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  1. Low back pain (LBP), with high incidence and prevalence rate, is one of the most common reasons to consult the health system and is responsible for a significant amount of sick leave, leading to high health an...

    Authors: Anna Berenguera, Enriqueta Pujol-Ribera, Teresa Rodriguez-Blanco, Concepció Violan, Marc Casajuana, Nelleke de Kort and Marta Trapero-Bertran
    Citation: BMC Musculoskeletal Disorders 2011 12:194
  2. Although back complaints are common among older people, limited information is available in the literature about the clinical course of back pain in older people and the identification of older persons at risk...

    Authors: Jantine Scheele, Pim AJ Luijsterburg, Manuela L Ferreira, Chris G Maher, Leani Pereira, Wilco C Peul, Maurits W van Tulder, Arthur M Bohnen, Marjolein Y Berger, Sita MA Bierma-Zeinstra and Bart W Koes
    Citation: BMC Musculoskeletal Disorders 2011 12:193
  3. Impingement can be a serious complication after total hip arthroplasty (THA), and is one of the major causes of postoperative pain, dislocation, aseptic loosening, and implant breakage. Minimally invasive THA ...

    Authors: Tobias Renkawitz, Martin Haimerl, Lars Dohmen, Sabine Gneiting, Melanie Wegner, Nicole Ehret, Claudia Buchele, Mario Schubert, Philipp Lechler, Michael Woerner, Ernst Sendtner, Tibor Schuster, Kurt Ulm, Robert Springorum and Joachim Grifka
    Citation: BMC Musculoskeletal Disorders 2011 12:192
  4. Objectively assessed physical performance is a strong predictor for morbidity and premature death and there is an increasing interest in the role of sarcopenia in many chronic diseases. There is a need for rob...

    Authors: Lillemor A Nyberg, Mai-Lis Hellénius, Jan Kowalski, Per Wändell, Peter Andersson and Carl Johan Sundberg
    Citation: BMC Musculoskeletal Disorders 2011 12:191
  5. To compare data based on touch screen to data based on traditional paper versions of questionnaires frequently used to examine patient reported outcomes in knee osteoarthritis patients and to examine the impac...

    Authors: Henrik Gudbergsen, Else M Bartels, Peter Krusager, Eva E Wæhrens, Robin Christensen, Bente Danneskiold-Samsøe and Henning Bliddal
    Citation: BMC Musculoskeletal Disorders 2011 12:190
  6. Data on the clinical outcome after spinal fusion in the elderly patient are rare. To our knowledge there has been no clinical outcome assessment for instrumented spinal fusion in elderly patients comparing pos...

    Authors: Stefan Endres, Rene Aigner and Axel Wilke
    Citation: BMC Musculoskeletal Disorders 2011 12:189
  7. Shoulder problems are a common complaint of the musculoskeletal system. Physical therapists treat these patients with different modalities such as exercise, massage, and shoulder taping. Although different tec...

    Authors: Joeri Kalter, Adri T Apeldoorn, Raymond W Ostelo, Nicholas Henschke, Dirk L Knol and Maurits W van Tulder
    Citation: BMC Musculoskeletal Disorders 2011 12:188
  8. Osteoporosis is a major health problem worldwide, and is included in the WHO list of the top 10 major diseases. However, it is often undiagnosed until the first fracture occurs, due to inadequate patient educa...

    Authors: Leila Kolios, Caner Takur, Arash Moghaddam, Mirjam Hitzler, Heinrich Schmidt-Gayk, Arnold J Suda, Bernd Höner, Paul A Grützner and Christoph Wölfl
    Citation: BMC Musculoskeletal Disorders 2011 12:187
  9. Periprosthetic osteolysis is a major cause of aseptic loosening in joint arthroplasty. This study investigates the impact of CT (calcitonin) deficiency and CT substitution under in-vivo circumstances on partic...

    Authors: Max D Kauther, Hagen S Bachmann, Laura Neuerburg, Martina Broecker-Preuss, Gero Hilken, Florian Grabellus, Gabriele Koehler, Marius von Knoch and Christian Wedemeyer
    Citation: BMC Musculoskeletal Disorders 2011 12:186
  10. Skeletal muscle atrophy is a serious concern for the rehabilitation of patients afflicted by prolonged limb restriction. This debilitating condition is associated with a marked activation of NFκB activity. The...

    Authors: Annabelle Z Caron, Sonia Haroun, Élisabeth Leblanc, Frédéric Trensz, Chantal Guindi, Aziz Amrani and Guillaume Grenier
    Citation: BMC Musculoskeletal Disorders 2011 12:185
  11. Stiffness with decreased range of motion (ROM) has been described as a frustrating complication after TKA. If all methods of physiotherapeutic treatment have been exhausted trying to develop ROM, manipulation ...

    Authors: Ingmar Ipach, Falk Mittag, Julia Lahrmann, Beate Kunze and Torsten Kluba
    Citation: BMC Musculoskeletal Disorders 2011 12:184
  12. Modic changes (MCs) have been identified as a diagnostic subgroup associated with low back pain (LBP). The aetiology of MCs is still unknown and there is no effective treatment available. If MCs constitute a s...

    Authors: Rikke K Jensen and Charlotte Leboeuf-Yde
    Citation: BMC Musculoskeletal Disorders 2011 12:183
  13. The trapezius muscle is a neck muscle that is susceptible to chronic pain conditions associated with repetitive tasks, commonly referred to as chronic work-related myalgia, hence making the trapezius a muscle ...

    Authors: Jenny Hadrévi, Fredrik Hellström, Thomas Kieselbach, Christer Malm and Fatima Pedrosa-Domellöf
    Citation: BMC Musculoskeletal Disorders 2011 12:181
  14. The established treatment for bacterial arthritis of the knee joint is arthroscopic surgery with irrigation and debridement. The aim of this article is to summarize the relevant data in treating bacterial arth...

    Authors: Atesch Ateschrang, Dirk Albrecht, Steffen Schröter, Bernhard Hirt, Kuno Weise and Jürgen H Dolderer
    Citation: BMC Musculoskeletal Disorders 2011 12:180
  15. Chronic low back pain is a highly prevalent condition, which is associated with high direct and indirect costs to the society. Although this condition is highly prevalent, it is still extremely difficult to tr...

    Authors: Alessandra N Garcia, Francine LB Gondo, Renata A Costa, Fábio N Cyrillo, Tatiane M Silva, Luciola CM Costa and Leonardo OP Costa
    Citation: BMC Musculoskeletal Disorders 2011 12:179
  16. A study to evaluate the adherence to and appropriateness of anti-osteoporotic treatments in a cohort of men and women aged 50 and over participating in the ESOSVAL-R study.

    Authors: Gabriel Sanfélix-Gimeno, José Sanfélix-Genovés, Salvador Peiró, Isabel Hurtado, José Luis Trillo, Ruth Usó, Vicente Giner Ruiz, Manuel Pascual de la Torre and Inmaculada Ferreros
    Citation: BMC Musculoskeletal Disorders 2011 12:178
  17. Osteoarthritis (OA) is a prevalent chronic disease and a leading cause of disability in adults. For people with knee and hip OA, symptoms (e.g., pain and fatigue) can interfere with mobility and physical activ...

    Authors: Susan L Murphy, Angela K Lyden, Maria Clary, Michael E Geisser, Raymond L Yung, Daniel J Clauw and David A Williams
    Citation: BMC Musculoskeletal Disorders 2011 12:177
  18. Neck pain is related to impaired postural balance among patients and is highly prevalent among workers with high postural demands, for example, cleaners. We therefore hypothesised, that cleaners with neck pain...

    Authors: Marie B Jørgensen, Jørgen H Skotte, Andreas Holtermann, Gisela Sjøgaard, Nicolas C Petersen and Karen Søgaard
    Citation: BMC Musculoskeletal Disorders 2011 12:176
  19. Beside symptoms and clinical signs radiological findings are crucial in the diagnosis of lumbar spinal stenosis (LSS). We investigate which quantitative radiological signs are described in the literature and w...

    Authors: Johann Steurer, Simon Roner, Ralph Gnannt and Juerg Hodler
    Citation: BMC Musculoskeletal Disorders 2011 12:175
  20. Hypersensitivity of the central nervous system is widely present in pain patients and recognized as one of the determinants of chronic pain and disability. Electronic pressure algometry is often used to explor...

    Authors: Niklaus Egloff, Nicole Klingler, Roland von Känel, Rafael JA Cámara, Michele Curatolo, Barbara Wegmann, Elizabeth Marti and Marie-Louise Gander Ferrari
    Citation: BMC Musculoskeletal Disorders 2011 12:174
  21. In the light of both the importance and large numbers of case series and cohort studies (observational studies) in orthopaedic literature, it is remarkable that there is currently no validated measurement tool...

    Authors: Bart G Pijls, Olaf M Dekkers, Saskia Middeldorp, Edward R Valstar, Huub JL van der Heide, Henrica MJ Van der Linden-Van der Zwaag and Rob GHH Nelissen
    Citation: BMC Musculoskeletal Disorders 2011 12:173
  22. The expectations of patients for managing pain induced by exercise and mobilization (PIEM) have seldom been investigated. We identified the views of patients and care providers regarding pain management induce...

    Authors: Sophie Alami, Dominique Desjeux, Marie Martine Lefèvre-Colau, Anne Sophie Boisgard, Eric Boccard, François Rannou and Serge Poiraudeau
    Citation: BMC Musculoskeletal Disorders 2011 12:172
  23. There is a need for outcome measurement instruments for evaluation of disability after trauma. The Patient-Rated Wrist Evaluation (PRWE) is a self-administered region-specific outcome measuring instrument deve...

    Authors: Cecilia Mellstrand Navarro, Sari Ponzer, Hans Törnkvist, Leif Ahrengart and Gunnar Bergström
    Citation: BMC Musculoskeletal Disorders 2011 12:171
  24. While there is growing evidence for the efficacy of SM to treat LBP, little is known on the mechanisms and physiologic effects of these treatments. Accordingly, the purpose of this study was to determine wheth...

    Authors: Brian C Clark, David A Goss Jr, Stevan Walkowski, Richard L Hoffman, Andrew Ross and James S Thomas
    Citation: BMC Musculoskeletal Disorders 2011 12:170
  25. Many adults experience bothersome neck/shoulder pain. While research and treatment strategies often focus on the upper trapezius, other neck/shoulder muscles may be affected as well. The aim of the present stu...

    Authors: Lars L Andersen, Klaus Hansen, Ole S Mortensen and Mette K Zebis
    Citation: BMC Musculoskeletal Disorders 2011 12:169
  26. Assessment of shoulder mobility is essential for clinical follow-up of shoulder treatment. Only a few high sophisticated instruments for objective measurements of shoulder mobility are available. The interobse...

    Authors: Bilal Farouk El-Zayat, Turgay Efe, Annett Heidrich, Udo Wolf, Nina Timmesfeld, Thomas J Heyse, Stefan Lakemeier, Susanne Fuchs-Winkelmann and Markus D Schofer
    Citation: BMC Musculoskeletal Disorders 2011 12:168
  27. Monitoring osteoporosis therapy by measurement of bone turnover markers (BTMs) might detect non-compliance in an earlier stage of anti-osteoporosis treatment and improve persistence.

    Authors: Danielle A Eekman, Irene EM Bultink, Annemieke C Heijboer, Ben AC Dijkmans and Willem F Lems
    Citation: BMC Musculoskeletal Disorders 2011 12:167
  28. To determine safe surgical margins for soft tissue sarcoma, it is essential to perform a general evaluation of the extent of tumor, responses to auxiliary therapy, and other factors preoperatively using multip...

    Authors: Masahiro Yokouchi, Mikio Terahara, Satoshi Nagano, Yoshiya Arishima, Michihisa Zemmyo, Takako Yoshioka, Akihide Tanimoto and Setsuro Komiya
    Citation: BMC Musculoskeletal Disorders 2011 12:166
  29. Clinical analgesic trials typically report response as group mean results. However, research has shown that few patients are average and most have responses at the extremes. Moreover, group mean results do not...

    Authors: Paul M Peloso, Arnold Gammaitoni, Steven S Smugar, Hongwei Wang and Andrew R Moore
    Citation: BMC Musculoskeletal Disorders 2011 12:165
  30. Tenascin-C (TN-C) is an extracellular matrix glycoprotein that is involved in tissue injury and repair processes. We analyzed TN-C expression in normal and osteoarthritic (OA) human cartilage, and evaluated it...

    Authors: Lisha Patel, Weiyong Sun, Sonya S Glasson, Elisabeth A Morris, Carl R Flannery and Priya S Chockalingam
    Citation: BMC Musculoskeletal Disorders 2011 12:164
  31. BMP-2 is known to accelerate fracture healing and might also enhance osseointegration and implant fixation. Application of recombinant BMP-2 has a time-limited effect. Therefore, a gene transfer approach with ...

    Authors: Benjamin Faensen, Britt Wildemann, Christian Hain, Julius Höhne, Yvonne Funke, Christan Plank, Axel Stemberger and Gerhard Schmidmaier
    Citation: BMC Musculoskeletal Disorders 2011 12:163
  32. Increased center of pressure excursions are well documented in patients suffering from non-specific low back pain, whereby the altered postural sway includes both higher mean sway velocities and larger sway ar...

    Authors: Alexander Ruhe, René Fejer and Bruce Walker
    Citation: BMC Musculoskeletal Disorders 2011 12:162
  33. Despite the large volume of research dedicated to understanding chronic low back pain (CLBP), patient outcomes remain modest while healthcare costs continue to rise, creating a major public health burden. Heal...

    Authors: Andrew M Briggs, Joanne E Jordan, Peter B O'Sullivan, Rachelle Buchbinder, Angus F Burnett, Richard H Osborne and Leon M Straker
    Citation: BMC Musculoskeletal Disorders 2011 12:161
  34. The pathogenesis of osteonecrosis of the femoral head (ONFH) has been implicated in hypofibrinolysis and blood supply interruption. Previous studies have demonstrated that decreased fibrinolytic activity due t...

    Authors: Hye- Ok Kim, Chang- Hoon Cho, Yoon- Je Cho, Seong- Ho Cho, Kyung- Sik Yoon and Kang- Il Kim
    Citation: BMC Musculoskeletal Disorders 2011 12:160
  35. Authors: Wayne Hoskins, Henry Pollard, Chris Daff, Andrew Odell, Peter Garbutt, Andrew McHardy, Kate Hardy and George Dragasevic
    Citation: BMC Musculoskeletal Disorders 2011 12:159

    The original article was published in BMC Musculoskeletal Disorders 2010 11:241

  36. Authors: Wayne Hoskins, Henry Pollard, Chris Daff, Andrew Odell, Peter Garbutt, Andrew McHardy, Kate Hardy and George Dragasevic
    Citation: BMC Musculoskeletal Disorders 2011 12:158

    The original article was published in BMC Musculoskeletal Disorders 2009 10:38

  37. Musculoskeletal diseases are becoming increasingly important due to population aging. However, studies on the economic burden of musculoskeletal disease in Korea are scarce. Therefore, we conducted a populatio...

    Authors: In-Hwan Oh, Seok-Jun Yoon, Hye-Young Seo, Eun-Jung Kim and Young Ae Kim
    Citation: BMC Musculoskeletal Disorders 2011 12:157
  38. There is limited evidence for the clinical and cost effectiveness of occupational therapy (OT) approaches in the management of hand osteoarthritis (OA). Joint protection and hand exercises have been proposed b...

    Authors: Krysia S Dziedzic, Susan Hill, Elaine Nicholls, Alison Hammond, Helen Myers, Tracy Whitehurst, Jo Bailey, Charlotte Clements, David GT Whitehurst, Sue Jowett, June Handy, Rhian W Hughes, Elaine Thomas and Elaine M Hay
    Citation: BMC Musculoskeletal Disorders 2011 12:156
  39. Even though technological progress has provided us with more and more sophisticated equipment for making goniometric measurements, the most commonly used clinical tools are still the universal goniometer and, ...

    Authors: Pablo Herrero, Patricia Carrera, Elena García, Eva M Gómez-Trullén and Bárbara Oliván-Blázquez
    Citation: BMC Musculoskeletal Disorders 2011 12:155
  40. Subacromial disorders are considered to be one of the most common pathologies affecting the shoulder. Optimal therapy for shoulder pain (SP) in primary care is yet unknown, since clinical history and physical ...

    Authors: Ramon PG Ottenheijm, Manuela A Joore, Geert HIM Walenkamp, René E Weijers, Bjorn Winkens, Jochen WL Cals, Rob A de Bie and Geert-Jan Dinant
    Citation: BMC Musculoskeletal Disorders 2011 12:154
  41. Canakinumab is a fully human anti-interleukin IL-1beta monoclonal antibody, being investigated for the treatment of rheumatoid arthritis (RA). This multicenter, phase II, randomized, double-blind, placebo-cont...

    Authors: Rieke Alten, Juan Gomez-Reino, Patrick Durez, Andre Beaulieu, Anthony Sebba, Gerhard Krammer, Ralph Preiss, Udayasankar Arulmani, Albert Widmer, Xavier Gitton and Herbert Kellner
    Citation: BMC Musculoskeletal Disorders 2011 12:153
  42. Brief intervention programs are clinically beneficial, and cost efficient treatments for low back pain, when offered at 8-12 weeks, compared with treatment as usual. However, about 30% of the patients do not r...

    Authors: Silje E Reme, Torill H Tveito, Trudie Chalder, Tormod Bjørkkjær, Aage Indahl, Jens I Brox, Egil Fors, Eli M Hagen and Hege R Eriksen
    Citation: BMC Musculoskeletal Disorders 2011 12:152
  43. Posttraumatic osteoarthritis can develop after an intra-articular extremity fracture, leading to pain and loss of function. According to international guidelines, anatomical reduction and fixation are the basi...

    Authors: M Suzan H Beerekamp, Dirk Th Ubbink, Mario Maas, Jan SK Luitse, Peter Kloen, Taco JM Blokhuis, Michiel JM Segers, Meir Marmor, Niels WL Schep, Marcel GW Dijkgraaf and J Carel Goslings
    Citation: BMC Musculoskeletal Disorders 2011 12:151
  44. Regulation of cell death and cell division are key processes during chondrogenesis and in cartilage homeostasis and pathology. The oncogene survivin is considered to be critical for the coordination of mitosis...

    Authors: Philipp Lechler, Sanjeevi Balakrishnan, Jens Schaumburger, Susanne Grässel, Clemens Baier, Joachim Grifka, Rainer H Straub and Tobias Renkawitz
    Citation: BMC Musculoskeletal Disorders 2011 12:150
  45. A high quality decision requires that patients who meet clinical criteria for surgery are informed about the options (including non-surgical alternatives) and receive treatments that match their goals. The aim...

    Authors: Karen R Sepucha, Dawn Stacey, Catharine F Clay, Yuchiao Chang, Carol Cosenza, Geoffrey Dervin, Janet Dorrwachter, Sandra Feibelmann, Jeffrey N Katz, Stephen A Kearing, Henrik Malchau, Monica Taljaard, Ivan Tomek, Peter Tugwell and Carrie A Levin
    Citation: BMC Musculoskeletal Disorders 2011 12:149
  46. Ankle fractures are common. Management of ankle fractures generally involves a period of immobilisation followed by rehabilitation to reduce pain, stiffness, weakness and swelling. The effects of a rehabilitat...

    Authors: Paula R Beckenkamp, C Christine Lin, Robert D Herbert, Marion Haas, Kriti Khera and Anne M Moseley
    Citation: BMC Musculoskeletal Disorders 2011 12:148
  47. The present study was conducted to address whether the intervertebral disc of rabbit could be considered (i) as a valuable model to provide new insights into the tissue and cellular changes of Nucleus pulposus...

    Authors: Johann Clouet, Marianne Pot-Vaucel, Gaël Grimandi, Martial Masson, Julie Lesoeur, Borhane H Fellah, Olivier Gauthier, Marion Fusellier, Yan Cherel, Yves Maugars, Jérôme Guicheux and Claire Vinatier
    Citation: BMC Musculoskeletal Disorders 2011 12:147
  48. One of the sources of knee pain in osteoarthritis (OA) is believed to be related to local chronic inflammation of the knee joints, which involves the production of inflammatory cytokines such as tumor necrosis...

    Authors: Sumihisa Orita, Takana Koshi, Takeshi Mitsuka, Masayuki Miyagi, Gen Inoue, Gen Arai, Tetsuhiro Ishikawa, Eiji Hanaoka, Keishi Yamashita, Masaomi Yamashita, Yawara Eguchi, Tomoaki Toyone, Kazuhisa Takahashi and Seiji Ohtori
    Citation: BMC Musculoskeletal Disorders 2011 12:144

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