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  1. Nitric oxide (NO) is a messenger implicated in the destruction and inflammation of joint tissues. Cartilage and synovial membrane from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) have high ...

    Authors: Berta Cillero-Pastor, Miguel A Martin, Joaquín Arenas, María J López-Armada and Francisco J Blanco

    Citation: BMC Musculoskeletal Disorders 2011 12:42

    Content type: Research article

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  2. The neutral zone (NZ) is the range over which a spinal motion segment (SMS) moves with minimal resistance. Clear as this may seem, the various methods to quantify NZ described in the literature depend on rathe...

    Authors: Theodoor H Smit, Manon SLM van Tunen, Albert J van der Veen, Idsart Kingma and Jaap H van Dieën

    Citation: BMC Musculoskeletal Disorders 2011 12:38

    Content type: Research article

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  3. Gender differences in the prevalence and occupational consequences of musculoskeletal disorders (MSDs) are consistently found in epidemiological studies. The study investigated whether gender differences also ...

    Authors: Sturla Gjesdal, Espen Bratberg and John G Mæland

    Citation: BMC Musculoskeletal Disorders 2011 12:37

    Content type: Research article

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  4. The purpose of our study was to evaluate the clinical value of hybrid SPECT/CT for the assessment of patients with painful total knee arthroplasty (TKA).

    Authors: Michael T Hirschmann, Praveen Konala, Farhad Iranpour, Anna Kerner, Helmut Rasch and Niklaus F Friederich

    Citation: BMC Musculoskeletal Disorders 2011 12:36

    Content type: Research article

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  5. Many (artificial) bone substitute materials are currently available for use in orthopaedic trauma surgery. Objective data on their biological and biomechanical characteristics, which determine their clinical a...

    Authors: Esther MM Van Lieshout, Gerdine H Van Kralingen, Youssef El-Massoudi, Harrie Weinans and Peter Patka

    Citation: BMC Musculoskeletal Disorders 2011 12:34

    Content type: Research article

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  6. Pedicle screws with PMMA cement augmentation have been shown to significantly improve the fixation strength in a severely osteoporotic spine. However, the efficacy of screw fixation for different cement augmen...

    Authors: Lih-Huei Chen, Ching-Lung Tai, De-Mei Lee, Po-Liang Lai, Yen-Chen Lee, Chi-Chien Niu and Wen-Jer Chen

    Citation: BMC Musculoskeletal Disorders 2011 12:33

    Content type: Research article

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  7. Total hip replacement is considered the best option for treatment of displaced intracapsular fractures of the femoral neck (FFN). The size of the femoral head is an important factor that influences the outcome...

    Authors: Giuseppe Solarino, Andrea Piazzolla, Claudio M Mori, Lorenzo Moretti, Silvio Patella and Angela Notarnicola

    Citation: BMC Musculoskeletal Disorders 2011 12:32

    Content type: Research article

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  8. Bone grafts are required to repair large bone defects after tumour resection or large trauma. The availability of patients' own bone tissue that can be used for these procedures is limited. Thus far bone tissu...

    Authors: Eric Farrell, Sanne K Both, Kathrin I Odörfer, Wendy Koevoet, Nicole Kops, Fergal J O'Brien, Robert J Baatenburg de Jong, Jan A Verhaar, Vincent Cuijpers, John Jansen, Reinhold G Erben and Gerjo JVM van Osch

    Citation: BMC Musculoskeletal Disorders 2011 12:31

    Content type: Research article

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  9. Age-related bone loss is asymptomatic, and the morbidity of osteoporosis is secondary to the fractures that occur. Common sites of fracture include the spine, hip, forearm and proximal humerus. Fractures at th...

    Authors: Rafael Azagra, Genís Roca, Gloria Encabo, Daniel Prieto, Amada Aguyé, Marta Zwart, Sílvia Güell, Núria Puchol, Emili Gene, Enrique Casado, Pilar Sancho, Sílvia Solà, Pere Torán, Milagros Iglesias, Victòria Sabaté, Francesc López-Expósito…

    Citation: BMC Musculoskeletal Disorders 2011 12:30

    Content type: Study protocol

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  10. Back pain is one of the UK's costliest and least understood health problems, whose prevalence still seems to be increasing. Educational interventions for general practitioners on back pain appear to have had l...

    Authors: Alan C Breen, Eloise Carr, Jennifer E Langworthy, Clive Osmond and Louise Worswick

    Citation: BMC Musculoskeletal Disorders 2011 12:28

    Content type: Research article

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  11. Control of skeletal muscle mass and force production is a complex physiological process involving numerous regulatory systems. Agents that increase skeletal muscle cAMP levels have been shown to modulate skele...

    Authors: Deborah L Reichart, Richard T Hinkle, Frank R Lefever, Elizabeth T Dolan, Jeffrey A Dietrich, David R Sibley and Robert J Isfort

    Citation: BMC Musculoskeletal Disorders 2011 12:27

    Content type: Research article

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  12. Tenocytes have been implicated in the development of tendinosis, a chronic condition commonly seen in musculoskeletal overuse syndromes. However, the relation between abnormal tenocyte morphology and early cha...

    Authors: Thomas Abraham, Gloria Fong and Alex Scott

    Citation: BMC Musculoskeletal Disorders 2011 12:26

    Content type: Research article

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  13. Subacromial impingement syndrome is a frequently observed disorder in orthopedic practice. Lasting symptoms and impairment may occur when a subsequent atraumatic rotator cuff rupture is also present. However, ...

    Authors: Frederik O Lambers Heerspink, Roy AG Hoogeslag, Ron L Diercks, Pepijn JM van Eerden, Inge van den Akker-Scheek and Jos JAM van Raay

    Citation: BMC Musculoskeletal Disorders 2011 12:25

    Content type: Study protocol

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  14. Physiotherapy and occupational therapy are two professions at high risk of work related musculoskeletal disorders (WRMD). This investigation aimed to identify risk factors for WRMD as perceived by the health p...

    Authors: Leanne Passier and Steven McPhail

    Citation: BMC Musculoskeletal Disorders 2011 12:24

    Content type: Research article

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  15. Low back pain (LBP) is common among office workers and is the most common cause of work-related disability in people under 45 years of age. The aetiology of LBP is widely accepted to be multi-factorial. Progno...

    Authors: Prawit Janwantanakul, Praneet Pensri, Patriya Moolkay and Wiroj Jiamjarasrangsi

    Citation: BMC Musculoskeletal Disorders 2011 12:23

    Content type: Research article

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  16. Heparin-induced thrombocytopenia (HIT) is a thromboembolic complication that can occur with unfractionated heparin (UFH) or low molecular weight heparin (LMWH). Our objective was to determine and compare the i...

    Authors: Satoru Motokawa, Takafumi Torigoshi, Yumi Maeda, Kazushige Maeda, Yuka Jiuchi, Takayuki Yamaguchi, Shinsuke Someya, Hiroyuki Shindo and Kiyoshi Migita

    Citation: BMC Musculoskeletal Disorders 2011 12:22

    Content type: Research article

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  17. There is a paucity of information describing patients with musculoskeletal disorders (MSDs) using complementary and alternative medicines (CAMs) and almost none distinguishing homeopathy from other CAMs. The o...

    Authors: Michel Rossignol, Bernard Bégaud, Bernard Avouac, France Lert, Frédéric Rouillon, Jacques Bénichou, Jacques Massol, Gérard Duru, Anne-Marie Magnier, Didier Guillemot, Lamiae Grimaldi-Bensouda and Lucien Abenhaim

    Citation: BMC Musculoskeletal Disorders 2011 12:21

    Content type: Research article

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  18. Different conditions may alter tendon characteristics. Clinical evidence suggests that tendon injuries are more frequent in athletes that change type, intensity and duration of training. Aim of the study was t...

    Authors: Antonio Frizziero, Milena Fini, Francesca Salamanna, Arsenio Veicsteinas, Nicola Maffulli and Marina Marini

    Citation: BMC Musculoskeletal Disorders 2011 12:20

    Content type: Research article

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  19. A number of recent reports published in the UK have put the quality of care of adults with Rheumatoid Arthritis (RA) centre stage. These documents set high standards for health care professionals and commissio...

    Authors: Louise C Pollard, Helen Graves, David L Scott, Gabrielle H Kingsley and Heidi Lempp

    Citation: BMC Musculoskeletal Disorders 2011 12:19

    Content type: Research article

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  20. There is growing evidence that adiponectin, a physiologically active polypeptide secreted by adipocytes, controls not only adipose tissue but also bone metabolism. However, a role for adiponectin in bone devel...

    Authors: Yasuhiro Mitsui, Masafumi Gotoh, Nobuhiro Fukushima, Isao shirachi, Shuichi Otabe, Xiaohong Yuan, Toshihiko Hashinaga, Nobuhiko Wada, Akiko Mitsui, Tatsuhiro Yoshida, Shiro Yoshida, Kentaro Yamada and Kensei Nagata

    Citation: BMC Musculoskeletal Disorders 2011 12:18

    Content type: Research article

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  21. There is emerging evidence for a beneficial effect of meat consumption on the musculoskeletal system. However, whether it affects the risk of knee and hip osteoarthritis is unknown. We performed a prospective ...

    Authors: Yuanyuan Wang, Julie Anne Simpson, Anita E Wluka, Dallas R English, Graham G Giles, Stephen Graves and Flavia M Cicuttini

    Citation: BMC Musculoskeletal Disorders 2011 12:17

    Content type: Research article

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  22. Navigation was introduced into total knee arthroplasty (TKA) to improve accuracy of component position, function and survival of implants. This study was designed to assess the outcome of navigated TKA in comp...

    Authors: Jan Schmitt, Carsten Hauk, Heino Kienapfel, Michael Pfeiffer, Turgay Efe, Susanne Fuchs-Winkelmann and Thomas J Heyse

    Citation: BMC Musculoskeletal Disorders 2011 12:16

    Content type: Research article

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  23. Muscle weakness is associated with a variety of chronic disorders such as emphysema (EMP) and congestive heart failure (CHF) as well as aging. Therapies to treat muscle weakness associated with chronic disease...

    Authors: Richard T Hinkle, Frank R Lefever, Elizabeth T Dolan, Deborah L Reichart, Janice M Zwolshen, Timothy P Oneill, Kris G Maloney, John P Mattson, Leonardo F Ferreira, Timothy I Musch, David C Poole and Robert J Isfort

    Citation: BMC Musculoskeletal Disorders 2011 12:15

    Content type: Research article

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  24. Neck and shoulder complaints are common among employees in sedentary occupations characterized by intensive computer use. Such musculoskeletal pain - which is often associated with restricted range of motion a...

    Authors: Christoffer H Andersen, Lars L Andersen, Ole S Mortensen, Mette K Zebis and Gisela Sjøgaard

    Citation: BMC Musculoskeletal Disorders 2011 12:14

    Content type: Study protocol

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  25. As many patients with rheumatoid arthritis (RA) have increased fat mass (FM) and increased frequency of cardiovascular diseases we evaluated if total physical activity (MET-hours) had impact on body compositio...

    Authors: Ann-Charlotte Elkan, Niclas Håkansson, Johan Frostegård and Ingiäld Hafström

    Citation: BMC Musculoskeletal Disorders 2011 12:13

    Content type: Research article

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  26. This study in patients with rheumatoid arthritis (RA) treated with infliximab describes prospectively the course of (anti)infliximab levels within an infusioncycle to assess at what moment patients develop low...

    Authors: Bart JF van den Bemt, Alfons A den Broeder, GJ Wolbink, Yechiel A Hekster, Piet LCM van Riel, Bart Benraad and Frank HJ van den Hoogen

    Citation: BMC Musculoskeletal Disorders 2011 12:12

    Content type: Research article

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  27. Substantial progress has been made in the medical management of rheumatoid arthritis (RA) over the past decade with the introduction of biologic therapies, including anti-tumour necrosis factor alpha (anti-TNF...

    Authors: Angela Reid, Audrey Brady, Catherine Blake, Anne-Barbara Mongey, Douglas J Veale, Oliver FitzGerald and Tara Cusack

    Citation: BMC Musculoskeletal Disorders 2011 12:11

    Content type: Study protocol

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  28. A two-stage revision arthroplasty was suggested optimal treatment for deep infections in hip joint. The effect of endoskeleton of cement spacers on the interim function and infection control remains unclear.

    Authors: Kuo-Ti Peng, Liang-Tseng Kuo, Wei-Hsiu Hsu, Tsan-Wen Huang and Yao-Hung Tsai

    Citation: BMC Musculoskeletal Disorders 2011 12:10

    Content type: Research article

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  29. Distal radius fracture is a common injury and may result in substantial dysfunction and pain. The purpose was to investigate the relationship between distal radius fracture malunion and arm-related disability.

    Authors: Elisabeth Brogren, Manfred Hofer, Michael Petranek, Philippe Wagner, Lars B Dahlin and Isam Atroshi

    Citation: BMC Musculoskeletal Disorders 2011 12:9

    Content type: Research article

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  30. The Shoulder Pain and Disability Index (SPADI) is a self-administered questionnaire that aims to measure pain and disability associated with shoulder disease. The aim of the present study was to investigate th...

    Authors: Catherine L Hill, Susan Lester, Anne W Taylor, Michael E Shanahan and Tiffany K Gill

    Citation: BMC Musculoskeletal Disorders 2011 12:8

    Content type: Research article

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  31. The study aimed to describe the characteristics of women treated for recently-diagnosed osteoporosis, to identify variables associated with different treatment regimens and to assess impact on quality of life.

    Authors: Bernard Cortet, Francis Blotman, Françoise Debiais, Dominique Huas, Florence Mercier, Chantal Rousseaux, Véronique Berger, Anne-Françoise Gaudin and François-Emery Cotté

    Citation: BMC Musculoskeletal Disorders 2011 12:7

    Content type: Research article

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  32. Different bone cements and various cementation techniques can lead to different bone loss in revision surgery. We investigated the degree of tibial bone loss depending on different cements and techniques.

    Authors: Turgay Efe, Jens Figiel, David Sibbert, Susanne Fuchs-Winkelmann, Carsten O Tibesku, Nina Timmesfeld, Jürgen RJR Paletta and Adrian Skwara

    Citation: BMC Musculoskeletal Disorders 2011 12:6

    Content type: Research article

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  33. Reduced sleep quality is a common complaint among patients with chronic pain, with 50-80% of patients reporting sleep disturbance. Improvements in pain and quality of life measures have been achieved using a m...

    Authors: Jennifer M Cunningham, Catherine Blake, Camillus K Power, Declan O'Keeffe, Valerie Kelly, Sheila Horan, Orla Spencer and Brona M Fullen

    Citation: BMC Musculoskeletal Disorders 2011 12:5

    Content type: Study protocol

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  34. Fibromyalgia (FM) is a prevalent and disabling disorder characterized by a history of widespread pain for at least three months. Pain is considered a complex experience in which affective and cognitive aspects...

    Authors: Sara Maurel, Baltasar Rodero, Yolanda Lopez-del-Hoyo, Juan V Luciano, Eva Andrés, Miquel Roca, Raquel del Moral Bergos, Yolanda Ruiz-Lancina and Javier García-Campayo

    Citation: BMC Musculoskeletal Disorders 2011 12:4

    Content type: Study protocol

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  35. Musculoskeletal hand pain is common in the general population. This study aims to investigate the inter- and intra-observer reliability of two trained observers conducting a simple clinical interview and physi...

    Authors: Helen L Myers, Elaine Thomas, Elaine M Hay and Krysia S Dziedzic

    Citation: BMC Musculoskeletal Disorders 2011 12:3

    Content type: Research article

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  36. Exercise therapy for knee pain and osteoarthritis remains a key element of conservative treatment, recommended in clinical guidelines. Yet systematic reviews point to only modest benefits from exercise interve...

    Authors: Laurence RJ Wood, George M Peat, Ricky Mullis, Elaine Thomas and Nadine E Foster

    Citation: BMC Musculoskeletal Disorders 2011 12:2

    Content type: Study protocol

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  37. Osteoporosis is associated with changes in balance and physical performance and has psychosocial consequences which increase the risk of falling. Most falls occur during walking; therefore an efficient obstacl...

    Authors: Ellen Smulders, Wim van Lankveld, Roland Laan, Jacques Duysens and Vivian Weerdesteyn

    Citation: BMC Musculoskeletal Disorders 2011 12:1

    Content type: Research article

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  38. There have been few studies examining the associations between menstrual irregularity, androgens and bone mass in population-based samples of premenopausal women. This study aimed to describe the associations ...

    Authors: Shuying Wei, Graeme Jones, Russell Thomson, Petr Otahal, Terry Dwyer and Alison Venn

    Citation: BMC Musculoskeletal Disorders 2010 11:288

    Content type: Research article

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  39. Bone mineral density (BMD) accrual during childhood and adolescence is important for attaining peak bone mass. BMD decrements have been reported in survivors of childhood bone sarcomas. However, little is know...

    Authors: Carsten Müller, Corinna C Winter, Dieter Rosenbaum, Joachim Boos, Georg Gosheger, Jendrik Hardes and Volker Vieth

    Citation: BMC Musculoskeletal Disorders 2010 11:287

    Content type: Research article

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  40. Our objective was to explore outcome and clinical changes in hand function, satisfaction in daily occupations, sleep disturbances, health and quality of life in consecutive patients after a severe or major han...

    Authors: Ragnhild I Cederlund, Eva Ramel, Hans-Eric Rosberg and Lars B Dahlin

    Citation: BMC Musculoskeletal Disorders 2010 11:286

    Content type: Research article

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  41. The aim of this non-randomized controlled trial was to evaluate the effectiveness of a Global Postural Reeducation (GPR) program as compared to a Stabilization Exercise (SE) program in subjects with persistent...

    Authors: Francesca Bonetti, Stefania Curti, Stefano Mattioli, Raffaele Mugnai, Carla Vanti, Francesco S Violante and Paolo Pillastrini

    Citation: BMC Musculoskeletal Disorders 2010 11:285

    Content type: Research article

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  42. Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the female sex hormone estradiol and the select...

    Authors: Caroline Jochems, Ulrika Islander, Malin Erlandsson, Cecilia Engdahl, Marie Lagerquist, Inger Gjertsson, Claes Ohlsson, Rikard Holmdahl and Hans Carlsten

    Citation: BMC Musculoskeletal Disorders 2010 11:284

    Content type: Research article

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  43. Primary stability of cartilage repair constructs is of the utmost importance in the clinical setting but few continuous passive motion (CPM) models are available. Our study aimed to establish a novel ex vivo C...

    Authors: Turgay Efe, Markus D Schofer, Alexander Füglein, Nina Timmesfeld, Susanne Fuchs-Winkelmann, Thomas Stein, Bilal Farouk El-Zayat, Jürgen RJ Paletta and Thomas J Heyse

    Citation: BMC Musculoskeletal Disorders 2010 11:283

    Content type: Research article

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  44. Malunion is the most common complication of distal radius fracture. It has previously been demonstrated that there is a correlation between the quality of anatomical correction and overall wrist function. Howe...

    Authors: Natalie L Leong, Geert A Buijze, Eric C Fu, Filip Stockmans and Jesse B Jupiter

    Citation: BMC Musculoskeletal Disorders 2010 11:282

    Content type: Study protocol

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  45. With the relatively high rate of injuries to the lower extremity due to jump-landing movement patterns and the accompanied high costs, there is need for determining potential preventive programs. A program on ...

    Authors: Inne Aerts, Elke Cumps, Evert Verhagen and Romain Meeusen

    Citation: BMC Musculoskeletal Disorders 2010 11:281

    Content type: Study protocol

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  46. Patterns of food intake and prevalent osteoarthritis of the hand, hip, and knee were studied using the twin design to limit the effect of confounding factors. Compounds found in associated food groups were fur...

    Authors: Frances MK Williams, Jane Skinner, Tim D Spector, Aedin Cassidy, Ian M Clark, Rose M Davidson and Alex J MacGregor

    Citation: BMC Musculoskeletal Disorders 2010 11:280

    Content type: Research article

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  47. One of the most distinctive features of ankylosing spondylitis (AS) is new bone formation and bone resorption at sites of chronic inflammation. Previous studies have indicated that the hyperplasia and inflamma...

    Authors: Xiaotian Chang, Jinxiang Han, Yan Zhao, Xinfeng Yan, Shui Sun and Yazhou Cui

    Citation: BMC Musculoskeletal Disorders 2010 11:279

    Content type: Research article

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