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Pathophysiology of musculoskeletal disorders

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

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  1. Inflammatory mediators in the synovial fluid (SF) play critical roles in the initiation and development of pain in knee osteoarthritis (KOA). However, data for inflammatory marker expression are conflicting, a...

    Authors: Li Li, Zhenxing Li, Yuyan Li, Xi Hu, Yu Zhang and Pei Fan

    Citation: BMC Musculoskeletal Disorders 2020 21:99

    Content type: Research article

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  2. This article systematically reviews the current evidence regarding inflammation in Tendinopathy with the aim to increase understanding of a potential common pathophysiology.

    Authors: George Jomaa, Cheuk-Kin Kwan, Sai-Chuen Fu, Samuel Ka-Kin Ling, Kai-Ming Chan, Patrick Shu-Hang Yung and Christer Rolf

    Citation: BMC Musculoskeletal Disorders 2020 21:78

    Content type: Research article

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  3. The leptin receptor-deficient knockout (db/db) mouse is a well-established model for studying type II diabetes mellitus (T2DM). T2DM is an important risk factor of intervertebral disc degeneration (IVDD). Alth...

    Authors: Xinhua Li, Xiaoming Liu, Yiru Wang, Fuming Cao, Zhaoxiong Chen, Zhouyang Hu, Bin Yu, Hang Feng, Zhaoyu Ba, Tao Liu, Haoxi Li, Bei Jiang, Yufeng Huang, Lijun Li and Desheng Wu

    Citation: BMC Musculoskeletal Disorders 2020 21:77

    Content type: Research article

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  4. Musculoskeletal disorders can result from prolonged repetitive and/or forceful movements. Performance of an upper extremity high repetition high force task increases serum pro-inflammatory cytokines and upper ...

    Authors: Tianqi Tenchi Gao Smith, Ann E. Barr-Gillespie, David M. Klyne, Michelle Y. Harris, Mamta Amin, Ryan W. Paul, Geneva E. Cruz, Huaqing Zhao, Sean Gallagher and Mary F. Barbe

    Citation: BMC Musculoskeletal Disorders 2020 21:57

    Content type: Research article

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  5. Osteonecrosis of the femoral head (ONFH) is a common disease that greatly affects the quality of life of patients. Repair of the necrotic area is key to successful treatment. Currently, the combination of stem...

    Authors: Zhan Yu Wu, Qi Sun, Ming Liu, Brian E. Grottkau, Zhi Xu He, Qiang Zou and Chuan Ye

    Citation: BMC Musculoskeletal Disorders 2020 21:55

    Content type: Research article

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  6. Calf muscle strain and Achilles tendon injuries are common in many sports. For the treatment of muscular and tendinous injuries, one of the newer approaches in sports medicine is capacitive-resistive electric ...

    Authors: Carlos López-de-Celis, César Hidalgo-García, Albert Pérez-Bellmunt, Pablo Fanlo-Mazas, Vanessa González-Rueda, José Miguel Tricás-Moreno, Sara Ortiz and Jacobo Rodríguez-Sanz

    Citation: BMC Musculoskeletal Disorders 2020 21:46

    Content type: Research article

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  7. Peripheral nerve injury causes limb muscle/bone atrophy, leading to chronic pain. However, the mechanisms underlying muscle/bone atrophy after peripheral nerve injury remain unknown. It was recently reported t...

    Authors: Nobuhiro Shimada, Asuka Sakata, Takashi Igarashi, Mamoru Takeuchi and Satoshi Nishimura

    Citation: BMC Musculoskeletal Disorders 2020 21:44

    Content type: Research article

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  8. There is some limited evidence for the presence of viruses in herniated disc material including a previous case series that claimed to provide “unequivocal evidence of the presence of herpes virus DNA in inter...

    Authors: B. F. Walker, A. J. Armson, M. A. O’Dea, J. R. White, C. R. P. Lind and P. R. Woodland

    Citation: BMC Musculoskeletal Disorders 2020 21:27

    Content type: Research article

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  9. Bone mineral density of the humeral head is an independent determining factor for postoperative rotator cuff tendon healing. Bisphosphonates, which are commonly used to treat osteoporosis, have raised concerns...

    Authors: Chang-Meen Sung, Ra Jeong Kim, Young-Sool Hah, Ji-Yong Gwark and Hyung Bin Park

    Citation: BMC Musculoskeletal Disorders 2020 21:19

    Content type: Research article

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  10. The CHD7 (chromosome domain helicase DNA binding protein 7) gene has been associated with familial idiopathic scoliosis (IS) in families of European descent. The CHD7 single-nucleotide polymorphisms have never be...

    Authors: Karolina Borysiak, Piotr Janusz, Mirosław Andrusiewicz, Małgorzata Chmielewska, Mateusz Kozinoga, Tomasz Kotwicki and Małgorzata Kotwicka

    Citation: BMC Musculoskeletal Disorders 2020 21:18

    Content type: Research article

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  11. Rad is the prototypic member of a subfamily of Ras-related small G-proteins and is highly expressed in the skeletal muscle of patients with type II diabetes. Our previous microarray analysis suggested that Rad...

    Authors: Takahiro Oda, Takahiro Niikura, Tomoaki Fukui, Michio Arakura, Keisuke Oe, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita and Ryosuke Kuroda

    Citation: BMC Musculoskeletal Disorders 2019 20:602

    Content type: Research article

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  12. Fibroblast-like synoviocytes (FLS) are essential cellular components in inflammatory joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). Despite the growing use of FLS isolated from OA an...

    Authors: Wei Huang, Linlin Zhang, Chao Cheng, Wenshan Shan, Ruixiang Ma, Zongsheng Yin and Chen Zhu

    Citation: BMC Musculoskeletal Disorders 2019 20:591

    Content type: Research article

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  13. Recent reports indicate that oxidative stress induced by reactive oxygen species is associated with the pathobiology of neurodegenerative disorders that involve neuronal cell apoptosis. Here we conducted a cro...

    Authors: Hiroshi Takahashi, Yasuchika Aoki, Junya Saito, Arata Nakajima, Masato Sonobe, Yorikazu Akatsu, Shinji Taniguchi, Manabu Yamada, Keita Koyama, Yuki Akiyama, Yasuhiro Shiga, Kazuhide Inage, Sumihisa Orita, Yawara Eguchi, Satoshi Maki, Takeo Furuya…

    Citation: BMC Musculoskeletal Disorders 2019 20:589

    Content type: Research article

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  14. LBP is a common and serious problem affecting vast populations of the world. However, only few studies on LBP in sub-Saharan Africa have been conducted. Studies report that LBP and pelvic angle are interrelate...

    Authors: Masataka Tatsumi, Egfrid Michael Mkoba, Yusuke Suzuki, Yuu Kajiwara, Hala Zeidan, Keiko Harada, Tsubasa Bitoh, Yuichi Nishida, Kengo Nakai, Kanako Shimoura and Tomoki Aoyama

    Citation: BMC Musculoskeletal Disorders 2019 20:584

    Content type: Research article

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  16. The meniscus plays a vital role in the normal biomechanics of the knee. However, it is not well studied at the molecular level. The purpose of this study was to determine whether molecular and pathological cha...

    Authors: Yi Long, Jingping Xie, Zhi-Qi Zhang, Ziji Zhang, Fangang Meng and Aishan He

    Citation: BMC Musculoskeletal Disorders 2019 20:577

    Content type: Research article

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  18. Degenerative intervertebral disc (IVD) disease can cause lower back pain. However, the change of lactic acid content during disc degeneration process still unclear. The objective of this study was to investiga...

    Authors: Jinhui Shi, Xichao Zhou, Zhen Wang, Swamy Kurra, Junjie Niu and Huilin Yang

    Citation: BMC Musculoskeletal Disorders 2019 20:551

    Content type: Research article

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  19. It is theorized that neck pain may cause reduced postural control due to the known physiological connection between the receptors in the cervical spine and the vestibular system. The purpose of this study was ...

    Authors: Mari K. Knapstad, Frederik K. Goplen, Tove Ask, Jan S. Skouen and Stein Helge G. Nordahl

    Citation: BMC Musculoskeletal Disorders 2019 20:528

    Content type: Research article

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  22. Adolescent idiopathic scoliosis (AIS) which characterized by complex three-dimensional deformity of spine has been difficult to cure because of the unknown etiopathology and uncertainty of progression. Nowaday...

    Authors: Jiong Li, Longjie Wang, Guanteng Yang, Yunjia Wang, Chaofeng Guo, Shaohua Liu, Qile Gao and Hongqi Zhang

    Citation: BMC Musculoskeletal Disorders 2019 20:479

    Content type: Research article

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  23. One of the characteristics of lumbar spinal stenosis (LSS) is elastin degradation and fibrosis in the ligamentum flavum (LF). However, the biochemical factors that cause these histologic changes is unclear. P1...

    Authors: Wei Hu, Shunli Kan, Guang Liu, Zegang Cao and Rusen Zhu

    Citation: BMC Musculoskeletal Disorders 2019 20:458

    Content type: Research article

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  24. Mesenchymal chondrosarcoma (MCS) is a rare malignant variant of chondrosarcoma with a high tendency of recurrence and metastasis. Intradural extramedullary spinal MCS is exceedingly rare and usually found in p...

    Authors: Chih-Wei Chen, I-Hsin Chen, Ming-Hsiao Hu, Jen-Chieh Lee, Hsuan-Ying Huang, Ruey-Long Hong and Shu-Hua Yang

    Citation: BMC Musculoskeletal Disorders 2019 20:408

    Content type: Case report

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  25. Using mass spectrometry, we evaluated the metabolic profiles of patients who had rotator cuff tears with shoulder stiffness, or shoulder stiffness only, and compared these with samples from a control group.

    Authors: Hyo-Jin Lee, Oak-Kee Hong, Dong-Ho Kwak and Yang-Soo Kim

    Citation: BMC Musculoskeletal Disorders 2019 20:364

    Content type: Research article

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  26. There are only a few published case reports of irreducible Galeazzi fracture-dislocation, and patients in these studies had undergone reduction by open surgical methods. Arthroscopy for the distal radioulnar j...

    Authors: Masayoshi Iwamae, Koichi Yano, Yasunori Kaneshiro and Hideki Sakanaka

    Citation: BMC Musculoskeletal Disorders 2019 20:354

    Content type: Case report

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  27. The relationship between spinal alignment and skeletal muscle mass (SMM) has attracted attention in recent years. Sagittal alignment is known to deteriorate with age, but it is not known whether this is relate...

    Authors: Akihiko Hiyama, Hiroyuki Katoh, Daisuke Sakai, Masahiro Tanaka, Masato Sato and Masahiko Watanabe

    Citation: BMC Musculoskeletal Disorders 2019 20:352

    Content type: Research article

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  28. Female patients are more likely to have tendon injuries than males, especially those who has a higher concentration of relaxin. Previous studies have demonstrated that relaxin attenuates extracellular matrix (...

    Authors: Tianpeng Xu, Jiaxiang Bai, Menglei Xu, Binqing Yu, Jiayi Lin, Xiaobin Guo, Yu Liu, Di Zhang, Kai Yan, Dan Hu, Yuefeng Hao and Dechun Geng

    Citation: BMC Musculoskeletal Disorders 2019 20:349

    Content type: Research article

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  29. Impaired lumbar artery flow has been reported in clinical and epidemiological studies to be associated with low back pain and lumbar disc degeneration. However, it has not been experimentally demonstrated that...

    Authors: Takao Imanishi, Koji Akeda, Koichiro Murata and Akihiro Sudo

    Citation: BMC Musculoskeletal Disorders 2019 20:347

    Content type: Research article

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  30. Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, w...

    Authors: Katherine A. Staines, Ekele Ikpegbu, Anna E. Törnqvist, Scott Dillon, Behzad Javaheri, Anish K. Amin, Dylan N. Clements, David J. Buttle, Andrew A. Pitsillides and Colin Farquharson

    Citation: BMC Musculoskeletal Disorders 2019 20:344

    Content type: Research article

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  31. Previous basic research and clinical studies examined the effects of mesenchymal stem cells (MSCs) on regeneration and maintenance of articular cartilage. However, our pilot study suggested that MSCs are more ...

    Authors: Takumi Sakamoto, Tsuyoshi Miyazaki, Shuji Watanabe, Ai Takahashi, Kazuya Honjoh, Hideaki Nakajima, Hisashi Oki, Yasuo Kokubo and Akihiko Matsumine

    Citation: BMC Musculoskeletal Disorders 2019 20:335

    Content type: Research article

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  32. The aetiology of bone marrow oedema-like abnormalities (BMOA) seen on magnetic resonance imaging (MRI) is as yet not fully understood. The current study aimed to investigate the potential of projection radiogr...

    Authors: Christine J. Heales, Ian R. Summers, Jonathan Fulford, Karen M. Knapp and C. Peter Winlove

    Citation: BMC Musculoskeletal Disorders 2019 20:330

    Content type: Research article

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  33. Oestrogen-deficiency induced by menopause is associated with reduced bone density and primary osteoporosis, resulting in an increased risk of fracture. While the exact etiology of menopause-induced primary ost...

    Authors: Fraser L. Collins, Michael D. Stone, Jane Turton, Laura R. McCabe, Eddie C. Y. Wang and Anwen S. Williams

    Citation: BMC Musculoskeletal Disorders 2019 20:326

    Content type: Research article

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  34. Synovial mesenchymal stem cells (MSCs) are an attractive cell source for cartilage and meniscus regeneration. The optimum cryopreservation medium has not been determined, but dimethylsulfoxide (DMSO) should be...

    Authors: Ryota Fujisawa, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga and Ichiro Sekiya

    Citation: BMC Musculoskeletal Disorders 2019 20:316

    Content type: Research article

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  35. The incidence of proximal humeral fractures (PHF) increased by more than 30% over the last decade, which is accompanied by an increased number of operations. However, the evidence on operative vs. non-operativ...

    Authors: Corinna Nerz, Lars Schwickert, Sabine Schölch, Katharina Gordt, Philip-Christian Nolte, Inga Kröger, Peter Augat and Clemens Becker

    Citation: BMC Musculoskeletal Disorders 2019 20:315

    Content type: Research article

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  36. People who have had anterior cruciate ligament reconstruction (ACLR) are at a high risk of developing tibiofemoral joint (TFJ) osteoarthritis (OA), with concomitant meniscal injury elevating this risk. This st...

    Authors: Xinyang Wang, Kim L. Bennell, Yuanyuan Wang, Tim V. Wrigley, Ans Van Ginckel, Karine Fortin, David J. Saxby, Flavia M. Cicuttini, David G. Lloyd, Christopher J. Vertullo, Julian A. Feller, Tim Whitehead, Price Gallie and Adam L. Bryant

    Citation: BMC Musculoskeletal Disorders 2019 20:312

    Content type: Research article

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  37. A vitamin A derivative, 13-cis-retinoic acid (isotretinoin), has been administered to treat several types of pediatric cancer and has improved survival rates in patients despite being known to induce premature...

    Authors: Masatake Matsuoka, Tomohiro Onodera, Tokifumi Majima, Koji Iwasaki, Daisuke Takahashi, Eiji Kondo and Norimasa Iwasaki

    Citation: BMC Musculoskeletal Disorders 2019 20:287

    Content type: Case report

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  38. McH-lpr/lpr-RA1 mice are a new strain of mice which spontaneously develop destructive arthritis and enthesitis in the ankle. There is no published data that drug treatment has been trialed on these mice. This ...

    Authors: Takuya Izumiyama, Yu Mori, Shiro Mori, Naoko Mori, Tetsuya Kodama and Eiji Itoi

    Citation: BMC Musculoskeletal Disorders 2019 20:286

    Content type: Research article

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  39. Musculoskeletal injuries (MSKIs) are common in military trainees and present a considerable threat to occupational fitness, deployability, and overall military readiness. Despite the negative effects of MSKIs ...

    Authors: Julie M. Hughes, Stephen A. Foulis, Kathryn M. Taylor, Katelyn I. Guerriere, Leila A. Walker, Amy F. Hand, Kristin L. Popp, Erin Gaffney-Stomberg, Kristin J. Heaton, Marilyn A. Sharp, Tyson L. Grier, Keith G. Hauret, Bruce H. Jones, Mary L. Bouxsein, James P. McClung, Ronald W. Matheny Jr…

    Citation: BMC Musculoskeletal Disorders 2019 20:282

    Content type: Study protocol

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  40. Understanding interactions between bone and muscle based on endocrine factors may help elucidate the relationship between osteoporosis and sarcopenia. However, whether the abundance or activity of these endocr...

    Authors: Kenta Moriwaki, Hiromi Matsumoto, Shinji Tanishima, Chika Tanimura, Mari Osaki, Hideki Nagashima and Hiroshi Hagino

    Citation: BMC Musculoskeletal Disorders 2019 20:276

    Content type: Research article

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  41. A considerable number of patients with whiplash-associated disorders (WAD) report variable and indefinite symptoms involving the whole body, despite there being no evidence of direct injuries to organs other t...

    Authors: Takayoshi Matsui, Makoto Iwata, Yuzo Endo, Nobuyuki Shitara, Shuntaro Hojo, Hideoki Fukuoka, Kazuhiro Hara and Hiroshi Kawaguchi

    Citation: BMC Musculoskeletal Disorders 2019 20:251

    Content type: Research article

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  42. Musculoskeletal (MSK) pain represents a considerable worldwide healthcare burden. This study aimed to gain consensus from practitioners who work with MSK pain patients, on the most appropriate primary care tre...

    Authors: Joanne Protheroe, Benjamin Saunders, Bernadette Bartlam, Kate M. Dunn, Vince Cooper, Paul Campbell, Jonathan C. Hill, Stephanie Tooth, Christian D. Mallen, Elaine M. Hay and Nadine E. Foster

    Citation: BMC Musculoskeletal Disorders 2019 20:271

    Content type: Research article

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  43. Low back pain (LBP) is a ubiquitous, heterogeneous disorder that affects most people at some point in their lives. The efficient management of LBP remains elusive, with direct and indirect costs attributed to ...

    Authors: Mehul J. Desai, Holly Jonely, Meagan Blackburn, Sangeeth Wanasinghage, Sidrah Sheikh and Rod S. Taylor

    Citation: BMC Musculoskeletal Disorders 2019 20:249

    Content type: Study protocol

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  44. Although the pathogenesis of adolescent idiopathic scoliosis (AIS) remains unclear, there are little evidences of the pathogenesis in patients with thoracolumbar/lumbar AIS. The purpose of this study was to id...

    Authors: Hiroto Makino, Shoji Seki, Isao Kitajima, Hiraku Motomura, Makiko Nogami, Yasuhito Yahara, Naoko Ejiri and Tomoatsu Kimura

    Citation: BMC Musculoskeletal Disorders 2019 20:247

    Content type: Research article

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  45. Accelerated knee osteoarthritis (AKOA) is characterized by more pain, impaired physical function, and greater likelihood to receive a joint replacement compared to individuals who develop the typical gradual o...

    Authors: Matthew S. Harkey, Julie E. Davis, Bing Lu, Lori Lyn Price, Robert J. Ward, James W. MacKay, Charles B. Eaton, Grace H. Lo, Mary F. Barbe, Ming Zhang, Jincheng Pang, Alina C. Stout, Timothy E. McAlindon and Jeffrey B. Driban

    Citation: BMC Musculoskeletal Disorders 2019 20:241

    Content type: Research article

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  46. A detailed evaluation focusing on the fibrocartilage layers in the anterior cruciate ligament (ACL) insertion is necessary to consider regeneration of the insertion. This study examined the development of the ...

    Authors: Hirotaka Mutsuzaki, Hiromi Nakajima, Maika Someji and Masataka Sakane

    Citation: BMC Musculoskeletal Disorders 2019 20:233

    Content type: Research article

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  47. In osteoarthritis (OA), cartilage matrix is lost despite vigorous chondrocyte anabolism. In this study, we attempted to determine whether altered matrix synthesis is involved in this paradox in disease progres...

    Authors: Nobuho Tanaka, Toshiyuki Tashiro, Yozo Katsuragawa, Motoji Sawabe, Hiroshi Furukawa and Naoshi Fukui

    Citation: BMC Musculoskeletal Disorders 2019 20:232

    Content type: Research article

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  48. The expression of the receptor activator of nuclear factor kappa B (RANK) /RANK ligand (RANKL) /osteoprotegerin (OPG) system and its association with the progression of intervertebral disc (IVD) degeneration h...

    Authors: Tomohiko Sano, Koji Akeda, Junichi Yamada, Norihiko Takegami, Takao Sudo and Akihiro Sudo

    Citation: BMC Musculoskeletal Disorders 2019 20:225

    Content type: Research article

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  49. There is increasing interest in the role of pro-inflammatory cytokines in the pathogenesis of sciatica and whether these could be potential targets for treatment. We sought to investigate serum biomarker level...

    Authors: Samantha L. Hider, Kika Konstantinou, Elaine M. Hay, John Glossop and Derek L. Mattey

    Citation: BMC Musculoskeletal Disorders 2019 20:202

    Content type: Research article

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  50. Chronic inflammation with aging contributes to sarcopenia. Previous studies have suggested that the accumulation of adipose tissue in skeletal muscle, referred to as intermuscular adipose tissue (IMAT), increa...

    Authors: Ryo Tazawa, Kentaro Uchida, Hisako Fujimaki, Masayuki Miyagi, Gen Inoue, Hiroyuki Sekiguchi, Kosuke Murata, Ken Takata, Ayumu Kawakubo and Masashi Takaso

    Citation: BMC Musculoskeletal Disorders 2019 20:199

    Content type: Research article

    Published on:

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BMC Musculoskeletal Disorders

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