Author Country Year Setting Referral [Reference] | Mean age (years) Women % | Exclusion criteria | Diagnosis of FMS | Total study population Screened/randomized N (%) Total/Completing therapy N(%) | Treatment group Total/Completing therapy N(%) | Control group Total/Completing therapy N (%) | Outcomes used for metaanalysis |
---|---|---|---|---|---|---|---|
Alvarez 2007 Mexico University Hospital Rheumatology clinics [23] | 44 yrs 100% women 100% Mexican mez-stizos | No other significant painful or chronic comorbidities | ACR | 50/43 (86) 43/11 (26) | 20/7 * (35) | 23/4* (17) | Pain VAS 0-100 * Fatigue NA Sleep NA Depressed mood NA HRQOL: FIQ total * No follow- up |
Castel 2009 Spain University Hospital Pain clinic [24] | 44 yrs 95% women 100% white | Other severe chronic pain condition; severe psychopathology; moderate cognitive impairment;pending litigation | ACR 18-60 years At least 6 years education | NR/47 35/32 (91) | 17/16 (94) | 18/16 (89) | Pain NRS 0-10 Fatigue NA Sleep NA Depressed mood NA HRQOL FIQ total No follow-up |
Grøndhal 2008 Norway General practice General practices [25] | 23-54 yrs 75% women 100% white | Organic diseases Severe psychiatric disorder | Clinical diagnosis of chronic widespread pain | 18/16 (89) 16/12 (75) | 8/7 (88) | 8/5 (63) | Pain NRS 1-7* (a) Fatigue NRS 1-7 * (a) Sleep NA Depressed mood NRS 1-7 * (a) HRQOL NA 1 year without control |
Haanen 1991 Netherlands Rheumatology department regional hospital NR [26] | 45 yrs 95% women NR | Organic diseases | Smythe Normal blood test | NP 40/37 (93) | 20/17 (85) | 20/20 (100) | Pain VAS 0-10 ** Sleep VAS 0-10 ** Fatigue VAS 0-10 *** Depressed mood NA HRQOL NA 12 weeks |
Menziers 2006 USA University hospital Physicians and clinics [27] | 50 yrs 98% women 90% white | Inflammatory rheumatic disease Major communicative disorder | Clinical diagnosis Age > 18 FIQ-Total > 20 MMSE score > 25 | NP 48/NP | 24/NR | 24/NR | Pain VAS 0-10 Fatigue: NA Sleep NA Depressed mood NA HRQOL FIQ total 4 weeks |
Rucco 1995 Italy Regional hospital [28] | 38 yrs 100% women NR | Analgesic medication Major psychiatric disorder | ACR criteria Normal blood tests | NP 53/35 (66) | 26/24 (92) | 27/11 (41) | Pain VAS 0-10 Fatigue NA Sleep VAS 0-10 Depressed mood NA HRQOL NA No follow up |