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Table 3 Associations between baseline characteristics and pain phenotypes at 24-month follow-up

From: Phenotypes of osteoarthritis-related knee pain and their transition over time: data from the osteoarthritis initiative

Baseline characteristics

No Pain

RR (95% CI)

Mild P-A

RR (95% CI)

Mild P-R-A

RR (95% CI)

Mod P-R-A

RR (95% CI)

Age, yeara

  < 60

1.00 (reference)

1.00 (reference)

1.00 (reference)

1.00 (reference)

  ≥ 65

1.00 (reference)

1.01 (0.94, 1.08)

0.89 (0.80, 0.99)

0.68 (0.56, 0.82)

Genderb

 Female

1.00 (reference)

1.11 (1.04, 1.20)

1.16 (1.05, 1.29)

1.89 (1.55, 2.31)

CES-D score

1.00 (reference)

1.01 (1.00, 1.01)

1.02 (1.02, 1.03)

1.04 (1.03, 1.14)

BMI, kg/m2

  < 25

1.00 (reference)

1.00 (reference)

1.00 (reference)

1.00 (reference)

 25–29.9

1.00 (reference)

1.08 (0.98, 1.19)

1.43 (1.21, 1.68)

2.01 (1.46, 2.75)

  ≥ 30

1.00 (reference)

1.21 (1.10, 1.33)

1.81 (1.55, 2.13)

1.92 (1.40, 2.64)

Education

 College or above

1.00 (reference)

0.96 (0.87, 1.06)

0.83 (0.75, 0.93)

0.80 (0.72, 0.88)

Race

 Whites

1.00 (reference)

1.00 (reference)

1.00 (reference)

1.00 (reference)

 Non-whites

1.00 (reference)

1.04 (0.96, 1.14)

1.22 (1.11, 1.35)

2.08 (1.74, 2.49)

Injury

1.00 (reference)

1.18 (1.10, 1.27)

1.34 (1.22, 1.47)

1.30 (1.17, 1.44)

KL grade

 0

1.00 (reference)

1.00 (reference)

1.00 (reference)

1.00 (reference)

 1

1.00 (reference)

1.28 (1.15, 1.43)

1.32 (1.10, 1.58)

1.45 (1.03, 2.05)

 2

1.00 (reference)

1.63 (1.49, 1.79)

2.04 (1.76, 2.36)

3.08 (2.36, 4.02)

 3

1.00 (reference)

1.84 (1.65, 2.06)

3.00 (2.58, 3.49)

3.88 (2.95, 5.10)

 4

1.00 (reference)

2.63 (2.29, 3.01)

4.00 (3.45, 4.65)

5.42 (4.18, 7.03)

  1. Mild P-A mild pain during activity, Mild P-R-A mild pain during both rest and activity, Mod P-R-A moderate pain during both rest and activity, RR relative risk, CI confidence interval, CES-D Center for Epidemiological Studies-Depression, BMI body mass index, KL Kellgren and Lawrence
  2. aAge and bgender were adjusted mutually
  3. The rest factors were adjusted for all variables listed above