Table 1 Main characteristic of data sources of the instrumental variables used in the MR study
Risk factors | SNPs | Sample size | Ancestry | Unit | PubMed ID/GWAS ID |
|---|---|---|---|---|---|
Smoking initiation | 334 | 1,232,091 | European | Ever smoked regularly compared with never smoked | 30,643,251/NA |
Alcoholic drinks per week | 89 | 46,568 | European | 1 SD increase in log-transformed alcoholic drinks/week | 30,643,251/NA |
Coffee consumption | 14 | 375,833 | European | 50% change in cups of coffee intake per day | 31,046,077/NA |
Moderate-to-vigorous physical activity | 18 | 377,234 | European | 1 SD increase in MET min/week | 29,899,525/ebi-a-GCST006097 |
Sedentary behavior | 4 | 91,105 | European | 1 SD increase in sedentary time | 30,531,941/NA |
Insomnia | 227 | 1,331,010 | European | Not available for binary trait | 30,804,565/NA |
Sleep duration | 70 | 446,118 | European | h/day | 30,846,698/NA |
Short sleep duration | 24 | 411,934 | European | < 7 h vs. 7–8 h daily sleep duration | 30,846,698/NA |
Time spent using computers | 76 | 360,895 | European | 1 SD increase in time spent using computers | NA/ukb-b-4522 |
Weekly usage of mobile phones in last 3 months | 11 | 386,626 | European | 1 SD increase in time using mobile phones | NA/ukb-b-17,999 |
Job involves heavy manual or physical work | 21 | 263,615 | European | 1 SD increase in frequency of heavy manual or physical work | NA/ukb-b-2002 |