Variable | Baseline | Intermediate | Primary endpoint | Follow-up |
---|---|---|---|---|
 | T = 0 mths | T = 3 mths | T = 2 yrs | T = 5 yrs |
Baseline data | Â | Â | Â | Â |
  Age – yr | @ | n.a. | n.a. | n.a. |
  Female sex - no. (%) | @ | n.a. | n.a. | n.a. |
  Duration of knee symptoms - months | @ | n.a. | n.a. | n.a. |
  Height - cm | @ | n.a. | n.a. | n.a. |
  Body weight - kg | @ | n.a. | @ | @ |
  Self-efficacy scale | @ | n.a. | n.a. | n.a. |
Knee injury and Osteoarthritis Outcome Score (KOOS) | Â | Â | Â | Â |
  Pain – range: 0-100 | @ | @ | @ | @ |
  Symptoms - range: 0-100 | @ | @ | @ | @ |
  Function in daily living – range: 0-100 | @ | @ | @ | @ |
  Function in sport and recreation – range: 0-100 | @ | @ | @ | @ |
  Knee related Quality of life – range: 0-100 | @ | @ | @ | @ |
EQ-5D | Â | Â | Â | Â |
  Global disease descriptive system | @ | @ | @ | @ |
  VAS patient global assessment of disease status - 0-100 | @ | @ | @ | @ |
Short-Form-36 health survey - acute form | Â | Â | Â | Â |
  Physical component summary – range: 0-100 | @ | @ | @ | @ |
  Mental component summary – range: 0-100 | @ | @ | @ | @ |
Global Perceived Effect | Â | Â | Â | Â |
  7 step scale ranging from much worse to much better | n.a. | @ | @ | @ |
Standardized knee radiographic with SynaFlexer | Â | Â | Â | Â |
  JSW and presence of osteophytes | @ | n.a | n.a | @ |
Performance measures | Â | Â | Â | Â |
  Single leg hop test | @ | @ | @ | n.a. |
  Knee-bending test | @ | @ | @ | n.a. |
  Isometric knee extensor strength | @ | @ | @ | n.a. |