Figure 2

Remodelled bone graft. Inside the chamber, almost the entire graft has been revascularized at harvest with a fibrous tissue penetrating deepest into the graft and with the zone of new-forming bone (arrows) and resorbing osteoclasts lagging behind. Behind this layer of new-forming bone and close to the ingrowth openings, the new-formed bone as well as remnants of the graft is resorbed and replaced by a fatty bone marrow in the saline treated samples (a). In the zoledronic acid treated grafts this marrow still consists of non-resorbed bone and both graft bone and newly formed bone are retained (b). Hematoxyllin/Eosin x 4.