Table 1 Serum cytokine levels in control mice and arthritic AIA mice
Cytokine | Control mice, day 14 | AIA mice, day 14 | ||
|---|---|---|---|---|
|  | Wild-type (n = 15) | Transgenic (n = 14) | Wild-type (n = 17) | Transgenic (n = 17) |
TNF-α (pg/ml) | 36 (36–408) | 36 (36–36) | 409 (36–476) | 36 (36–341) |
IL-1α (pg/ml) | 67 (58–71) | 5 (5–64) | 89 (54–97) | 44 (5–66)# |
IL-1β (pg/ml) | 558 (46–1,050) | 46 (46–1,097) | 574 (46–1,397) | 46 (46–431) |
IL-6 (pg/ml) | 6 (6–6) | 6 (6–6) | 6 (6–6) | 6 (6–6) |
IL-10 (pg/ml) | 50 (5–111) | 5 (5–61) | 72 (46–107) | 50 (5–64) |
IL-12 (p40) (pg/ml) | 175 (114–222) | 131 (114–183) | 193 (147–272) | 152 (130–224) |
IL-12 (p70) (pg/ml) | 149 (13–202) | 108 (13–149) | 162 (123–236) | 108 (13–130)# |
IL-13 (pg/ml) | 45 (45–964) | 45 (45–523) | 852 (361–1470) | 45 (45–45)# |
M-CSF (pg/ml) | 204 (119–593) | 548 (158–612) | 295 (115–481) | 488 (146–608) |
G-CSF (pg/ml) | 121 (13–257) | 59 (13–140) | 165 (13–216) | 105 (13–189) |
Cytokine | Control mice, day 28 | AIA mice, day 28 | ||
|  | Wild-type (n = 8) | Transgenic (n = 9) | Wild-type (n = 7) | Transgenic (n = 6) |
TNF-α (pg/ml) | 1,361 (903–2310) | 1,255 (655–1468) | 1,255 (655–1468) | 1,577 (848–1685) |
IL-1α (pg/ml) | 9 (9–9) | 9 (9–9) | 9 (9–9) | 9 (9–9) |
IL-1β (pg/ml) | 14 (14–144) | 14 (14–14) | 14 (14–979) | 517 (14–1073) |
IL-6 (pg/ml) | 6 (6–6) | 6 (6–6) | 6 (6–6) | 6 (6–6) |
IL-10 (pg/ml) | 56 (49–68) | 44 (44–54) | 49 (40–54) | 68 (35–130) |
IL-12 (p40) (pg/ml) | 98 (90–136) | 70 (56–103) | 110 (81–147) | 83 (72–90) |
IL-12 (p70) (pg/ml) | 8 (8–8) | 8 (8–8) | 8 (8–8) | 86 (8–105) §, # |
IL-13 (pg/ml) | 101 (8–253) | 8 (8–8) | 160 (113–254) | 254 (66–1374) § |
M-CSF (pg/ml) | 95 (85–103) | 106 (81–112) | 86 (79–120) | 88 (77–470) |
G-CSF (pg/ml) | 12 (12–12) | 12 (12–12) | 12 (12–12) | 12 (12–12) |