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Pathophysiology of musculoskeletal disorders

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

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  1. Inflammation is associated with the onset and progression of osteoarthritis in multiple joints. It is well known that mechanical properties differ between different joints, however, it remains unknown if the i...

    Authors: Guomin Ren, Ian Lutz, Pamela Railton, J. Preston Wiley, Jenelle McAllister, James Powell and Roman J. Krawetz

    Citation: BMC Musculoskeletal Disorders 2018 19:39

    Content type: Research article

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  2. Microendoscopic foraminotomy has been reported to be effective for the treatment of cervical radiculopathy, using outcome measurement scores such as the neck disability index (NDI) and numerical rating scale (...

    Authors: Juichi Tonosu, Hirohiko Inanami, Hiroyuki Oka, Yuichi Takano, Hisashi Koga, Yohei Yuzawa, Ryutaro Shiboi, Yasushi Oshima, Satoshi Baba, Sakae Tanaka and Ko Matsudaira

    Citation: BMC Musculoskeletal Disorders 2018 19:30

    Content type: Research article

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  3. Chondrosarcoma is the second most common primary malignant bone tumor. Because of their heterogeneity, with differences in invasive and metastatic behavior, it is important to identify biological markers that ...

    Authors: Dominik Malcherczyk, Thomas J. Heyse, Bilal F. El-Zayat, Vanessa Kunzke, Roland Moll, Susanne Fuchs-Winkelmann and Jürgen R. J. Paletta

    Citation: BMC Musculoskeletal Disorders 2018 19:9

    Content type: Research article

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  4. Greater age and body mass index are strong risk factors for osteoarthritis (OA). Older and overweight individuals may be more susceptible to OA because these factors alter tissue turnover in menisci, articular...

    Authors: Alina C. Stout, Mary F. Barbe, Charles B. Eaton, Mamta Amin, Fatimah Al-Eid, Lori Lyn Price, Bing Lu, Grace H. Lo, Ming Zhang, Jincheng Pang, Timothy E. McAlindon and Jeffrey B. Driban

    Citation: BMC Musculoskeletal Disorders 2018 19:1

    Content type: Research article

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  5. Transplanting myogenic cells and scaffolds for tissue engineering in skeletal muscle have shown inconsistent results. One of the limiting factors is neovascularization at the recipient site. Low intensity shoc...

    Authors: Lise K. Hansen, Henrik D. Schrøder, Lars Lund, Karthikeyan Rajagopal, Vrisha Maduri and Jeeva Sellathurai

    Citation: BMC Musculoskeletal Disorders 2017 18:557

    Content type: Research article

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  6. The objective of this study was to evaluate the extent of stromal cell-derived factor-1’s (SDF-1) involvement in the pathogenesis of idiopathic versus post-traumatic OA by comparing differences in synovial mem...

    Authors: Nathan P. Thomas, Wesley J. Wu, Braden C. Fleming, Fangyuan Wei, Qian Chen and Lei Wei

    Citation: BMC Musculoskeletal Disorders 2017 18:556

    Content type: Research article

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  7. Studies have investigated the correlation between tumor necrosis factor related apoptosis-inducing ligand (TRAIL) gene polymorphisms and the susceptibility and severity of intervertebral disc degeneration (IDD...

    Authors: Qi-ling Yuan, Liang Liu, Yong-song Cai and Yin-gang Zhang

    Citation: BMC Musculoskeletal Disorders 2017 18:555

    Content type: Research article

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  8. Some reports have shown that intermittent parathyroid hormone (PTH) (1–34) treatment for patients with delayed union or nonunion have led to successful healing. In this study, we investigated whether systemic ...

    Authors: Yohei Kumabe, Sang Yang Lee, Takahiro Waki, Takashi Iwakura, Shunsuke Takahara, Michio Arakura, Yu Kuroiwa, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda and Takahiro Niikura

    Citation: BMC Musculoskeletal Disorders 2017 18:545

    Content type: Research article

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  9. TNF-alpha is suggested to be involved in muscle damage and muscle inflammation (myositis). In order to evaluate whether TNF-alpha is involved in the myositis that occurs in response to muscle overuse, the aim ...

    Authors: Lina Renström, Per Stål, Yafeng Song and Sture Forsgren

    Citation: BMC Musculoskeletal Disorders 2017 18:498

    Content type: Research article

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  10. Glucocorticoid-associated osteonecrosis is an intractable condition, making the establishment of preventative strategies of particular importance. Recently various studies using mesenchymal stem cells (MSC) ha...

    Authors: Shusuke Ueda, Miyako Shimasaki, Toru Ichiseki, Yoshimichi Ueda, Masanobu Tsuchiya, Ayumi Kaneuji and Norio Kawahara

    Citation: BMC Musculoskeletal Disorders 2017 18:480

    Content type: Research article

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  11. Blunt trauma is the most frequent mechanism of injury in multiple trauma, commonly resulting from road traffic collisions or falls. Two of the most frequent injuries in patients with multiple trauma are chest ...

    Authors: Stefanie Fitschen-Oestern, Sebastian Lippross, Tim Klueter, Matthias Weuster, Deike Varoga, Mersedeh Tohidnezhad, Thomas Pufe, Stefan Rose-John, Hagen Andruszkow, Frank Hildebrand, Nadine Steubesand, Andreas Seekamp and Claudia Neunaber

    Citation: BMC Musculoskeletal Disorders 2017 18:468

    Content type: Research article

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    The Correction to this article has been published in BMC Musculoskeletal Disorders 2019 20:72

  12. ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteins play an important pathological role in matrix degeneration. Aggrecan degradation is a significant and critical event in early-stag...

    Authors: Takuya Tajima, Tomohisa Sekimoto, Nami Yamaguchi, Noboru Taniguchi, Syuji Kurogi, Masugi Maruyama and Etsuo Chosa

    Citation: BMC Musculoskeletal Disorders 2017 18:449

    Content type: Research article

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  13. Rotator cuff (RTC) tears are a common clinical problem resulting in adverse changes to the muscle, but there is limited information comparing histopathology to contractile function. This study assessed suprasp...

    Authors: Ana P. Valencia, Shama R. Iyer, Espen E. Spangenburg, Mohit N. Gilotra and Richard M. Lovering

    Citation: BMC Musculoskeletal Disorders 2017 18:436

    Content type: Research article

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  14. p21(WAF1/CIP1/SDI1), a cyclin dependent kinase inhibitor has been shown to influence cell proliferation, differentiation and apoptosis; but more recently, p21 has been implicated in tissue repair. Studies on p21(

    Authors: Priyatha Premnath, Britta Jorgenson, Ricarda Hess, Pankaj Tailor, Dante Louie, Jaymi Taiani, Steven Boyd and Roman Krawetz

    Citation: BMC Musculoskeletal Disorders 2017 18:435

    Content type: Research article

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  15. The aim was to investigate whether resident chondrocytes in human articular cartilage and in subculture express vitamin D receptor (VDR) and the enzyme that hydroxylates the prohormone 25(OH)D3 to the active horm...

    Authors: Ann Kristin Hansen, Yngve Figenschau and Inigo Zubiaurre-Martinez

    Citation: BMC Musculoskeletal Disorders 2017 18:432

    Content type: Research article

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  16. Nerve growth factor (NGF) is not only an important factor in nerve growth but also a major contributor to the production of inflammation. It has been reported that inhibiting NGF could reduce several types of ...

    Authors: Masayuki Miyagi, Tetsuhiro Ishikawa, Hiroto Kamoda, Miyako Suzuki, Gen Inoue, Yoshihiro Sakuma, Yasuhiro Oikawa, Sumihisa Orita, Kentaro Uchida, Kazuhisa Takahashi, Masashi Takaso and Seiji Ohtori

    Citation: BMC Musculoskeletal Disorders 2017 18:428

    Content type: Research article

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  17. Osteoarthritis research has been most commonly performed in the setting of the articular cartilage of the knee. To the best of our knowledge, no studies have evaluated the role of adiponectin in osteoarthritis...

    Authors: Qi Lai, Yuan Liu, Leitao Huang, Xuqiang Liu, Xionglong Yu, Qiang Wang, Runsheng Guo, Jianghao Zhu, Hanxiong Cheng, Min Dai and Bin Zhang

    Citation: BMC Musculoskeletal Disorders 2017 18:427

    Content type: Research article

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  18. Significant amount of bone mass is lost during the process of aging due to an imbalance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption in bone marrow microenvironment, which...

    Authors: Xia Chen, Junsong Chen, Dongliang Xu, Shuangxia Zhao, Huaidong Song and Yongde Peng

    Citation: BMC Musculoskeletal Disorders 2017 18:423

    Content type: Research article

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  19. Pure exercise intolerance associated with exclusive affection of skeletal muscle is a very rare phenotype of patients with mitochondrial myopathy. Moreover, the exercise intolerance in these rare patients is y...

    Authors: Patrick Soldath, Karen Lindhardt Madsen, Astrid Emilie Buch, Morten Duno, Flemming Wibrand and John Vissing

    Citation: BMC Musculoskeletal Disorders 2017 18:419

    Content type: Case report

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  20. At present, there are no registered products for the treatment of subchondral Bone Marrow Edema Lesion (BML) and associated knee pain. Patients who do not respond to current anti-inflammatory therapies are lef...

    Authors: Matthew J. Sampson, Margie Kabbani, Ravi Krishnan, Michael Nganga, Annika Theodoulou and Jeganath Krishnan

    Citation: BMC Musculoskeletal Disorders 2017 18:396

    Content type: Case report

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  21. Neuroimmune axis is central in the physiopathology of hip osteoarthritis (OA), but its specific pathways are still unclear. This systematic review aims to assess the nervous and immune system profile of patien...

    Authors: Manuel Ribeiro da Silva, Daniela Linhares, Daniel Marques Vasconcelos, Cecilia Juliana Alves, Nuno Neves, Gilberto Costa and Meriem Lamghari

    Citation: BMC Musculoskeletal Disorders 2017 18:394

    Content type: Research article

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  22. Subchondral osteopenia is important for the pathophysiology of osteoarthritis (OA). Although previous studies suggest that plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, is related to...

    Authors: Akihiro Moritake, Naoyuki Kawao, Kiyotaka Okada, Kohei Tatsumi, Masayoshi Ishida, Katsumi Okumoto, Osamu Matsuo, Masao Akagi and Hiroshi Kaji

    Citation: BMC Musculoskeletal Disorders 2017 18:392

    Content type: Research article

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  23. The objectives are to compare the efficacy of intra-articular hyaluronic acid (IA-HA) alone and in combination with anti-inflammatory drugs (IA-HA + AI), corticosteroids (CS) or non-steroidal anti-inflammatory...

    Authors: Thippaporn Euppayo, Veerasak Punyapornwithaya, Siriwadee Chomdej, Siriwan Ongchai and Korakot Nganvongpanit

    Citation: BMC Musculoskeletal Disorders 2017 18:387

    Content type: Research article

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  24. The major types of commercially available gelatin hydrolysates are prepared from mammals or fish. Dietary gelatin hydrolysates from mammals were reported to improve bone mineral density (BMD) in some animal mo...

    Authors: Teruyuki Noma, Satoshi Takasugi, Miho Shioyama, Taketo Yamaji, Hiroyuki Itou, Yoshio Suzuki, Keishoku Sakuraba and Keisuke Sawaki

    Citation: BMC Musculoskeletal Disorders 2017 18:385

    Content type: Research article

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    The Correction to this article has been published in BMC Musculoskeletal Disorders 2017 18:422

  25. Knee osteoarthritis (KOA) is a degenerative knee disease commonly found in the ageing population. DNA methylation works with histone acetylation to participate in aging. Alterations of DNA methylation may invo...

    Authors: Xinxin Wang, Dezhi Tang, Peng Shen, Hao Xu, Hongfu Qiu, Tao Wu and Xiang Gao

    Citation: BMC Musculoskeletal Disorders 2017 18:377

    Content type: Research article

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  26. The pathophysiology, including the impact of gene expression, of polymyalgia rheumatica (PMR) remains elusive. We profiled the gene expression in muscle tissue in PMR patients before and after glucocorticoid t...

    Authors: Frederik Flindt Kreiner, Rehannah Borup, Finn Cilius Nielsen, Peter Schjerling and Henrik Galbo

    Citation: BMC Musculoskeletal Disorders 2017 18:341

    Content type: Research article

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  27. We had previously established concentrated autologous bone marrow aspirate transplantation (CABMAT), a one-step, low-invasive, joint-preserving surgical technique for treating osteonecrosis of the femoral head...

    Authors: Yohei Tomaru, Tomokazu Yoshioka, Hisashi Sugaya, Katsuya Aoto, Hiroshi Wada, Hiroshi Akaogi, Masashi Yamazaki and Hajime Mishima

    Citation: BMC Musculoskeletal Disorders 2017 18:292

    Content type: Research article

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  28. Somatosensory profiling in affected and non-affected body regions can strengthen our insight regarding the underlying pain mechanisms, which can be valuable in treatment decision making and to improve outcomes...

    Authors: Yvonne Lindbäck, Hans Tropp, Paul Enthoven, Björn Gerdle, Allan Abbott and Birgitta Öberg

    Citation: BMC Musculoskeletal Disorders 2017 18:264

    Content type: Research article

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  29. Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether intra-articular admi...

    Authors: Carlos Vaamonde-García, Jesús Loureiro, Marta N. Valcárcel-Ares, Romina R. Riveiro-Naveira, Olalla Ramil-Gómez, Laura Hermida-Carballo, Alberto Centeno, Rosa Meijide-Failde, Francisco J. Blanco and María J. López-Armada

    Citation: BMC Musculoskeletal Disorders 2017 18:254

    Content type: Research article

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  30. Negative Pressure Wound Therapy (NPWT) is being increasingly used to treat postoperative infections after osteosynthetic fracture fixation. The aim of the present study was to analyze the influence of epidemio...

    Authors: Kaywan Izadpanah, Stephanie Hansen, Julia Six-Merker, Peter Helwig, Norbert P Südkamp and Hagen Schmal

    Citation: BMC Musculoskeletal Disorders 2017 18:247

    Content type: Research article

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  31. Leptin plays an important role in mediating chondrogenesis of limb growth plate. Previous studies suggest that bone structures and development of spine and limb are different. The expression of Ob-Rb, the gene...

    Authors: Bo Yu, Kaibiao Jiang, Bin Chen, Hantao Wang, Xinfeng Li and Zude Liu

    Citation: BMC Musculoskeletal Disorders 2017 18:235

    Content type: Research article

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  32. Ankylosing spondylitis (AS) is characterised by immune-mediated arthritis and osteoproliferation, ultimately leading to joint ankylosis. Whether inflammation is necessary for osteoproliferation is controversia...

    Authors: Hsu-Wen Tseng, Tibor T. Glant, Matthew A. Brown, Tony J. Kenna, Gethin P. Thomas and Allison R. Pettit

    Citation: BMC Musculoskeletal Disorders 2017 18:228

    Content type: Research article

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  33. A body of evidence demonstrating changes to the glutaminergic system in tendinopathy has recently emerged. This hypothesis was further tested by studying the effects of glutamate on the tenocyte phenotype, and...

    Authors: Christoph Spang, Ludvig J. Backman, Sandrine Le Roux, Jialin Chen and Patrik Danielson

    Citation: BMC Musculoskeletal Disorders 2017 18:218

    Content type: Research article

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  34. Invossa™ (TissueGene-C) is a cell and gene therapy for osteoarthritis. It is composed of primary human chondrocytes (hChonJ cells) and irradiated human chondrocytes modified to express TGF-β1 (hChonJb#7 cells)...

    Authors: Chae-Lyul Lim, Yeon-Ju Lee, Jong-Ho Cho, Heonsik Choi, Bumsup Lee, Myung Chul Lee and Sujeong Kim

    Citation: BMC Musculoskeletal Disorders 2017 18:199

    Content type: Research article

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  35. Joint inflammation causes meniscus degeneration and can exacerbate post-traumatic meniscus injuries by extracellular matrix degradation, cellular de-differentiation and cell death. The aim of this study was to...

    Authors: P. Behrendt, K. Häfelein, A. Preusse-Prange, A. Bayer, A. Seekamp and B. Kurz

    Citation: BMC Musculoskeletal Disorders 2017 18:197

    Content type: Research article

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  36. Back pain and disc degeneration have a growing socioeconomic healthcare impact. Mucin 1 (MUC1) is a transmembrane glycoprotein whose extracellular and intracellular domains participate in cellular signaling. L...

    Authors: Helen E. Gruber, Jane A. Ingram, Gretchen L. Hoelscher, Emilio Marrero and Edward N. Hanley Jr

    Citation: BMC Musculoskeletal Disorders 2017 18:182

    Content type: Research article

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  37. Humeral head fractures requiring surgical intervention are severe injuries, which might affect the return to sports and daily activities. We hypothesize that athletic patients will be constrained regarding the...

    Authors: Philipp Ahrens, Frank Martetschläger, Sebastian Siebenlist, Johann Attenberger, Moritz Crönlein, Peter Biberthaler, Ulrich Stöckle and Gunther H. Sandmann

    Citation: BMC Musculoskeletal Disorders 2017 18:173

    Content type: Research article

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  38. Degenerative lumbar spinal stenosis (DLSS) is a common health problem in the elderly and usually associated with three-joint complex degeneration. Schmorl’s nodes (SNs) are described as vertical herniation of ...

    Authors: Janan Abbas, Viviane Slon, Dan Stein, Natan Peled, Israel Hershkovitz and Kamal Hamoud

    Citation: BMC Musculoskeletal Disorders 2017 18:164

    Content type: Research article

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  39. Accelerometric analysis of gait abnormalities in golden retriever muscular dystrophy (GRMD) dogs is of limited sensitivity, and produces highly complex data. The use of discriminant analysis may enable simpler...

    Authors: Bodvaël Fraysse, Inès Barthélémy, El Mostafa Qannari, Karl Rouger, Chantal Thorin, Stéphane Blot, Caroline Le Guiner, Yan Chérel and Jean-Yves Hogrel

    Citation: BMC Musculoskeletal Disorders 2017 18:153

    Content type: Technical advance

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  40. Evidence is lacking on whether fat infiltration in the multifidus muscles affects outcomes after total disc replacement (TDR) surgery and if it develops after surgery. The aims of this study were 1) to investi...

    Authors: Kjersti Storheim, Linda Berg, Christian Hellum, Øivind Gjertsen, Gesche Neckelmann, Ansgar Espeland and Anne Keller

    Citation: BMC Musculoskeletal Disorders 2017 18:145

    Content type: Research article

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  41. Human-beta defensins (HBD) belong to the family of acute phase peptides and hold a broad antimicrobial spectrum that includes gram-positive and gram-negative bacteria. HBD are up-regulated after severe injurie...

    Authors: Stefanie Fitschen-Oestern, Matthias Weuster, Sebastian Lippross, Peter Behrendt, Sabine Fuchs, Thomas Pufe, Mersedeh Tohidnezhad, Andreas Bayer, Andreas Seekamp, Deike Varoga and Tim Klüter

    Citation: BMC Musculoskeletal Disorders 2017 18:100

    Content type: Research article

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  42. Facet tropism is the angular asymmetry between the left and right facet joint orientation. Although debatable, facet tropism was suggested to be associated with disc degeneration, facet degeneration and degene...

    Authors: Xin Rong, Ziyang Liu, Beiyu Wang, Xuelin Pan and Hao Liu

    Citation: BMC Musculoskeletal Disorders 2017 18:86

    Content type: Research article

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  43. Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by renal phosphate wasting, hypophosphatemia, reduction of 1,25-dihydroxyl vitamin D, and bone calcification disorders. Tumors a...

    Authors: Ryuta Arai, Tomohiro Onodera, Mohamad Alaa Terkawi, Tomoko Mitsuhashi, Eiji Kondo and Norimasa Iwasaki

    Citation: BMC Musculoskeletal Disorders 2017 18:79

    Content type: Case report

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  44. Osteoarthritis (OA) involves cartilage changes as well as modifications of subchondral bone and synovial tissues. Strontium ranelate (SR), an anti-osteoporosis compound, which is currently in phase III clinica...

    Authors: Jian-Guo Chu, Mu-Wei Dai, Yu Wang, Fa-Ming Tian, Hui-Ping Song, Ya-Ping Xiao, Li-Tao Shao, Ying-Ze Zhang and Liu Zhang

    Citation: BMC Musculoskeletal Disorders 2017 18:78

    Content type: Research article

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  45. The vast majority of dynamometer-based animal models for investigation of the response to chronic muscle contraction exposure has been limited to analysis of isometric, lengthening, or shortening contractions ...

    Authors: Erik P. Rader, Marshall A. Naimo, James Ensey and Brent A. Baker

    Citation: BMC Musculoskeletal Disorders 2017 18:60

    Content type: Research article

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  46. The objective of this study was to investigate the protective effects of molecular hydrogen, a novel and selective antioxidant, on steroid-induced osteonecrosis (ON) in a rabbit model.

    Authors: Jia Li, Zhaogang Ge, Lihong Fan and Kunzheng Wang

    Citation: BMC Musculoskeletal Disorders 2017 18:58

    Content type: Research article

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  47. Inflammation is a major cause of cartilage destruction and leads to the imbalance of metabolic activities in the arthritic joint. Pigment epithelium-derived factor (PEDF) has been reported to have both pro- an...

    Authors: Daisy S. Nakamura, Judith M. Hollander, Tomoya Uchimura, Heber C. Nielsen and Li Zeng

    Citation: BMC Musculoskeletal Disorders 2017 18:39

    Content type: Research article

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