|  | Unadjusted | Adjusteda | ||
---|---|---|---|---|---|
 | Reference | OR | (95% CI) | aOR | (95% CI) |
Male gender | Female | 1.15 | (0.92, 1.45) | 1.22 | (0.96, 1.55) |
Age (years) | per year | 0.96 | (0.95, 0.98) | 0.96 | (0.94, 0.97) |
Body mass index (kg/m2) | per kg/m2 | 1.05 | (1.03, 1.08) | 1.03 | (1.01, 1.06) |
Occupational class | Managerial/professional | Â | Â | Â | Â |
Intermediate | Â | 0.90 | (0.56, 1.45) | Â | Â |
Routine and manual | Â | 0.76 | (0.51, 1.12) | Â | Â |
PF-10 physical function (0–100) | per unit | 0.99 | (0.99, 0.99) | ns | ns |
WOMAC knee pain (0–20) | per unit | 1.08 | (1.05, 1.11) | 1.06 | (1.03, 1.10) |
WOMAC knee function (0–68) | per unit | 1.02 | (1.01, 1.03) | mc | mc |
Compartmental distribution of radiographic OAb | Normal | Â | Â | Â | Â |
Isolated tibiofemoral | Â | 1.03 | (0.58, 1.81) | Â | Â |
Isolated patellofemoral | Â | 0.94 | (0.70, 1.28) | Â | Â |
Combined tibiofemoral and patellofemoral | Â | 1.06 | (0.81, 1.38) | Â | Â |
Overall severity of radiographic OAb | Normal | Â | Â | Â | Â |
Mild | Â | 0.94 | (0.70, 1.25) | Â | Â |
Mod/severe | Â | 1.08 | (0.82, 1.41) | Â | Â |
HADS anxiety (0–21) | per unit | 1.04 | (1.01, 1.07) | mc | mc |
HADS depression (0–21) | per unit | 1.07 | (1.03, 1.10) | ns | ns |
Previous knee injury | None | Â | Â | ns | ns |
Unilateral | Â | 1.25 | (0.95, 1.64) | Â | Â |
Bilateral | Â | 1.82 | (1.17, 2.85) | Â | Â |
Time since onset of knee problemb | <1Â year | Â | Â | Â | Â |
1 year to < 5 years |  | 1.97 | (1.29, 3.01) | 1.79 | (1.16, 2.75) |
5 years to < 10 years |  | 1.94 | (1.23, 3.05) | 1.82 | (1.15, 2.89) |
≥10 years |  | 2.02 | (1.32, 3.08) | 1.82 | (1.18, 2.82) |
Duration of morning stiffnessb | None | Â | Â | Â | Â |
≤30 min |  | 1.63 | (1.28, 2.07) | 1.43 | (1.10, 1.85) |
>30Â min | Â | 2.26 | (1.34, 3.81) | 1.44 | (0.83, 2.50) |
Knee given way during past monthb | No | 1.38 | (1.08, 1.77) | ns | ns |
Seen hospital doctor about kneeb | No | 1.61 | (1.23, 2.10) | ns | ns |
Severity of effusionb | None | Â | Â | Â | Â |
Mild | Â | 0.99 | (0.77, 1.30) | Â | Â |
Moderate/gross | Â | 1.15 | (0.79, 1.67) | Â | Â |
Nodal symptomatic hand OA | No | 0.90 | (0.66, 1.24) | Â | Â |
Frequent sedentary activity | No | 1.59 | (1.07, 2.35) | Â | Â |
Frequent moderate activity | No | 0.85 | (0.68, 1.07) | Â | Â |
Frequent vigorous activity | No | 0.88 | (0.68, 1.13) | Â | Â |