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BMC Musculoskeletal Disorders

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Pathophysiology of musculoskeletal disorders

Section edited by Ali Mobasheri

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

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  1. Content type: Research article

    The vast majority of dynamometer-based animal models for investigation of the response to chronic muscle contraction exposure has been limited to analysis of isometric, lengthening, or shortening contractions ...

    Authors: Erik P. Rader, Marshall A. Naimo, James Ensey and Brent A. Baker

    Citation: BMC Musculoskeletal Disorders 2017 18:60

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  2. Content type: Research article

    Inflammation is a major cause of cartilage destruction and leads to the imbalance of metabolic activities in the arthritic joint. Pigment epithelium-derived factor (PEDF) has been reported to have both pro- an...

    Authors: Daisy S. Nakamura, Judith M. Hollander, Tomoya Uchimura, Heber C. Nielsen and Li Zeng

    Citation: BMC Musculoskeletal Disorders 2017 18:39

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  3. Content type: Research article

    Chronic hematogenous osteomyelitis often results from the improper treatment of acute hematogenous osteomyelitis. At present, there is lack of uniform standards for the treatment, and the clinical features of ...

    Authors: Xiaohua Wang, Zhen Wang, Jingshu Fu, Ke Huang and Zhao Xie

    Citation: BMC Musculoskeletal Disorders 2017 18:33

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  4. Content type: Research article

    Inhibition of activin/myostatin pathway has emerged as a novel approach to increase muscle mass and bone strength. Duchenne muscular dystrophy (DMD) is a neuromuscular disorder that leads to progressive muscle...

    Authors: Tero Puolakkainen, Hongqian Ma, Heikki Kainulainen, Arja Pasternack, Timo Rantalainen, Olli Ritvos, Kristiina Heikinheimo, Juha J. Hulmi and Riku Kiviranta

    Citation: BMC Musculoskeletal Disorders 2017 18:20

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  5. Content type: Research article

    There are few studies with an assessment of the levels of cytokines or neuropeptides as correlates of pain and pain relief in patients with painful joint diseases. Our objective was to assess whether improveme...

    Authors: Jasvinder A. Singh, Siamak Noorbaloochi and Keith L. Knutson

    Citation: BMC Musculoskeletal Disorders 2017 18:17

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  6. Content type: Research article

    Lumbar multifidus muscles (LMM) are important for spinal motion and stability. Low back pain (LBP) is often associated with fat infiltration in LMM. An increasing fat infiltration of LMM may lead to lumbar dys...

    Authors: Markus Hildebrandt, Gabriela Fankhauser, André Meichtry and Hannu Luomajoki

    Citation: BMC Musculoskeletal Disorders 2017 18:12

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  7. Content type: Research article

    The aim of the present study was to provide an overview of the literature addressing the role of genetic factors and biomarkers predicting pain recovery in newly diagnosed lumbar radicular pain (LRP) patients.

    Authors: Siri Bjorland, Aurora Moen, Elina Schistad, Johannes Gjerstad and Cecilie Røe

    Citation: BMC Musculoskeletal Disorders 2016 17:500

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  8. Content type: Research article

    Patients with rheumatoid arthritis (RA) have increased risk of sudden cardiac death (SCD), which is two-fold higher than general population. The driving cause of SCD was considered due to lift-threatening arrh...

    Authors: Ting-Tse Lin, Yen-Ling Sung, Chih-En Wu, Hong Zhang, Yen-Bin Liu and Shien-Fong Lin

    Citation: BMC Musculoskeletal Disorders 2016 17:491

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  9. Content type: Research article

    Leading theories about the pathogenesis of fibromyalgia focus on central nervous dysregulation or sensitization, which can cause altered perception. There is growing evidence that fibromyalgia involves altered...

    Authors: Magne Stranden, Håvard Solvin, Egil A. Fors, Linn Getz and Anne-S. Helvik

    Citation: BMC Musculoskeletal Disorders 2016 17:477

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  10. Content type: Research article

    Dupuytren’s disease (DD) is a complex fibro-proliferative disorder of the hand that is often progressive and eventually can cause contractures of the affected fingers. Transforming growth factor beta (TGF-β1) has...

    Authors: Chaoming Zhou, Fang Liu, Phillip H. Gallo, Mark E. Baratz, Sandeep Kathju and Latha Satish

    Citation: BMC Musculoskeletal Disorders 2016 17:469

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  11. Content type: Research article

    The use of corticosteroids (e.g., dexamethasone) as treatment for tendinopathy has recently been questioned as higher risks for ruptures have been observed clinically. In vitro studies have reported that dexam...

    Authors: Christoph Spang, Jialin Chen and Ludvig J. Backman

    Citation: BMC Musculoskeletal Disorders 2016 17:467

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  12. Content type: Research article

    Increased reactive oxygen species and estrogen deficiency contribute to the pathophysiology of postmenopausal osteoporosis. Reactive oxygen species contribute to bone degradation and is necessary for RANKL-ind...

    Authors: Alexandra Stubelius, Annica Andersson, Rikard Holmdahl, Claes Ohlsson, Ulrika Islander and Hans Carlsten

    Citation: BMC Musculoskeletal Disorders 2016 17:464

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  13. Content type: Research article

    Systemic sclerosis (SSc) is a rheumatologic disease with a multifactorial etiology. Genome-wide association studies imply a polygenic, complex mode of inheritance with contributions from variation at the human...

    Authors: Christopher J. Cardinale, Dong Li, Lifeng Tian, John J. Connolly, Michael E. March, Cuiping Hou, Fengxiang Wang, James Snyder, Cecilia E. Kim, Rosetta M. Chiavacci, Patrick M. Sleiman, Jon M. Burnham and Hakon Hakonarson

    Citation: BMC Musculoskeletal Disorders 2016 17:462

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  14. Content type: Research article

    Cumulative evidence indicates that statins induce myotoxicity. However, the lack of understanding of how statins affect skeletal muscles at the structural, functional, and physiological levels hampers proper h...

    Authors: Antoine Boulanger Piette, Sébastien S. Dufresne and Jérôme Frenette

    Citation: BMC Musculoskeletal Disorders 2016 17:449

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  15. Content type: Research article

    The aim of this study is to clarify the following two points: First, whether a cyclooxygenase-2 mediated pathway is involved in the formation of immobilization-induced joint contracture and, second, the effect...

    Authors: Junya Ozawa, Akinori Kaneguchi, Ryo Tanaka, Nobuhiro Kito and Hideki Moriyama

    Citation: BMC Musculoskeletal Disorders 2016 17:446

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  16. Content type: Research article

    Many people with Whiplash Associated Disorders (WAD) report problems with vision, some of which may be due to impaired eye movements. Better understanding of such impaired eye movements could improve diagnosti...

    Authors: Britta Kristina Ischebeck, Jurryt de Vries, Jos N Van der Geest, Malou Janssen, Jan Paul Van Wingerden, Gert Jan Kleinrensink and Maarten A Frens

    Citation: BMC Musculoskeletal Disorders 2016 17:441

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  17. Content type: Research article

    Aseptic loosening is a significant impediment to joint implant longevity. Prosthetic wear particles are postulated to play a central role in the onset and progression of periprosthetic osteolysis, leading to a...

    Authors: Chu-qiang Qin, Dong-sheng Huang, Chi Zhang, Bin Song, Jian-bin Huang and Yue Ding

    Citation: BMC Musculoskeletal Disorders 2016 17:431

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  18. Content type: Research article

    Type 2 diabetes mellitus (T2DM) is associated with an increased risk of osteoporotic fracture. Several factors have been identified as being potentially responsible for this risk, such as alterations in bone r...

    Authors: Cristina Miranda, Mercè Giner, M. José Montoya, M. Angeles Vázquez, M. José Miranda and Ramón Pérez-Cano

    Citation: BMC Musculoskeletal Disorders 2016 17:377

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  19. Content type: Research article

    Although articular cartilage is the primary tissues affected by osteoarthritis (OA), the underlying subchondral bone also undergoes noticeable changes. Despite the growing body of research into the biophysical...

    Authors: Qiliang Zuo, Shifeier Lu, Zhibin Du, Thor Friis, Jiangwu Yao, Ross Crawford, Indira Prasadam and Yin Xiao

    Citation: BMC Musculoskeletal Disorders 2016 17:367

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