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Table 5 SF-36 component scores throughout the study (mean ± sd) (ES: effect sizes)

From: Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study

 

baseline

week 12

week 24

P

PF (physical function)

27.2 ± 18.4

29.2 ± 16.5

36.0 ± 21.4**

= 0.0079

ES

 

-0.11

-0.48

 

RP (role physical)

2.56 ± 12.6

8.33 ± 25.2

11.54 ± 28.0*

= 0.0657

ES

 

-0.46

-0.71

 

BP (bodily pain)

10.9 ± 14.4

18.2 ± 17.9*

24.2 ± 20.6***

<0.0001

ES

 

-0.51

-0.92

 

GH (global health)

26.3 ± 17.9

28.4 ± 18.5

29.6 ± 17.4

= 0.4321

ES

 

-0.12

-0.18

 

VT (vitality)

13.6 ± 13.4

18.7 ± 19.4

19.9 ± 18.6*

= 0.0301

ES

 

-0.38

-0.47

 

SF (social function)

35.6 ± 27.4

41.0 ± 28.5

42.2 ± 29.9

= 0.2150

ES

 

-0.20

-0.26

 

RE (role emotional)

19.7 ± 32.2

24.8 ± 38.8

29.1 ± 39.9

= 0.3293

ES

 

-0.16

-0.29

 

MH (mental health)

31.5 ± 21.5

38.1 ± 21.3

42.8 ± 24.6**

= 0.0023

ES

 

-0.31

-0.53

 
  1. *: p < 0.05, **: p < 0.01 and ***: p < 0.001 in relation to baseline (Dunnett's post-test). Bold: large effect sizes.