Table 1 Histological analysis of L-6r mAb treated and control (Kh-5) treated mdx and bl/10 mice
From: IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse
| Â | Regenerating fibers (n) | Diameter (um) | Central nucleated fibers (%) Gas | Central nucleated fibers (%) Dia | Inflamation score |
|---|---|---|---|---|---|
Kh5-mdx | 5.6 ± 1.2 | 34.1 ± 1.0 | 72.8 ± 2.6 | 32.8 ± 1.9 | 14.9 ± 3.4 |
IL6rab-mdx | 9.6 ± 1.7 | 31.7 ± 1.6 | 64.5 ± 6.9 | 29.3 ± 1.4 | 26.2 ± 3.1 |
kh5-bI/10 | 0.4 ± 0.1 | 38.2 ± 1.1 | 2.2 ± 0.5 | 1.8 ± 0.3 | 1.4 ± 1.2 |
IL6Ab-bl/10 | 0.2 ± 0.1 | 40.1 ± 0.8 | 1.5 + 0.5 | 0.9 ± 0.1 | 3.1 ± 1.1 |