Table 2 Prescription medications use in patients with a tibia shaft fracture by nonunion status
Prescription Medications | All tibia fractures (N = 853) | With Nonunion (N = 99) | Without Nonunion (N = 754) | P values |
|---|---|---|---|---|
Any Pain Medication | ||||
Patients on therapy, n (%) | 795 (93.2%) | 98 (99.0%) | 697 (92.4%) | 0.009† |
· Average therapy duration, months (SD) | N/A | N/A | N/A | X |
Strong Opioids | ||||
· Patients on therapy, n (%) | 665 (78.0%) | 89 (89.9%) | 576 (76.4%) | 0.002† |
· Average therapy duration, months (SD) | 3.2 (5.5) | 5.4 (6.8) | 2.8 (5.2) | < 0.001‡ |
Prescription NSAIDs | ||||
· Patients on therapy, n (%) | 301 (35.3%) | 47 (47.5%) | 254 (33.7%) | 0.007† |
· Average therapy duration, months (SD) | 3.6 (4.9) | 4.3 (6.0) | 3.5 (4.7) | 0.67‡ |
Weak Opiods | ||||
· Patients on therapy, n (%) | 247 (29.0%) | 34 (34.3%) | 213 (28.2%) | 0.21† |
· Average therapy duration, months (SD) | 2 (3.5) | 2.2 (3.5) | 2.0 (3.5) | 0.13‡ |
Benzodiazepines | ||||
· Patients on therapy, n (%) | 235 (27.5%) | 36 (36.4%) | 199 (26.4%) | 0.037† |
· Average therapy duration, months (SD) | 7.2 (7.6) | 7.4 (8.5) | 7.1 (7.4) | 0.68‡ |
Antidepressants: SSRI | ||||
· Patients on therapy, n (%) | 220 (25.8%) | 30 (30.3%) | 190 (25.2%) | 0.28† |
· Average therapy duration, months (SD) | 11.6 (7.2) | 8.1 (6.6) | 12.1 (7.1) | 0.003‡ |
Corticosteroids | ||||
· Patients on therapy, n (%) | 201 (23.6%) | 27 (27.3%) | 174 (23.1%) | 0.36† |
· Average therapy duration, months (SD) | 1.9 (4.1) | 2.3 (4.4) | 1.9 (4.1) | 0.21‡ |
Non-Benzodiazepines Sedative/Hypnotics | ||||
· Patients on therapy, n (%) | 197 (23.1%) | 29 (29.3%) | 168 (22.3%) | 0.12† |
· Average therapy duration, months (SD) | 4.4 (5.7) | 3.8 (3.9) | 4.5 (6) | |
Muscle Relaxants | ||||
· Patients on therapy, n (%) | 174 (20.4%) | 25 (25.3%) | 149 (19.8%) | 0.2† |
· Average therapy duration, months (SD) | 3.9 (6) | 5.0 (6.5) | 3.7 (6.0) | 0.061‡ |
Inject Corticosteroid | ||||
· Patients on therapy, n (%) | 168 (19.7%) | 28 (28.3%) | 140 (18.6%) | 0.022† |
· Average therapy duration, months (SD) | 0.1 (0.1) | 0.1 (0.1) | 0.1 (0.1) | 0.75‡ |
Anticonvulsant/Antiepileptic | ||||
· Patients on therapy, n (%) | 128 (15.0%) | 23 (23.2%) | 105 (13.9%) | 0.015† |
· Average therapy duration, months (SD) | 8.3 (7.1) | 9.1 (7.6) | 8.1 (7.0) | 0.59‡ |
Antidepressants: Other | ||||
· Patients on therapy, n (%) | 92 (10.8%) | 13 (13.1%) | 79 (10.5%) | 0.42† |
· Average therapy duration, months (SD) | 9.7 (8.0) | 8.4 (7.7) | 10.0 (8.1) | 0.76‡ |
Antidepressants: SNRI | ||||
· Patients on therapy, n (%) | 77 (9.0%) | 19 (19.2%) | 58 (7.7%) | < 0.001† |
· Average therapy duration, months (SD) | 10 (7.3) | 12.0 (7.8) | 9.3 (7.0) | 0.22‡ |
Antidepressants: TCAs | ||||
· Patients on therapy, n (%) | 71 (8.3%) | 11 (11.1%) | 60 (8.0%) | 0.29† |
· Average therapy duration, months (SD) | 8.5 (7.7) | 8.4 (9.1) | 8.5 (7.5) | 0.6‡ |
COX-2 Inhibitors | ||||
· Patients on therapy, n (%) | 62 (7.3%) | 10 (10.1%) | 52 (6.9%) | 0.25† |
· Average therapy duration, months (SD) | 7.2 (7.2) | 6.7 (8.0) | 7.3 (7.2) | 0.6‡ |
Analgesics/Antipyretics, NEC | ||||
· Patients on therapy, n (%) | 13 (1.5%) | 1 (1.0%) | 12 (1.6%) | 1.0† |
· Average therapy duration, months (SD) | 1.3 (2.7) | 2 (MISS) | 1.3 (2.8) | 0.28‡ |