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Table 2 Effect of CsA on the bone mineral density.

From: Effects of cyclosporin-a on rat skeletal biomechanical properties

 

BMD (g/cm2)

BMC (g)

Area (cm2)

Lumbar Vertebra

   

   Baseline (n = 8)

0.237 ± 0.018

0.502 ± 0.073

2.124 ± 0.287

   Control (n = 12)

0.259 ± 0.026

0.609 ± 0.107

2.343 ± 0.297

   1.5 mg CsA (n = 11)

0.204 ± 0.030**

0.473 ± 0.091**

2.325 ± 0.260

   7.5 mg CsA (n = 9)

0.201 ± 0.015**

0.462 ± 0.073 **

2.291 ± 0.462

Proximal Femur

   

   Baseline (n = 8)

0.245 ± 0.038

0.126 ± 0.022

0.513 ± 0.028

   Control (n = 12)

0.258 ± 0.046

0.139 ± 0.029

0.536 ± 0.029

   1.5 mg CsA (n = 11)

0.181 ± 0.036*

0.099 ± 0.017**

0.542 ± 0.037

   7.5 mg CsA (n = 9)

0.171 ± 0.039**

0.092 ± 0.025**

0.530 ± 0.027

Middle Femur

   

   Baseline (n = 8)

0.298 ± 0.075

0.228 ± 0.058

0.762 ± 0.021

   Control (n = 12)

0.323 ± 0.068

0.258 ± 0.052

0.794 ± 0.058

   1.5 mg CsA (n = 11)

0.311 ± 0.066

0.241 ± 0.058

0.771 ± 0.052

   7.5 mg CsA (n = 9)

0.317 ± 0.058

0.243 ± 0.045

0.767 ± 0.065

  1. Data are expressed as means ± SD. Compared with the control group, p < 0.05 *, p < 0.01 **.
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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