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BMC Musculoskeletal Disorders

Pathophysiology of musculoskeletal disorders

Section edited by Ali Mobasheri

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

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  1. Content type: Research article

    Inflammation is associated with the onset and progression of osteoarthritis in multiple joints. It is well known that mechanical properties differ between different joints, however, it remains unknown if the i...

    Authors: Guomin Ren, Ian Lutz, Pamela Railton, J. Preston Wiley, Jenelle McAllister, James Powell and Roman J. Krawetz

    Citation: BMC Musculoskeletal Disorders 2018 19:39

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  2. Content type: Research article

    Microendoscopic foraminotomy has been reported to be effective for the treatment of cervical radiculopathy, using outcome measurement scores such as the neck disability index (NDI) and numerical rating scale (...

    Authors: Juichi Tonosu, Hirohiko Inanami, Hiroyuki Oka, Yuichi Takano, Hisashi Koga, Yohei Yuzawa, Ryutaro Shiboi, Yasushi Oshima, Satoshi Baba, Sakae Tanaka and Ko Matsudaira

    Citation: BMC Musculoskeletal Disorders 2018 19:30

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  3. Content type: Research article

    Chondrosarcoma is the second most common primary malignant bone tumor. Because of their heterogeneity, with differences in invasive and metastatic behavior, it is important to identify biological markers that ...

    Authors: Dominik Malcherczyk, Thomas J. Heyse, Bilal F. El-Zayat, Vanessa Kunzke, Roland Moll, Susanne Fuchs-Winkelmann and Jürgen R. J. Paletta

    Citation: BMC Musculoskeletal Disorders 2018 19:9

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  4. Content type: Research article

    Greater age and body mass index are strong risk factors for osteoarthritis (OA). Older and overweight individuals may be more susceptible to OA because these factors alter tissue turnover in menisci, articular...

    Authors: Alina C. Stout, Mary F. Barbe, Charles B. Eaton, Mamta Amin, Fatimah Al-Eid, Lori Lyn Price, Bing Lu, Grace H. Lo, Ming Zhang, Jincheng Pang, Timothy E. McAlindon and Jeffrey B. Driban

    Citation: BMC Musculoskeletal Disorders 2018 19:1

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  5. Content type: Research article

    The objective of this study was to evaluate the extent of stromal cell-derived factor-1’s (SDF-1) involvement in the pathogenesis of idiopathic versus post-traumatic OA by comparing differences in synovial mem...

    Authors: Nathan P. Thomas, Wesley J. Wu, Braden C. Fleming, Fangyuan Wei, Qian Chen and Lei Wei

    Citation: BMC Musculoskeletal Disorders 2017 18:556

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  6. Content type: Research article

    Transplanting myogenic cells and scaffolds for tissue engineering in skeletal muscle have shown inconsistent results. One of the limiting factors is neovascularization at the recipient site. Low intensity shoc...

    Authors: Lise K. Hansen, Henrik D. Schrøder, Lars Lund, Karthikeyan Rajagopal, Vrisha Maduri and Jeeva Sellathurai

    Citation: BMC Musculoskeletal Disorders 2017 18:557

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  7. Content type: Research article

    Studies have investigated the correlation between tumor necrosis factor related apoptosis-inducing ligand (TRAIL) gene polymorphisms and the susceptibility and severity of intervertebral disc degeneration (IDD...

    Authors: Qi-ling Yuan, Liang Liu, Yong-song Cai and Yin-gang Zhang

    Citation: BMC Musculoskeletal Disorders 2017 18:555

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  8. Content type: Research article

    Some reports have shown that intermittent parathyroid hormone (PTH) (1–34) treatment for patients with delayed union or nonunion have led to successful healing. In this study, we investigated whether systemic ...

    Authors: Yohei Kumabe, Sang Yang Lee, Takahiro Waki, Takashi Iwakura, Shunsuke Takahara, Michio Arakura, Yu Kuroiwa, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda and Takahiro Niikura

    Citation: BMC Musculoskeletal Disorders 2017 18:545

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  9. Content type: Research article

    TNF-alpha is suggested to be involved in muscle damage and muscle inflammation (myositis). In order to evaluate whether TNF-alpha is involved in the myositis that occurs in response to muscle overuse, the aim ...

    Authors: Lina Renström, Per Stål, Yafeng Song and Sture Forsgren

    Citation: BMC Musculoskeletal Disorders 2017 18:498

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  10. Content type: Research article

    Blunt trauma is the most frequent mechanism of injury in multiple trauma, commonly resulting from road traffic collisions or falls. Two of the most frequent injuries in patients with multiple trauma are chest ...

    Authors: Stefanie Fitschen-Oestern, Sebastian Lippross, Tim Klueter, Matthias Weuster, Deike Varoga, Mersedeh Tohidnezhad, Thomas Pufe, Stefan Rose-John, Hagen Andruszkow, Frank Hildebrand, Nadine Steubesand, Andreas Seekamp and Claudia Neunaber

    Citation: BMC Musculoskeletal Disorders 2017 18:468

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  11. Content type: Research article

    Glucocorticoid-associated osteonecrosis is an intractable condition, making the establishment of preventative strategies of particular importance. Recently various studies using mesenchymal stem cells (MSC) ha...

    Authors: Shusuke Ueda, Miyako Shimasaki, Toru Ichiseki, Yoshimichi Ueda, Masanobu Tsuchiya, Ayumi Kaneuji and Norio Kawahara

    Citation: BMC Musculoskeletal Disorders 2017 18:480

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  12. Content type: Research article

    ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteins play an important pathological role in matrix degeneration. Aggrecan degradation is a significant and critical event in early-stag...

    Authors: Takuya Tajima, Tomohisa Sekimoto, Nami Yamaguchi, Noboru Taniguchi, Syuji Kurogi, Masugi Maruyama and Etsuo Chosa

    Citation: BMC Musculoskeletal Disorders 2017 18:449

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  13. Content type: Research article

    p21(WAF1/CIP1/SDI1), a cyclin dependent kinase inhibitor has been shown to influence cell proliferation, differentiation and apoptosis; but more recently, p21 has been implicated in tissue repair. Studies on p21(

    Authors: Priyatha Premnath, Britta Jorgenson, Ricarda Hess, Pankaj Tailor, Dante Louie, Jaymi Taiani, Steven Boyd and Roman Krawetz

    Citation: BMC Musculoskeletal Disorders 2017 18:435

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  14. Content type: Research article

    Rotator cuff (RTC) tears are a common clinical problem resulting in adverse changes to the muscle, but there is limited information comparing histopathology to contractile function. This study assessed suprasp...

    Authors: Ana P. Valencia, Shama R. Iyer, Espen E. Spangenburg, Mohit N. Gilotra and Richard M. Lovering

    Citation: BMC Musculoskeletal Disorders 2017 18:436

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  15. Content type: Research article

    The aim was to investigate whether resident chondrocytes in human articular cartilage and in subculture express vitamin D receptor (VDR) and the enzyme that hydroxylates the prohormone 25(OH)D3 to the active horm...

    Authors: Ann Kristin Hansen, Yngve Figenschau and Inigo Zubiaurre-Martinez

    Citation: BMC Musculoskeletal Disorders 2017 18:432

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  16. Content type: Research article

    Nerve growth factor (NGF) is not only an important factor in nerve growth but also a major contributor to the production of inflammation. It has been reported that inhibiting NGF could reduce several types of ...

    Authors: Masayuki Miyagi, Tetsuhiro Ishikawa, Hiroto Kamoda, Miyako Suzuki, Gen Inoue, Yoshihiro Sakuma, Yasuhiro Oikawa, Sumihisa Orita, Kentaro Uchida, Kazuhisa Takahashi, Masashi Takaso and Seiji Ohtori

    Citation: BMC Musculoskeletal Disorders 2017 18:428

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  17. Content type: Research article

    Osteoarthritis research has been most commonly performed in the setting of the articular cartilage of the knee. To the best of our knowledge, no studies have evaluated the role of adiponectin in osteoarthritis...

    Authors: Qi Lai, Yuan Liu, Leitao Huang, Xuqiang Liu, Xionglong Yu, Qiang Wang, Runsheng Guo, Jianghao Zhu, Hanxiong Cheng, Min Dai and Bin Zhang

    Citation: BMC Musculoskeletal Disorders 2017 18:427

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  18. Content type: Research article

    Significant amount of bone mass is lost during the process of aging due to an imbalance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption in bone marrow microenvironment, which...

    Authors: Xia Chen, Junsong Chen, Dongliang Xu, Shuangxia Zhao, Huaidong Song and Yongde Peng

    Citation: BMC Musculoskeletal Disorders 2017 18:423

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  19. Content type: Case report

    Pure exercise intolerance associated with exclusive affection of skeletal muscle is a very rare phenotype of patients with mitochondrial myopathy. Moreover, the exercise intolerance in these rare patients is y...

    Authors: Patrick Soldath, Karen Lindhardt Madsen, Astrid Emilie Buch, Morten Duno, Flemming Wibrand and John Vissing

    Citation: BMC Musculoskeletal Disorders 2017 18:419

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