Acute effects of physical exercise on the serum insulin-like growth factor system in women with fibromyalgia

Table 2 Values obtained at moderate intensive exercise performance in women with fibromyalgia (FM) and the healthy reference group. Mean value and SD for baseline values, differences (∆), p-value for within-group differences as well as for between- group differences are presented

Moderate intensity exercise performance
	Women with FM, n = 22			Healthy reference group, n = 27			Between-group differences
	0 min	15 min–0 min		0 min	15 min–0 min		0 min	Change 0–15 min
	Mean ± sd	∆ mean ± sd	p-value	Mean ± sd	∆ mean ± sd	p-value	p-value	p-value
S-IGF-1 (ng/ml)	178 ± 58	11 ± 10	<0.001	179 ± 69	13 ± 10	<0.001	0.825	0.629
free IGF-I (ng/ml)	3.5 ± 1.6	−0.15 ± 0.34	0.014	4.0 ± 2.09	−0.38 ± 0.47	<0.001	0.457	0.119
S-IGFBP3 (ng/ml)	428 ± 44	11 ± 16	0.007	426 ± 37	14 ± 19	0.001	0.880	0.662
sCRP (μg/ml)	2.0 ± 2.2	0.14 ± 0.18	0.001	0.56 ± 0.48	0.35 ± 0.46	<0.001	<0.001	0.215
IL-8 (pg/ml)	9.2 ± 4.5	−5.9 ± 1.6	0.105	9.6 ± 2.5	−0.3 ± 1.0	0.077	0.769	0.600
Pain (0–100 mm)	40 ± 19	7.6 ± 16	0.044	0.8 ± 2.1	2.0 ± 6.8	0.093	<0.001	0.015
Fatigue in legs (0–100 mm)	26 ± 23	28 ± 24	<0.001	1 ± 2.4	6.0 ± 8.5	0.002	<0.000	<0.001
Fatigue global (0–100 mm)	51 ± 27	9.2 ± 17	0.038	4 ± 6.4	10 ± 12	0.002	<0.001	0.672

S-IGF-1 serum insulin-like growth factor-1, S-IGFBP3 Insulin-like growth factor binding protein-3, sCRP human high sensitivity C-reactive protein, IL-8 interleukin-8

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