Effect of leisure time physical activity on severe knee or hip osteoarthritis leading to total joint replacement: a population-based prospective cohort study

Table 2 Incidence of knee replacement/high tibial osteotomy (TKR) due to osteoarthritis in relation to leisure time physical activity

Physical activity leisure, baseline	Cases, n	RR (95% CI)*	P, trend	RR (95% CI)†	P, trend	RR (95% CI) ‡	P, trend
TKR
*All*
Low (n = 6934)	104	1.0	0.398	1.0	0.898	1.0	0.087
Low-moderate (n = 6949)	122	1.15 (0.88, 1.49)		1.13 (0.87, 1.47)		1.31 (1.00, 1.70)
Moderate-high (n = 6973)	124	1.16 (0.89, 1.51)		1.13 (0.87, 1.46)		1.36 (1.04, 1.77)
High (n = 6957)	117	1.13 (0.86, 1.47)		1.03 (0.79, 1.34)		1.27 (0.97, 1.66)
*Men*
Low (n = 2777)	34	1.0	0.046	1.0	0.390	1.0	0.163
Low-moderate (n = 2639)	36	1.09 (0.68, 1.74)		1.03 (0.64, 1.64)		1.08 (0.68, 1.73)
Moderate-high (n = 2604)	48	1.47 (0.95, 2.29)		1.31 (0.84, 2.03)		1.44 (0.93, 2.25)
High (n = 2925)	51	1.44 (0.94, 2.22)		1.15 (0.74, 1.77)		1.28 (0.83, 1.99)
*Women*
Low (n = 4157)	70	1.0	0.648	1.0	0.548	1.0	0.349
Low-moderate (n = 4310)	86	1.17 (0.85, 1.60)		1.18 (0.86, 1.62)		1.42 (1.03, 1.96)
Moderate-high (n = 4369)	76	1.02 (0.73, 1.41)		1.03 (0.74, 1.43)		1.29 (0.93, 1.79)
High (n = 4032)	66	0.97 (0.69, 1.36)		0.94 (0.67, 1.32)		1.22 (0.87, 1.72)

Incidence of knee replacement, or high tibial osteotomy, due to osteoarthritis during a mean follow-up of 11 years, in relation to leisure time physical activity at baseline (low (Q1), low–moderate (Q2), moderate–high (Q3), and high physical activity (Q4)).
*crude, † adjusted for age, gender, ‡ adjusted for age, gender (for all subjects only), BMI, education, smoking, marital status.

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