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Pathophysiology of musculoskeletal disorders

Section edited by Ali Mobasheri

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

Page 1 of 6

  1. Content type: Review

    We live in a world with an ever-increasing ageing population. Studying healthy ageing and reducing the socioeconomic impact of age-related diseases is a key research priority for the industrialised and develop...

    Authors: Rebecca Lewis, Constanza B. Gómez Álvarez, Margaret Rayman, Susan Lanham-New, Anthony Woolf and Ali Mobasheri

    Citation: BMC Musculoskeletal Disorders 2019 20:164

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  2. Content type: Research article

    This systematic review focusses on inflammation as an underlying pathogenic mechanism in sciatica. We addressed two questions in particular: (1) what inflammatory biomarkers have been identified in patients wi...

    Authors: Maarten J. Jungen, Bastiaan C. ter Meulen, Tim van Osch, Henry C. Weinstein and Raymond W. J. G. Ostelo

    Citation: BMC Musculoskeletal Disorders 2019 20:156

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  3. Content type: Research article

    Surgical treatment is mainly used for atlantoaxial tuberculosis with neurological damage. However, the anatomic structure around the atlantoaxial joint is complex, and the position of vertebral body is deep, w...

    Authors: Biao Wang, Rongan Shang, Tong Yang, Haiping Zhang, Huimin Hu, Wei Hu and Dingjun Hao

    Citation: BMC Musculoskeletal Disorders 2019 20:148

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  4. Content type: Study protocol

    Adhesive capsulitis (AC) is a disabling and poorly understood pathological condition of the shoulder joint. The current study aims to increase our understanding of the pathogenesis, diagnosis and clinical outc...

    Authors: Richard S. Page, Sean L. McGee, Kevin Eng, Graeme Brown, Sally Beattie, Fiona Collier and Stephen D. Gill

    Citation: BMC Musculoskeletal Disorders 2019 20:145

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  5. Content type: Research article

    Dupuytren’s disease (DD) is a progressive, debilitating condition of the hand that can eventually cause contractures of the affected fingers. Transforming growth factor- β1 (TGF-β1) has been reported to play a...

    Authors: Chaoming Zhou, Yael Zeldin, Mark E. Baratz, Sandeep Kathju and Latha Satish

    Citation: BMC Musculoskeletal Disorders 2019 20:135

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  6. Content type: Research article

    The synovial membrane adjacent to the articular cartilage is home to synovial mesenchymal progenitor cell (sMPC) populations that have the ability to undergo chondrogenesis. While it has been hypothesized that...

    Authors: Asmaa Affan, Nedaa Al-Jezani, Pamela Railton, James N. Powell and Roman J. Krawetz

    Citation: BMC Musculoskeletal Disorders 2019 20:125

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  7. Content type: Research article

    Aging impairs tendon healing and is a potential risk factor for chronic tendinitis. During normal aging, tendons undergo structural and biomechanical degenerative changes, accompanied by a reduction in the num...

    Authors: Yasuhiro Ueda, Atsuyuki Inui, Yutaka Mifune, Fumiaki Takase, Takeshi Kataoka, Takashi Kurosawa, Kohei Yamaura, Takeshi Kokubu and Ryosuke Kuroda

    Citation: BMC Musculoskeletal Disorders 2019 20:120

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  8. Content type: Research article

    Locomotive syndrome (LS) is associated with weakness and loss of function in the musculoskeletal organs. We aimed to determine the association between LS components and blood parameters in middle-aged and elde...

    Authors: Toshinori Yoshihara, Hayao Ozaki, Takashi Nakagata, Toshiharu Natsume, Tomoharu Kitada, Yoshihiko Ishihara, Shuji Sawada, Masayoshi Ishibashi, Hiroyuki Kobayashi, Shuichi Machida and Hisashi Naito

    Citation: BMC Musculoskeletal Disorders 2019 20:104

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  9. Content type: Research article

    Myotonic dystrophy type 1 (DM1) is a neuromuscular disease characterized by multisystemic involvements including a progressive loss of maximal muscle strength and muscle wasting. Poor lower-limb strength is an...

    Authors: Marie-Pier Roussel, Marika Morin, Cynthia Gagnon and Elise Duchesne

    Citation: BMC Musculoskeletal Disorders 2019 20:101

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  10. Content type: Research article

    The objective of this study was to use confocal fluorescence recovery after photobleaching (FRAP) to examine the specific and dose-dependent effect of proteoglycan 4 (PRG4) on hyaluronan (HA) solutions of diff...

    Authors: Adam K. Bloom, Michael L. Samsom, Suresh C. Regmi, Bridgett L. Steele and Tannin A. Schmidt

    Citation: BMC Musculoskeletal Disorders 2019 20:93

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  11. Content type: Case report

    The incidence of bilateral corticosteroid-induced osteonecrosis of the femoral head (ONFH) is high. Although the precise mechanism of corticosteroid-induced ONFH development is unclear, hepatic enzyme abnormal...

    Authors: Hirokazu Shimizu, Tomohiro Shimizu, Daisuke Takahashi, Tsuyoshi Asano, Ryuta Arai, Yasunari Takakuwa and Norimasa Iwasaki

    Citation: BMC Musculoskeletal Disorders 2019 20:88

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  12. Content type: Case report

    Gorham’s disease (GSD) is a rare osteolytic disease with unclear etiology, and no known prevention or effective treatment. Here we report a new surgical treatment for a case of GSD in September 2017.

    Authors: Linjie Feng, Yaoping Wu, Xiangqian Yu and Wenguo Zhao

    Citation: BMC Musculoskeletal Disorders 2019 20:73

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  13. Content type: Research article

    Preclinical osteoarthritis models where damage occurs spontaneously may better reflect the initiation and development of human osteoarthritis. The aim was to assess the commercial pig as a model of spontaneous...

    Authors: Mhairi A. Macfadyen, Zoe Daniel, Sara Kelly, Tim Parr, John M. Brameld, Andrew J. Murton and Simon W. Jones

    Citation: BMC Musculoskeletal Disorders 2019 20:70

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  14. Content type: Study protocol

    There is insufficient knowledge of pathophysiological parameters to understand the mechanism behind prolonged whiplash associated disorders (WAD), and it is not known whether or not changes can be restored by ...

    Authors: Anneli Peolsson, Anette Karlsson, Bijar Ghafouri, Tino Ebbers, Maria Engström, Margaretha Jönsson, Karin Wåhlén, Thobias Romu, Magnus Borga, Eythor Kristjansson, Hilla Sarig Bahat, Dmitry German, Peter Zsigmond and Gunnel Peterson

    Citation: BMC Musculoskeletal Disorders 2019 20:51

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  15. Content type: Research article

    Osteoarthritis (OA) is a common joint disease in aging societies, which is accompanied by chronic inflammation and degeneration of the joint structure. Inflammation of the infrapatellar fat pad (IFP) and synov...

    Authors: Kei Inomata, Kunikazu Tsuji, Hiroaki Onuma, Takashi Hoshino, Mio Udo, Masako Akiyama, Yusuke Nakagawa, Hiroki Katagiri, Kazumasa Miyatake, Ichiro Sekiya, Takeshi Muneta and Hideyuki Koga

    Citation: BMC Musculoskeletal Disorders 2019 20:8

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  16. Content type: Case report

    Nodular fasciitis is a benign proliferation of myofibroblasts that usually arises in subcutaneous tissues of the trunk, neck, head, and upper extremities of young adults. It is not reported to arise in the joi...

    Authors: Wei Wang, Yiting Huang, Changxing Wang, Jianqiao Hong, Chiyuan Ma, Nong Lin, Zhaoming Ye, Shiyuan Yan and Haobo Wu

    Citation: BMC Musculoskeletal Disorders 2019 20:5

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  17. Content type: Research article

    Osteoarthritis is a degradative joint disease found in humans and commercial swine which can develop from a number of factors, including prior joint trauma. An impact injury model was developed to deliver in v...

    Authors: R. S. McCulloch, P. L. Mente, A. T. O’Nan and M. S. Ashwell

    Citation: BMC Musculoskeletal Disorders 2018 19:449

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  18. Content type: Research article

    Axial spondyloarthritis (axSpA) is characterized by significant bone loss caused by dysregulation of physiological bone turnover, possibly resulting from intensified differentiation of osteoclasts. The aim of ...

    Authors: Mariusz Korkosz, Marcin Czepiel, Zofia Guła, Małgorzata Stec, Kazimierz Węglarczyk, Magdalena Rutkowska-Zapała, Anna Gruca, Marzena Lenart, Jarosław Baran, Jerzy Gąsowski, Przemysław Błyszczuk and Maciej Siedlar

    Citation: BMC Musculoskeletal Disorders 2018 19:434

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  19. Content type: Research article

    Studies have shown that cytokines play a role in bone remodeling.

    Authors: Ana Maria Baptista Menezes, Paula Duarte Oliveira, Helen Gonçalves, Isabel O. Oliveira, Maria Cecilia F. Assunção, Luciana Tovo-Rodrigues, Gustavo Dias Ferreira and Fernando César Wehrmeister

    Citation: BMC Musculoskeletal Disorders 2018 19:427

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  20. Content type: Research article

    Tendon disorders are common and lead to significant disability and pain. Our knowledge of the ‘tennis elbow’, the ‘jumpers knee’, and Achilles tendinosis has increased over the years, but changes in denervated...

    Authors: Roine El-Habta, Jialin Chen, Jessica Pingel and Ludvig J. Backman

    Citation: BMC Musculoskeletal Disorders 2018 19:426

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  21. Content type: Research article

    Proteomics is an emerging field in the study of joint disease. Our two aims with this pilot analysis were to compare healthy human knee articular cartilage with meniscus, two tissues both known to become affec...

    Authors: Elin Folkesson, Aleksandra Turkiewicz, Martin Englund and Patrik Önnerfjord

    Citation: BMC Musculoskeletal Disorders 2018 19:416

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  22. Content type: Research article

    Myofascial trigger points (MTrPs) are hyperirritable areas in the fascia of the affected muscle, possibly related to mitochondrial impairment. They can result in pain and hypoxic areas within the muscle. This ...

    Authors: Michael J. Fischer, Gergo Horvath, Martin Krismer, Erich Gnaiger, Georg Goebel and Dominik H. Pesta

    Citation: BMC Musculoskeletal Disorders 2018 19:388

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  23. Content type: Research article

    Cyclops nodule formation is a serious complication after anterior cruciate ligament (ACL) reconstruction. The purpose of our study was to investigate whether an increase in thymol turbidity test (TTT) values i...

    Authors: Yuya Kodama, Takayuki Furumatsu, Tomohito Hino, Yusuke Kamatsuki, Yoshiki Okazaki, Shin Masuda, Yuki Okazaki and Toshifumi Ozaki

    Citation: BMC Musculoskeletal Disorders 2018 19:367

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  24. Content type: Research article

    The phenotypes of osteoarthritis (OA) consist of cartilage extracellular matrix (ECM) metabolism disorder and the breakdown of cartilage homeostasis, which are induced by pro-inflammatory factors and oxidative...

    Authors: Jianli Xue, Zixin Min, Zhuqing Xia, Bin Cheng, Binshang Lan, Fujun Zhang, Yan Han, Kunzheng Wang and Jian Sun

    Citation: BMC Musculoskeletal Disorders 2018 19:355

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  25. Content type: Research article

    Fibroblast behavior and cell-matrix interactions of cells from normal and idiopathic carpal tunnel syndrome (CTS) subsynovial connective tissue (SSCT) with and without Triamcinolone Acetonide (TA) were compare...

    Authors: Tai-Hua Yang, Anne Gingery, Andrew R. Thoreson, Dirk R. Larson, Chunfeng Zhao and Peter C. Amadio

    Citation: BMC Musculoskeletal Disorders 2018 19:342

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  26. Content type: Research article

    To explore and evaluate the predictive value of preoperative Neutrophil-lymphocyte ratio (NLR) on the recurrence of pigmented villonodular synovitis (PVNS) of the knee joint treated by arthroscopic surgery com...

    Authors: Guanglei Zhao, Jin Wang, Jun Xia, Yibing Wei, Siqun Wang, Gangyong Huang, Feiyan Chen, Jie Chen, Jingsheng Shi and Yuanqing Yang

    Citation: BMC Musculoskeletal Disorders 2018 19:339

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  27. Content type: Research article

    Formation of lamellar bone in non-osseus tissue is a pathological process called heterotopic ossification. It is the aim of this study to analyse the morphology and immunological status of patients with hetero...

    Authors: Klemens Trieb, Andreas Meryk, Sascha Senck, Erin Naismith and Beatrix Grubeck-Loebenstein

    Citation: BMC Musculoskeletal Disorders 2018 19:327

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  28. Content type: Research article

    The age-related osteoporosis is an increasing risk severely threatening the live quality of aged people. Human parathyroid hormone (hPTH) is applied to the therapy of osteoporosis successfully, however, the me...

    Authors: Wei Li, Liang Yuan, Guojun Tong, Youhua He, Yue Meng, Song Hao, Jianting Chen, Jun Guo, Richard Bringhurst and Dehong Yang

    Citation: BMC Musculoskeletal Disorders 2018 19:311

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  29. Content type: Research article

    Pain in osteoarthritis (OA) remains poorly understood. Different types of somatosensory alterations exist in OA including hyperesthesia and increased sensitivity to painful stimuli as well as those of decrease...

    Authors: Anisha B. Dua, Tuhina Neogi, Rachel A. Mikolaitis, Joel A. Block and Najia Shakoor

    Citation: BMC Musculoskeletal Disorders 2018 19:307

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  30. Content type: Research article

    The major complaint of knee osteoarthritis (OA) is persistent pain. Unlike acute inflammatory pain, persistent pain is usually difficult to manage since its pathology is not fully understood. To elucidate the ...

    Authors: Takashi Hoshino, Kunikazu Tsuji, Hiroaki Onuma, Mio Udo, Hiroko Ueki, Masako Akiyama, Kahaer Abula, Hiroki Katagiri, Kazumasa Miyatake, Toshihumi Watanabe, Ichiro Sekiya, Hideyuki Koga and Takeshi Muneta

    Citation: BMC Musculoskeletal Disorders 2018 19:291

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  31. Content type: Research article

    Knee osteoarthritis (KOA) is the most common form of chronic degenerative joint disease worldwide. Its incidence has increased in recent years. Aberrant expression profile of lncRNAs in damaged bone and cartil...

    Authors: Kejie Wang, Minjie Chu, Wenge Ding and Qing Jiang

    Citation: BMC Musculoskeletal Disorders 2018 19:284

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  32. Content type: Research article

    Injury prevalence data commonly indicate trends of higher rates of work-related musculoskeletal disorders in older workers over their younger counterparts, and for females more than males. The purpose of this ...

    Authors: John D. Collins and Leonard O’Sullivan

    Citation: BMC Musculoskeletal Disorders 2018 19:280

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  33. Content type: Research article

    Although aneurysmal bone cysts (ABCs) are benign tumours, they have the potential to be locally aggressive. Various treatment approaches, such as en bloc resection, open curettage, radiotherapy, sclerotherapy,...

    Authors: Hisaki Aiba, Masaaki Kobayashi, Yuko Waguri-Nagaya, Hideyuki Goto, Jun Mizutani, Satoshi Yamada, Hideki Okamoto, Masahiro Nozaki, Hiroto Mitsui, Shinji Miwa, Makoto Kobayashi, Kojiro Endo, Shiro Saito, Taeko Goto and Takanobu Otsuka

    Citation: BMC Musculoskeletal Disorders 2018 19:268

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  34. Content type: Research article

    The aims of this study were to analyse the serum concentrations of clusterin (CLU) in patients with hand osteoarthritis (OA) and in healthy controls, to compare CLU levels between patients with erosive and non...

    Authors: Tereza Kropáčková, Olga Šléglová, Olga Růžičková, Jiří Vencovský, Karel Pavelka and Ladislav Šenolt

    Citation: BMC Musculoskeletal Disorders 2018 19:264

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  35. Content type: Research article

    Mesenchymal stromal cells (MSC) have shown promising results in the treatment of tendinopathy in equine medicine, making this therapeutic approach seem favorable for translation to human medicine. Having demon...

    Authors: A. B. Ahrberg, C. Horstmeier, D. Berner, W. Brehm, C. Gittel, A. Hillmann, C. Josten, G. Rossi, S. Schubert, K. Winter and J. Burk

    Citation: BMC Musculoskeletal Disorders 2018 19:230

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  36. Content type: Research article

    Bone structure and strength are rapidly lost during conditions of decreased mechanical loading, and aged bones have a diminished ability to adapt to increased mechanical loading. This is a concern for older pa...

    Authors: Hailey C. Cunningham, Daniel W. D. West, Leslie M. Baehr, Franklin D. Tarke, Keith Baar, Sue C. Bodine and Blaine A. Christiansen

    Citation: BMC Musculoskeletal Disorders 2018 19:223

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  37. Content type: Research article

    To evaluate synchrotron radiation-based Fourier transform infrared microspectroscopy (SR-FTIR) as a tool for quantitative mapping of the content and distribution of the extracellular matrix in decellularized f...

    Authors: Yongchun Zhou, Can Chen, Zhu Guo, Shanshan Xie, Jianzhong Hu and Hongbin Lu

    Citation: BMC Musculoskeletal Disorders 2018 19:220

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  38. Content type: Correspondence

    Recent reported results by Fang et al. published in BMC Musculoskeletal Disorders have added to the weight of evidence supporting association between gluteal pain and lumbar disc hernia. Their clinical finding...

    Authors: Yu Wang, Jin Yang, Yuqing Yan, Lifeng Zhang, Chuan Guo, Zhiyu Peng and Qingquan Kong

    Citation: BMC Musculoskeletal Disorders 2018 19:214

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  39. Content type: Research article

    Research suggests that vascular endothelial growth factor (VEGF) levels in the synovial fluid of knee osteoarthritis (KOA) patients are positively correlated with KOA severity. The relationship between synovia...

    Authors: Shotaro Takano, Kentaro Uchida, Gen Inoue, Toshihide Matsumoto, Jun Aikawa, Dai Iwase, Manabu Mukai, Masayuki Miyagi and Masashi Takaso

    Citation: BMC Musculoskeletal Disorders 2018 19:204

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  40. Content type: Research article

    The anterior cruciate ligament (ACL) is responsible for braking forward movement of the tibia relative to the femur and for tibial rotation. After ACL injury, this braking performance deteriorates, inducing ab...

    Authors: Yuichi Nishikawa, Takanori Kokubun, Naohiko Kanemura, Tetsuya Takahashi, Masayasu Matsumoto, Hirofumi Maruyama and Kiyomi Takayanagi

    Citation: BMC Musculoskeletal Disorders 2018 19:175

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  41. Content type: Research article

    Autologous chondrocyte implantation (ACI) is a therapy for articular cartilage and osteochondral lesions that relies on notch- or trochlea-derived primary chondrocytes. An alternative cell source for ACI could...

    Authors: Matthias Aurich, Gunther O. Hofmann, Florian Gras and Bernd Rolauffs

    Citation: BMC Musculoskeletal Disorders 2018 19:168

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  42. Content type: Research article

    It was indicated that inhibition of PPARγ probably represents a novel therapy for steroid-related osteonecrosis. In this study, we investigated the preventive effects of PPARγ inhibition on steroid-related ost...

    Authors: Na Yuan, Jia Li, Meng Li, Wenchen Ji, Zhaogang Ge, Lihong Fan and Kunzheng Wang

    Citation: BMC Musculoskeletal Disorders 2018 19:129

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  43. Content type: Research article

    Tendon is a commonly injured soft musculoskeletal tissue, however, poor healing potential and ineffective treatment strategies result in persistent injuries and tissue that is unable to perform its normal phys...

    Authors: Katie Joanna Lee, Peter David Clegg, Eithne Josephine Comerford and Elizabeth Gail Canty-Laird

    Citation: BMC Musculoskeletal Disorders 2018 19:116

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  44. Content type: Research article

    Steroid therapy, a key therapy for inflammatory, allergic, and immunological disorders, is often associated with steroid myopathy as one of the side effects. Steroid therapy is considered the first-line therap...

    Authors: Takashi Nawata, Makoto Kubo, Takafumi Nomura, Keiji Oishi, Kosaku Shiragami, Tadayoshi Ikegami, Munemasa Okada, Shigeki Kobayashi and Masafumi Yano

    Citation: BMC Musculoskeletal Disorders 2018 19:93

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  45. Content type: Research article

    Mobilization of mesenchymal stem cells (MSCs) from the synovium was revealed using a “suspended synovium culture model” of osteoarthritis (OA). The pathology of rheumatoid arthritis (RA) differs from that of O...

    Authors: Yuji Kohno, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Koji Otabe, Hideyuki Koga, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa and Ichiro Sekiya

    Citation: BMC Musculoskeletal Disorders 2018 19:78

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  46. Content type: Research article

    Inflammation is associated with the onset and progression of osteoarthritis in multiple joints. It is well known that mechanical properties differ between different joints, however, it remains unknown if the i...

    Authors: Guomin Ren, Ian Lutz, Pamela Railton, J. Preston Wiley, Jenelle McAllister, James Powell and Roman J. Krawetz

    Citation: BMC Musculoskeletal Disorders 2018 19:39

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  47. Content type: Research article

    Microendoscopic foraminotomy has been reported to be effective for the treatment of cervical radiculopathy, using outcome measurement scores such as the neck disability index (NDI) and numerical rating scale (...

    Authors: Juichi Tonosu, Hirohiko Inanami, Hiroyuki Oka, Yuichi Takano, Hisashi Koga, Yohei Yuzawa, Ryutaro Shiboi, Yasushi Oshima, Satoshi Baba, Sakae Tanaka and Ko Matsudaira

    Citation: BMC Musculoskeletal Disorders 2018 19:30

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  48. Content type: Research article

    Chondrosarcoma is the second most common primary malignant bone tumor. Because of their heterogeneity, with differences in invasive and metastatic behavior, it is important to identify biological markers that ...

    Authors: Dominik Malcherczyk, Thomas J. Heyse, Bilal F. El-Zayat, Vanessa Kunzke, Roland Moll, Susanne Fuchs-Winkelmann and Jürgen R. J. Paletta

    Citation: BMC Musculoskeletal Disorders 2018 19:9

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  49. Content type: Research article

    Greater age and body mass index are strong risk factors for osteoarthritis (OA). Older and overweight individuals may be more susceptible to OA because these factors alter tissue turnover in menisci, articular...

    Authors: Alina C. Stout, Mary F. Barbe, Charles B. Eaton, Mamta Amin, Fatimah Al-Eid, Lori Lyn Price, Bing Lu, Grace H. Lo, Ming Zhang, Jincheng Pang, Timothy E. McAlindon and Jeffrey B. Driban

    Citation: BMC Musculoskeletal Disorders 2018 19:1

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