Figure 3

Effect of statin exposure on primary Schwann cell and cortical neuron cultures. A) Statin treatment of Schwann cells for 24 h did not result in significant toxicity except for very high concentrations of fluvastatin and simvastatin (500 μM). Three different statins are shown: fluvastatin, solid line; simvastatin, long dash; pravastatin, short dash. B) Statin treatment of cortical neurons for 24 h did not result in significant toxicity. Three different statins are shown: fluvastatin, solid line; lovastatin, long dash; pravastatin, short dash. Data are shown normalized to vehicle control, error bars indicate standard deviation from the mean.