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Pathophysiology of musculoskeletal disorders

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

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  1. Studies have shown that ischemia-reperfusion (I/R) produces free radicals leading to lipid peroxidation and damage to skeletal muscle. The purposes of this study were 1) to assess the histological findings of ...

    Authors: Kazuichiro Hori, Masaya Tsujii, Takahiro Iino, Haruhiko Satonaka, Takeshi Uemura, Koji Akeda, Masahiro Hasegawa, Atsumasa Uchida and Akihiro Sudo

    Citation: BMC Musculoskeletal Disorders 2013 14:113

    Content type: Research article

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  2. Inflammatory and matrix degrading gene variants have been reported to be associated with disc degeneration. Some of these variants also modulate peripheral pain. This study examines the association of these ge...

    Authors: Ahmad Omair, Marit Holden, Benedicte Alexandra Lie, Olav Reikeras and Jens Ivar Brox

    Citation: BMC Musculoskeletal Disorders 2013 14:105

    Content type: Research article

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  3. The purpose of this study was to investigate whether uphill treadmill running in rats created histopathological changes within the Achilles tendon consistent with Achilles tendinosis in humans.

    Authors: Rachel C Dirks, Jeffrey S Richard, Angela M Fearon, Alexander Scott, Lauren G Koch, Steven L Britton and Stuart J Warden

    Citation: BMC Musculoskeletal Disorders 2013 14:90

    Content type: Research article

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  4. The single nucleotide polymorphism (SNP) rs2615977 is associated with osteoarthritis (OA) and is located in intron 31 of COL11A1, a strong candidate gene for this degenerative musculoskeletal disease. Furthermore...

    Authors: Emma V A Raine, Andrew W Dodd, Louise N Reynard and John Loughlin

    Citation: BMC Musculoskeletal Disorders 2013 14:85

    Content type: Research article

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  5. It is well documented that osteoarthritis (OA) can develop following traumatic joint injury and is the leading cause of lameness and subsequent wastage of equine athletes. Although much research of injury indu...

    Authors: Christina M Lee, John D Kisiday, C Wayne McIlwraith, Alan J Grodzinsky and David D Frisbie

    Citation: BMC Musculoskeletal Disorders 2013 14:54

    Content type: Research article

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  6. Serum preptin levels among subjects with different bone mineral densities (BMD) were measured and investigated to determine the correlation between BMD and bone-metabolic markers.

    Authors: Ning Li, Yi-Bo Zheng, Jie Han, Wei Liang, Jia-Yi Wang, Jie-Ru Zhou, Yi Shen and Jie Zhang

    Citation: BMC Musculoskeletal Disorders 2013 14:49

    Content type: Research article

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  7. Rheumatoid arthritis (RA) is an autoimmune disease of which the pathogenetic mechanisms are not fully understood. Semaphorin3A (Sema3A) has an immune regulatory role. Neuropilin1 (NRP1), the primary receptor f...

    Authors: Shu Takagawa, Fumio Nakamura, Ken Kumagai, Yoji Nagashima, Yoshio Goshima and Tomoyuki Saito

    Citation: BMC Musculoskeletal Disorders 2013 14:40

    Content type: Research article

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  8. Peripheral skeletal muscle is altered in patients suffering from emphysema and chronic obstructive pulmonary disease (COPD). Oxidative stress have been demonstrated to participate on skeletal muscle loss of se...

    Authors: Jair Tonon, Alessandra Lourenço Cecchini, Cláudia Roberta Brunnquell, Sara Santos Bernardes, Rubens Cecchini and Flávia Alessandra Guarnier

    Citation: BMC Musculoskeletal Disorders 2013 14:39

    Content type: Research article

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  9. Duchenne Muscular Dystrophy is an inherited degenerative neuromuscular disease characterised by rapidly progressive muscle weakness. Currently, curative treatment is not available. Approaches for new treatment...

    Authors: Cordula Pertl, Markus Eblenkamp, Anja Pertl, Stefan Pfeifer, Erich Wintermantel, Hanns Lochmüller, Maggie C Walter, Sabine Krause and Christian Thirion

    Citation: BMC Musculoskeletal Disorders 2013 14:26

    Content type: Technical advance

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  10. It remains to be shown whether OA shares molecular similarities between different joints in humans. This study provides evidence for similarities in cartilage molecular damage in osteoarthritic (OA) joints.

    Authors: Shahrzad Hosseininia, Lisbeth R Lindberg and Leif E Dahlberg

    Citation: BMC Musculoskeletal Disorders 2013 14:18

    Content type: Research article

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  11. The CatWalk system, a video based automated gait analysis system developed to evaluate footfall and gait changes in rodents, has been used for studying rodent models of arthritis, mainly the rat model. However...

    Authors: Subramanian S Parvathy and Willias Masocha

    Citation: BMC Musculoskeletal Disorders 2013 14:14

    Content type: Research article

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  12. Most tendon pathology is associated with degeneration, which is thought to involve cyclic loading and cumulative age-related changes in tissue architecture. However, the association between aging and degenerat...

    Authors: Tung-Yang Yu, Jong-Hwei S Pang, Katie Pei-Hsuan Wu, Max J-L Chen, Chien-Hung Chen and Wen-Chung Tsai

    Citation: BMC Musculoskeletal Disorders 2013 14:2

    Content type: Research article

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  13. The formation of contractile myofibrils requires the stepwise onset of expression of muscle specific proteins. It is likely that elucidation of the expression patterns of muscle-specific sarcomeric proteins is...

    Authors: Saba Abdul-Hussein, Peter F M van der Ven and Homa Tajsharghi

    Citation: BMC Musculoskeletal Disorders 2012 13:262

    Content type: Research article

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  14. Studies have demonstrated that carbonic anhydrase I (CA1) stimulates calcium salt precipitation and cell calcification, which is an essential step in new bone formation. Our study had reported that CA1 encodin...

    Authors: Yabing Zheng, Lin Wang, Wei Zhang, Hengwei Xu and Xiaotian Chang

    Citation: BMC Musculoskeletal Disorders 2012 13:256

    Content type: Research article

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  15. Biomarkers of peripheral muscle fatigue (BPMFs) are used to offer insights into mechanisms of exhaustion during exercise in order to detect abnormal fatigue or to detect defective metabolic pathways. This revi...

    Authors: Josef Finsterer

    Citation: BMC Musculoskeletal Disorders 2012 13:218

    Content type: Review

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  16. Bone repair is dependent on the presence of osteocompetent progenitors that are able to differentiate and generate new bone. Muscle is found in close association with orthopaedic injury, however its capacity t...

    Authors: Renjing Liu, Oliver Birke, Alyson Morse, Lauren Peacock, Kathy Mikulec, David G Little and Aaron Schindeler

    Citation: BMC Musculoskeletal Disorders 2011 12:288

    Content type: Research article

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  17. Oxidative stress due to the overproduction of nitric oxide (NO) and other oxygen reactive species (ROS), play a main role in the initiation and progression of the OA disease and leads to the degeneration of mi...

    Authors: Mercedes Fernández-Moreno, María Tamayo, Angel Soto-Hermida, Alejandro Mosquera, Natividad Oreiro, Carlos Fernández-López, José Luis Fernández, Ignacio Rego-Pérez and Francisco J Blanco

    Citation: BMC Musculoskeletal Disorders 2011 12:283

    Content type: Research article

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  18. Osteoporosis and associated fractures are a major public health burden and there is great need for a large animal model. Melatonin, the hormone of the pineal gland, has been shown to influence bone metabolism....

    Authors: Marcus Egermann, Christian Gerhardt, Alain Barth, Georges J Maestroni, Erich Schneider and Mauro Alini

    Citation: BMC Musculoskeletal Disorders 2011 12:271

    Content type: Research article

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  19. Oxidative stress play a main role in the initiation and progression of the OA disease and leads to the degeneration of mitochondria. To prevent this, the chondrocytes possess a well-coordinated enzymatic antio...

    Authors: Mercedes Fernandez-Moreno, Angel Soto-Hermida, Sonia Pertega, Natividad Oreiro, Carlos Fernandez-Lopez, Ignacio Rego-Perez and Francisco J Blanco

    Citation: BMC Musculoskeletal Disorders 2011 12:264

    Content type: Research article

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  20. Plasma d-dimer levels have been associated with the status of tumor progression or oncological outcomes in cancer. Although there are many evidences suggesting the involvement of procoagulant trend in musculos...

    Authors: Takeshi Morii, Kazuo Mochizuki, Takashi Tajima, Shoichi Ichimura and Kazuhiko Satomi

    Citation: BMC Musculoskeletal Disorders 2011 12:250

    Content type: Research article

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  21. Current treatments for the prevention of thromboembolism include heparin and low-molecular weight heparins (LMWHs). A number of studies have suggested that long term administration of these drugs may adversely...

    Authors: Gandhi N Solayar, Pauline M Walsh and Kevin J Mulhall

    Citation: BMC Musculoskeletal Disorders 2011 12:247

    Content type: Research article

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  22. Age-related sarcopenia is a disease state of loss of muscle mass and strength that affects physical function and mobility leading to falls, fractures, and disability. The need for therapies to treat age-relate...

    Authors: Chi-Sung Chiu, Hans Weber, Sharon Adamski, Albert Rauch, Michael A Gentile, Stephen E Alves, Gary Kath, Osvaldo Flores and Hilary A Wilkinson

    Citation: BMC Musculoskeletal Disorders 2011 12:246

    Content type: Research article

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  23. Cyclosprin A (CsA) has been widely used clinically to treat the patients who have undergone organ transplantation or acquired autoimmune disease. The purpose of this study is to determine the effects of three ...

    Authors: Yixin Chen, Xin Zheng, Rui Zou and Junfei Wang

    Citation: BMC Musculoskeletal Disorders 2011 12:240

    Content type: Research article

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  24. Hsp90β is a member of the Hsp90 family of protein chaperones. This family plays essential roles in the folding, maturation and activity of many proteins that are involved in signal transduction and transcripti...

    Authors: Valentina Calamia, Maria C de Andrés, Natividad Oreiro, Cristina Ruiz-Romero and Francisco J Blanco

    Citation: BMC Musculoskeletal Disorders 2011 12:237

    Content type: Research article

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  25. We have recently found a phenomenon that spontaneous regeneration of a hyaline cartilage-like tissue can be induced in a large osteochondral defect by implanting a double-network (DN) hydrogel plug, which was ...

    Authors: Ryusei Imabuchi, Yoshihiro Ohmiya, Hyuck Joon Kwon, Shin Onodera, Nobuto Kitamura, Takayuki Kurokawa, Jian Ping Gong and Kazunori Yasuda

    Citation: BMC Musculoskeletal Disorders 2011 12:213

    Content type: Research article

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  26. Skeletal muscle atrophy is a serious concern for the rehabilitation of patients afflicted by prolonged limb restriction. This debilitating condition is associated with a marked activation of NFκB activity. The...

    Authors: Annabelle Z Caron, Sonia Haroun, Élisabeth Leblanc, Frédéric Trensz, Chantal Guindi, Aziz Amrani and Guillaume Grenier

    Citation: BMC Musculoskeletal Disorders 2011 12:185

    Content type: Research article

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  27. Regulation of cell death and cell division are key processes during chondrogenesis and in cartilage homeostasis and pathology. The oncogene survivin is considered to be critical for the coordination of mitosis...

    Authors: Philipp Lechler, Sanjeevi Balakrishnan, Jens Schaumburger, Susanne Grässel, Clemens Baier, Joachim Grifka, Rainer H Straub and Tobias Renkawitz

    Citation: BMC Musculoskeletal Disorders 2011 12:150

    Content type: Research article

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  28. The present study was conducted to address whether the intervertebral disc of rabbit could be considered (i) as a valuable model to provide new insights into the tissue and cellular changes of Nucleus pulposus...

    Authors: Johann Clouet, Marianne Pot-Vaucel, Gaël Grimandi, Martial Masson, Julie Lesoeur, Borhane H Fellah, Olivier Gauthier, Marion Fusellier, Yan Cherel, Yves Maugars, Jérôme Guicheux and Claire Vinatier

    Citation: BMC Musculoskeletal Disorders 2011 12:147

    Content type: Research article

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  29. One of the sources of knee pain in osteoarthritis (OA) is believed to be related to local chronic inflammation of the knee joints, which involves the production of inflammatory cytokines such as tumor necrosis...

    Authors: Sumihisa Orita, Takana Koshi, Takeshi Mitsuka, Masayuki Miyagi, Gen Inoue, Gen Arai, Tetsuhiro Ishikawa, Eiji Hanaoka, Keishi Yamashita, Masaomi Yamashita, Yawara Eguchi, Tomoaki Toyone, Kazuhisa Takahashi and Seiji Ohtori

    Citation: BMC Musculoskeletal Disorders 2011 12:144

    Content type: Research article

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  30. The exact mechanism of knee osteoarthritis (OA)-associated pain is unclear, whereas mixed evidence of inflammatory pain and neuropathic pain has been noted. We aimed to investigate pain-related sensory innerva...

    Authors: Sumihisa Orita, Tetsuhiro Ishikawa, Masayuki Miyagi, Nobuyasu Ochiai, Gen Inoue, Yawara Eguchi, Hiroto Kamoda, Gen Arai, Tomoaki Toyone, Yasuchika Aoki, Takekazu Kubo, Kazuhisa Takahashi and Seiji Ohtori

    Citation: BMC Musculoskeletal Disorders 2011 12:134

    Content type: Research article

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  31. Duchenne muscular dystrophy (DMD) is a severe neuromuscular disease that affects 1 in 3500 boys. The disease is characterized by progressive muscle degeneration that results from mutations in or loss of the cy...

    Authors: Nabeel Ahmad, Ian Welch, Robert Grange, Jennifer Hadway, Savita Dhanvantari, David Hill, Ting-Yim Lee and Lisa M Hoffman

    Citation: BMC Musculoskeletal Disorders 2011 12:127

    Content type: Research article

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  32. Myofibroblasts, a derived subset of fibroblasts especially important in scar formation and wound contraction, have been found at elevated levels in affected Dupuytren's tissues. Transformation of fibroblasts t...

    Authors: Latha Satish, Phillip H Gallo, Mark E Baratz, Sandra Johnson and Sandeep Kathju

    Citation: BMC Musculoskeletal Disorders 2011 12:113

    Content type: Research article

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  33. Chronic tendon injuries, also known as tendinopathies, are common among professional and recreational athletes. These injuries result in a significant amount of morbidity and health care expenditure, yet littl...

    Authors: Scott A Jelinsky, Scott A Rodeo, Jian Li, Lawrence V Gulotta, Joanne M Archambault and Howard J Seeherman

    Citation: BMC Musculoskeletal Disorders 2011 12:86

    Content type: Research article

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  34. Osteonecrosis of the femoral head is a common complication of high-dose glucocorticoid treatment. Intravascular thrombosis is thought to be associated with the ischemic state of the femoral head. Plasminogen a...

    Authors: Kazutaka Sakamoto, Makoto Osaki, Akira Hozumi, Hisataka Goto, Tatsuya Fukushima, Hideo Baba and Hiroyuki Shindo

    Citation: BMC Musculoskeletal Disorders 2011 12:82

    Content type: Research article

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  35. We previously reported early tissue injury, increased serum and tissue inflammatory cytokines and decreased grip in young rats performing a moderate demand repetitive task. The tissue cytokine response was tra...

    Authors: Dong L Xin, Michelle Y Harris, Christine K Wade, Mamta Amin, Ann E Barr and Mary F Barbe

    Citation: BMC Musculoskeletal Disorders 2011 12:63

    Content type: Research article

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  36. Nitric oxide (NO) is a messenger implicated in the destruction and inflammation of joint tissues. Cartilage and synovial membrane from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) have high ...

    Authors: Berta Cillero-Pastor, Miguel A Martin, Joaquín Arenas, María J López-Armada and Francisco J Blanco

    Citation: BMC Musculoskeletal Disorders 2011 12:42

    Content type: Research article

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  37. Tenocytes have been implicated in the development of tendinosis, a chronic condition commonly seen in musculoskeletal overuse syndromes. However, the relation between abnormal tenocyte morphology and early cha...

    Authors: Thomas Abraham, Gloria Fong and Alex Scott

    Citation: BMC Musculoskeletal Disorders 2011 12:26

    Content type: Research article

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  38. Different conditions may alter tendon characteristics. Clinical evidence suggests that tendon injuries are more frequent in athletes that change type, intensity and duration of training. Aim of the study was t...

    Authors: Antonio Frizziero, Milena Fini, Francesca Salamanna, Arsenio Veicsteinas, Nicola Maffulli and Marina Marini

    Citation: BMC Musculoskeletal Disorders 2011 12:20

    Content type: Research article

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  39. There is growing evidence that adiponectin, a physiologically active polypeptide secreted by adipocytes, controls not only adipose tissue but also bone metabolism. However, a role for adiponectin in bone devel...

    Authors: Yasuhiro Mitsui, Masafumi Gotoh, Nobuhiro Fukushima, Isao shirachi, Shuichi Otabe, Xiaohong Yuan, Toshihiko Hashinaga, Nobuhiko Wada, Akiko Mitsui, Tatsuhiro Yoshida, Shiro Yoshida, Kentaro Yamada and Kensei Nagata

    Citation: BMC Musculoskeletal Disorders 2011 12:18

    Content type: Research article

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  40. Minocycline and a non-steroidal anti-inflammatory drug (NSAID) indomethacin, have anti-inflammatory activities and are both used in the management of rheumatoid arthritis. However, there are no reports on whet...

    Authors: Ala'a Ahmed Abu-Ghefreh and Willias Masocha

    Citation: BMC Musculoskeletal Disorders 2010 11:276

    Content type: Research article

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  41. Long head biceps (LHB) degeneration, in combination with rotator cuff tears, can be a source of chronic shoulder pain. LHB tenotomy reduces pain and improves joint function although the pathophysiological cont...

    Authors: Stefan Lakemeier, Soeren A Schwuchow, Christian D Peterlein, Christian Foelsch, Susanne Fuchs-Winkelmann, Eleni Archontidou-Aprin, Juergen RJ Paletta and Markus D Schofer

    Citation: BMC Musculoskeletal Disorders 2010 11:271

    Content type: Research article

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  42. Interleukin (IL)-17 is an important factor in rheumatoid arthritis (RA) pathogenesis. MicroRNA (miRNA)s are a family of non coding RNAs and associated with human diseases including RA. The purpose of this stud...

    Authors: Takuya Niimoto, Tomoyuki Nakasa, Masakazu Ishikawa, Atsushi Okuhara, Bunichiro Izumi, Masataka Deie, Osami Suzuki, Nobuo Adachi and Mitsuo Ochi

    Citation: BMC Musculoskeletal Disorders 2010 11:209

    Content type: Research article

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