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Pathophysiology of musculoskeletal disorders

Section edited by Ali Mobasheri

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

Page 3 of 6

  1. Content type: Research article

    Real-world data regarding anti-tumor necrosis factor alpha (anti-TNFα) biologic therapy use in psoriatic arthritis (PsA) are limited; therefore, we described treatment patterns and costs of anti-TNFα therapy i...

    Authors: Jacqueline B. Palmer, Yunfeng Li, Vivian Herrera, Minlei Liao, Melody Tran and Zafer E. Ozturk

    Citation: BMC Musculoskeletal Disorders 2016 17:261

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  2. Content type: Research article

    Arthritis secondary to developmental hip dysplasia often mandates implant surgery at a relatively young age. Hip resurfacing arthroplasty (HRA), compared with standard stemmed total hip arthroplasty (THA), aff...

    Authors: Melissa D. Gaillard and Thomas P. Gross

    Citation: BMC Musculoskeletal Disorders 2016 17:251

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  3. Content type: Research article

    Although osteoarthritis (OA) is a multifactorial disease, little has been reported regarding the cooperative interaction among these factors on cartilage metabolism. Here we examined the synergistic effect of ...

    Authors: Kazumasa Miyatake, Takeshi Muneta, Miyoko Ojima, Jun Yamada, Yu Matsukura, Kahaer Abula, Ichiro Sekiya and Kunikazu Tsuji

    Citation: BMC Musculoskeletal Disorders 2016 17:238

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  4. Content type: Review

    Osteoarthritis is a leading cause of pain and disability across the world. With an aging population its prevalence is likely to further increase. Current accepted medical treatment strategies are aimed at symp...

    Authors: Julien Freitag, Dan Bates, Richard Boyd, Kiran Shah, Adele Barnard, Leesa Huguenin and Abi Tenen

    Citation: BMC Musculoskeletal Disorders 2016 17:230

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  5. Content type: Research article

    Atypical femoral fractures (AFF) are a rare type of femoral stress fracture recently described, potentially associated with prolonged bisphosphonate therapy. Evidence-based recommendations regarding diagnosis ...

    Authors: Giuseppe Toro, Cristina Ojeda-Thies, Giampiero Calabrò, Gabriella Toro, Antimo Moretti, Guillermo Martínez-Díaz Guerra, Pedro Caba-Doussoux and Giovanni Iolascon

    Citation: BMC Musculoskeletal Disorders 2016 17:227

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  6. Content type: Research article

    Duchenne muscular dystrophy (DMD) is an X-linked muscle disease that leads to fibre necrosis and progressive paralysis. At present, DMD remains a lethal disease without any effective treatment, requiring a bet...

    Authors: Florence Robriquet, Candice Babarit, Thibaut Larcher, Laurence Dubreil, Mireille Ledevin, Hélicia Goubin, Karl Rouger and Laëtitia Guével

    Citation: BMC Musculoskeletal Disorders 2016 17:209

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  7. Content type: Research article

    Farmers have an increased risk for musculoskeletal disorders (MSD) such as osteoarthritis of the hip, low back pain, and neck and upper limb complaints. The underlying mechanisms are not fully understood. Work...

    Authors: Bijar Ghafouri, Anders Carlsson, Sara Holmberg, Anders Thelin and Christer Tagesson

    Citation: BMC Musculoskeletal Disorders 2016 17:206

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  8. Content type: Research article

    Cross-linked hyaluronan—also called Hylan G-F 20—is a medical device developed to treat osteoarthritis of the knee. However, it is still controversial whether Hylan G-F 20 has a cartilage protective effect in ...

    Authors: Katsuaki Yanagisawa, Takeshi Muneta, Nobutake Ozeki, Yusuke Nakagawa, Mio Udo, Ryusuke Saito, Hideyuki Koga, Kunikazu Tsuji and Ichiro Sekiya

    Citation: BMC Musculoskeletal Disorders 2016 17:188

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  9. Content type: Research article

    Animal models serve as an important tool to understand peri-implant infection. Most of the models use high bacterial loads (>104 colony forming units, CFU) to provide high infection rates. Therefore these animals...

    Authors: Norbert Harrasser, Johannes Gorkotte, Andreas Obermeier, Susanne Feihl, Melanie Straub, Julia Slotta-Huspenina, Ruediger von Eisenhart-Rothe, Walter Moser, Philipp Gruner, Michael de Wild, Hans Gollwitzer and Rainer Burgkart

    Citation: BMC Musculoskeletal Disorders 2016 17:152

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  10. Content type: Research article

    Recent studies have shown that autophagy was associated with the development of osteoarthritis (OA), the purpose of this research was to determine the exact role of autophagy in OA and investigate effective th...

    Authors: Ni-Tao Cheng, Ai Guo and Hai Meng

    Citation: BMC Musculoskeletal Disorders 2016 17:150

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  11. Content type: Research article

    The use of a prefabricated spacer in two-stage revision arthroplasty remains one of the few surgery strategies for infected-joint arthroplasty treatment, despite the many unidentified microorganisms in the inf...

    Authors: Przemysław Bereza, Alicja Ekiel, Aleksandra Auguściak-Duma, Małgorzata Aptekorz, Iwona Wilk, Damian Kusz, Piotr Wojciechowski, Aleksander L. Sieroń and Gayane Martirosian

    Citation: BMC Musculoskeletal Disorders 2016 17:138

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  12. Content type: Research article

    The maintenance of nucleus pulposus (NP) viability in vitro is difficult. The annulus fibrosus (AF) pathway reflects one nutrient transport channel and may have an important effect on NP viability in disc orga...

    Authors: Pei Li, Rongmao Shi, Daosen Chen, Yibo Gan, Yuan Xu, Lei Song, Songtao Li and Qiang Zhou

    Citation: BMC Musculoskeletal Disorders 2016 17:133

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  13. Content type: Research article

    Immediate early genes (IEGs) encode transcription factors which serve as first line response modules to altered conditions and mediate appropriate cell responses. The immediate early response gene EGR1 is invo...

    Authors: Guus G. H. van den Akker, Don A. M. Surtel, Andy Cremers, Martijn F. G. A. Hoes, Marjolein M. Caron, Stephen M. Richardson, Ricardo Rodrigues-Pinto, Lodewijk W. van Rhijn, Judith A. Hoyland, Tim J. M. Welting and Jan Willem Voncken

    Citation: BMC Musculoskeletal Disorders 2016 17:124

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  14. Content type: Research article

    Of all the most frequent soft tissue disorders of the shoulder, idiopathic frozen shoulder (IFS) offers the greatest potential for studying proprioception. Studies concerning the presence of proprioception dys...

    Authors: Jaroslaw Fabis, Remigiusz Rzepka, Anna Fabis, Jacek Zwierzchowski, Grzegorz Kubiak, Arkadiusz Stanula, Michal Polguj and Radek Maciej

    Citation: BMC Musculoskeletal Disorders 2016 17:123

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  15. Content type: Research article

    New tissue engineering strategies for bone regeneration need to be investigated in a relevant preclinical large animal model before making the translation into human patients. Therefore, our interdisciplinary ...

    Authors: Anne-Marie Pobloth, Kenneth A. Johnson, Hanna Schell, Nicolai Kolarczik, Dag Wulsten, Georg N. Duda and Katharina Schmidt-Bleek

    Citation: BMC Musculoskeletal Disorders 2016 17:111

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  16. Content type: Research article

    Low-molecular-weight heparins (e.g. Enoxaparin) are widely used to prevent venous thromboembolism after orthopaedic surgery, but there are reports about serious side effects including reduction in bone density...

    Authors: Hakan Pilge, Julia Fröbel, Silvia J. Mrotzek, Johannes C. Fischer, Peter M. Prodinger, Christoph Zilkens, Bernd Bittersohl and Rüdiger Krauspe

    Citation: BMC Musculoskeletal Disorders 2016 17:108

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  17. Content type: Research article

    Lethal multiple pterygium syndrome (LMPS, OMIM 253290), is a fatal disorder associated with anomalies of the skin, muscles and skeleton. It is characterised by prenatal growth failure with pterygium present in...

    Authors: Ariana Kariminejad, Siavash Ghaderi-Sohi, Hamid Hossein-Nejad Nedai, Vahid Varasteh, Ali-Reza Moslemi and Homa Tajsharghi

    Citation: BMC Musculoskeletal Disorders 2016 17:109

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  18. Content type: Research article

    In contrast to the well-characterized body growth and development of females with adolescent idiopathic scoliosis (AIS), the pubertal growth pattern of male patients has not been well-documented. Recently, sig...

    Authors: Weijun Wang, Zhiwei Wang, Zezhang Zhu, Feng Zhu and Yong Qiu

    Citation: BMC Musculoskeletal Disorders 2016 17:107

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  19. Content type: Research article

    Chronic musculoskeletal pain may be associated with changes in the balance of algogenic and anti-nociceptive compounds, and such changes may be visible in plasma samples. We have undertaken an exploratory stud...

    Authors: Fredrik Hellström, Sandra Gouveia-Figueira, Malin L. Nording, Martin Björklund and Christopher J. Fowler

    Citation: BMC Musculoskeletal Disorders 2016 17:103

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  20. Content type: Research article

    Ehlers Danlos Syndrome is a rare form of inherited connective tissue disorder, which primarily affects skin, joints, muscle, and blood cells. The current study aimed at finding the mutation that causing EDS ty...

    Authors: Akshatha Desai, John J. Connolly, Michael March, Cuiping Hou, Rosetta Chiavacci, Cecilia Kim, Gholson Lyon, Dexter Hadley and Hakon Hakonarson

    Citation: BMC Musculoskeletal Disorders 2016 17:80

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  21. Content type: Case report

    FBN1 (15q21.1) encodes fibrillin-1, a large glycoprotein which is a major component of microfibrils that are widely distributed in structural elements of elastic and non-elastic tissue...

    Authors: Octavio D. Reyes-Hernández, Carmen Palacios-Reyes, Sonia Chávez-Ocaña, Enoc M. Cortés-Malagón, Patricia Garcia Alonso-Themann, Víctor Ramos-Cano, Julián Ramírez-Bello and Mónica Sierra-Martínez

    Citation: BMC Musculoskeletal Disorders 2016 17:79

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  22. Content type: Research article

    The purpose of this study was to determine the relationships among hip geometry, bone mineral density, and the risk of hip fracture in premenopausal women.

    Authors: Dong-Hwa Lee, Kyong Yeun Jung, A Ram Hong, Jung Hee Kim, Kyoung Min Kim, Chan Soo Shin, Seong Yeon Kim and Sang Wan Kim

    Citation: BMC Musculoskeletal Disorders 2016 17:42

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  23. Content type: Research article

    Expression of the growth factor osteoactivin (OA) increases during tissue degeneration and regeneration, fracture repair and after denervation-induced disuse atrophy, concomitant with increased matrix metallop...

    Authors: Nagat Frara, Samir M. Abdelmagid, Michael Tytell, Mamta Amin, Steven N. Popoff, Fayez F. Safadi and Mary F. Barbe

    Citation: BMC Musculoskeletal Disorders 2016 17:34

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  24. Content type: Research article

    The need for revision surgery after a spinal surgery can cause a variety of problems, including reduced quality of life for the patient, additional medical expenses, and patient-physician conflicts. The purpos...

    Authors: Tsung-Ting Tsai, Sheng-Hsun Lee, Chi-Chien Niu, Po-Liang Lai, Lih-Huei Chen and Wen-Jer Chen

    Citation: BMC Musculoskeletal Disorders 2016 17:28

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  25. Content type: Research article

    A lumbar disc herniation (LDH) is a localised displacement of disc material, which may initiate changes in the disc and adjacent structures such as the nerve root and the spinal canal. Knowledge about how morp...

    Authors: Per Kjaer, Andreas Tunset, Eleanor Boyle and Tue Secher Jensen

    Citation: BMC Musculoskeletal Disorders 2016 17:26

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  26. Content type: Research article

    Previous studies suggest that a greater proportion of neck injury patients, whose injuries were sustained through whiplash accidents, become chronic due to a component of sickness-focusing. However, it is also...

    Authors: Tom Bendix, Jakob Kjellberg, Rikke Ibsen and Poul Jørgen Jennum

    Citation: BMC Musculoskeletal Disorders 2016 17:24

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  27. Content type: Research article

    The transforming growth factor beta-1 (TGFB1) gene was recently reported to be a new susceptible gene of adolescent idiopathic scoliosis (AIS) in Russian population. This study aimed to replicate the relations...

    Authors: Leilei Xu, Weixiang Sun, Xiaodong Qin, Yong Qiu and Zezhang Zhu

    Citation: BMC Musculoskeletal Disorders 2016 17:15

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  28. Content type: Research article

    Anterior cruciate ligament (ACL) tear is considered a risk factor for osteoarthritis development. The purpose of our study was to investigate the expression levels of the apoptotic enzyme caspase 3, pro-inflam...

    Authors: Ioanna Papathanasiou, Sotirios Michalitsis, Michael E. Hantes, Marianna Vlychou, Lydia Anastasopoulou, Konstantinos N. Malizos and Aspasia Tsezou

    Citation: BMC Musculoskeletal Disorders 2016 17:21

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  29. Content type: Research article

    No treatment to date is available which specifically targets bone formation in ankylosing spondylitis (AS). Several recent studies have shown that sclerostin (SOST), a Wnt inhibitor specific to osteocytes and ...

    Authors: Katelin R. Haynes, Hsu-Wen Tseng, Michaela Kneissel, Tibor T. Glant, Matthew A. Brown and Gethin P. Thomas

    Citation: BMC Musculoskeletal Disorders 2015 16:368

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  30. Content type: Research article

    Prolonged bisphosphonate treatment might suppress bone remodeling to the extent that normal bone repair is impaired. While this adverse side effect is usually ascribed to the negative effects of bisphosphonate...

    Authors: Kuo-Chin Huang, Chin-Chang Cheng, Po-Yao Chuang and Tien-Yu Yang

    Citation: BMC Musculoskeletal Disorders 2015 16:355

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  31. Content type: Research article

    In cerebral palsy (CP) there is an increased risk of scoliosis. It is important to identify a progressive scoliosis early-on because the results of surgery depend on the magnitude of the curve. The Swedish fol...

    Authors: Måns Persson-Bunke, Tomasz Czuba, Gunnar Hägglund and Elisabet Rodby-Bousquet

    Citation: BMC Musculoskeletal Disorders 2015 16:351

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  32. Content type: Research article

    Intervertebral disc (IVD) degeneration and pathological changes in the spinal cord are major causes of back pain. In addition to its well-established anti-resorptive effect on bone, calcitonin (CT) potentially...

    Authors: Chang-Cheng Liu, Fa-Ming Tian, Zhuang Zhou, Peng Wang, Yu Gou, Heng Zhang, Wen-Ya Wang, Yong Shen, Ying-Ze Zhang and Liu Zhang

    Citation: BMC Musculoskeletal Disorders 2015 16:342

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  33. Content type: Research article

    Knee osteoarthritis (OA) is one of the leading causes of disability within the adult population. Current treatment options for OA of the knee include intra-articular (IA) hyaluronic acid (HA), a molecule found...

    Authors: RD Altman, A. Manjoo, A. Fierlinger, F. Niazi and M. Nicholls

    Citation: BMC Musculoskeletal Disorders 2015 16:321

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  34. Content type: Research article

    The etiology of de Quervain's tenosynovitis (dQ) has been based on conflicting small case series and cohort studies lacking methodological rigor. A prospective case-control study was conducted to analyze the m...

    Authors: Stéphane Stahl, Daniel Vida, Christoph Meisner, Adelana Santos Stahl, Hans-Eberhard Schaller and Manuel Held

    Citation: BMC Musculoskeletal Disorders 2015 16:126

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  35. Content type: Research article

    Immunoglobulin (Ig) G4-related disease (IgG4-RD) is characterized by elevated serum IgG4 and infiltration of IgG4+ plasma cells into multiple organs. It is not known whether serum IgG4 is autoreactive in IgG4-RD.

    Authors: Kazuhiro Kiyama, Hajime Yoshifuji, Tsugumitsu Kandou, Yuji Hosono, Koji Kitagori, Ran Nakashima, Yoshitaka Imura, Naoichiro Yukawa, Koichiro Ohmura, Takao Fujii, Daisuke Kawabata and Tsuneyo Mimori

    Citation: BMC Musculoskeletal Disorders 2015 16:129

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  36. Content type: Research article

    Contractures of the knee joint cause disability and handicap. Recovering range of motion is recognized by arthritic patients as their preference for improved health outcome secondary only to pain management. C...

    Authors: Kayleigh Wong, Fangui Sun, Guy Trudel, Paola Sebastiani and Odette Laneuville

    Citation: BMC Musculoskeletal Disorders 2015 16:125

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  37. Content type: Research article

    Accumulating evidence has demonstrated a pathogenic role of advanced glycation end products (AGEs) and receptors for AGEs (RAGE) in inflammation. Soluble RAGE (sRAGE), with the same ligands-binding capacity as...

    Authors: Der-Yuan Chen, Yi-Ming Chen, Chi-Chen Lin, Chia-Wei Hsieh, Yen-Ching Wu, Wei-Ting Hung, Hsin-Hua Chen and Joung-Liang Lan

    Citation: BMC Musculoskeletal Disorders 2015 16:111

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  38. Content type: Research article

    Endothelial progenitor cells (EPC) promote angiogenesis and vascular repair. Though reduced EPC levels have been shown in rheumatoid arthritis, no study has so far evaluated EPCs in children with juvenile idio...

    Authors: Giorgia Martini, Francesca Biscaro, Elisa Boscaro, Fiorella Calabrese, Francesca Lunardi, Monica Facco, Carlo Agostini, Francesco Zulian and Gian Paolo Fadini

    Citation: BMC Musculoskeletal Disorders 2015 16:103

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  39. Content type: Research article

    Osteoarthritis (OA) is the most frequent articular disease and a leading cause of disability. There is a need for effective treatments able to slow the progression of disease. Some of the available treatments ...

    Authors: María Luisa Ferrándiz, María Carmen Terencio, María Carmen Carceller, Ramón Ruhí, Pere Dalmau, Josep Vergés, Eulàlia Montell, Anna Torrent and María José Alcaraz

    Citation: BMC Musculoskeletal Disorders 2015 16:92

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  40. Content type: Research article

    OA is a complex disease caused by environmental and genetic risk factors. The purpose of this study is to identify candidate copy number variations (CNVs) associated with OA.

    Authors: Sanghoon Moon, Bhumsuk Keam, Mi Yeong Hwang, Young Lee, Suyeon Park, Ji Hee Oh, Yeon-Jung Kim, Heun-Sik Lee, Nam Hee Kim, Young Jin Kim, Dong-Hyun Kim, Bok-Ghee Han, Bong-Jo Kim and Juyoung Lee

    Citation: BMC Musculoskeletal Disorders 2015 16:76

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  41. Content type: Research article

    Degeneration of cartilage will change load distribution, affecting bone remodeling progress and trabecular structure and strength. However, in human primary osteoporosis, whether cartilage lesions would also a...

    Authors: Houchen Lv, Licheng Zhang, Fei Yang, Zhe Zhao, Qi Yao, Lihai Zhang and Peifu Tang

    Citation: BMC Musculoskeletal Disorders 2015 16:72

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  42. Content type: Research article

    The restoration of damaged meniscus has always been a challenge due to its limited healing capacity. Recently, bone marrow-derived mesenchymal stem cells (BMSCs) provide a promising alternative to repair menis...

    Authors: Zhe Ding and He Huang

    Citation: BMC Musculoskeletal Disorders 2015 16:65

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  43. Content type: Research article

    The previous studies indicated that CrmA could ameliorate the interleukin-1β induced osteoarthritis. In this study, we investigated the controlled-released cytokine response modifier A (CrmA) from hyaluronic a...

    Authors: Bei-lei Ma, Pang-Hu Zhou, Ting Xie, Lei Shi, Bo Qiu and Qian Wang

    Citation: BMC Musculoskeletal Disorders 2015 16:61

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  44. Content type: Research article

    Neck pain is associated with several alterations in neck motion and motor control. Previous studies have investigated single constructs of neck motor control, while few have applied a comprehensive set of test...

    Authors: Ingebrigt Meisingset, Astrid Woodhouse, Ann- Katrin Stensdotter, Øyvind Stavdahl, Håvard Lorås, Sigmund Gismervik, Hege Andresen, Kristian Austreim and Ottar Vasseljen

    Citation: BMC Musculoskeletal Disorders 2015 16:56

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  45. Content type: Research article

    Pro-inflammatory cytokines are directly implicated in the pathogenesis of Rheumatoid arthritis (RA). Variable clinical response to cytokine targeted therapies as TNFalpha and IL-6, strongly highlights the hete...

    Authors: Alicia Santos Savio, Ana Cecilia Machado Diaz, Araceli Chico Capote, Jamilet Miranda Navarro, Yunier Rodríguez Alvarez, Ricardo Bringas Pérez, Miguel Estévez del Toro and Gerardo E Guillen Nieto

    Citation: BMC Musculoskeletal Disorders 2015 16:51

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  46. Content type: Research article

    Spinal muscular atrophy (SMA) is caused by SMN1 dysfunction, and the copy number of SMN2 and NAIP can modify the phenotype of SMA. The aim of this study was to analyze the copy numbers and gene structures of SMA-...

    Authors: Ping Fang, Liang Li, Jian Zeng, Wan-Jun Zhou, Wei-Qing Wu, Ze-Yan Zhong, Ti-Zhen Yan, Jian-Sheng Xie, Jing Huang, Li Lin, Ying Zhao and Xiang-Min Xu

    Citation: BMC Musculoskeletal Disorders 2015 16:11

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  47. Content type: Research article

    Caffeine is an active alkaloid that can cause damage to bones in formation during prenatal life into adulthood. This compound can pass across the placenta and into the mother’s milk, causing a reduction in bon...

    Authors: Amanda Maria Sena Reis, Lorena Gabriela Rocha Ribeiro, Natália de Melo Ocarino, Alfredo Miranda Goes and Rogéria Serakides

    Citation: BMC Musculoskeletal Disorders 2015 16:10

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