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  1. Glucocorticoids (GCs), such as prednisone, are the standard of care for several inflammatory and immunologically mediated diseases, but their chronic systemic administration is severely limited by serious adve...

    Authors: Dona L. Fleishaker, Arnab Mukherjee, Fredrick S. Whaley, Shanthini Daniel and Bernhardt G. Zeiher
    Citation: BMC Musculoskeletal Disorders 2016 17:293
  2. Focal lesions to the articular cartilage in the knee might have demolishing consequences to the knee. There exists a wide range of possible surgical procedures targeting these injuries, however no significant ...

    Authors: Tommy Frøseth Aae, Per-Henrik Randsborg, Anne Berg Breen, Håvard Visnes, Søren Vindfeld, Einar Andreas Sivertsen, Sverre Løken, Jan Brinchmann, Heidi Andreassen Hanvold and Asbjørn Årøen
    Citation: BMC Musculoskeletal Disorders 2016 17:292
  3. The treatment of elderly patients with Kashin-Beck disease (KBD) remains clinically challenging, and clinical data are very lacking. The aim of this study was to retrospectively evaluate pain and functional ou...

    Authors: Xin Tang, Jing Zhu, Zongke Zhou, Bin Shen, Pengde Kang, Fuxing Pei and Jian Li
    Citation: BMC Musculoskeletal Disorders 2016 17:289
  4. The management of displaced intra-articular calcaneal fractures (DIACFs) remains challenging and controversial. A prospective randomized controlled trial was conducted to compare percutaneous reduction, cannul...

    Authors: Yongzeng Feng, Xiaolong Shui, Jianshun Wang, Leyi Cai, Yang Yu, Xiaozhou Ying, Jianzhong Kong and Jianjun Hong
    Citation: BMC Musculoskeletal Disorders 2016 17:288
  5. Tibial head depression fractures demand a high level of fracture stabilization to prevent a secondary loss of reduction after surgery. Elderly individuals are at an increased risk of developing these fractures...

    Authors: Martin C. Jordan, Christina Zimmermann, Sheridan A. Gho, Soenke P. Frey, Torsten Blunk, Rainer H. Meffert and Stefanie Hoelscher-Doht
    Citation: BMC Musculoskeletal Disorders 2016 17:287
  6. Reconstruction of a segmental fracture with massive bone loss is still a challenge for orthopaedic surgeons. The aim of our study was to develop a suitable biodegradable thermosensitive hydrogel system as a ca...

    Authors: Kuo-Ti Peng, Meng-Yow Hsieh, Carl T. Lin, Chin-Fu Chen, Mel S. Lee, Yi-You Huang and Pey-Jium Chang
    Citation: BMC Musculoskeletal Disorders 2016 17:286
  7. To update community-based prevalence values for Polymyalgia Rheumatic (PMR) and Giant Cell Arteritis (GCA) using case record review supplemented by population survey and subsequent clinical review.

    Authors: Max Yates, Karly Graham, Richard Arthur Watts and Alexander James MacGregor
    Citation: BMC Musculoskeletal Disorders 2016 17:285
  8. Patients with painful knee osteoarthritis (OA) demonstrate hyperalgesia and altered pain-modulatory responses. While some prior work has demonstrated cross-sectional associations between laboratory and clinica...

    Authors: Robert R. Edwards, Andrew J. Dolman, Marc. O. Martel, Patrick H. Finan, Asimina Lazaridou, Marise Cornelius and Ajay D. Wasan
    Citation: BMC Musculoskeletal Disorders 2016 17:284
  9. Calcification of the medial collateral ligament (MCL) of the knee is a very rare disease. We report on a case of a patient with a calcifying lesion within the MCL and simultaneous calcifying tendinitis of the ...

    Authors: Yama Kamawal, Andre F. Steinert, Boris M. Holzapfel, Maximilian Rudert and Thomas Barthel
    Citation: BMC Musculoskeletal Disorders 2016 17:283
  10. Motor vehicle related moderate-severe orthopaedic trauma has a major impact on the burden of injury. In Australia, all states and territories provide access to financial compensation following injury in a moto...

    Authors: Darnel F. Murgatroyd, Ian A. Harris, Yvonne Tran and Ian D. Cameron
    Citation: BMC Musculoskeletal Disorders 2016 17:282
  11. Physical activity levels are decreased and sedentary behaviour levels are increased in patients with knee osteoarthritis (OA). However, previous studies have shown that following total knee arthroplasty (TKA),...

    Authors: Rebecca M. Meiring, Emmanuel Frimpong, Lipalo Mokete, Jurek Pietrzak, Dick Van Der Jagt, Mohammed Tikly and Joanne A. McVeigh
    Citation: BMC Musculoskeletal Disorders 2016 17:281
  12. In total hip arthroplasty (THA), tilting of the pelvis alters the cup placement angles. Thus, the cup angles need to be planned with consideration of the effects of pelvic tilt. In the present study, we evalua...

    Authors: Yutaka Inaba, Naomi Kobayashi, Haruka Suzuki, Hiroyuki Ike, So Kubota and Tomoyuki Saito
    Citation: BMC Musculoskeletal Disorders 2016 17:280
  13. Low back pain (LBP) is a leading cause of referral to occupational health clinics and of consequent work absenteeism. There is lack of data concerning ages 18–21. The objective of our study was to evaluate the...

    Authors: Shlomo Moshe, Oren Zack, Aharon S. Finestone, Menashe Mishal, Noa Segal, Dan Slodownik and Yaron Yagev
    Citation: BMC Musculoskeletal Disorders 2016 17:279
  14. Axial spondyloarthritis (axSpA) is a disabling inflammatory joint disease with chronic low back pain (CLBP) as leading symptom. Recognizing axSpA in the large amount of CLBP patients is difficult for general p...

    Authors: Lonneke van Hoeven, Yvonne Vergouwe, Bart W. Koes, Johanna M. W. Hazes and Angelique E. A. M. Weel
    Citation: BMC Musculoskeletal Disorders 2016 17:278
  15. Pelvic girdle pain (PGP) is a multifactorial condition, which can be mentally and physically compromising both during and after pregnancy. However, long-term pregnancy-related PGP has been poorly investigated....

    Authors: Helen Elden, Annelie Gutke, Gunilla Kjellby-Wendt, Monika Fagevik-Olsen and Hans-Christian Ostgaard
    Citation: BMC Musculoskeletal Disorders 2016 17:276
  16. Identifying patients who will benefit from spine surgery is still a challenge. This is especially the case when patients’ complaints and medical history, together with clinical observations, do not correspond ...

    Authors: Ulf Krister Hofmann, Marco Gesicki and Falk Mittag
    Citation: BMC Musculoskeletal Disorders 2016 17:275
  17. Having observed a tendency towards femoral overgrowth (FO) of the affected limb in children with atrophic-type congenital pseudarthrosis of the tibia (CPT), we aimed to identify the incidence of, contributors ...

    Authors: Mi Hyun Song, Moon Seok Park, Won Joon Yoo, Tae-Joon Cho and In Ho Choi
    Citation: BMC Musculoskeletal Disorders 2016 17:274
  18. Many physical examination (PE) maneuvers exist to assess knee function, none of which are specific to knee osteoarthritis (KOA). The Osteoarthritis Research Society International also recommends the use of six...

    Authors: Maura D. Iversen, Lori Lyn Price, Johan von Heideken, William F. Harvey and Chenchen Wang
    Citation: BMC Musculoskeletal Disorders 2016 17:273
  19. The impact of physical exercise on joints and tendons is still a matter of debate. The aim of this study was to investigate with ultrasound the acute effects of extreme physical exercise on knee and ankle join...

    Authors: Fabian Proft, Mathias Grunke, Christiane Reindl, Felix Mueller, Maximilian Kriegmair, Jan Leipe, Peter Weinert, Hendrik Schulze-Koops and Matthias Witt
    Citation: BMC Musculoskeletal Disorders 2016 17:272

    The Erratum to this article has been published in BMC Musculoskeletal Disorders 2016 17:381

  20. To study the reliability and validity of high-resolution peripheral quantitative CT (HR-pQCT) with microCT (μCT) as gold standard in the visual detection of cortical breaks in metacarpophalangeal (MCP) and pro...

    Authors: A. Scharmga, M. Peters, A. van Tubergen, J. van den Bergh, J. de Jong, D. Loeffen, B. van Rietbergen, R. Weijers and P. Geusens
    Citation: BMC Musculoskeletal Disorders 2016 17:271
  21. Current guidelines for the management of patients with specific low back pain pathology suggest non-surgical intervention as first-line treatment, but there is insufficient evidence to make recommendations of ...

    Authors: Yvonne Lindbäck, Hans Tropp, Paul Enthoven, Allan Abbott and Birgitta Öberg
    Citation: BMC Musculoskeletal Disorders 2016 17:270
  22. The purpose of this study was to evaluate whether PFNA-II (Asia proximal femoral nail anti-rotation) and DHS (dynamic hip screw) carry substantial post-operative hidden blood loss and to compare PFNA-II with D...

    Authors: Weiguang Yu, Xinchao Zhang, Rongbo Wu, Xingfei Zhu, Jun Hu, Yinfeng Xu, Jianhua Yi and Yunjiang Liu
    Citation: BMC Musculoskeletal Disorders 2016 17:269
  23. Osteoporosis is a well-known complication of ankylosing spondylitis (AS). However, data about body composition modifications and muscle performance showed conflicting results. The aim of the study was to deter...

    Authors: Abdellah El Maghraoui, François Bertin Ebo’o, Siham Sadni, Abderrahim Majjad, Toufik Hamza and Aziza Mounach
    Citation: BMC Musculoskeletal Disorders 2016 17:268
  24. A recent publication on efficacy of Sprifermin for knee osteoarthritis (OA) using quantitatively MRI-defined central medial tibio-femoral compartment cartilage thickness as the structural primary endpoint repo...

    Authors: Frank W. Roemer, Aida Aydemir, Stefan Lohmander, Michel D. Crema, Monica Dias Marra, Norma Muurahainen, David T. Felson, Felix Eckstein and Ali Guermazi
    Citation: BMC Musculoskeletal Disorders 2016 17:267
  25. The National Institute for Health and Care Excellence’s Osteoarthritis (OA) guidelines recommended that future research should consider the benefits of combination therapies in people with OA across multiple j...

    Authors: Andrew Finney, Emma Healey, Joanne L. Jordan, Sarah Ryan and Krysia S. Dziedzic
    Citation: BMC Musculoskeletal Disorders 2016 17:266
  26. Patient-reported health-related quality of life is an important outcome measure when assessing the quality of hip fracture surgery. The frequently used EQ-5D index score has unfortunately important limitations...

    Authors: Jan-Erik Gjertsen, Valborg Baste, Jonas M. Fevang, Ove Furnes and Lars Birger Engesæter
    Citation: BMC Musculoskeletal Disorders 2016 17:265
  27. The purpose of this study was to compare the clinical results between osteosynthesis and endoprosthesis for femoral neck fractures in asian elderly patients, and to analysis the factors that may affect the fai...

    Authors: Joon Soon Kang, Yoon Sang Jeon, Chi Hoon Ahn and Tae Hoon Roh
    Citation: BMC Musculoskeletal Disorders 2016 17:264
  28. The objective of this study was to investigate the prevalence of self-reported low back pain (LBP) and neck and shoulder pain (NSP), and the related factors in members and non-members of adolescents’ sports cl...

    Authors: M. Rossi, K. Pasanen, S. Kokko, L. Alanko, O. J. Heinonen, R. Korpelainen, K. Savonen, H. Selänne, T. Vasankari, L. Kannas, U. Kujala, J. Villberg and J. Parkkari
    Citation: BMC Musculoskeletal Disorders 2016 17:263
  29. The FRAX® tool estimates the risk of a fragility fracture among the population and many countries have been evaluating its performance among their populations since its creation in 2007.

    Authors: Rafael Azagra, Marta Zwart, Gloria Encabo, Amada Aguyé, Juan Carlos Martin-Sánchez, Nuria Puchol-Ruiz, Paula Gabriel-Escoda, Sergio Ortiz-Alinque, Emilio Gené, Milagros Iglesias, David Moriña, Miguel Angel Diaz-Herrera, Mireia Utzet and Josep Maria Manresa
    Citation: BMC Musculoskeletal Disorders 2016 17:262
  30. Real-world data regarding anti-tumor necrosis factor alpha (anti-TNFα) biologic therapy use in psoriatic arthritis (PsA) are limited; therefore, we described treatment patterns and costs of anti-TNFα therapy i...

    Authors: Jacqueline B. Palmer, Yunfeng Li, Vivian Herrera, Minlei Liao, Melody Tran and Zafer E. Ozturk
    Citation: BMC Musculoskeletal Disorders 2016 17:261
  31. Total knee arthroplasty (TKA) is effective in reducing pain and improving function for end-stage knee osteoarthritis. However, muscle weakness and functional limitations persist despite assistance from post-op...

    Authors: Margaret B. Schache, Jodie A. McClelland and Kate E. Webster
    Citation: BMC Musculoskeletal Disorders 2016 17:259
  32. Recommendations in clinical practice guidelines for non-specific low back pain (NSLBP) are not necessarily translated into practice. Multiple studies have investigated different interventions to implement best...

    Authors: Simon Alexander Mesner, Nadine E. Foster and Simon David French
    Citation: BMC Musculoskeletal Disorders 2016 17:258
  33. Physiotherapist-led orthopaedic triage, where physiotherapists diagnose and determine management plans, aims to enhance effectiveness and provide the best care. However, scientific evidence for the effectivene...

    Authors: Karin S. Samsson, Susanne Bernhardsson and Maria E. H. Larsson
    Citation: BMC Musculoskeletal Disorders 2016 17:257
  34. Some aspects of validity are missing for the Harris Hip Score (HHS). Our objective was to examine the clinically meaningful change thresholds, responsiveness and the predictive ability of the HHS questionnaire.

    Authors: Jasvinder A. Singh, Cathy Schleck, Scott Harmsen and David Lewallen
    Citation: BMC Musculoskeletal Disorders 2016 17:256
  35. Bisphosphonates are a main component in the therapy of osteoporosis and other bone resorptive diseases. Previous studies have shown a positive effect of systemically applied bisphosphonates on fracture healing...

    Authors: Leif Menzdorf, Matthias Weuster, Tim Klüter, Stefan Brüggemann, Peter Behrendt, Stefanie Fitchen-Oestern, Deike Varoga, Andreas Seekamp, Nicolai Purcz, Claus C Glueer, Thomas Pufe and Sebastian Lippross
    Citation: BMC Musculoskeletal Disorders 2016 17:255
  36. Both gravitational loading and the forces generated by muscle contraction have direct effects on serum markers of bone metabolism. The object of this study was to examine the direct effects of a single session...

    Authors: Gabriella Császárné Gombos, Viktória Bajsz, Emese Pék, Béla Schmidt, Eszter Sió, Bálint Molics and József Betlehem
    Citation: BMC Musculoskeletal Disorders 2016 17:254
  37. Our purpose was to evaluate outcome following arthroscopic treatment of femoroacetabular impingement (FAI) in middle-aged patients and to define risk factors for conversion to total hip arthroplasty (THA).

    Authors: Simon Jakob Herrmann, Manuel Bernauer, Benjamin Erdle, Norbert Paul Südkamp, Peter Helwig and Oliver Hauschild
    Citation: BMC Musculoskeletal Disorders 2016 17:253
  38. Rotator cuff rupture is associated with dysfunction, pain and muscular weakness related to the upper extremity. Some evidence exists to support the beneficial effect of exercises but there is lack of evidence ...

    Authors: Birgitte Hede Christensen, Kathrine Skov Andersen, Sten Rasmussen, Elizabeth Lykholt Andreasen, Lotte Mejlvig Nielsen and Steen Lund Jensen
    Citation: BMC Musculoskeletal Disorders 2016 17:252
  39. Arthritis secondary to developmental hip dysplasia often mandates implant surgery at a relatively young age. Hip resurfacing arthroplasty (HRA), compared with standard stemmed total hip arthroplasty (THA), aff...

    Authors: Melissa D. Gaillard and Thomas P. Gross
    Citation: BMC Musculoskeletal Disorders 2016 17:251
  40. International recommendations suggest exercise and self-management programs, including non-pharmacological treatments, for knee osteoarthritis (KOA) because they can benefit pain relief and improve function an...

    Authors: Priscila Marconcin, Margarida Espanha, Flávia Yázigi and Pedro Campos
    Citation: BMC Musculoskeletal Disorders 2016 17:250
  41. Although international guidelines encourage urate lowering therapy (ULT) for people who have more than two attacks of gout, only 30 % of patients are prescribed it and only 40 % of those adhere to the treatmen...

    Authors: Jane C. Richardson, Jennifer Liddle, Christian D. Mallen, Edward Roddy, Samantha Hider, Suman Prinjha and Sue Ziebland
    Citation: BMC Musculoskeletal Disorders 2016 17:249
  42. A scaphoid fracture is the most common type of carpal fracture affecting young active people. The optimal management of this fracture is uncertain. When treated with a cast, 88 to 90 % of these fractures unite...

    Authors: Joseph Dias, Stephen Brealey, Surabhi Choudhary, Liz Cook, Matthew Costa, Caroline Fairhurst, Catherine Hewitt, Stephen Hodgson, Laura Jefferson, Kanagaratnam Jeyapalan, Ada Keding, Paul Leighton, Amar Rangan, Gerry Richardson, Claire Rothery, Nicholas Taub…
    Citation: BMC Musculoskeletal Disorders 2016 17:248
  43. Plantaris tendon, peronus brevis tendon and flexor hallucis longus tendon augmentation, commonly used in Achilles tendon rupture, often lead to weakening of injured foot and they require the immobilization aft...

    Authors: Tomasz Piontek, Paweł Bąkowski, Kinga Ciemniewska-Gorzela and Monika Grygorowicz
    Citation: BMC Musculoskeletal Disorders 2016 17:247
  44. Seronegative rheumatoid arthritis is associated with a milder course of progression compared to seropositive disease. However, long-term follow-up data of the clinical course of seronegative rheumatoid arthrit...

    Authors: Elena Nikiphorou, Christopher Sjöwall, Pekka Hannonen, Tuomas Rannio and Tuulikki Sokka
    Citation: BMC Musculoskeletal Disorders 2016 17:246
  45. Injuries to the human native cartilage tissue are particularly problematic because cartilage has little to no ability to heal or regenerate itself. Employing a tissue engineering strategy that combines suitabl...

    Authors: Xing Zhao, Anestis Papadopoulos, Shinichi Ibusuki, David A. Bichara, Daniel B. Saris, Jos Malda, Kristi S. Anseth, Thomas J. Gill and Mark A. Randolph
    Citation: BMC Musculoskeletal Disorders 2016 17:245
  46. Internalised stigma is theorized to be the internalisation and legitimisation of stereotypes of the diagnosis held in society and has not been quantified within patients with Rheumatoid Arthritis. This study a...

    Authors: Elizabeth Corker, R. Claire Henderson, Heidi Lempp and June S. L. Brown
    Citation: BMC Musculoskeletal Disorders 2016 17:244
  47. Implant infections are a major complication in the field of orthopaedics. Bacteria attach to the implant-surface and form biofilm-colonies which makes them difficult to treat. Not only immune cells exclusively...

    Authors: Ulrike Dapunt, Thomas Giese, Sabine Stegmaier, Arash Moghaddam and Gertrud Maria Hänsch
    Citation: BMC Musculoskeletal Disorders 2016 17:243
  48. Patellofemoral pain is one of the most frequent knee conditions among adolescents with a prevalence of 7 %. Evidence-based treatment consists of patient education combined with hip and quadriceps strengthening...

    Authors: Henrik Riel, Mark Matthews, Bill Vicenzino, Thomas Bandholm, Kristian Thorborg and Michael Skovdal Rathleff
    Citation: BMC Musculoskeletal Disorders 2016 17:242

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