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Figure 3 | BMC Musculoskeletal Disorders

Figure 3

From: Silencing Dkk1 expression rescues dexamethasone-induced suppression of primary human osteoblast differentiation

Figure 3

A reduction in β-catenin expression during dexamethasone treatment results in a reduction in Wnt/β-catenin signaling through TCF/LEF mediated transcription. Primary human osteoblasts were transiently transfected with pBAR (wild type promoter) and pfuBAR (mutant promoter), and exposed them to 10-8 M dexamethasone over a 48 h time course. Significant reductions in luciferase activity were identified at 24 h and 48 h after treatment in the pBAR cells, whilst luciferase activity in the pfuBAR cells remained unchanged. **p < 0.01, ***p < 0.001 versus pfuBAR.

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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