Figure 4

Histopathologic feature of quadriceps femoris in NADH-TR and ATPase staining. NADH-TR and ATPase staining in a naive animal (A-1 and B-1) and a CIA animal (A-2 and B-2). In NADH-TR stain, a clear difference in stainability between muscle fibers reflecting the classification into type I and type II muscle fibers was observed in the naive animal; however, a difference in stain ability was not shown and irregularity in the size of muscle fibers was observed in the CIA animal. ATPase staining in CIA animal showed that the atrophic changes in the type II muscle fibers were more significant than those in the type I muscle fibers.