Efficacy and safety of single injection of cross-linked sodium hyaluronate vs. three injections of high molecular weight sodium hyaluronate for osteoarthritis of the knee: a double-blind, randomized, multi-center, non-inferiority study

Table 6 Adverse drug reactions

Adverse Drug Reactions	HMWHA	XLHA	P-value
Adverse Drug Reactions	N = 146	N = 139	P-value
Injection site pruritus	1 (1)	1 (1)^A	1.00
Pain	0 (0)	1 (2)^A	0.49
Swelling	0 (0)	1 (1)	0.49
Injection site hemorrhage	0 (0)	1 (1)	0.49
Joint swelling	0 (0)	1 (1)	0.49
Erythema	0 (0)	2 (2)^A	0.24
Total number	1 (1)	7 (8)	0.03

Data are number of patients experiencing adverse drug reaction and the numbers in parenthesis are number of events
^A, In XLHA group, 3 adverse drug reactions (each event of injection site pruritus, pain, and erythema) occurred after placebo injection, which preceded XLHA injection

ISSN: 1471-2474