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BMC Musculoskeletal Disorders

Pathophysiology of musculoskeletal disorders

Section edited by Ali Mobasheri

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

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  1. Content type: Research article

    Degenerative lumbar spinal stenosis (DLSS) is a common health problem in the elderly and usually associated with three-joint complex degeneration. Schmorl’s nodes (SNs) are described as vertical herniation of ...

    Authors: Janan Abbas, Viviane Slon, Dan Stein, Natan Peled, Israel Hershkovitz and Kamal Hamoud

    Citation: BMC Musculoskeletal Disorders 2017 18:164

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  2. Content type: Technical advance

    Accelerometric analysis of gait abnormalities in golden retriever muscular dystrophy (GRMD) dogs is of limited sensitivity, and produces highly complex data. The use of discriminant analysis may enable simpler...

    Authors: Bodvaël Fraysse, Inès Barthélémy, El Mostafa Qannari, Karl Rouger, Chantal Thorin, Stéphane Blot, Caroline Le Guiner, Yan Chérel and Jean-Yves Hogrel

    Citation: BMC Musculoskeletal Disorders 2017 18:153

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  3. Content type: Research article

    Evidence is lacking on whether fat infiltration in the multifidus muscles affects outcomes after total disc replacement (TDR) surgery and if it develops after surgery. The aims of this study were 1) to investi...

    Authors: Kjersti Storheim, Linda Berg, Christian Hellum, Øivind Gjertsen, Gesche Neckelmann, Ansgar Espeland and Anne Keller

    Citation: BMC Musculoskeletal Disorders 2017 18:145

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  4. Content type: Research article

    Human-beta defensins (HBD) belong to the family of acute phase peptides and hold a broad antimicrobial spectrum that includes gram-positive and gram-negative bacteria. HBD are up-regulated after severe injurie...

    Authors: Stefanie Fitschen-Oestern, Matthias Weuster, Sebastian Lippross, Peter Behrendt, Sabine Fuchs, Thomas Pufe, Mersedeh Tohidnezhad, Andreas Bayer, Andreas Seekamp, Deike Varoga and Tim Klüter

    Citation: BMC Musculoskeletal Disorders 2017 18:100

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  5. Content type: Research article

    Facet tropism is the angular asymmetry between the left and right facet joint orientation. Although debatable, facet tropism was suggested to be associated with disc degeneration, facet degeneration and degene...

    Authors: Xin Rong, Ziyang Liu, Beiyu Wang, Xuelin Pan and Hao Liu

    Citation: BMC Musculoskeletal Disorders 2017 18:86

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  6. Content type: Case report

    Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by renal phosphate wasting, hypophosphatemia, reduction of 1,25-dihydroxyl vitamin D, and bone calcification disorders. Tumors a...

    Authors: Ryuta Arai, Tomohiro Onodera, Mohamad Alaa Terkawi, Tomoko Mitsuhashi, Eiji Kondo and Norimasa Iwasaki

    Citation: BMC Musculoskeletal Disorders 2017 18:79

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  7. Content type: Research article

    Osteoarthritis (OA) involves cartilage changes as well as modifications of subchondral bone and synovial tissues. Strontium ranelate (SR), an anti-osteoporosis compound, which is currently in phase III clinica...

    Authors: Jian-Guo Chu, Mu-Wei Dai, Yu Wang, Fa-Ming Tian, Hui-Ping Song, Ya-Ping Xiao, Li-Tao Shao, Ying-Ze Zhang and Liu Zhang

    Citation: BMC Musculoskeletal Disorders 2017 18:78

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  8. Content type: Research article

    The vast majority of dynamometer-based animal models for investigation of the response to chronic muscle contraction exposure has been limited to analysis of isometric, lengthening, or shortening contractions ...

    Authors: Erik P. Rader, Marshall A. Naimo, James Ensey and Brent A. Baker

    Citation: BMC Musculoskeletal Disorders 2017 18:60

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  9. Content type: Research article

    The objective of this study was to investigate the protective effects of molecular hydrogen, a novel and selective antioxidant, on steroid-induced osteonecrosis (ON) in a rabbit model.

    Authors: Jia Li, Zhaogang Ge, Lihong Fan and Kunzheng Wang

    Citation: BMC Musculoskeletal Disorders 2017 18:58

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  10. Content type: Research article

    Inflammation is a major cause of cartilage destruction and leads to the imbalance of metabolic activities in the arthritic joint. Pigment epithelium-derived factor (PEDF) has been reported to have both pro- an...

    Authors: Daisy S. Nakamura, Judith M. Hollander, Tomoya Uchimura, Heber C. Nielsen and Li Zeng

    Citation: BMC Musculoskeletal Disorders 2017 18:39

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  11. Content type: Research article

    Chronic hematogenous osteomyelitis often results from the improper treatment of acute hematogenous osteomyelitis. At present, there is lack of uniform standards for the treatment, and the clinical features of ...

    Authors: Xiaohua Wang, Zhen Wang, Jingshu Fu, Ke Huang and Zhao Xie

    Citation: BMC Musculoskeletal Disorders 2017 18:33

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  12. Content type: Research article

    Inhibition of activin/myostatin pathway has emerged as a novel approach to increase muscle mass and bone strength. Duchenne muscular dystrophy (DMD) is a neuromuscular disorder that leads to progressive muscle...

    Authors: Tero Puolakkainen, Hongqian Ma, Heikki Kainulainen, Arja Pasternack, Timo Rantalainen, Olli Ritvos, Kristiina Heikinheimo, Juha J. Hulmi and Riku Kiviranta

    Citation: BMC Musculoskeletal Disorders 2017 18:20

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  13. Content type: Research article

    There are few studies with an assessment of the levels of cytokines or neuropeptides as correlates of pain and pain relief in patients with painful joint diseases. Our objective was to assess whether improveme...

    Authors: Jasvinder A. Singh, Siamak Noorbaloochi and Keith L. Knutson

    Citation: BMC Musculoskeletal Disorders 2017 18:17

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  14. Content type: Research article

    Lumbar multifidus muscles (LMM) are important for spinal motion and stability. Low back pain (LBP) is often associated with fat infiltration in LMM. An increasing fat infiltration of LMM may lead to lumbar dys...

    Authors: Markus Hildebrandt, Gabriela Fankhauser, André Meichtry and Hannu Luomajoki

    Citation: BMC Musculoskeletal Disorders 2017 18:12

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  15. Content type: Research article

    The aim of the present study was to provide an overview of the literature addressing the role of genetic factors and biomarkers predicting pain recovery in newly diagnosed lumbar radicular pain (LRP) patients.

    Authors: Siri Bjorland, Aurora Moen, Elina Schistad, Johannes Gjerstad and Cecilie Røe

    Citation: BMC Musculoskeletal Disorders 2016 17:500

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  16. Content type: Research article

    Patients with rheumatoid arthritis (RA) have increased risk of sudden cardiac death (SCD), which is two-fold higher than general population. The driving cause of SCD was considered due to lift-threatening arrh...

    Authors: Ting-Tse Lin, Yen-Ling Sung, Chih-En Wu, Hong Zhang, Yen-Bin Liu and Shien-Fong Lin

    Citation: BMC Musculoskeletal Disorders 2016 17:491

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  17. Content type: Research article

    Leading theories about the pathogenesis of fibromyalgia focus on central nervous dysregulation or sensitization, which can cause altered perception. There is growing evidence that fibromyalgia involves altered...

    Authors: Magne Stranden, Håvard Solvin, Egil A. Fors, Linn Getz and Anne-S. Helvik

    Citation: BMC Musculoskeletal Disorders 2016 17:477

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  18. Content type: Research article

    Dupuytren’s disease (DD) is a complex fibro-proliferative disorder of the hand that is often progressive and eventually can cause contractures of the affected fingers. Transforming growth factor beta (TGF-β1) has...

    Authors: Chaoming Zhou, Fang Liu, Phillip H. Gallo, Mark E. Baratz, Sandeep Kathju and Latha Satish

    Citation: BMC Musculoskeletal Disorders 2016 17:469

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  19. Content type: Research article

    The use of corticosteroids (e.g., dexamethasone) as treatment for tendinopathy has recently been questioned as higher risks for ruptures have been observed clinically. In vitro studies have reported that dexam...

    Authors: Christoph Spang, Jialin Chen and Ludvig J. Backman

    Citation: BMC Musculoskeletal Disorders 2016 17:467

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