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Pathophysiology of musculoskeletal disorders

Section edited by Ali Mobasheri

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

Page 3 of 13
  1. Content type: Research article

    Leptin plays an important role in mediating chondrogenesis of limb growth plate. Previous studies suggest that bone structures and development of spine and limb are different. The expression of Ob-Rb, the gene...

    Authors: Bo Yu, Kaibiao Jiang, Bin Chen, Hantao Wang, Xinfeng Li and Zude Liu

    Citation: BMC Musculoskeletal Disorders 2017 18:235

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  2. Content type: Research article

    Ankylosing spondylitis (AS) is characterised by immune-mediated arthritis and osteoproliferation, ultimately leading to joint ankylosis. Whether inflammation is necessary for osteoproliferation is controversia...

    Authors: Hsu-Wen Tseng, Tibor T. Glant, Matthew A. Brown, Tony J. Kenna, Gethin P. Thomas and Allison R. Pettit

    Citation: BMC Musculoskeletal Disorders 2017 18:228

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  3. Content type: Research article

    A body of evidence demonstrating changes to the glutaminergic system in tendinopathy has recently emerged. This hypothesis was further tested by studying the effects of glutamate on the tenocyte phenotype, and...

    Authors: Christoph Spang, Ludvig J. Backman, Sandrine Le Roux, Jialin Chen and Patrik Danielson

    Citation: BMC Musculoskeletal Disorders 2017 18:218

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  4. Content type: Research article

    Invossa™ (TissueGene-C) is a cell and gene therapy for osteoarthritis. It is composed of primary human chondrocytes (hChonJ cells) and irradiated human chondrocytes modified to express TGF-β1 (hChonJb#7 cells)...

    Authors: Chae-Lyul Lim, Yeon-Ju Lee, Jong-Ho Cho, Heonsik Choi, Bumsup Lee, Myung Chul Lee and Sujeong Kim

    Citation: BMC Musculoskeletal Disorders 2017 18:199

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  5. Content type: Research article

    Joint inflammation causes meniscus degeneration and can exacerbate post-traumatic meniscus injuries by extracellular matrix degradation, cellular de-differentiation and cell death. The aim of this study was to...

    Authors: P. Behrendt, K. Häfelein, A. Preusse-Prange, A. Bayer, A. Seekamp and B. Kurz

    Citation: BMC Musculoskeletal Disorders 2017 18:197

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  6. Content type: Research article

    Back pain and disc degeneration have a growing socioeconomic healthcare impact. Mucin 1 (MUC1) is a transmembrane glycoprotein whose extracellular and intracellular domains participate in cellular signaling. L...

    Authors: Helen E. Gruber, Jane A. Ingram, Gretchen L. Hoelscher, Emilio Marrero and Edward N. Hanley Jr

    Citation: BMC Musculoskeletal Disorders 2017 18:182

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  7. Content type: Research article

    Humeral head fractures requiring surgical intervention are severe injuries, which might affect the return to sports and daily activities. We hypothesize that athletic patients will be constrained regarding the...

    Authors: Philipp Ahrens, Frank Martetschläger, Sebastian Siebenlist, Johann Attenberger, Moritz Crönlein, Peter Biberthaler, Ulrich Stöckle and Gunther H. Sandmann

    Citation: BMC Musculoskeletal Disorders 2017 18:173

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  8. Content type: Research article

    Degenerative lumbar spinal stenosis (DLSS) is a common health problem in the elderly and usually associated with three-joint complex degeneration. Schmorl’s nodes (SNs) are described as vertical herniation of ...

    Authors: Janan Abbas, Viviane Slon, Dan Stein, Natan Peled, Israel Hershkovitz and Kamal Hamoud

    Citation: BMC Musculoskeletal Disorders 2017 18:164

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  9. Content type: Technical advance

    Accelerometric analysis of gait abnormalities in golden retriever muscular dystrophy (GRMD) dogs is of limited sensitivity, and produces highly complex data. The use of discriminant analysis may enable simpler...

    Authors: Bodvaël Fraysse, Inès Barthélémy, El Mostafa Qannari, Karl Rouger, Chantal Thorin, Stéphane Blot, Caroline Le Guiner, Yan Chérel and Jean-Yves Hogrel

    Citation: BMC Musculoskeletal Disorders 2017 18:153

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  10. Content type: Research article

    Evidence is lacking on whether fat infiltration in the multifidus muscles affects outcomes after total disc replacement (TDR) surgery and if it develops after surgery. The aims of this study were 1) to investi...

    Authors: Kjersti Storheim, Linda Berg, Christian Hellum, Øivind Gjertsen, Gesche Neckelmann, Ansgar Espeland and Anne Keller

    Citation: BMC Musculoskeletal Disorders 2017 18:145

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  11. Content type: Research article

    Human-beta defensins (HBD) belong to the family of acute phase peptides and hold a broad antimicrobial spectrum that includes gram-positive and gram-negative bacteria. HBD are up-regulated after severe injurie...

    Authors: Stefanie Fitschen-Oestern, Matthias Weuster, Sebastian Lippross, Peter Behrendt, Sabine Fuchs, Thomas Pufe, Mersedeh Tohidnezhad, Andreas Bayer, Andreas Seekamp, Deike Varoga and Tim Klüter

    Citation: BMC Musculoskeletal Disorders 2017 18:100

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  12. Content type: Research article

    Facet tropism is the angular asymmetry between the left and right facet joint orientation. Although debatable, facet tropism was suggested to be associated with disc degeneration, facet degeneration and degene...

    Authors: Xin Rong, Ziyang Liu, Beiyu Wang, Xuelin Pan and Hao Liu

    Citation: BMC Musculoskeletal Disorders 2017 18:86

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  13. Content type: Case report

    Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by renal phosphate wasting, hypophosphatemia, reduction of 1,25-dihydroxyl vitamin D, and bone calcification disorders. Tumors a...

    Authors: Ryuta Arai, Tomohiro Onodera, Mohamad Alaa Terkawi, Tomoko Mitsuhashi, Eiji Kondo and Norimasa Iwasaki

    Citation: BMC Musculoskeletal Disorders 2017 18:79

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  14. Content type: Research article

    Osteoarthritis (OA) involves cartilage changes as well as modifications of subchondral bone and synovial tissues. Strontium ranelate (SR), an anti-osteoporosis compound, which is currently in phase III clinica...

    Authors: Jian-Guo Chu, Mu-Wei Dai, Yu Wang, Fa-Ming Tian, Hui-Ping Song, Ya-Ping Xiao, Li-Tao Shao, Ying-Ze Zhang and Liu Zhang

    Citation: BMC Musculoskeletal Disorders 2017 18:78

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  15. Content type: Research article

    The vast majority of dynamometer-based animal models for investigation of the response to chronic muscle contraction exposure has been limited to analysis of isometric, lengthening, or shortening contractions ...

    Authors: Erik P. Rader, Marshall A. Naimo, James Ensey and Brent A. Baker

    Citation: BMC Musculoskeletal Disorders 2017 18:60

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  16. Content type: Research article

    The objective of this study was to investigate the protective effects of molecular hydrogen, a novel and selective antioxidant, on steroid-induced osteonecrosis (ON) in a rabbit model.

    Authors: Jia Li, Zhaogang Ge, Lihong Fan and Kunzheng Wang

    Citation: BMC Musculoskeletal Disorders 2017 18:58

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  17. Content type: Research article

    Inflammation is a major cause of cartilage destruction and leads to the imbalance of metabolic activities in the arthritic joint. Pigment epithelium-derived factor (PEDF) has been reported to have both pro- an...

    Authors: Daisy S. Nakamura, Judith M. Hollander, Tomoya Uchimura, Heber C. Nielsen and Li Zeng

    Citation: BMC Musculoskeletal Disorders 2017 18:39

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  18. Content type: Research article

    Chronic hematogenous osteomyelitis often results from the improper treatment of acute hematogenous osteomyelitis. At present, there is lack of uniform standards for the treatment, and the clinical features of ...

    Authors: Xiaohua Wang, Zhen Wang, Jingshu Fu, Ke Huang and Zhao Xie

    Citation: BMC Musculoskeletal Disorders 2017 18:33

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  19. Content type: Research article

    Inhibition of activin/myostatin pathway has emerged as a novel approach to increase muscle mass and bone strength. Duchenne muscular dystrophy (DMD) is a neuromuscular disorder that leads to progressive muscle...

    Authors: Tero Puolakkainen, Hongqian Ma, Heikki Kainulainen, Arja Pasternack, Timo Rantalainen, Olli Ritvos, Kristiina Heikinheimo, Juha J. Hulmi and Riku Kiviranta

    Citation: BMC Musculoskeletal Disorders 2017 18:20

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