| No incident hyperuricemia | Incident hyperuricemia |
---|---|---|
Baseline risk factors | n = 7,908 | n = 304 |
Male sex | 37 | 49** |
Age, years | 53.8 (6) | 54.3 (5) |
African American race | 18 | 33** |
High school education or higher | 83 | 73** |
Pre-menopause a,b | 35 | 37 |
Smoking status a | Â | Â |
Current smoker | 22 | 27 |
Former smoker | 31 | 28 |
Never smoker | 47 | 45 |
Diuretic use | 12 | 19** |
Hypertension | 24 | 44** |
Total cholesterol, mmol/L | 6 (1) | 6 (1) |
HDL cholesterol a | Â | Â |
< 1.03Â mmol/L | 20 | 26* |
1.03 ≤  HDL ≤  1.55 | 48 | 50 |
> 1.55 | 32 | 24 |
Diabetes | 8 | 11* |
Coronary heart disease | 3 | 6* |
Congestive heart failure | 2 | 5* |
BMI, kg/m 2a | Â | Â |
BMI ≥  35 | 6 | 14** |
30 ≤  BMI < 35 | 15 | 23 |
25 ≤  BMI < 30 | 39 | 45 |
BMI < 25 | 40 | 18 |
Early adult obesity | 3 | 7** |
Weight change from early adult, lb | 25 (26) | 32 (30)** |
Waist-to-hip ratio, quartiles a | Â | Â |
Waist-to-hip ratio ≥  0.97 | 23 | 38** |
0.92 ≤  Waist-to-hip ratio < 0.97 | 25 | 28 |
0.86 ≤ Waist -to-hip ratio < 0.92 | 26 | 22 |
0.86 ≤  Waist-to-hip ratio | 26 | 12 |
Categorical alcohol intake, grams/week a | Â | Â |
Abstain | 61 | 63* |
0–100 | 27 | 24 |
>100 | 12 | 13 |
Animal fat, grams/day | 35 (17) | 37 (18)* |
Animal protein, grams/day | 53 (23) | 53 (22) |
eGFR, ml/min/1.73Â m 2a | Â | Â |
<60 | 1 | 4** |
60–90 | 39 | 40 |
≥ 90 | 60 | 56 |
Baseline serum urate level, mg/dL | 5.3 (1.0) | 6.1 (0.78)** |
Serum urate level at 3Â year follow-up, mg/dL | 5.5 (1.2) | 7.0 (1.3)** |
3-year change in serum urate level, mg/dL | 0.2 (0.9) | 0.9 (1.3)** |