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Osteoarthritis - from basic and translational approaches to clinical practice

Guest Editor: Professor Ali Mobasheri (University of Surrey, UK)

Osteoarthritis (OA) is the most common form of arthritis and is characterised by damage or breakdown of articular cartilage in load-bearing joints, particularly in the knees, hips and hands. The disorder is one of the leading causes of disability worldwide and results in pain, stiffness, joint deformity and loss of joint mobility, which often develop slowly over time. There are a number of risk factors associated with OA, including age, obesity, metabolic disease, previous joint injury, abnormal joint loading and biomechanics, genetics and systemic inflammation. However, OA predominantly affects older people, often co-existing with other comorbid conditions associated with aging.

Read the published content in this thematic series covering all aspects of research into osteoarthritis from studies investigating the underlying pathophysiological mechanisms through to those describing clinical practice.