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Table 2 Low back symptoms and lumbar flexibility at baseline, one month and 12 months according to treatment group and between group comparisons of difference from baseline to one month and 12 months

From: Efficacy of zoledronic acid for chronic low back pain associated with Modic changes in magnetic resonance imaging

 

Mean (SD) original values

Mean (SD) change

Unadjusted analyses

Adjusted analyses

 

ZA

Placebo

ZA

Placebo

Difference

P

Difference

P*

 

n = 20

n = 20

  

(95% CI)

 

(95% CI)

 

Intensity of LBP

        

  Baseline

6.6 (1.4)

6.8 (1.6)

      

  1 month

4.3 (2.3)

5.8 (2.2)

−2.2 (2.7)

−0.9 (2.1)

1.3 (−0.2 to 2.8)

0.097

1.4 (0.01 to 2.9)

0.049

  12 months

3.8 (2.5)

4.6 (2.9)

−2.8 (2.9)

−2.2 (2.5)

0.6 (−1.1 to 2.4)

0.474

0.7 (−1.0 to 2.4)

0.387

Intensity of leg paina

        

  Baseline

3.0 (3.1)

2.9 (2.3)

      

  1 month

2.0 (2.3)

3.0 (2.4)

−0.6 (2.4)

0.1 (2.6)

0.8 (−0.9 to 2.4)

0.367

0.8 (−0.6 to 2.2)

0.237

  12 months

2.1 (2.8)

2.7 (2.6)

−0.9 (3.4)

−0.3 (3.0)

0.6 (−1.5 to 2.7)

0.573

0.5 (−1.3 to 2.2)

0.573

Oswestry disability index, %

        

  Baseline

30 (11)

35 (10)

      

  1 month

24 (10)

33 (13)

−5.9 (11)

−1.7 (9.7)

4.3 (−2.5 to 11)

0.212

6.0 (−0.6 to 13)

0.071

  12 months

25 (13)

33 (15)

−5.0 (15)

−1.9 (12)

3.1 (−5.6 to 12)

0.475

5.1 (−3.4 to 14)

0.231

Fingers-to-floor, cm

        

  Baseline

23 (19)

19 (18)

      

  1 month

17 (17)

19 (17)

−5.1 (20)

−0.1 (8.3)

5.0 (−4.8 to 15)

0.306

3.6 (−5.0 to 12)

0.403

  12 months

16 (16)

20 (19)

−6.3 (23)

0.9 (11)

7.1 (−4.3 to 18)

0.215

5.3 (−4.5 to 15)

0.277

Sidebending to right, cm

        

  Baseline

14.1 (4.9)

13.8 (7.2)

      

  1 month

15.7 (5.9)

13.3 (6.9)

1.5 (4.7)

−0.5 (2.2)

−2.0 (−4.3 to 0.4)

0.101

−2.0 (−4.4 to 0.3)

0.087

  12 months

15.7 (5.6)

13.8 (6.5)

1.6 (4.8)

−0.1 (3.5)

−1.6 (−4.3 to 1.1)

0.227

−1.7 (−4.2 to 0.8)

0.180

Sidebending to left, cm

        

  Baseline

15.0 (5.4)

13.3 (5.5)

      

  1 month

16.1 (5.3)

12.8 (5.9)

1.1 (3.0)

−0.5 (2.2)

−1.5 (−3.2 to 0.1)

0.072

−1.7 (−3.4 to 0.0)

0.051

  12 months

16.2 (6.7)

13.7 (5.7)

1.2 (5.3)

0.5 (3.2)

−0.7 (−3.5 to 2.1)

0.601

−1.0 (−3.8 to 1.8)

0.458

  1. SD = standard deviation, CI = confidence interval, ZA = zoledronic acid, LBP = low back pain.
  2. *ANCOVA: Difference between follow-up and baseline, treatment effect adjusted for baseline value.
  3. aOne subject missing at baseline in placebo group and in ZA group, and one subject at 1 month in ZA group.