| Placebo | ch-OSA | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  |  |  | 3 mg Si | 6 mg Si | 12 mg Si | ||||||
 | Baseline | 6 months | 12 months | Baseline | 6 months | 12 months | Baseline | 6 months | 12 months | Baseline | 6 months | 12 months |
serum OC (ng/mL) | 9.74 ± 3.16 | 9.11 ± 3.73a | 7.86 ± 2.26a | 10.17 ± 3.91 | 9.11 ± 3.02a | 8.33 ± 2.63a | 10.65 ± 3.32 | 9.74 ± 3.05a | 9.08 ± 2.56a | 10.16 ± 3.67 | 9.43 ± 3.02a | 8.79 ± 2.82a |
serum BAP (U/L) | 21.65 ± 6.30 | 18.91 ± 5.56 | 18.61 ± 5.56 | 20.43 ± 7.24 | 19.61 ± 6.66 | 18.97 ± 5.98 | 21.85 ± 6.31 | 20.59 ± 6.39 | 20.16 ± 6.01 | 21.58 ± 7.36 | 20.19 ± 5.62 | 19.75 ± 5.96 |
serum PINP (μg/L) | 47.20 ± 13.45 | 40.83 ± 14.05a | 36.49 ± 12.04a | 46.28 ± 21.46 | 40.27 ± 20.18a | 35.63 ± 12.34a | 44.78 ± 16.07 | 38.60 ± 13.35a | 42.04 ± 12.77a,1,2 | 48.77 ± 15.09 | 42.87 ± 11.89a,2 | 43.73 ± 12.11a,1,2 |
serum DPD (/Cr) | 5.57 ± 3.12 | 4.77 ± 1.12 | 4.74 ± 1.28 | 5.22 ± 1.50 | 5.17 ± 2.04 | 4.83 ± 1.62 | 5.74 ± 1.45 | 5.81 ± 1.68 | 5.49 ± 1.70 | 5.92 ± 1.57 | 5.36 ± 1.91 | 6.22 ± 2.62 |
serum CTX-I (μg/mmol Cr) | 359.01 ± 129.89 | 271.15 ± 124.21 | 284.66 ± 134.09 | 331.88 ± 155.87 | 245.03 ± 107.82 | 220.71 ± 98.08 | 349.10 ± 126.71 | 294.21 ± 137.802 | 319.38 ± 160.782 | 360.43 ± 139.00 | 310.95 ± 122.052 | 320.99 ± 113.632 |