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  1. Treatment outcome of low back pain (LBP) is associated with inter-individual variations in pain relief and functional disability. Genetic variants of catechol-O-methyltransferase (COMT) gene have previously been ...

    Authors: Ahmad Omair, Benedicte Alexandra Lie, Olav Reikeras, Marit Holden and Jens Ivar Brox

    Citation: BMC Musculoskeletal Disorders 2012 13:76

    Content type: Research article

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  2. A major problem with rehabilitation interventions for neck pain is that the condition may have multiple causes, thus a single treatment approach is seldom efficient. The present study protocol outlines a singl...

    Authors: Martin Björklund, Mats Djupsjöbacka, Åsa Svedmark and Charlotte Häger

    Citation: BMC Musculoskeletal Disorders 2012 13:75

    Content type: Study protocol

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  3. Consumer surveys provide information on effectiveness and side effects of medical interventions in routine clinical care. A report of fibromyalgia syndrome (FMS) consumers has not been carried out in Europe.

    Authors: Winfried Häuser, Eva Jung, Brigitte Erbslöh-Möller, Mechthild Gesmann, Hedi Kühn-Becker, Franz Petermann, Jost Langhorst, Reinhard Thoma, Thomas Weiss, Frederick Wolfe and Andreas Winkelmann

    Citation: BMC Musculoskeletal Disorders 2012 13:74

    Content type: Research article

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  4. Studies on leisure time physical activity as risk factor or protective factor for knee or hip osteoarthritis (OA) show divergent results. Longitudinal prospective studies are needed to clarify the association ...

    Authors: Eva Ageberg, Gunnar Engström, Maria Gerhardsson de Verdier, Jan Rollof, Ewa M Roos and L Stefan Lohmander

    Citation: BMC Musculoskeletal Disorders 2012 13:73

    Content type: Research article

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  5. Little is known about the biomechanical effectiveness of transforaminal lumbar interbody fusion (TLIF) cages in different positioning and various posterior implants used after decompressive surgery. The use of...

    Authors: Shih-Hao Chen, Shang-Chih Lin, Wen-Chi Tsai, Chih-Wei Wang and Shih-Heng Chao

    Citation: BMC Musculoskeletal Disorders 2012 13:72

    Content type: Research article

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  6. Few studies demonstrate effectiveness of therapies for oral rehabilitation of patients with cerebral palsy (CP), given the difficulties in chewing, swallowing and speech, besides the intellectual, sensory and ...

    Authors: Lilian Chrystiane Giannasi, Miriam Yumi Matsui, Sandra Regina de Freitas Batista, Camila Teixeira Hardt, Carla Paes Gomes, José Benedito Oliveira Amorim, Isabella de Carvalho Aguiar, Luanda Collange, Israel dos Reis dos Santos, Ismael Souza Dias, Cláudia Santos de Oliveira, Luis Vicente Franco de Oliveira and Mônica Fernandes Gomes

    Citation: BMC Musculoskeletal Disorders 2012 13:71

    Content type: Study protocol

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  7. Physical loading leads to a deformation of bone microstructure and may influence quantitative ultrasound (QUS) parameters. This study aims at evaluating the effect of physical loading on bone QUS measurement, ...

    Authors: Cheng-Rui Liu, Hai-Jun Niu, Fang Pu, Ling Wang, Lian-Wen Sun, Yu-Bo Fan and De-Yu Li

    Citation: BMC Musculoskeletal Disorders 2012 13:70

    Content type: Research article

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  8. In Western Australia (WA), health policy recommends encouraging the use of active self-management strategies as part of the co-care of consumers with persistent low back pain (LBP). As many areas in WA are geo...

    Authors: Helen Slater, Andrew M Briggs, Samantha Bunzli, Stephanie J Davies, Anne J Smith and John L Quintner

    Citation: BMC Musculoskeletal Disorders 2012 13:69

    Content type: Research article

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  9. Severe traumatic knee injury, including injury to the anterior cruciate ligament (ACL), leads to impaired sensorimotor function. Although improvements are achieved by training, impairment often persists. Becau...

    Authors: Eva Ageberg, Anders Björkman, Birgitta Rosén and Ewa M Roos

    Citation: BMC Musculoskeletal Disorders 2012 13:68

    Content type: Research article

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  10. There is a lack of high quality evidence concerning the efficacy of total knee arthroplasty (TKA). According to international evidence-based guidelines, treatment of knee osteoarthritis (KOA) should include pa...

    Authors: Soren T Skou, Ewa M Roos, Mogens B Laursen, Michael S Rathleff, Lars Arendt-Nielsen, Ole H Simonsen and Sten Rasmussen

    Citation: BMC Musculoskeletal Disorders 2012 13:67

    Content type: Study protocol

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  11. Patients with knee osteoarthritis patients have problems with walking, and tend to walk slower. An important aim of knee arthroplasty is functional recovery, which should include a post-operative increase in w...

    Authors: Hamid Abbasi-Bafghi, Hamid R Fallah-Yakhdani, Onno G Meijer, Henrica CW de Vet, Sjoerd M Bruijn, Li-Yong Yang, Dirk L Knol, Barend J Van Royen and Jaap H van Dieën

    Citation: BMC Musculoskeletal Disorders 2012 13:66

    Content type: Research article

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  12. There is a complex interaction among acetabular component position and antetorsion of the femoral stem in determining the maximum, impingement-free prosthetic range-of-motion (ROM) in total hip arthroplasty (T...

    Authors: Tobias Renkawitz, Martin Haimerl, Lars Dohmen, Sabine Gneiting, Philipp Lechler, Michael Woerner, Hans-Robert Springorum, Markus Weber, Patrick Sussmann, Ernst Sendtner and Joachim Grifka

    Citation: BMC Musculoskeletal Disorders 2012 13:65

    Content type: Research article

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  13. Back pain is one of the most important causes of functional limitation, disability, and utilization of health care resources for adults of all ages, but especially among older adults. Despite the high prevalen...

    Authors: Jeffrey G Jarvik, Bryan A Comstock, Brian W Bresnahan, Srdjan S Nedeljkovic, David R Nerenz, Zoya Bauer, Andrew L Avins, Kathryn James, Judith A Turner, Patrick Heagerty, Larry Kessler, Janna L Friedly, Sean D Sullivan and Richard A Deyo

    Citation: BMC Musculoskeletal Disorders 2012 13:64

    Content type: Study protocol

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  14. The utilization of total hip replacement (THR) surgery is rapidly increasing, however few data examine whether these procedures are associated with socioeconomic status (SES) within Australia. This study exami...

    Authors: Sharon L Brennan, Tyman Stanford, Anita E Wluka, Margaret J Henry, Richard S Page, Stephen E Graves, Mark A Kotowicz, Geoffrey C Nicholson and Julie A Pasco

    Citation: BMC Musculoskeletal Disorders 2012 13:63

    Content type: Research article

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  15. Shoulder pain is the third most common reason for consultation with a physiotherapist and up to 26% of the general population might be expected to experience an episode at any one time. Disorders of the should...

    Authors: Chris Littlewood, Jon Ashton, Sue Mawson, Stephen May and Stephen Walters

    Citation: BMC Musculoskeletal Disorders 2012 13:62

    Content type: Study protocol

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  16. Dupuytren’s contracture (DC) is a progressive fibroproliferative disorder characterized by development of nodules and collagen cords within the palmar fascia of the hand. Collagenase clostridium histolyticum (...

    Authors: Stephen Coleman, David Gilpin, James Tursi, Greg Kaufman, Nigel Jones and Brian Cohen

    Citation: BMC Musculoskeletal Disorders 2012 13:61

    Content type: Research article

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  17. Osteoarthritis (OA) of the hip and knee are among the most common chronic conditions, resulting in substantial pain and functional limitations. Adequate management of OA requires a combination of medical and b...

    Authors: Kelli D Allen, Hayden B Bosworth, Dorothea S Brock, Jennifer G Chapman, Ranee Chatterjee, Cynthia J Coffman, Santanu K Datta, Rowena J Dolor, Amy S Jeffreys, Karen A Juntilla, Jennifer Kruszewski, Laurie E Marbrey, Jennifer McDuffie, Eugene Z Oddone, Nina Sperber, Mary P Sochacki…

    Citation: BMC Musculoskeletal Disorders 2012 13:60

    Content type: Study protocol

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  18. Developmental dysplasia of the hip (DDH) is a congenital or acquired deformation or misalignment of the hip joint which affects mainly females. We hypothesized that HOXD9 gene could be regulated in acetabular siz...

    Authors: Wei Tian, Lixi Zhao, Jing Wang, Peisu Suo, Jianmin Wang, Longfei Cheng, Zhi Cheng, Jian Jia, Shilian Kan, Binbin Wang and Xu Ma

    Citation: BMC Musculoskeletal Disorders 2012 13:59

    Content type: Research article

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  19. Pain Exposure Physical Therapy is a new treatment option for patients with Complex Regional Pain Syndrome type 1. It has been evaluated in retrospective as well as in prospective studies and proven to be safe ...

    Authors: Karlijn J Barnhoorn, Rob A B Oostendorp, Robert T M van Dongen, Frank P Klomp, Han Samwel, Gert Jan van der Wilt, Eddy Adang, Hans Groenewoud, Henk van de Meent and Jan Paul M Frölke

    Citation: BMC Musculoskeletal Disorders 2012 13:58

    Content type: Study protocol

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  20. Osteochondroma is a disease of growing bone and thus typically presents in younger patients. It has rarely been described in middle-aged and elderly patients. Data on the occurrence of osteochondroma show that...

    Authors: Jung Hyun Shim, Choon Keun Park, Seung Ho Shin, Hee Sun Jeong and Jang Hoe Hwang

    Citation: BMC Musculoskeletal Disorders 2012 13:57

    Content type: Case report

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  21. Metal-on-metal hip resurfacing is an alternative to metal-on-metal total hip arthroplasty, especially for young and physically active patients. However, wear which might be detected by increased serum ion leve...

    Authors: W Maurer-Ertl, J Friesenbichler, P Sadoghi, M Pechmann, M Trennheuser and A Leithner

    Citation: BMC Musculoskeletal Disorders 2012 13:56

    Content type: Research article

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  22. Practice guidelines recommend various types of exercise for chronic back pain but there have been few head-to-head comparisons of these interventions. General exercise seems to be an effective option for manag...

    Authors: Vesa Lehtola, Hannu Luomajoki, Ville Leinonen, Sean Gibbons and Olavi Airaksinen

    Citation: BMC Musculoskeletal Disorders 2012 13:55

    Content type: Study protocol

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  23. Cell-based approaches towards restoration of prolapsed or degenerated intervertebral discs are hampered by a lack of measures for safe administration and placement of cell suspensions within a treated disc. In...

    Authors: Karin Benz, Claudia Stippich, Claudia Osswald, Christoph Gaissmaier, Nicolas Lembert, Andreas Badke, Eric Steck, Wilhelm K Aicher and Juergen A Mollenhauer

    Citation: BMC Musculoskeletal Disorders 2012 13:54

    Content type: Research article

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  24. The incidence of Achilles tendinopathy is high and underlying etiology as well as biochemical and morphological pathology associated with the disease is largely unknown. The aim of the present study was to des...

    Authors: Pingel J, Fredberg U, Qvortrup K, Larsen JO, Schjerling P, Heinemeier K, Kjaer M and Langberg H

    Citation: BMC Musculoskeletal Disorders 2012 13:53

    Content type: Research article

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  25. Lesions located in the area of the tibial spines are rare. In most cases, treatment follows histological diagnosis, but when imaging and clinical data are considered to be "very" characteristic for benign lesi...

    Authors: Carmine Zoccali, Giuseppe Teori, Nicola Salducca, Berardino Di Paola and Ezio Adriani

    Citation: BMC Musculoskeletal Disorders 2012 13:52

    Content type: Technical advance

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  26. Like all mammalian cells, normal adult chondrocytes have a limited replicative life span, which decreases with age. To facilitate the therapeutic use of chondrocytes from older donors, a method is needed to pr...

    Authors: Masato Sato, Kazuo Shin-ya, Jeong Ik Lee, Miya Ishihara, Toshihiro Nagai, Nagatoshi Kaneshiro, Genya Mitani, Hidetoshi Tahara and Joji Mochida

    Citation: BMC Musculoskeletal Disorders 2012 13:51

    Content type: Research article

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  27. Osteopetrosis is a rare, inherited, bone disorder, characterized by osteosclerosis, obliteration of the medullary cavity and calcified cartilage. The autosomal dominant form is compatible with a normal life sp...

    Authors: Giovanni Manzi, Delia Romanò, Laura Moneghini and Carlo L Romanò

    Citation: BMC Musculoskeletal Disorders 2012 13:50

    Content type: Case report

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  28. Chronic low back pain (CLBP) experienced in middle-age may have important implications for vertebral bone health, although this issue has not been investigated as a primary aim previously. This study investiga...

    Authors: Andrew M Briggs, Leon M Straker, Angus F Burnett and John D Wark

    Citation: BMC Musculoskeletal Disorders 2012 13:49

    Content type: Research article

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  29. Lumbar spinal stenosis is one of the most common causes of low back pain among older adults and can cause significant disability. Despite its prevalence, treatment of spinal stenosis symptoms remains controver...

    Authors: Janna L Friedly, Brian W Bresnahan, Bryan Comstock, Judith A Turner, Richard A Deyo, Sean D Sullivan, Patrick Heagerty, Zoya Bauer, Srdjan S Nedeljkovic, Andrew L Avins, David Nerenz and Jeffrey G Jarvik

    Citation: BMC Musculoskeletal Disorders 2012 13:48

    Content type: Study protocol

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  30. The purpose was to determine the professionally-guided and self-guided medication and supplement use for joint symptom management among patients with knee and/or hip osteoarthritis (OA) in an urban hospital-ba...

    Authors: Jeffrey B Driban, Sara A Boehret, Easwaran Balasubramanian, Nicole M Cattano, Joseph Glutting and Michael R Sitler

    Citation: BMC Musculoskeletal Disorders 2012 13:47

    Content type: Research article

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  31. Clinical approaches like mobilization, stretching, and/or massage may decrease shoulder tightness and improve symptoms in subjects with stiff shoulders. We investigated the effect and predictors of effectivene...

    Authors: Jing-lan Yang, Shiau-yee Chen, Ching-Lin Hsieh and Jiu-jenq Lin

    Citation: BMC Musculoskeletal Disorders 2012 13:46

    Content type: Research article

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  32. Fracture morphology is crucial for the clinical decision-making process preceding spinal fracture treatment. The presented experimental approach was designed in order to ensure reproducibility of induced fract...

    Authors: René Hartensuer, Adam Gasch, Dominic Gehweiler, Steffen Schanz, Martin Schulze, Lars Matuszewski, Martin Langer, Michael J Raschke and Thomas Vordemvenne

    Citation: BMC Musculoskeletal Disorders 2012 13:45

    Content type: Technical advance

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  33. Bone grafts from bone banks might be mixed with bisphosphonates to inhibit the osteoclastic response. This inhibition prevents the osteoclasts to resorb the allograft bone before new bone has been formed by th...

    Authors: Nina MC Mathijssen, Gerjon Hannink, Peter Pilot, B Wim Schreurs, Rolf M Bloem and Pieter Buma

    Citation: BMC Musculoskeletal Disorders 2012 13:44

    Content type: Research article

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  34. Limb girdle muscular dystrophy (LGMD) type 2A is caused by mutations in the CAPN3 gene and complete lack of functional calpain 3 leads to the most severe muscle wasting. Calpain 3 is suggested to be involved i...

    Authors: Simon Hauerslev, Marie-Louise Sveen, Morten Duno, Corrado Angelini, John Vissing and Thomas O Krag

    Citation: BMC Musculoskeletal Disorders 2012 13:43

    Content type: Research article

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  35. An implant coating with poly(D, L-lactide) (PDLLA) releasing incorporated Zoledronic acid (ZOL) has already proven to positively effect osteoblasts, to inhibit osteoclasts and to accelerate fracture healing. Aim ...

    Authors: David A Back, Stephan Pauly, Lisa Rommel, Norbert P Haas, Gerhard Schmidmaier, Britt Wildemann and Stefan H Greiner

    Citation: BMC Musculoskeletal Disorders 2012 13:42

    Content type: Research article

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  36. Musculoskeletal symptoms among adolescents are related to the time spent using a computer, but little is known about the seriousness of the symptoms or how much they affect everyday life. The purpose of the pr...

    Authors: Paula T Hakala, Lea A Saarni, Raija-Leena Punamäki, Marjut A Wallenius, Clas-Håkan Nygård and Arja H Rimpelä

    Citation: BMC Musculoskeletal Disorders 2012 13:41

    Content type: Research article

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  37. The Bath Ankylosing Spondylitis Functional Index (BASFI) has been commonly used in rheumatology to quantify functional disability in patients with Ankylosing Spondylitis (AS). Our aim was to evaluate the discr...

    Authors: Ghizlane Wariaghli, Fadoua Allali, Kenza Berrada, Zineb Idrissi, Ihsane Hmamouchi, Redouane Abouqal and Najia Hajjaj-Hassouni

    Citation: BMC Musculoskeletal Disorders 2012 13:40

    Content type: Research article

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  38. Increased postural sway is well documented in patients suffering from non-specific low back pain, whereby a linear relationship between higher pain intensities and increasing postural sway has been described. ...

    Authors: Alexander Ruhe, René Fejer and Bruce Walker

    Citation: BMC Musculoskeletal Disorders 2012 13:39

    Content type: Research article

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  39. The aim of this study was to investigate whether perceived exertion, perceived comfort and working technique is associated with the incidence of neck and upper extremity symptoms among professional computer us...

    Authors: Agneta Lindegård, Jens Wahlström, Mats Hagberg, Rebecka Vilhelmsson, Allan Toomingas and Ewa Wigaeus Tornqvist

    Citation: BMC Musculoskeletal Disorders 2012 13:38

    Content type: Research article

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  40. To analyze changes in incidence and outcomes of patients undergoing revision total hip arthroplasty (RTHA) over an 8-year study period in Spain.

    Authors: Manuel Villanueva-Martınez, Valentın Hernandez-Barrera, Francisco Chana-Rodríguez, José Rojo-Manaute, Antonio Rıos-Luna, Jesus San Roman Montero, Angel Gil-de-Miguel and Rodrigo Jimenez-Garcıa

    Citation: BMC Musculoskeletal Disorders 2012 13:37

    Content type: Research article

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  41. Polyneuropathy is a complication of diabetes mellitus that has been very challenging for clinicians. It results in high public health costs and has a huge impact on patients' quality of life. Preventive interv...

    Authors: Cristina Dallemole Sartor, Ricky Watari, Anice Campos Pássaro, Andreja Paley Picon, Renata Haydée Hasue and Isabel CN Sacco

    Citation: BMC Musculoskeletal Disorders 2012 13:36

    Content type: Study protocol

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  42. Quality improvement is important to facilitate valid patient outcomes. Standardized examination procedures may improve the validity of US.

    Authors: Karen Ellegaard, Søren Torp-Pedersen, Robin Christensen, Michael Stoltenberg, Annette Hansen, Tove Lorenzen, Dorthe V Jensen, Hanne Lindegaard, Lars Juul, Henrik Røgind, Per Bülow, Stavros Chrysidis, Marcin Kowalski, Bente Danneskiold-Samsoe and Henning Bliddal

    Citation: BMC Musculoskeletal Disorders 2012 13:35

    Content type: Research article

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  43. Early diagnosis of Osteoarthritis (OA) is essential for preventing further cartilage destruction and decreasing severe complications. The aims of this study are to explore the relationship between OA pathologi...

    Authors: Hai-jun Niu, Qing Wang, Yue-xiang Wang, De-yu Li, Yu-bo Fan and Wu-fan Chen

    Citation: BMC Musculoskeletal Disorders 2012 13:34

    Content type: Research article

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  44. Fracture-healing depends on interfragmentary motion. For improved osteosynthesis and fracture-healing, the micromotion between fracture fragments is undergoing intensive research. The detection of 3D micromoti...

    Authors: Stefan Doebele, Sebastian Siebenlist, Helen Vester, Petra Wolf, Ulrich Hagn, Ulrich Schreiber, Ulrich Stöckle and Martin Lucke

    Citation: BMC Musculoskeletal Disorders 2012 13:33

    Content type: Technical advance

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  45. In the present study, 4 different metallic implant materials, either partly coated or polished, were tested for their osseointegration and biocompatibility in a pelvic implantation model in sheep.

    Authors: Michael Plecko, Christine Sievert, Daniel Andermatt, Robert Frigg, Peter Kronen, Karina Klein, Stefan Stübinger, Katja Nuss, Alexander Bürki, Stephen Ferguson, Ulrich Stoeckle and Brigitte von Rechenberg

    Citation: BMC Musculoskeletal Disorders 2012 13:32

    Content type: Research article

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  46. A high percentage of young children present with flatfeet. Although the percentage of those with flatfeet declines with age, about 15% of the population maintains a flat arch. A reduction in longitudinal arch ...

    Authors: Yi-Fen Shih, Chao-Yin Chen, Wen-Yin Chen and Hsiu-Chen Lin

    Citation: BMC Musculoskeletal Disorders 2012 13:31

    Content type: Research article

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  47. Lumbar spinal stenosis (LSS) is prevalent in those over the age of 65 years and the leading cause of spinal surgery in this population. Recent systematic reviews have examined the effectiveness of conservative...

    Authors: Mark S Jarrett, Joseph F Orlando and Karen Grimmer-Somers

    Citation: BMC Musculoskeletal Disorders 2012 13:30

    Content type: Research article

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  48. Musculoskeletal pain is detrimental to quality of life (QOL) and disruptive to activities of daily living. It also places a major economic burden on healthcare systems and wider society. In 2006, the Welsh Ass...

    Authors: Ceri J Phillips, Rhiannon Phillips (nee Buck), Chris J Main, Paul J Watson, Shân Davies, Angela Farr, Christie Harper, Gareth Noble, Mansel Aylward, Julie Packman, Matt Downton and Janine Hale

    Citation: BMC Musculoskeletal Disorders 2012 13:29

    Content type: Research article

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  49. Low back pain (LBP) and leisure time physical activity (LTPA) are considered to be closely related, and clinical guidelines for the treatment of acute LBP recommend patients stay physically active. However, th...

    Authors: Tobias Jespersen, Marie B Jørgensen, Jørgen V Hansen, Andreas Holtermann and Karen Søgaard

    Citation: BMC Musculoskeletal Disorders 2012 13:28

    Content type: Research article

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