| Baseline | 6 weeks | 13 weeks | 27 weeks | 52 weeks |
---|---|---|---|---|---|
RCTs | Â | Â | Â | Â | Â |
Pain | 48.1 (45.8, 50.5) | 34.1 (31.0, 37.2) | 27.8 (25.1, 30.6) | 26.4 (24.3, 28.6) | 28.9 (25.7, 32.0) |
Arms, n | 165 | 58 | 94 | 97 | 78 |
Sample size* | 10655 | 3577 | 6109 | 6640 | 4499 |
Cohorts | Â | Â | Â | Â | Â |
Pain | 47.3 (38.6, 56.0) | 31.7 (18.5, 44.8) | 30.7 (25.6, 35.8) | 24.7 (12.9, 36.4) | 26.7 (19.8, 33.6) |
n | 19 | 6 | 10 | 10 | 12 |
Sample size* | 13096 | 6122 | 6848 | 5496 | 6284 |