Section edited by Ali Mobasheri
This section concerns all aspects of the pathophysiology of musculoskeletal disorders.
Case report
Pure exercise intolerance associated with exclusive affection of skeletal muscle is a very rare phenotype of patients with mitochondrial myopathy. Moreover, the exercise intolerance in these rare patients is y...
BMC Musculoskeletal Disorders 2017 18:419
Published on: 19 October 2017
Case report
At present, there are no registered products for the treatment of subchondral Bone Marrow Edema Lesion (BML) and associated knee pain. Patients who do not respond to current anti-inflammatory therapies are lef...
BMC Musculoskeletal Disorders 2017 18:396
Published on: 12 September 2017
Research article
Neuroimmune axis is central in the physiopathology of hip osteoarthritis (OA), but its specific pathways are still unclear. This systematic review aims to assess the nervous and immune system profile of patien...
BMC Musculoskeletal Disorders 2017 18:394
Published on: 11 September 2017
Research article
Subchondral osteopenia is important for the pathophysiology of osteoarthritis (OA). Although previous studies suggest that plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, is related to...
BMC Musculoskeletal Disorders 2017 18:392
Published on: 11 September 2017
Research article
The objectives are to compare the efficacy of intra-articular hyaluronic acid (IA-HA) alone and in combination with anti-inflammatory drugs (IA-HA + AI), corticosteroids (CS) or non-steroidal anti-inflammatory...
BMC Musculoskeletal Disorders 2017 18:387
Published on: 6 September 2017
Research article
The major types of commercially available gelatin hydrolysates are prepared from mammals or fish. Dietary gelatin hydrolysates from mammals were reported to improve bone mineral density (BMD) in some animal mo...
BMC Musculoskeletal Disorders 2017 18:385
Published on: 5 September 2017
Research article
Knee osteoarthritis (KOA) is a degenerative knee disease commonly found in the ageing population. DNA methylation works with histone acetylation to participate in aging. Alterations of DNA methylation may invo...
BMC Musculoskeletal Disorders 2017 18:377
Published on: 31 August 2017
Research article
To investigate the effect of intra-articular injection of Chitosan (Cs) added to hyaluronic acid (HA) on subchondral bone during osteoarthritis (OA), microarchitectural parameters and mineral density were meas...
BMC Musculoskeletal Disorders 2017 18:350
Published on: 15 August 2017
Research article
The pathophysiology, including the impact of gene expression, of polymyalgia rheumatica (PMR) remains elusive. We profiled the gene expression in muscle tissue in PMR patients before and after glucocorticoid t...
BMC Musculoskeletal Disorders 2017 18:341
Published on: 7 August 2017
Research article
We had previously established concentrated autologous bone marrow aspirate transplantation (CABMAT), a one-step, low-invasive, joint-preserving surgical technique for treating osteonecrosis of the femoral head...
BMC Musculoskeletal Disorders 2017 18:292
Published on: 6 July 2017
Research article
Somatosensory profiling in affected and non-affected body regions can strengthen our insight regarding the underlying pain mechanisms, which can be valuable in treatment decision making and to improve outcomes...
BMC Musculoskeletal Disorders 2017 18:264
Published on: 17 June 2017
Research article
Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether intra-articular admi...
BMC Musculoskeletal Disorders 2017 18:254
Published on: 12 June 2017
Research article
Negative Pressure Wound Therapy (NPWT) is being increasingly used to treat postoperative infections after osteosynthetic fracture fixation. The aim of the present study was to analyze the influence of epidemio...
BMC Musculoskeletal Disorders 2017 18:247
Published on: 7 June 2017
Research article
Leptin plays an important role in mediating chondrogenesis of limb growth plate. Previous studies suggest that bone structures and development of spine and limb are different. The expression of Ob-Rb, the gene...
BMC Musculoskeletal Disorders 2017 18:235
Published on: 31 May 2017
Research article
Ankylosing spondylitis (AS) is characterised by immune-mediated arthritis and osteoproliferation, ultimately leading to joint ankylosis. Whether inflammation is necessary for osteoproliferation is controversia...
BMC Musculoskeletal Disorders 2017 18:228
Published on: 30 May 2017
Research article
A body of evidence demonstrating changes to the glutaminergic system in tendinopathy has recently emerged. This hypothesis was further tested by studying the effects of glutamate on the tenocyte phenotype, and...
BMC Musculoskeletal Disorders 2017 18:218
Published on: 25 May 2017
Research article
Invossa™ (TissueGene-C) is a cell and gene therapy for osteoarthritis. It is composed of primary human chondrocytes (hChonJ cells) and irradiated human chondrocytes modified to express TGF-β1 (hChonJb#7 cells)...
BMC Musculoskeletal Disorders 2017 18:199
Published on: 18 May 2017
Research article
Joint inflammation causes meniscus degeneration and can exacerbate post-traumatic meniscus injuries by extracellular matrix degradation, cellular de-differentiation and cell death. The aim of this study was to...
BMC Musculoskeletal Disorders 2017 18:197
Published on: 16 May 2017
Research article
Back pain and disc degeneration have a growing socioeconomic healthcare impact. Mucin 1 (MUC1) is a transmembrane glycoprotein whose extracellular and intracellular domains participate in cellular signaling. L...
BMC Musculoskeletal Disorders 2017 18:182
Published on: 8 May 2017
Research article
Humeral head fractures requiring surgical intervention are severe injuries, which might affect the return to sports and daily activities. We hypothesize that athletic patients will be constrained regarding the...
BMC Musculoskeletal Disorders 2017 18:173
Published on: 26 April 2017
