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Pathophysiology of musculoskeletal disorders

Section edited by Ali Mobasheri

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

Page 2 of 6

  1. Content type: Research article

    The pathophysiology, including the impact of gene expression, of polymyalgia rheumatica (PMR) remains elusive. We profiled the gene expression in muscle tissue in PMR patients before and after glucocorticoid t...

    Authors: Frederik Flindt Kreiner, Rehannah Borup, Finn Cilius Nielsen, Peter Schjerling and Henrik Galbo

    Citation: BMC Musculoskeletal Disorders 2017 18:341

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  2. Content type: Research article

    We had previously established concentrated autologous bone marrow aspirate transplantation (CABMAT), a one-step, low-invasive, joint-preserving surgical technique for treating osteonecrosis of the femoral head...

    Authors: Yohei Tomaru, Tomokazu Yoshioka, Hisashi Sugaya, Katsuya Aoto, Hiroshi Wada, Hiroshi Akaogi, Masashi Yamazaki and Hajime Mishima

    Citation: BMC Musculoskeletal Disorders 2017 18:292

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  3. Content type: Research article

    Somatosensory profiling in affected and non-affected body regions can strengthen our insight regarding the underlying pain mechanisms, which can be valuable in treatment decision making and to improve outcomes...

    Authors: Yvonne Lindbäck, Hans Tropp, Paul Enthoven, Björn Gerdle, Allan Abbott and Birgitta Öberg

    Citation: BMC Musculoskeletal Disorders 2017 18:264

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  4. Content type: Research article

    Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether intra-articular admi...

    Authors: Carlos Vaamonde-García, Jesús Loureiro, Marta N. Valcárcel-Ares, Romina R. Riveiro-Naveira, Olalla Ramil-Gómez, Laura Hermida-Carballo, Alberto Centeno, Rosa Meijide-Failde, Francisco J. Blanco and María J. López-Armada

    Citation: BMC Musculoskeletal Disorders 2017 18:254

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  5. Content type: Research article

    Negative Pressure Wound Therapy (NPWT) is being increasingly used to treat postoperative infections after osteosynthetic fracture fixation. The aim of the present study was to analyze the influence of epidemio...

    Authors: Kaywan Izadpanah, Stephanie Hansen, Julia Six-Merker, Peter Helwig, Norbert P Südkamp and Hagen Schmal

    Citation: BMC Musculoskeletal Disorders 2017 18:247

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  6. Content type: Research article

    Leptin plays an important role in mediating chondrogenesis of limb growth plate. Previous studies suggest that bone structures and development of spine and limb are different. The expression of Ob-Rb, the gene...

    Authors: Bo Yu, Kaibiao Jiang, Bin Chen, Hantao Wang, Xinfeng Li and Zude Liu

    Citation: BMC Musculoskeletal Disorders 2017 18:235

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  7. Content type: Research article

    Ankylosing spondylitis (AS) is characterised by immune-mediated arthritis and osteoproliferation, ultimately leading to joint ankylosis. Whether inflammation is necessary for osteoproliferation is controversia...

    Authors: Hsu-Wen Tseng, Tibor T. Glant, Matthew A. Brown, Tony J. Kenna, Gethin P. Thomas and Allison R. Pettit

    Citation: BMC Musculoskeletal Disorders 2017 18:228

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  8. Content type: Research article

    A body of evidence demonstrating changes to the glutaminergic system in tendinopathy has recently emerged. This hypothesis was further tested by studying the effects of glutamate on the tenocyte phenotype, and...

    Authors: Christoph Spang, Ludvig J. Backman, Sandrine Le Roux, Jialin Chen and Patrik Danielson

    Citation: BMC Musculoskeletal Disorders 2017 18:218

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  9. Content type: Research article

    Invossa™ (TissueGene-C) is a cell and gene therapy for osteoarthritis. It is composed of primary human chondrocytes (hChonJ cells) and irradiated human chondrocytes modified to express TGF-β1 (hChonJb#7 cells)...

    Authors: Chae-Lyul Lim, Yeon-Ju Lee, Jong-Ho Cho, Heonsik Choi, Bumsup Lee, Myung Chul Lee and Sujeong Kim

    Citation: BMC Musculoskeletal Disorders 2017 18:199

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  10. Content type: Research article

    Joint inflammation causes meniscus degeneration and can exacerbate post-traumatic meniscus injuries by extracellular matrix degradation, cellular de-differentiation and cell death. The aim of this study was to...

    Authors: P. Behrendt, K. Häfelein, A. Preusse-Prange, A. Bayer, A. Seekamp and B. Kurz

    Citation: BMC Musculoskeletal Disorders 2017 18:197

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  11. Content type: Research article

    Back pain and disc degeneration have a growing socioeconomic healthcare impact. Mucin 1 (MUC1) is a transmembrane glycoprotein whose extracellular and intracellular domains participate in cellular signaling. L...

    Authors: Helen E. Gruber, Jane A. Ingram, Gretchen L. Hoelscher, Emilio Marrero and Edward N. Hanley Jr

    Citation: BMC Musculoskeletal Disorders 2017 18:182

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  12. Content type: Research article

    Humeral head fractures requiring surgical intervention are severe injuries, which might affect the return to sports and daily activities. We hypothesize that athletic patients will be constrained regarding the...

    Authors: Philipp Ahrens, Frank Martetschläger, Sebastian Siebenlist, Johann Attenberger, Moritz Crönlein, Peter Biberthaler, Ulrich Stöckle and Gunther H. Sandmann

    Citation: BMC Musculoskeletal Disorders 2017 18:173

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  13. Content type: Research article

    Degenerative lumbar spinal stenosis (DLSS) is a common health problem in the elderly and usually associated with three-joint complex degeneration. Schmorl’s nodes (SNs) are described as vertical herniation of ...

    Authors: Janan Abbas, Viviane Slon, Dan Stein, Natan Peled, Israel Hershkovitz and Kamal Hamoud

    Citation: BMC Musculoskeletal Disorders 2017 18:164

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  14. Content type: Technical advance

    Accelerometric analysis of gait abnormalities in golden retriever muscular dystrophy (GRMD) dogs is of limited sensitivity, and produces highly complex data. The use of discriminant analysis may enable simpler...

    Authors: Bodvaël Fraysse, Inès Barthélémy, El Mostafa Qannari, Karl Rouger, Chantal Thorin, Stéphane Blot, Caroline Le Guiner, Yan Chérel and Jean-Yves Hogrel

    Citation: BMC Musculoskeletal Disorders 2017 18:153

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  15. Content type: Research article

    Evidence is lacking on whether fat infiltration in the multifidus muscles affects outcomes after total disc replacement (TDR) surgery and if it develops after surgery. The aims of this study were 1) to investi...

    Authors: Kjersti Storheim, Linda Berg, Christian Hellum, Øivind Gjertsen, Gesche Neckelmann, Ansgar Espeland and Anne Keller

    Citation: BMC Musculoskeletal Disorders 2017 18:145

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  16. Content type: Research article

    Human-beta defensins (HBD) belong to the family of acute phase peptides and hold a broad antimicrobial spectrum that includes gram-positive and gram-negative bacteria. HBD are up-regulated after severe injurie...

    Authors: Stefanie Fitschen-Oestern, Matthias Weuster, Sebastian Lippross, Peter Behrendt, Sabine Fuchs, Thomas Pufe, Mersedeh Tohidnezhad, Andreas Bayer, Andreas Seekamp, Deike Varoga and Tim Klüter

    Citation: BMC Musculoskeletal Disorders 2017 18:100

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  17. Content type: Research article

    Facet tropism is the angular asymmetry between the left and right facet joint orientation. Although debatable, facet tropism was suggested to be associated with disc degeneration, facet degeneration and degene...

    Authors: Xin Rong, Ziyang Liu, Beiyu Wang, Xuelin Pan and Hao Liu

    Citation: BMC Musculoskeletal Disorders 2017 18:86

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  18. Content type: Case report

    Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by renal phosphate wasting, hypophosphatemia, reduction of 1,25-dihydroxyl vitamin D, and bone calcification disorders. Tumors a...

    Authors: Ryuta Arai, Tomohiro Onodera, Mohamad Alaa Terkawi, Tomoko Mitsuhashi, Eiji Kondo and Norimasa Iwasaki

    Citation: BMC Musculoskeletal Disorders 2017 18:79

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  19. Content type: Research article

    Osteoarthritis (OA) involves cartilage changes as well as modifications of subchondral bone and synovial tissues. Strontium ranelate (SR), an anti-osteoporosis compound, which is currently in phase III clinica...

    Authors: Jian-Guo Chu, Mu-Wei Dai, Yu Wang, Fa-Ming Tian, Hui-Ping Song, Ya-Ping Xiao, Li-Tao Shao, Ying-Ze Zhang and Liu Zhang

    Citation: BMC Musculoskeletal Disorders 2017 18:78

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  20. Content type: Research article

    The vast majority of dynamometer-based animal models for investigation of the response to chronic muscle contraction exposure has been limited to analysis of isometric, lengthening, or shortening contractions ...

    Authors: Erik P. Rader, Marshall A. Naimo, James Ensey and Brent A. Baker

    Citation: BMC Musculoskeletal Disorders 2017 18:60

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  21. Content type: Research article

    The objective of this study was to investigate the protective effects of molecular hydrogen, a novel and selective antioxidant, on steroid-induced osteonecrosis (ON) in a rabbit model.

    Authors: Jia Li, Zhaogang Ge, Lihong Fan and Kunzheng Wang

    Citation: BMC Musculoskeletal Disorders 2017 18:58

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  22. Content type: Research article

    Inflammation is a major cause of cartilage destruction and leads to the imbalance of metabolic activities in the arthritic joint. Pigment epithelium-derived factor (PEDF) has been reported to have both pro- an...

    Authors: Daisy S. Nakamura, Judith M. Hollander, Tomoya Uchimura, Heber C. Nielsen and Li Zeng

    Citation: BMC Musculoskeletal Disorders 2017 18:39

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  23. Content type: Research article

    Chronic hematogenous osteomyelitis often results from the improper treatment of acute hematogenous osteomyelitis. At present, there is lack of uniform standards for the treatment, and the clinical features of ...

    Authors: Xiaohua Wang, Zhen Wang, Jingshu Fu, Ke Huang and Zhao Xie

    Citation: BMC Musculoskeletal Disorders 2017 18:33

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  24. Content type: Research article

    Inhibition of activin/myostatin pathway has emerged as a novel approach to increase muscle mass and bone strength. Duchenne muscular dystrophy (DMD) is a neuromuscular disorder that leads to progressive muscle...

    Authors: Tero Puolakkainen, Hongqian Ma, Heikki Kainulainen, Arja Pasternack, Timo Rantalainen, Olli Ritvos, Kristiina Heikinheimo, Juha J. Hulmi and Riku Kiviranta

    Citation: BMC Musculoskeletal Disorders 2017 18:20

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  25. Content type: Research article

    There are few studies with an assessment of the levels of cytokines or neuropeptides as correlates of pain and pain relief in patients with painful joint diseases. Our objective was to assess whether improveme...

    Authors: Jasvinder A. Singh, Siamak Noorbaloochi and Keith L. Knutson

    Citation: BMC Musculoskeletal Disorders 2017 18:17

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  26. Content type: Research article

    Lumbar multifidus muscles (LMM) are important for spinal motion and stability. Low back pain (LBP) is often associated with fat infiltration in LMM. An increasing fat infiltration of LMM may lead to lumbar dys...

    Authors: Markus Hildebrandt, Gabriela Fankhauser, André Meichtry and Hannu Luomajoki

    Citation: BMC Musculoskeletal Disorders 2017 18:12

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  27. Content type: Research article

    The aim of the present study was to provide an overview of the literature addressing the role of genetic factors and biomarkers predicting pain recovery in newly diagnosed lumbar radicular pain (LRP) patients.

    Authors: Siri Bjorland, Aurora Moen, Elina Schistad, Johannes Gjerstad and Cecilie Røe

    Citation: BMC Musculoskeletal Disorders 2016 17:500

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  28. Content type: Research article

    Patients with rheumatoid arthritis (RA) have increased risk of sudden cardiac death (SCD), which is two-fold higher than general population. The driving cause of SCD was considered due to lift-threatening arrh...

    Authors: Ting-Tse Lin, Yen-Ling Sung, Chih-En Wu, Hong Zhang, Yen-Bin Liu and Shien-Fong Lin

    Citation: BMC Musculoskeletal Disorders 2016 17:491

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  29. Content type: Research article

    Leading theories about the pathogenesis of fibromyalgia focus on central nervous dysregulation or sensitization, which can cause altered perception. There is growing evidence that fibromyalgia involves altered...

    Authors: Magne Stranden, Håvard Solvin, Egil A. Fors, Linn Getz and Anne-S. Helvik

    Citation: BMC Musculoskeletal Disorders 2016 17:477

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  30. Content type: Research article

    Dupuytren’s disease (DD) is a complex fibro-proliferative disorder of the hand that is often progressive and eventually can cause contractures of the affected fingers. Transforming growth factor beta (TGF-β1) has...

    Authors: Chaoming Zhou, Fang Liu, Phillip H. Gallo, Mark E. Baratz, Sandeep Kathju and Latha Satish

    Citation: BMC Musculoskeletal Disorders 2016 17:469

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  31. Content type: Research article

    The use of corticosteroids (e.g., dexamethasone) as treatment for tendinopathy has recently been questioned as higher risks for ruptures have been observed clinically. In vitro studies have reported that dexam...

    Authors: Christoph Spang, Jialin Chen and Ludvig J. Backman

    Citation: BMC Musculoskeletal Disorders 2016 17:467

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  32. Content type: Research article

    Increased reactive oxygen species and estrogen deficiency contribute to the pathophysiology of postmenopausal osteoporosis. Reactive oxygen species contribute to bone degradation and is necessary for RANKL-ind...

    Authors: Alexandra Stubelius, Annica Andersson, Rikard Holmdahl, Claes Ohlsson, Ulrika Islander and Hans Carlsten

    Citation: BMC Musculoskeletal Disorders 2016 17:464

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  33. Content type: Research article

    Systemic sclerosis (SSc) is a rheumatologic disease with a multifactorial etiology. Genome-wide association studies imply a polygenic, complex mode of inheritance with contributions from variation at the human...

    Authors: Christopher J. Cardinale, Dong Li, Lifeng Tian, John J. Connolly, Michael E. March, Cuiping Hou, Fengxiang Wang, James Snyder, Cecilia E. Kim, Rosetta M. Chiavacci, Patrick M. Sleiman, Jon M. Burnham and Hakon Hakonarson

    Citation: BMC Musculoskeletal Disorders 2016 17:462

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  34. Content type: Research article

    Cumulative evidence indicates that statins induce myotoxicity. However, the lack of understanding of how statins affect skeletal muscles at the structural, functional, and physiological levels hampers proper h...

    Authors: Antoine Boulanger Piette, Sébastien S. Dufresne and Jérôme Frenette

    Citation: BMC Musculoskeletal Disorders 2016 17:449

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  35. Content type: Research article

    The aim of this study is to clarify the following two points: First, whether a cyclooxygenase-2 mediated pathway is involved in the formation of immobilization-induced joint contracture and, second, the effect...

    Authors: Junya Ozawa, Akinori Kaneguchi, Ryo Tanaka, Nobuhiro Kito and Hideki Moriyama

    Citation: BMC Musculoskeletal Disorders 2016 17:446

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  36. Content type: Research article

    Many people with Whiplash Associated Disorders (WAD) report problems with vision, some of which may be due to impaired eye movements. Better understanding of such impaired eye movements could improve diagnosti...

    Authors: Britta Kristina Ischebeck, Jurryt de Vries, Jos N Van der Geest, Malou Janssen, Jan Paul Van Wingerden, Gert Jan Kleinrensink and Maarten A Frens

    Citation: BMC Musculoskeletal Disorders 2016 17:441

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  37. Content type: Research article

    Aseptic loosening is a significant impediment to joint implant longevity. Prosthetic wear particles are postulated to play a central role in the onset and progression of periprosthetic osteolysis, leading to a...

    Authors: Chu-qiang Qin, Dong-sheng Huang, Chi Zhang, Bin Song, Jian-bin Huang and Yue Ding

    Citation: BMC Musculoskeletal Disorders 2016 17:431

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  38. Content type: Research article

    Type 2 diabetes mellitus (T2DM) is associated with an increased risk of osteoporotic fracture. Several factors have been identified as being potentially responsible for this risk, such as alterations in bone r...

    Authors: Cristina Miranda, Mercè Giner, M. José Montoya, M. Angeles Vázquez, M. José Miranda and Ramón Pérez-Cano

    Citation: BMC Musculoskeletal Disorders 2016 17:377

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  39. Content type: Research article

    Although articular cartilage is the primary tissues affected by osteoarthritis (OA), the underlying subchondral bone also undergoes noticeable changes. Despite the growing body of research into the biophysical...

    Authors: Qiliang Zuo, Shifeier Lu, Zhibin Du, Thor Friis, Jiangwu Yao, Ross Crawford, Indira Prasadam and Yin Xiao

    Citation: BMC Musculoskeletal Disorders 2016 17:367

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  40. Content type: Research article

    Dopamine receptor 2 (DR2) expressions on B cells from Rheumatoid arthritis (RA) patients has been found to be negatively correlated with disease activity and can potentially predict the response to treatment. ...

    Authors: Lei Wei, Ying Sun, Xiu-Fang Kong, Chi Zhang, Tao Yue, Qi Zhu, Dong-Yi He and Lin-Di Jiang

    Citation: BMC Musculoskeletal Disorders 2016 17:352

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  41. Content type: Research article

    Frozen shoulder is a common yet poorly understood musculoskeletal condition, which for many, is associated with substantial and protracted morbidity. Understanding the pathology associated with this condition ...

    Authors: Victoria Ryan, Hazel Brown, Catherine J. Minns Lowe and Jeremy S. Lewis

    Citation: BMC Musculoskeletal Disorders 2016 17:340

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  42. Content type: Research article

    Multiple small drilling for core decompression is widely used to preserve the femoral head in patients with avascular necrosis of the femoral head (ANFH). Nevertheless, the clinical outcome remains controversi...

    Authors: Han Yin, Zhenfeng Yuan and Dawei Wang

    Citation: BMC Musculoskeletal Disorders 2016 17:344

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  43. Content type: Research article

    Patients with systemic sclerosis (SSc) are endagered by tissue fibrosis and by microvasculopathy, with the latter caused by endothelial cell expansion/proliferation. SSc-associated fibrosis potentially results...

    Authors: S. Patschan, D. Tampe, C. Müller, C. Seitz, C. Herink, G. A. Müller, E. Zeisberg, M. Zeisberg, E. Henze and D. Patschan

    Citation: BMC Musculoskeletal Disorders 2016 17:339

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  44. Content type: Research article

    Both osteoarthritis (OA) and cardiovascular diseases (CVD) are prevalent conditions which often co-exist. Vascular involvement in the pathogenesis of these diseases, as well as increased cardiovascular risk in...

    Authors: Kaspar Tootsi, Aare Märtson, Mihkel Zilmer, Kaido Paapstel and Jaak Kals

    Citation: BMC Musculoskeletal Disorders 2016 17:335

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  45. Content type: Research article

    Osteoarthritis (OA) is a complex arthritic condition in which the genetic factor plays a crucial role. A single nucleotide polymorphism (SNP), rs1137101 (Gln223Arg) of leptin receptor (LEPR) gene has been demo...

    Authors: Jianhui Yang, Heng Du, Jianguo Lv and Lianhe Zhang

    Citation: BMC Musculoskeletal Disorders 2016 17:311

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  46. Content type: Research article

    Giant cell tumor of the bone (GCTB) is classified as an intermediate, locally aggressive but rarely metastasizing tumor. The mainstay of treatment for the treatment of GCTB had been the surgical removal until ...

    Authors: Akihiko Takeuchi, Hiroyuki Tsuchiya, Takeshi Ishii, Yoshihiro Nishida, Satoshi Abe, Akihiko Matsumine, Akira Kawai, Kenichi Yoshimura and Takafumi Ueda

    Citation: BMC Musculoskeletal Disorders 2016 17:306

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  47. Content type: Research article

    Spinal sagittal imbalance is a widely acknowledged problem, but there is insufficient knowledge regarding its occurrence. In some patients with lumbar disc herniation (LDH), their symptom is similar to spinal ...

    Authors: Chen Liang, Jianmin Sun, Xingang Cui, Zhensong Jiang, Wen Zhang and Tao Li

    Citation: BMC Musculoskeletal Disorders 2016 17:305

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  48. Content type: Research article

    The balance between Th17 cells and regulatory T (Treg) cells has been shown to play an important role in the development of rheumatoid arthritis (RA). Recent studies have shown that treatment with abatacept (A...

    Authors: Yoshifumi Tada, Nobuyuki Ono, Rie Suematsu, Satoko Tashiro, Yuri Sadanaga, Yukiko Tokuda, Yukihide Ono, Yoshinobu Nakao, Akihito Maruyama, Akihide Ohta and Syuichi Koarada

    Citation: BMC Musculoskeletal Disorders 2016 17:290

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