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  1. Fibroblast proliferation is a common manifestation of chronic inflammatory diseases, including rheumatoid arthritis (RA), Crohn’s disease and ulcerative colitis, etc. To alleviate patient suffering, the mechan...

    Authors: Zheng-de Xi, Chang-yi Xie and Ye-bin Xi
    Citation: BMC Musculoskeletal Disorders 2016 17:43
  2. The purpose of this study was to determine the relationships among hip geometry, bone mineral density, and the risk of hip fracture in premenopausal women.

    Authors: Dong-Hwa Lee, Kyong Yeun Jung, A Ram Hong, Jung Hee Kim, Kyoung Min Kim, Chan Soo Shin, Seong Yeon Kim and Sang Wan Kim
    Citation: BMC Musculoskeletal Disorders 2016 17:42
  3. Multiple-ligament injured knee (MLIK) is a rare but severe injury. Although the principles of MLIK management have progressed over the past 40 years, there is a paucity of high-quality evidence upon which to b...

    Authors: Xingyi Hua, Hui Tao, Wang Fang and Jian Tang
    Citation: BMC Musculoskeletal Disorders 2016 17:41
  4. Previous studies have provided the initial evidence for construct validity and test-retest reliability of the Mayo Hip Score. Instruments used for Total Hip Arthroplasty (THA) outcomes assessment should be val...

    Authors: Jasvinder A. Singh, Cathy Schleck, W. Scott Harmsen and David G. Lewallen
    Citation: BMC Musculoskeletal Disorders 2016 17:39
  5. Developmental dysplasia of the hip (DDH) is the most common orthopaedic disorder in newborns. Despite this considerable variation in practice exists. The aim of this study was to determine the clinical relevan...

    Authors: Daniel Williams, Evangelia Protopapa, Kuldeep Stohr, James B. Hunter and Andreas Roposch
    Citation: BMC Musculoskeletal Disorders 2016 17:38
  6. Although most patients achieve favorable results following bipolar hip hemiarthroplasty (BHA), some experience rapid migration of the prosthesis. We retrospectively reviewed 18 patients with BHA that necessita...

    Authors: Takao Setoguchi, Hirotaka Kawakami, Yasuhiro Ishidou, Hideki Kawamura, Junichiro Nishi, Takako Yoshioka, Hironori Kakoi, Satoshi Nagano, Masahiro Yokouchi, Akihide Tanimoto and Setsuro Komiya
    Citation: BMC Musculoskeletal Disorders 2016 17:37
  7. It is well recognised that low back pain is a significant public health problem and engagement in moderate levels of physical activity is associated with positive outcomes.

    Authors: Anita B. Amorim, Evangelos Pappas, Milena Simic, Manuela L. Ferreira, Anne Tiedemann, Matthew Jennings and Paulo H. Ferreira
    Citation: BMC Musculoskeletal Disorders 2016 17:36
  8. It is usually assumed that musculoskeletal pain is associated with both the physical workload and the psychosocial work environment, as well as with personal and lifestyle factors. This study aims to ascertain...

    Authors: Inger Arvidsson, Jenny Gremark Simonsen, Camilla Dahlqvist, Anna Axmon, Björn Karlson, Jonas Björk and Catarina Nordander
    Citation: BMC Musculoskeletal Disorders 2016 17:35
  9. Expression of the growth factor osteoactivin (OA) increases during tissue degeneration and regeneration, fracture repair and after denervation-induced disuse atrophy, concomitant with increased matrix metallop...

    Authors: Nagat Frara, Samir M. Abdelmagid, Michael Tytell, Mamta Amin, Steven N. Popoff, Fayez F. Safadi and Mary F. Barbe
    Citation: BMC Musculoskeletal Disorders 2016 17:34
  10. Little is known on how well targeted treatment, for instance targeting towards low DAS, is implemented in clinical practice. Our aim was to evaluate treatment adjustments in response to DAS in RA patients in c...

    Authors: Emilia Gvozdenović, Ron Wolterbeek, Désirée van der Heijde, Tom Huizinga, Cornelia Allaart and Robert Landewé
    Citation: BMC Musculoskeletal Disorders 2016 17:33
  11. The association between low levels of vitamin D and the occurrence of chronic widespread pain (CWP) remains unclear. The aim of our analysis was to determine the relationship between low vitamin D levels and t...

    Authors: Paul S. McCabe, Stephen R. Pye, John Mc Beth, David M. Lee, Abdelouahid Tajar, Gyorgy Bartfai, Steven Boonen, Roger Bouillon, Felipe Casanueva, Joseph D. Finn, Gianni Forti, Aleksander Giwercman, Ilpo T. Huhtaniemi, Krzysztof Kula, Neil Pendleton, Margus Punab…
    Citation: BMC Musculoskeletal Disorders 2016 17:32
  12. Plantar fasciopathy is a common cause of foot pain, accounting for 11 to 15 % of all foot symptoms requiring professional care in adults. Although many patients have complete resolution of symptoms within 12 m...

    Authors: N. Rasenberg, L. Fuit, E. Poppe, A. J. A. Kruijsen-Terpstra, K. J. Gorter, M. S. Rathleff, P. L. J. van Veldhoven, P. J. Bindels, S. M. Bierma-Zeinstra and M. van Middelkoop
    Citation: BMC Musculoskeletal Disorders 2016 17:31
  13. Our study was performed to evaluate the image quality of 3 T MR wrist arthrograms with attention to ulnar wrist structures, comparing image quality of isotropic 3D proton density fat suppressed turbo spin echo...

    Authors: John K. Sutherland, Taiki Nozaki, Yasuhito Kaneko, Hon J. Yu, Gregory Rafijah, David Hitt and Hiroshi Yoshioka
    Citation: BMC Musculoskeletal Disorders 2016 17:30
  14. Fibromyalgia (FM) is a pain syndrome, the mechanisms and predictors of which are still unclear. We have earlier validated a set of FM-symptom questions for detecting possible FM in an epidemiological survey an...

    Authors: Ritva A. Markkula, Eija A. Kalso and Jaakko A. Kaprio
    Citation: BMC Musculoskeletal Disorders 2016 17:29
  15. The need for revision surgery after a spinal surgery can cause a variety of problems, including reduced quality of life for the patient, additional medical expenses, and patient-physician conflicts. The purpos...

    Authors: Tsung-Ting Tsai, Sheng-Hsun Lee, Chi-Chien Niu, Po-Liang Lai, Lih-Huei Chen and Wen-Jer Chen
    Citation: BMC Musculoskeletal Disorders 2016 17:28
  16. The aim of this study was to design a new minimally invasive percutaneous lag screw guide apparatus and to verify its adjuvant treatment of acetabular anterior column fracture on pelvis specimens.

    Authors: Li-hai Zhang, Li-cheng Zhang, Qing-hua Si, Yuan Gao, Xiu-yun Su, Zhe Zhao and Pei-fu Tang
    Citation: BMC Musculoskeletal Disorders 2016 17:27
  17. A lumbar disc herniation (LDH) is a localised displacement of disc material, which may initiate changes in the disc and adjacent structures such as the nerve root and the spinal canal. Knowledge about how morp...

    Authors: Per Kjaer, Andreas Tunset, Eleanor Boyle and Tue Secher Jensen
    Citation: BMC Musculoskeletal Disorders 2016 17:26
  18. Change in knee cartilage volume is frequently used as a proxy for change in knee joint space width over time, but longitudinal data on these associations is limited. We aimed to determine whether change in kne...

    Authors: Joanna Hall, Laura L. Laslett, Johanne Martel-Pelletier, Jean-Pierre Pelletier, François Abram, Chang-Hai Ding, Flavia M. Cicuttini and Graeme Jones
    Citation: BMC Musculoskeletal Disorders 2016 17:25
  19. Previous studies suggest that a greater proportion of neck injury patients, whose injuries were sustained through whiplash accidents, become chronic due to a component of sickness-focusing. However, it is also...

    Authors: Tom Bendix, Jakob Kjellberg, Rikke Ibsen and Poul Jørgen Jennum
    Citation: BMC Musculoskeletal Disorders 2016 17:24
  20. Lumbar stabilization exercises have gained popularity and credibility in patients with non-acute low back pain. Previous research provides more support to strength/resistance and coordination/stabilisation pro...

    Authors: Jean-Alexandre Boucher, Richard Preuss, Sharon M. Henry, Jean-Pierre Dumas and Christian Larivière
    Citation: BMC Musculoskeletal Disorders 2016 17:23
  21. People with rheumatoid arthritis (RA) have an increased risk of falls. The foot is a common site of pathology in RA and foot problems are reported in up to 90 % of patients with established disease. The aim of...

    Authors: Angela Brenton-Rule, Nicola Dalbeth, Hylton B. Menz, Sandra Bassett and Keith Rome
    Citation: BMC Musculoskeletal Disorders 2016 17:22
  22. Anterior cruciate ligament (ACL) tear is considered a risk factor for osteoarthritis development. The purpose of our study was to investigate the expression levels of the apoptotic enzyme caspase 3, pro-inflam...

    Authors: Ioanna Papathanasiou, Sotirios Michalitsis, Michael E. Hantes, Marianna Vlychou, Lydia Anastasopoulou, Konstantinos N. Malizos and Aspasia Tsezou
    Citation: BMC Musculoskeletal Disorders 2016 17:21
  23. Range of motion is the most frequently reported measure used in practice to evaluate outcomes. A goniometer is the most reliable tool to assess range of motion yet, the lack of consistency in reporting prevent...

    Authors: Anna L. Pratt and Catherine Ball
    Citation: BMC Musculoskeletal Disorders 2016 17:20
  24. The last decades have for patients with inflammatory rheumatic diseases seen a shift towards more physically active rehabilitation programs, often provided as out-patients with less use of inpatient facilities...

    Authors: Till Uhlig, Olav Bjørneboe, Frode Krøll, Øyvind Palm, Inge Christoffer Olsen and Margreth Grotle
    Citation: BMC Musculoskeletal Disorders 2016 17:18
  25. Trabecular bone score (TBS), which has been proposed to be used in complementary with bone mineral density (BMD) to improve the assessment of fracture risk, is negatively associated with body mass index (BMI)....

    Authors: Sasithorn Amnuaywattakorn, Chanika Sritara, Chirawat Utamakul, Wichana Chamroonrat, Arpakorn Kositwattanarerk, Kanungnij Thamnirat and Boonsong Ongphiphadhanakul
    Citation: BMC Musculoskeletal Disorders 2016 17:17
  26. Lower extremity tendinopathy is a common sports injury, but it can also affect non-athletes. Because tendinopathy is difficult to treat and has negative effects on the ability to work and quality of life, deve...

    Authors: Iris Sophie Albers, Johannes Zwerver, Ronald Leo Diercks, Janny Hendrika Dekker and Inge Van den Akker-Scheek
    Citation: BMC Musculoskeletal Disorders 2016 17:16
  27. The transforming growth factor beta-1 (TGFB1) gene was recently reported to be a new susceptible gene of adolescent idiopathic scoliosis (AIS) in Russian population. This study aimed to replicate the relations...

    Authors: Leilei Xu, Weixiang Sun, Xiaodong Qin, Yong Qiu and Zezhang Zhu
    Citation: BMC Musculoskeletal Disorders 2016 17:15
  28. Total joint replacements (TJRs) should be considered as one of few definite endpoints in osteoarthritis research. We analyzed factors associated with late-life prevalence and risk factors for incidence of TJRs...

    Authors: Helgi Jonsson, Sigurbjorg Olafsdottir, Solveig Sigurdardottir, Thor Aspelund, Gudny Eiriksdottir, Sigurdur Sigurdsson, Tamara B. Harris, Lenore Launer and Vilmundur Gudnason
    Citation: BMC Musculoskeletal Disorders 2016 17:14
  29. Lag screw position is very important in the treatment of intertrochanteric femoral fracture to prevent complications such as screw cut-out. Current studies recommend central or inferior placement of the lag sc...

    Authors: Mitsuru Munemoto, Akira Kido, Yoshihiro Sakamoto, Kazuya Inoue, Kazuyuki Yokoi, Yasushi Shinohara and Yasuhito Tanaka
    Citation: BMC Musculoskeletal Disorders 2016 17:13
  30. Recently percutaneous vertebroplasty (PVP) was frequently performed for treatment of osteoporotic vertebral fractures (VFs). It is widely accepted that new compression fractures tend to occur adjacent to the v...

    Authors: Kenji Takahara, Mikio Kamimura, Hideki Moriya, Ryohei Ashizawa, Tsuyoshi Koike, Yohei Hidai, Shota Ikegami, Yukio Nakamura and Hiroyuki Kato
    Citation: BMC Musculoskeletal Disorders 2016 17:12
  31. Cervical Disc Arthroplasty (CDA) seems to be an alternative to Anterior Cervical Decompression and Fusion (ACDF) and was developed to minimize the risk of Adjacent Segment Disease (ASD). The ROTAIO Cervical Di...

    Authors: J. Obernauer, J. Landscheidt, S. Hartmann, G. A. Schubert, C. Thomé and C. Lumenta
    Citation: BMC Musculoskeletal Disorders 2016 17:11
  32. There is abundant evidence that low socioeconomic status (SES) is associated with worse health outcomes among people with Rheumatoid Arthritis (RA); however, the influence of socioeconomic disadvantage in earl...

    Authors: Antoine R. Baldassari, Rebecca J. Cleveland, My-Linh N. Luong, Beth L. Jonas, Doyt L. Conn, Larry W. Moreland, S. Louis Bridges Jr and Leigh F. Callahan
    Citation: BMC Musculoskeletal Disorders 2016 17:10
  33. Selecting an interbody cage with appropriate height is one of the key steps in lumbar interbody fusion, and has an important impact on clinical efficacy. How to choose the appropriate height of the cage become...

    Authors: Hongli Wang, Wenjie Chen, Jianyuan Jiang, Feizhou Lu, Xiaosheng Ma and Xinlei Xia
    Citation: BMC Musculoskeletal Disorders 2016 17:9
  34. Internal fixation is one treatment for femoral neck fracture. Some devices and techniques reported improved accuracy and decreased fluoroscopic time. However, these are not widely used nowadays due to the lack...

    Authors: Varah Yuenyongviwat, Pakjai Tuntarattanapong and Boonsin Tangtrakulwanich
    Citation: BMC Musculoskeletal Disorders 2016 17:8
  35. Neck pain is one of the most common musculoskeletal disorders in clinical practice. However neck pain may mask more serious pathology. Although uncommon in most musculoskeletal physiotherapy practices, it is p...

    Authors: Firas Mourad, Giuseppe Giovannico, Filippo Maselli, Francesca Bonetti, César Fernández de las Peñas and James Dunning
    Citation: BMC Musculoskeletal Disorders 2016 17:7
  36. Randomized controlled trials and retrospective studies in ANCA-associated vasculitis (AAV) concurred that rituximab (RTX) is effective to induce and maintain remission. Infections and hypogammaglobulinemia dur...

    Authors: Emilio Besada
    Citation: BMC Musculoskeletal Disorders 2016 17:6
  37. Patellofemoral pain (PFP) is highly prevalent in runners, and often leads to functional limitations and cessation of running. Training errors as well as decreased lower limb strength and control during running...

    Authors: Jean-Francois Esculier, Laurent J. Bouyer, Blaise Dubois, Pierre Frémont, Lynne Moore and Jean-Sébastien Roy
    Citation: BMC Musculoskeletal Disorders 2016 17:5
  38. There is limited longitudinal data available on the natural history of meniscal tears especially in middle-aged adults with a low prevalence of osteoarthritis (OA). The aim of this study was to describe the na...

    Authors: Hussain Ijaz Khan, Dawn Aitken, Changhai Ding, Leigh Blizzard, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Flavia Cicuttini and Graeme Jones
    Citation: BMC Musculoskeletal Disorders 2016 17:4
  39. Although autogenous iliac bone graft (AIBG) remains the gold standard for spine fusion, harvesting morbidity has prompted the search for alternatives especially for multi-segment fusion. This study aimed to ev...

    Authors: Tsai-Sheng Fu, I-Chun Wang, Meng-Ling Lu, Ming-Kai Hsieh, Lih-Huei Chen and Wen-Jer Chen
    Citation: BMC Musculoskeletal Disorders 2016 17:3
  40. Primary Sjögren syndrome (pSS) is a common autoimmune condition which primarily affects epithelial tissue, often including the kidney causing either tubulointerstitial nephritis (TIN) or more rarely, an immune...

    Authors: Rhys D. R. Evans, Christopher M. Laing, Coziana Ciurtin and Stephen B. Walsh
    Citation: BMC Musculoskeletal Disorders 2016 17:2
  41. In addition to Bankart repair engaging Hill-Sachs defects in glenohumeral instability have been treated successfully with remplissage procedure. The purpose of this study was to compare three remplissage techn...

    Authors: Chung Hui James Tan, Tim Saier, Constantin von Deimling, Frank Martetschläger, Philipp Minzlaff, Matthias J. Feucht, Horazio Martinez, Sepp Braun, Andreas B. Imhoff and Rainer Burgkart
    Citation: BMC Musculoskeletal Disorders 2016 17:1
  42. Rheumatoid arthritis (RA) is a common chronic inflammatory disease causing joint damage, disability, and reduced life expectancy. Highly effective drugs are now available for the treatment of RA. However, poor...

    Authors: Kanta Kumar, Karim Raza, Peter Nightingale, Robert Horne, Sarah Chapman, Sheila Greenfield and Paramjit Gill
    Citation: BMC Musculoskeletal Disorders 2015 16:396
  43. Isolated fractures of the greater trochanter (GT) of the femur are uncommon and few studies have assessed the diagnosis and appropriate therapeutic schedule for these fractures. The current data regarding asse...

    Authors: Seung-Ju Kim, Joonghyun Ahn, Hyung Kook Kim and Jong Hun Kim
    Citation: BMC Musculoskeletal Disorders 2015 16:395
  44. In vivo assessment of inflammatory responses in the synovia of patients with MoM hip replacements would be useful in the determination of the prognosis of the hip replacement. Aims of the study was to investig...

    Authors: Aleksi Reito, Jyrki Parkkinen, Timo Puolakka, Jorma Pajamäki and Antti Eskelinen
    Citation: BMC Musculoskeletal Disorders 2015 16:393
  45. Accurate prevalence data are important when interpreting diagnostic tests and planning for the health needs of a population, yet no such data exist for axial spondyloarthritis (axSpA) in the UK. In this cross-...

    Authors: Louise Hamilton, Alex Macgregor, Andoni Toms, Victoria Warmington, Edward Pinch and Karl Gaffney
    Citation: BMC Musculoskeletal Disorders 2015 16:392
  46. The NKSS has recently been translated into Dutch version. The reliability and validity were also assessed. However, there is no Simplified Chinese version of New Society Knee Scoring System (SC-NKSS) for Chine...

    Authors: Denghui Liu, Xiaokang He, Wei Zheng, Yu Zhang, Dahe Li, Wei Wang, J. Li and Weidong Xu
    Citation: BMC Musculoskeletal Disorders 2015 16:391
  47. Although only 39 % of patients with wrist trauma have sustained a fracture, the majority of patients is routinely referred for radiography. The purpose of this study was to derive and externally validate a cli...

    Authors: Monique M. J. Walenkamp, Abdelali Bentohami, Annelie Slaar, M. Suzan H. Beerekamp, Mario Maas, L. Cara Jager, Nico L. Sosef, Romuald van Velde, Jan M. Ultee, Ewout W. Steyerberg, J. Carel Goslings and Niels W. L. Schep
    Citation: BMC Musculoskeletal Disorders 2015 16:389

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