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BMC Musculoskeletal Disorders

Pathophysiology of musculoskeletal disorders

Section edited by Ali Mobasheri

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

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  1. Content type: Case report

    Pure exercise intolerance associated with exclusive affection of skeletal muscle is a very rare phenotype of patients with mitochondrial myopathy. Moreover, the exercise intolerance in these rare patients is y...

    Authors: Patrick Soldath, Karen Lindhardt Madsen, Astrid Emilie Buch, Morten Duno, Flemming Wibrand and John Vissing

    Citation: BMC Musculoskeletal Disorders 2017 18:419

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  2. Content type: Case report

    At present, there are no registered products for the treatment of subchondral Bone Marrow Edema Lesion (BML) and associated knee pain. Patients who do not respond to current anti-inflammatory therapies are lef...

    Authors: Matthew J. Sampson, Margie Kabbani, Ravi Krishnan, Michael Nganga, Annika Theodoulou and Jeganath Krishnan

    Citation: BMC Musculoskeletal Disorders 2017 18:396

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  3. Content type: Research article

    Neuroimmune axis is central in the physiopathology of hip osteoarthritis (OA), but its specific pathways are still unclear. This systematic review aims to assess the nervous and immune system profile of patien...

    Authors: Manuel Ribeiro da Silva, Daniela Linhares, Daniel Marques Vasconcelos, Cecilia Juliana Alves, Nuno Neves, Gilberto Costa and Meriem Lamghari

    Citation: BMC Musculoskeletal Disorders 2017 18:394

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  4. Content type: Research article

    Subchondral osteopenia is important for the pathophysiology of osteoarthritis (OA). Although previous studies suggest that plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, is related to...

    Authors: Akihiro Moritake, Naoyuki Kawao, Kiyotaka Okada, Kohei Tatsumi, Masayoshi Ishida, Katsumi Okumoto, Osamu Matsuo, Masao Akagi and Hiroshi Kaji

    Citation: BMC Musculoskeletal Disorders 2017 18:392

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  5. Content type: Research article

    The objectives are to compare the efficacy of intra-articular hyaluronic acid (IA-HA) alone and in combination with anti-inflammatory drugs (IA-HA + AI), corticosteroids (CS) or non-steroidal anti-inflammatory...

    Authors: Thippaporn Euppayo, Veerasak Punyapornwithaya, Siriwadee Chomdej, Siriwan Ongchai and Korakot Nganvongpanit

    Citation: BMC Musculoskeletal Disorders 2017 18:387

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  6. Content type: Research article

    The major types of commercially available gelatin hydrolysates are prepared from mammals or fish. Dietary gelatin hydrolysates from mammals were reported to improve bone mineral density (BMD) in some animal mo...

    Authors: Teruyuki Noma, Satoshi Takasugi, Miho Shioyama, Taketo Yamaji, Hiroyuki Itou, Yoshio Suzuki, Keishoku Sakuraba and Keisuke Sawaki

    Citation: BMC Musculoskeletal Disorders 2017 18:385

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    The Correction to this article has been published in BMC Musculoskeletal Disorders 2017 18:422

  7. Content type: Research article

    Knee osteoarthritis (KOA) is a degenerative knee disease commonly found in the ageing population. DNA methylation works with histone acetylation to participate in aging. Alterations of DNA methylation may invo...

    Authors: Xinxin Wang, Dezhi Tang, Peng Shen, Hao Xu, Hongfu Qiu, Tao Wu and Xiang Gao

    Citation: BMC Musculoskeletal Disorders 2017 18:377

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  8. Content type: Research article

    The pathophysiology, including the impact of gene expression, of polymyalgia rheumatica (PMR) remains elusive. We profiled the gene expression in muscle tissue in PMR patients before and after glucocorticoid t...

    Authors: Frederik Flindt Kreiner, Rehannah Borup, Finn Cilius Nielsen, Peter Schjerling and Henrik Galbo

    Citation: BMC Musculoskeletal Disorders 2017 18:341

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  9. Content type: Research article

    We had previously established concentrated autologous bone marrow aspirate transplantation (CABMAT), a one-step, low-invasive, joint-preserving surgical technique for treating osteonecrosis of the femoral head...

    Authors: Yohei Tomaru, Tomokazu Yoshioka, Hisashi Sugaya, Katsuya Aoto, Hiroshi Wada, Hiroshi Akaogi, Masashi Yamazaki and Hajime Mishima

    Citation: BMC Musculoskeletal Disorders 2017 18:292

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  10. Content type: Research article

    Somatosensory profiling in affected and non-affected body regions can strengthen our insight regarding the underlying pain mechanisms, which can be valuable in treatment decision making and to improve outcomes...

    Authors: Yvonne Lindbäck, Hans Tropp, Paul Enthoven, Björn Gerdle, Allan Abbott and Birgitta Öberg

    Citation: BMC Musculoskeletal Disorders 2017 18:264

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  11. Content type: Research article

    Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether intra-articular admi...

    Authors: Carlos Vaamonde-García, Jesús Loureiro, Marta N. Valcárcel-Ares, Romina R. Riveiro-Naveira, Olalla Ramil-Gómez, Laura Hermida-Carballo, Alberto Centeno, Rosa Meijide-Failde, Francisco J. Blanco and María J. López-Armada

    Citation: BMC Musculoskeletal Disorders 2017 18:254

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  12. Content type: Research article

    Negative Pressure Wound Therapy (NPWT) is being increasingly used to treat postoperative infections after osteosynthetic fracture fixation. The aim of the present study was to analyze the influence of epidemio...

    Authors: Kaywan Izadpanah, Stephanie Hansen, Julia Six-Merker, Peter Helwig, Norbert P Südkamp and Hagen Schmal

    Citation: BMC Musculoskeletal Disorders 2017 18:247

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  13. Content type: Research article

    Leptin plays an important role in mediating chondrogenesis of limb growth plate. Previous studies suggest that bone structures and development of spine and limb are different. The expression of Ob-Rb, the gene...

    Authors: Bo Yu, Kaibiao Jiang, Bin Chen, Hantao Wang, Xinfeng Li and Zude Liu

    Citation: BMC Musculoskeletal Disorders 2017 18:235

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  14. Content type: Research article

    Ankylosing spondylitis (AS) is characterised by immune-mediated arthritis and osteoproliferation, ultimately leading to joint ankylosis. Whether inflammation is necessary for osteoproliferation is controversia...

    Authors: Hsu-Wen Tseng, Tibor T. Glant, Matthew A. Brown, Tony J. Kenna, Gethin P. Thomas and Allison R. Pettit

    Citation: BMC Musculoskeletal Disorders 2017 18:228

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  15. Content type: Research article

    A body of evidence demonstrating changes to the glutaminergic system in tendinopathy has recently emerged. This hypothesis was further tested by studying the effects of glutamate on the tenocyte phenotype, and...

    Authors: Christoph Spang, Ludvig J. Backman, Sandrine Le Roux, Jialin Chen and Patrik Danielson

    Citation: BMC Musculoskeletal Disorders 2017 18:218

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  16. Content type: Research article

    Invossa™ (TissueGene-C) is a cell and gene therapy for osteoarthritis. It is composed of primary human chondrocytes (hChonJ cells) and irradiated human chondrocytes modified to express TGF-β1 (hChonJb#7 cells)...

    Authors: Chae-Lyul Lim, Yeon-Ju Lee, Jong-Ho Cho, Heonsik Choi, Bumsup Lee, Myung Chul Lee and Sujeong Kim

    Citation: BMC Musculoskeletal Disorders 2017 18:199

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  17. Content type: Research article

    Joint inflammation causes meniscus degeneration and can exacerbate post-traumatic meniscus injuries by extracellular matrix degradation, cellular de-differentiation and cell death. The aim of this study was to...

    Authors: P. Behrendt, K. Häfelein, A. Preusse-Prange, A. Bayer, A. Seekamp and B. Kurz

    Citation: BMC Musculoskeletal Disorders 2017 18:197

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  18. Content type: Research article

    Back pain and disc degeneration have a growing socioeconomic healthcare impact. Mucin 1 (MUC1) is a transmembrane glycoprotein whose extracellular and intracellular domains participate in cellular signaling. L...

    Authors: Helen E. Gruber, Jane A. Ingram, Gretchen L. Hoelscher, Emilio Marrero and Edward N. Hanley Jr

    Citation: BMC Musculoskeletal Disorders 2017 18:182

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  19. Content type: Research article

    Humeral head fractures requiring surgical intervention are severe injuries, which might affect the return to sports and daily activities. We hypothesize that athletic patients will be constrained regarding the...

    Authors: Philipp Ahrens, Frank Martetschläger, Sebastian Siebenlist, Johann Attenberger, Moritz Crönlein, Peter Biberthaler, Ulrich Stöckle and Gunther H. Sandmann

    Citation: BMC Musculoskeletal Disorders 2017 18:173

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