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BMC Musculoskeletal Disorders

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Pathophysiology of musculoskeletal disorders

Section edited by Ali Mobasheri

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

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  1. Content type: Research article

    TNF-alpha is suggested to be involved in muscle damage and muscle inflammation (myositis). In order to evaluate whether TNF-alpha is involved in the myositis that occurs in response to muscle overuse, the aim ...

    Authors: Lina Renström, Per Stål, Yafeng Song and Sture Forsgren

    Citation: BMC Musculoskeletal Disorders 2017 18:498

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  2. Content type: Research article

    Blunt trauma is the most frequent mechanism of injury in multiple trauma, commonly resulting from road traffic collisions or falls. Two of the most frequent injuries in patients with multiple trauma are chest ...

    Authors: Stefanie Fitschen-Oestern, Sebastian Lippross, Tim Klueter, Matthias Weuster, Deike Varoga, Mersedeh Tohidnezhad, Thomas Pufe, Stefan Rose-John, Hagen Andruszkow, Frank Hildebrand, Nadine Steubesand, Andreas Seekamp and Claudia Neunaber

    Citation: BMC Musculoskeletal Disorders 2017 18:468

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  3. Content type: Research article

    Glucocorticoid-associated osteonecrosis is an intractable condition, making the establishment of preventative strategies of particular importance. Recently various studies using mesenchymal stem cells (MSC) ha...

    Authors: Shusuke Ueda, Miyako Shimasaki, Toru Ichiseki, Yoshimichi Ueda, Masanobu Tsuchiya, Ayumi Kaneuji and Norio Kawahara

    Citation: BMC Musculoskeletal Disorders 2017 18:480

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  4. Content type: Research article

    ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteins play an important pathological role in matrix degeneration. Aggrecan degradation is a significant and critical event in early-stag...

    Authors: Takuya Tajima, Tomohisa Sekimoto, Nami Yamaguchi, Noboru Taniguchi, Syuji Kurogi, Masugi Maruyama and Etsuo Chosa

    Citation: BMC Musculoskeletal Disorders 2017 18:449

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  5. Content type: Research article

    p21(WAF1/CIP1/SDI1), a cyclin dependent kinase inhibitor has been shown to influence cell proliferation, differentiation and apoptosis; but more recently, p21 has been implicated in tissue repair. Studies on p21(

    Authors: Priyatha Premnath, Britta Jorgenson, Ricarda Hess, Pankaj Tailor, Dante Louie, Jaymi Taiani, Steven Boyd and Roman Krawetz

    Citation: BMC Musculoskeletal Disorders 2017 18:435

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  6. Content type: Research article

    Rotator cuff (RTC) tears are a common clinical problem resulting in adverse changes to the muscle, but there is limited information comparing histopathology to contractile function. This study assessed suprasp...

    Authors: Ana P. Valencia, Shama R. Iyer, Espen E. Spangenburg, Mohit N. Gilotra and Richard M. Lovering

    Citation: BMC Musculoskeletal Disorders 2017 18:436

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  7. Content type: Research article

    The aim was to investigate whether resident chondrocytes in human articular cartilage and in subculture express vitamin D receptor (VDR) and the enzyme that hydroxylates the prohormone 25(OH)D3 to the active horm...

    Authors: Ann Kristin Hansen, Yngve Figenschau and Inigo Zubiaurre-Martinez

    Citation: BMC Musculoskeletal Disorders 2017 18:432

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  8. Content type: Research article

    Nerve growth factor (NGF) is not only an important factor in nerve growth but also a major contributor to the production of inflammation. It has been reported that inhibiting NGF could reduce several types of ...

    Authors: Masayuki Miyagi, Tetsuhiro Ishikawa, Hiroto Kamoda, Miyako Suzuki, Gen Inoue, Yoshihiro Sakuma, Yasuhiro Oikawa, Sumihisa Orita, Kentaro Uchida, Kazuhisa Takahashi, Masashi Takaso and Seiji Ohtori

    Citation: BMC Musculoskeletal Disorders 2017 18:428

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  9. Content type: Research article

    Osteoarthritis research has been most commonly performed in the setting of the articular cartilage of the knee. To the best of our knowledge, no studies have evaluated the role of adiponectin in osteoarthritis...

    Authors: Qi Lai, Yuan Liu, Leitao Huang, Xuqiang Liu, Xionglong Yu, Qiang Wang, Runsheng Guo, Jianghao Zhu, Hanxiong Cheng, Min Dai and Bin Zhang

    Citation: BMC Musculoskeletal Disorders 2017 18:427

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  10. Content type: Research article

    Significant amount of bone mass is lost during the process of aging due to an imbalance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption in bone marrow microenvironment, which...

    Authors: Xia Chen, Junsong Chen, Dongliang Xu, Shuangxia Zhao, Huaidong Song and Yongde Peng

    Citation: BMC Musculoskeletal Disorders 2017 18:423

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  11. Content type: Case report

    Pure exercise intolerance associated with exclusive affection of skeletal muscle is a very rare phenotype of patients with mitochondrial myopathy. Moreover, the exercise intolerance in these rare patients is y...

    Authors: Patrick Soldath, Karen Lindhardt Madsen, Astrid Emilie Buch, Morten Duno, Flemming Wibrand and John Vissing

    Citation: BMC Musculoskeletal Disorders 2017 18:419

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  12. Content type: Case report

    At present, there are no registered products for the treatment of subchondral Bone Marrow Edema Lesion (BML) and associated knee pain. Patients who do not respond to current anti-inflammatory therapies are lef...

    Authors: Matthew J. Sampson, Margie Kabbani, Ravi Krishnan, Michael Nganga, Annika Theodoulou and Jeganath Krishnan

    Citation: BMC Musculoskeletal Disorders 2017 18:396

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  13. Content type: Research article

    Neuroimmune axis is central in the physiopathology of hip osteoarthritis (OA), but its specific pathways are still unclear. This systematic review aims to assess the nervous and immune system profile of patien...

    Authors: Manuel Ribeiro da Silva, Daniela Linhares, Daniel Marques Vasconcelos, Cecilia Juliana Alves, Nuno Neves, Gilberto Costa and Meriem Lamghari

    Citation: BMC Musculoskeletal Disorders 2017 18:394

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  14. Content type: Research article

    Subchondral osteopenia is important for the pathophysiology of osteoarthritis (OA). Although previous studies suggest that plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, is related to...

    Authors: Akihiro Moritake, Naoyuki Kawao, Kiyotaka Okada, Kohei Tatsumi, Masayoshi Ishida, Katsumi Okumoto, Osamu Matsuo, Masao Akagi and Hiroshi Kaji

    Citation: BMC Musculoskeletal Disorders 2017 18:392

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  15. Content type: Research article

    The objectives are to compare the efficacy of intra-articular hyaluronic acid (IA-HA) alone and in combination with anti-inflammatory drugs (IA-HA + AI), corticosteroids (CS) or non-steroidal anti-inflammatory...

    Authors: Thippaporn Euppayo, Veerasak Punyapornwithaya, Siriwadee Chomdej, Siriwan Ongchai and Korakot Nganvongpanit

    Citation: BMC Musculoskeletal Disorders 2017 18:387

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  16. Content type: Research article

    The major types of commercially available gelatin hydrolysates are prepared from mammals or fish. Dietary gelatin hydrolysates from mammals were reported to improve bone mineral density (BMD) in some animal mo...

    Authors: Teruyuki Noma, Satoshi Takasugi, Miho Shioyama, Taketo Yamaji, Hiroyuki Itou, Yoshio Suzuki, Keishoku Sakuraba and Keisuke Sawaki

    Citation: BMC Musculoskeletal Disorders 2017 18:385

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    The Correction to this article has been published in BMC Musculoskeletal Disorders 2017 18:422

  17. Content type: Research article

    Knee osteoarthritis (KOA) is a degenerative knee disease commonly found in the ageing population. DNA methylation works with histone acetylation to participate in aging. Alterations of DNA methylation may invo...

    Authors: Xinxin Wang, Dezhi Tang, Peng Shen, Hao Xu, Hongfu Qiu, Tao Wu and Xiang Gao

    Citation: BMC Musculoskeletal Disorders 2017 18:377

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  18. Content type: Research article

    The pathophysiology, including the impact of gene expression, of polymyalgia rheumatica (PMR) remains elusive. We profiled the gene expression in muscle tissue in PMR patients before and after glucocorticoid t...

    Authors: Frederik Flindt Kreiner, Rehannah Borup, Finn Cilius Nielsen, Peter Schjerling and Henrik Galbo

    Citation: BMC Musculoskeletal Disorders 2017 18:341

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