TOTAL HIP REPLACEMENT STUDIES | N | Measure | Pooled effect size | Confidence Interval | P-value | I2(%) | Ï„2 |
---|---|---|---|---|---|---|---|
(A + B) Any wound infiltration analgesia + usual anaesthesia vs Usual anaesthesia |  |  |  | ||||
  Pain at rest at 24 h | 12 | SMD | -0.605 | ( -1.051, -0.160) | 0.0078 | 89 | 0.541 |
  Pain during activity at 24 h | 9 | SMD | -0.848 | ( -1.450, -0.246) | 0.0058 | 92 | 0.765 |
  Pain at rest at 48 h | 11 | SMD | -0.285 | ( -0.520, -0.050) | 0.018 | 58 | 0.09 |
  Pain during activity at 48 h | 8 | SMD | -0.432 | ( -0.776, -0.089) | 0.014 | 71 | 0.171 |
  Length of hospital stay | 9 | MD | -0.829 | ( -1.540, -0.118) | 0.022 | 84 | 0.866 |
(A) Wound infiltration analgesia + usual analgesia vs Usual anaesthesia |  |  |  | ||||
  Pain at rest 24 h post-op | 7 | SMD | -0.633 | ( -1.208, -0.059) | 0.031 | 90 | 0.529 |
  Pain during activity 24 h post-op | 4 | SMD | -0.241 | ( -0.637, 0.155) | 0.23 | 68 | 0.11 |
  Pain at rest 48 h post-op | 6 | SMD | -0.134 | ( -0.348, 0.080) | 0.22 | 19 | 0.014 |
  Pain during activity 48 h post-op | 3 | SMD | -0.225 | ( -0.559, 0.109) | 0.19 | 35 | 0.03 |
  Length of Hospital Stay | 5 | MD | -0.257 | ( -0.622, 0.108) | 0.17 | 14 | 0.029 |
(B) Wound infiltration analgesia + post closure analgesia + usual anaesthesia vs Usual anaesthesia |  |  | |||||
  Pain at rest 24 h post-op | 5 | SMD | -0.572 | ( -1.383, 0.240) | 0.17 | 90 | 0.767 |
  Pain during activity 24 h post-op | 5 | SMD | -1.378 | ( -2.499, -0.257) | 0.016 | 94 | 1.525 |
  Pain at rest 48 h post-op | 5 | SMD | -0.489 | ( -0.963, -0.015) | 0.043 | 73 | 0.209 |
  Pain during activity 48 h post-op | 5 | SMD | -0.599 | ( -1.158, -0.040) | 0.036 | 80 | 0.319 |
  Length of Hospital Stay | 4 | MD | -1.117 | ( -2.474, 0.239) | 0.11 | 88 | 1.621 |
TOTAL KNEE REPLACEMENT STUDIES | N | Measure | Pooled effect size | Confidence Interval | P-value | I2 (%) | Ï„2 |
(A + B) Any wound infiltration analgesia + usual anaesthesia vs Usual anaesthesia |  |  |  | ||||
  Pain at rest at 24 h | 12 | SMD | -0.398 | ( -0.576, -0.219) | p < 0.001 | 32 | 0.032 |
  Pain during activity at 24 h | 12 | SMD | -0.453 | ( -0.671, -0.235) | p < 0.001 | 54 | 0.078 |
  Pain at rest at 48 h | 12 | SMD | -0.325 | ( -0.546, -0.103) | 0.0041 | 56 | 0.084 |
  Pain during activity at 48 h | 11 | SMD | -0.273 | ( -0.500, -0.046) | 0.018 | 56 | 0.081 |
  Length of hospital stay | 8 | MD | -0.866 | ( -1.622, -0.109) | 0.025 | 77 | 0.805 |
(A) Wound infiltration analgesia with no additional post closure analgesia + usual anaesthesia vs Usual anaesthesia | |||||||
  Pain at rest 24 h post-op | 6 | SMD | -0.248 | ( -0.452, -0.044) | 0.017 | 14 | 0.009 |
  Pain during activity 24 h post-op | 6 | SMD | -0.283 | ( -0.470, -0.096) | 0.0031 | 0 | 0 |
  Pain at rest 48 h post-op | 6 | SMD | -0.155 | ( -0.458, 0.148) | 0.32 | 61 | 0.086 |
  Pain during activity 48 h post-op | 6 | SMD | -0.077 | ( -0.263, 0.110) | 0.42 | 0 | 0 |
  Length of Hospital Stay | 1 | MD | 0.092 | ( -0.890, 1.073) | 0.85 | 100 | p < 0.001 |
(B) Wound infiltration analgesia + post wound closure analgesia + usual anaesthesia vs Usual anaesthesia |  | ||||||
  Pain at rest 24 h post-op | 6 | SMD | -0.587 | ( -0.829, -0.346) | p < 0.001 | 9 | 0.008 |
  Pain during activity 24 h post-op | 6 | SMD | -0.693 | ( -1.152, -0.234) | 0.0031 | 74 | 0.24 |
  Pain at rest 48 h post-op | 6 | SMD | -0.52 | ( -0.778, -0.262) | p < 0.001 | 21 | 0.022 |
  Pain during activity 48 h post-op | 5 | SMD | -0.594 | ( -0.997, -0.191) | 0.0039 | 61 | 0.128 |
  Length of Hospital Stay | 7 | MD | -1.023 | ( -1.822, -0.224) | 0.012 | 76 | 0.761 |
(C) Wound infiltration analgesia + post wound closure analgesia + usual anaesthesia vs Femoral nerve block + usual anaesthesia | |||||||
  Pain at rest 24 h post-op | 3 | SMD | 0.253 | ( -0.514, 1.021) | 0.52 | 81 | 0.37 |
  Pain during activity 24 h post-op | 3 | SMD | 0 | ( -0.317, 0.317) | 1 | 0 | 0 |
  Pain at rest 48 h post-op | 2 | SMD | 0.254 | ( -0.429, 0.937) | 0.47 | 67 | 0.166 |
  Pain during activity 48 h post-op | 2 | SMD | -0.073 | ( -0.446, 0.299) | 0.7 | 0 | 0 |
  Length of Hospital Stay | 2 | MD | 0.07 | ( -0.838, 0.978) | 0.88 | 0 | 0 |
(D) Wound infiltration analgesia + Femoral nerve block + usual analgesia vs Femoral nerve block + usual anaesthesia | |||||||
  Pain at rest 24 h post-op | 3 | SMD | -0.241 | ( -0.604, 0.122) | 0.19 | 44 | 0.046 |
  Pain during activity 24 h post-op | 0 |  |  |  |  |  |  |
  Pain at rest 48 h post-op | 1 | SMD | -0.18 | ( -0.571, 0.211) | 0.37 | 100 | 0 |
  Pain during activity 48 h post-op | 1 | SMD | 0.094 | ( -0.296, 0.485) | 0.64 | 100 | 0 |
  Length of Hospital Stay | 1 | MD | 1.52 | ( 0.054, 2.986) | 0.042 | 100 | 0 |
(E) Wound infiltration analgesia + usual anaesthesia vs Femoral nerve block + usual anaesthesia |  |  | |||||
  Pain at rest 24 h post-op | 3 | SMD | -0.076 | ( -0.632, 0.480) | 0.79 | 69 | 0.166 |
  Pain during activity 24 h post-op | 3 | SMD | 0.159 | ( -0.869, 1.187) | 0.76 | 90 | 0.741 |
  Pain at rest 48 h post-op | 2 | SMD | 0.056 | ( -0.300, 0.412) | 0.76 | 0 | 0 |
  Pain during activity 48 h post-op | 2 | SMD | -0.202 | ( -1.034, 0.631) | 0.63 | 75 | 0.275 |
  Length of Hospital Stay | 2 | MD | -0.069 | ( -0.634, 0.497) | 0.81 | 0 | 0 |