0.60 (0.39)	0.13	0.67
	MR-PRESSO distortion test			NA
Insomnia	MR Egger	1.59 (0.76, 3.32)	0.46 (0.38)	0.22	0.0018
	MR Egger intercept		0.00093 (0.0071)			0.90
	Weighted median	1.52 (1.16, 2.00)	0.42 (0.14)	0.0025
	IVW	1.66 (1.38, 2.00)	0.51 (0.10)	8.86E-08	0.0021
	MR-PRESSO distortion test			0.78
Sleep duration	MR Egger	1.00 (0.97, 1.02)	-0.0043 (0.13)	0.74	0.087
	MR Egger intercept		0.0059 (0.013)			0.64
	Weighted median	1.00 (0.99, 1.01)	-0.0062 (0.045)	0.56
	IVW	1.00 (1.00, 1.01)	0.0016 (0.0033)	0.63	0.098
	MR-PRESSO distortion test			NA
Short sleep duration	MR Egger	1.59 (0.43, 5.90)	0.46 (0.67)	0.50	0.50
	MR Egger intercept		-0.0013 (0.023)			0.95
	Weighted median	1.41 (0.92, 2.16)	0.34 (0.22)	0.12
	IVW	1.53 (1.14, 2.05)	0.42 (0.15)	0.0043	0.56
	MR-PRESSO distortion test			NA
Time spent using computers	MR Egger	0.56 (0.049, 6.50)	-0.58 (1.25)	0.65	0.29
	MR Egger intercept		0.0047 (0.016)			0.76
	Weighted median	1.08 (0.60, 1.95)	0.074 (0.30)	0.81
	IVW	0.81 (0.53, 1.26)	-0.21 (0.22)	0.35	0.31
	MR-PRESSO distortion test			NA
Weekly usage of mobile phones in last 3 months	MR Egger	6.71 (0.0045, 9908.00)	1.90 (3.72)	0.62	0.0031
	MR Egger intercept		-0.0075 (0.075)			0.92
	Weighted median	5.46 (1.88, 15.91)	1.70 (0.55)	0.00019
	IVW	4.65 (1.59, 13.64)	1.54 (0.55)	0.0051	0.0055
	MR-PRESSO distortion test			0.50
Job involving heavy manual or physical work	MR Egger	0.12 (0.0031, 4.72)	-2.11 (1.87)	0.27	0.54
	MR Egger intercept		0.058 (0.030)			0.068
	Weighted median	4.25 (1.70, 10.67)	1.44 (0.47)	0.0033
	IVW	4.24 (2.17, 8.26)	1.44 (0.34)	0.000022	0.37
	MR-PRESSO distortion test			NA

MR: mendelian randomization; OR: odds ratio; 95%CI: 95% confidence interval; Beta was the estimated effect size; SE: standard error; P_− het: P value for heterogeneity test; P_− pleio: P value for pleiotropy test using MR-Egger regression analysis; IVW: inverse variance weighting; P < 0.05 was considered statistically significant

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