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Pathophysiology of musculoskeletal disorders

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

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  1. Osteoarthritis, rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, all have one clear common denominator; an altered turnover of bone. However, this may be more complex than a simple change...

    Authors: Christian S. Thudium, Signe Holm Nielsen, Samra Sardar, Ali Mobasheri, Willem Evert van Spil, Rik Lories, Kim Henriksen, Anne-Christine Bay-Jensen and Morten A. Karsdal

    Citation: BMC Musculoskeletal Disorders 2020 21:789

    Content type: Review

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  2. Dysferlinopathies are a group of muscle disorders causing muscle weakness and absence or low levels of dysferlin, a type-II transmembrane protein and the causative gene of these dystrophies. Dysferlin is impli...

    Authors: Esther Fernández-Simón, Cinta Lleixà, Xavier Suarez-Calvet, Jordi Diaz-Manera, Isabel Illa, Eduard Gallardo and Noemí de Luna

    Citation: BMC Musculoskeletal Disorders 2020 21:784

    Content type: Research article

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  3. Septic arthritis of digits needs urgent treatment. When treatments delayed or insufficient, patients may be referred to the upper-level hospital due to uncontrolled infection. We reviewed the treatment history...

    Authors: Sang Ho Kwak, Jung Yun Bae, Youngkwang Oh, Hyo Seok Jang, Tae Young Ahn and Sang Hyun Lee

    Citation: BMC Musculoskeletal Disorders 2020 21:780

    Content type: Research article

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  4. The hip abductors are crucial in maintaining pelvic stability. Tears in these tendons are common and often debilitating. There is uncertainty regarding both the histological and macroscopic features of hip abd...

    Authors: Mark F. Zhu, Brittany Smith, Sanjeev Krishna, David S. Musson, Peter R. Riordan, Sue R. McGlashan, Jillian Cornish and Jacob T. Munro

    Citation: BMC Musculoskeletal Disorders 2020 21:778

    Content type: Research article

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  5. Due to its unique arrangement, the deep and superficial fibers of the multifidus may have differential roles for maintaining spine stabilization and lumbar posture; the superficial multifidus is responsible fo...

    Authors: Jennifer Padwal, David B. Berry, James C. Hubbard, Vinko Zlomislic, R. Todd Allen, Steven R. Garfin, Samuel R. Ward and Bahar Shahidi

    Citation: BMC Musculoskeletal Disorders 2020 21:764

    Content type: Research article

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  6. Percutaneous endoscopic decompression (PED) is considered a minimally invasive and safe procedure in lumbar degenerative disease. Few authors report the success of PED for thoracic spinal stenosis (TSS) with t...

    Authors: Xiao-Kang Cheng, Fu-Cheng Bian, Zhao-Yu Liu, Feng-Kai Yang and Bin Chen

    Citation: BMC Musculoskeletal Disorders 2020 21:717

    Content type: Research article

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  7. Vascular injury is a very rare complication following arthroscopic knee surgery. This is the first report of pseudoaneurysm at the saphenous branch of the descending genicular artery complicating semitendinosu...

    Authors: Chung-Wei Ho, Shih-Han Lee, Shen-Han Wu, Chun-Yu Lin, Chian-Her Lee and Jia-Lin Wu

    Citation: BMC Musculoskeletal Disorders 2020 21:697

    Content type: Case report

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  8. Subcutaneous adipose tissue represents an abundant source of multipotent adult stem cells named as Adipose-derived stem cells (ADSCs). With a cell sheet approach, ADSCs survive longer, and can be delivered in ...

    Authors: Tomoharu Takagi, Tamon Kabata, Katsuhiro Hayashi, Xiang Fang, Yoshitomo Kajino, Daisuke Inoue, Takaaki Ohmori, Takuro Ueno, Junya Yoshitani, Ken Ueoka, Yuki Yamamuro and Hiroyuki Tsuchiya

    Citation: BMC Musculoskeletal Disorders 2020 21:691

    Content type: Research article

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  10. The objective of this cross-sectional case-control study was to determine the prevalence and size of marginal and subarticular osteophytes in patients with osteoarthritis (OA), and to compare these to that of ...

    Authors: Rasmus Klose-Jensen, Andreas Wiggers Nielsen, Louise Brøndt Hartlev, Jesper Skovhus Thomsen, Lene Warner Thorup Boel, Mogens Laursen, Kresten Krarup Keller and Ellen-Margrethe Hauge

    Citation: BMC Musculoskeletal Disorders 2020 21:653

    Content type: Research article

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  12. Modic changes (MC) in the lumbar spine are considered one potential etiological factor behind low back pain (LBP). Multiple risk factors for MC have been suggested, including male gender, smoking and factors a...

    Authors: Marella Modarress Julin, Jesperi Saukkonen, Petteri Oura, Maisa Niemelä, Juho-Antti Junno, Juhani Määttä, Jaakko Niinimäki, Timo Jämsä, Raija Korpelainen and Jaro Karppinen

    Citation: BMC Musculoskeletal Disorders 2020 21:630

    Content type: Research article

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  13. Among common findings in osteoporotic vertebral compression fractures (OVCFs), the intravertebral cleft (IVC) is usually considered a benign lesion. The current study was aimed to present a rare case of verteb...

    Authors: Liang Dong, Chunke Dong, Yuting Zhu and Hongyu Wei

    Citation: BMC Musculoskeletal Disorders 2020 21:619

    Content type: Case report

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  14. Tendon adhesion is one of the most common clinical problems, which poses a considerable challenge to orthopedics doctors. Quercetin (QUE) as a popular drug at present, it has various biological functions, incl...

    Authors: Yuan Liang, Keteng Xu, Pei Zhang, Jiale Zhang, Pengtao Chen, Jinshan He, Yongchao Fang, Yuelai Zhou, Jingcheng Wang and Jianzhong Bai

    Citation: BMC Musculoskeletal Disorders 2020 21:608

    Content type: Research article

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  15. Limb girdle muscular dystrophy type 2Y (LGMD2Y) is a rare subgroup of limb girdle muscular dystrophy featuring limb-girdle weakness, tendon contracture and cardiac involvement. It is caused by the mutation of ...

    Authors: Xuelin Feng, Jinlang Wu, Wenbiao Xian, Bing Liao, Songjie Liao, Xiaoli Yao and Weixi Zhang

    Citation: BMC Musculoskeletal Disorders 2020 21:588

    Content type: Case report

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  16. Gorham-Stout disease (GSD) is a rare disease characterized by bone lesions and osteolysis. Therapy usually involves surgical resection. Sirolimus (Rapamycin) is used in some patients with GSD but the efficacy ...

    Authors: Yu Liang, Ruicheng Tian, Jing Wang, Yuhua Shan, Hongxiang Gao, Chenjie Xie, Jingjing Li, Min Xu and Song Gu

    Citation: BMC Musculoskeletal Disorders 2020 21:577

    Content type: Case report

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  17. The prognostic value of Neutrophil-to-Lymphocyte Ratio (NLR) for the outcome of acute cervical traumatic spinal cord injury (tSCI) patients has rarely been studied by now throughout the world.

    Authors: Jian-Lan Zhao, Song-Tao Lai, Zhuo-Ying Du, Jian Xu, Yi-Rui Sun, Qiang Yuan, Xing Wu, Zhi-Qi Li, Jin Hu and Rong Xie

    Citation: BMC Musculoskeletal Disorders 2020 21:548

    Content type: Research article

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  18. Transient osteoporosis of the hip (TOH) is a rare and temporary clinical condition characterised by bone marrow edema (BME), severe pain, and functional limitation. It commonly occurs in middle-aged men or in ...

    Authors: Marco Paoletta, Antimo Moretti, Sara Liguori, Matteo Bertone, Giuseppe Toro and Giovanni Iolascon

    Citation: BMC Musculoskeletal Disorders 2020 21:543

    Content type: Case report

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  19. The differentiation of human stromal (mesenchymal) stem cells (hMSCs) is a critical procedure for the development of osteoblast. SNHG14 is a newly discovered lncRNA that has been barely studied. Our preliminar...

    Authors: Mingchang Du, Bo Wu, Shiwen Fan, Ye Liu, Xu Ma and Xun Fu

    Citation: BMC Musculoskeletal Disorders 2020 21:525

    Content type: Research article

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  20. Elderly patients with hip fractures often have multiple medical comorbidities, and vitamin D deficiency is common in this population. Accumulating evidence links low vitamin D levels to various comorbidities. ...

    Authors: Ing How Moo, Carmen Jia Wen Kam, Eric Wei Liang Cher, Bryan Ce Jie Peh, Chung Ean Lo, David Thai Chong Chua, Ngai Nung Lo, Tet Sen Howe and Joyce Suang Bee Koh

    Citation: BMC Musculoskeletal Disorders 2020 21:524

    Content type: Research article

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  21. Bone tumors are often treated with intralesional curettage. High-speed burring, an adjuvant therapy, was performed to maximize the tumor cell killing; however, tumor recurrence might still occur, which may be ...

    Authors: Pai-Han Wang, Chia-Lun Wu, Chao-Ming Chen, Jir-You Wang, Po-Kuei Wu and Wei-Ming Chen

    Citation: BMC Musculoskeletal Disorders 2020 21:507

    Content type: Research article

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  22. Previous research indicated that nitric oxide synthase (NOS) is the key molecule for S-nitrosylation of ryanodine receptor 1 (RyR1) in DMD model mice (mdx mice) and that both neuronal NOS (nNOS) and inducible NOS...

    Authors: Ken’ichiro Nogami, Yusuke Maruyama, Ahmed Elhussieny, Fusako Sakai-Takemura, Jun Tanihata, Jun-ichi Kira, Yuko Miyagoe-Suzuki and Shin’ichi Takeda

    Citation: BMC Musculoskeletal Disorders 2020 21:479

    Content type: Research article

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  23. Adolescent idiopathic scoliosis (AIS) has been associated with diminished postural stability and a greater prevalence of back pain. Currently, the literature is lacking information on the effect of spinal fusi...

    Authors: Maxime St-Georges, Alisson R. Teles, Oded Rabau, Neil Saran, Jean A. Ouellet and Catherine E. Ferland

    Citation: BMC Musculoskeletal Disorders 2020 21:466

    Content type: Research article

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  24. Pelvic obliquity (PO) is common in individuals with cerebral palsy (CP). The prevalence of PO in a population of children with CP and its associations with scoliosis, hip displacement and asymmetric range of h...

    Authors: Gunnar Hägglund

    Citation: BMC Musculoskeletal Disorders 2020 21:464

    Content type: Research article

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  25. Clinical treatment of osteosarcoma suffers from high recurrence rate. Therefore, is of great clinical values to develop predictive markers for recurrent osteosarcoma. Cervical carcinoma high-expressed lncRNA 1...

    Authors: Zhi Zhang, Tao Yu and Wei Geng

    Citation: BMC Musculoskeletal Disorders 2020 21:462

    Content type: Research article

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  26. Randomised trials on antibiotic treatment for patients with chronic low back pain and vertebral endplate changes visible on MRI (Modic changes) have shown mixed results. A possible explanation might be a real ...

    Authors: Lars Christian Haugli Bråten, Lars Grøvle, Ansgar Espeland, Are Hugo Pripp, Margreth Grotle, Christian Helllum, Anne Julsrud Haugen, Anne Froholdt, Mads Peder Rolfsen, Øystein Petter Nygaard, Olav Lutro, Per Martin Kristoffersen, Audny Anke, Elina Iordanova Schistad, Jan Sture Skouen, Jens Ivar Brox…

    Citation: BMC Musculoskeletal Disorders 2020 21:458

    Content type: Research article

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  27. Clinically, skeletal muscle ischemia/reperfusion injury is a life-threatening syndrome that is often caused by skeletal muscle damage and is characterized by oxidative stress and inflammatory responses. Biloba...

    Authors: Ying Li, Jiliang Jiang, Liangcheng Tong, Tingting Gao, Lei Bai, Qing Xue, Jianxin Xing, Qin Wang, Haoran Lyu, Min Cai and Zhongyang Sun

    Citation: BMC Musculoskeletal Disorders 2020 21:449

    Content type: Research article

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    The Correction to this article has been published in BMC Musculoskeletal Disorders 2020 21:584

  29. The optimal treatment of osteoporosis after reconstruction surgery for osteoporotic vertebral fractures (OVF) remains unclear. In this multicentre retrospective study, we investigated the effects of typically ...

    Authors: Atsuyuki Kawabata, Toshitaka Yoshii, Takashi Hirai, Shuta Ushio, Takashi Kaito, Tomoya Yamashita, Hiroyasu Fujiwara, Yukitaka Nagamoto, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Hidetomi Terai, Koji Tamai, Atsushi Tagami, Syuta Yamada, Shinji Adachi…

    Citation: BMC Musculoskeletal Disorders 2020 21:420

    Content type: Research article

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  30. Multiple primary tumors, especially quadruple primary neoplasms is extremely rare. Fibrous dysplasia (FD), osteosarcoma (OS), and giant cell tumor of bone (GCTB) are three bone tumors with low incidence while ...

    Authors: Zhiqing Zhao, Kunkun Sun, Taiqiang Yan, Ran Wei and Wei Guo

    Citation: BMC Musculoskeletal Disorders 2020 21:394

    Content type: Case report

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  31. Age-dependent male osteoporosis remains a poorly studied medical problem despite its significance. It is estimated that at least 1 of 5 men will suffer from osteoporotic consequences. Given that multiple mecha...

    Authors: Omnia Ameen, Rania I. Yassien and Yahya M. Naguib

    Citation: BMC Musculoskeletal Disorders 2020 21:375

    Content type: Research article

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  32. Lumbar spinal stenosis (LSS) is a common degenerative disease, which can lead to neurological dysfunction and requires surgical treatment. In the previous study, we used H&E staining and immunohistochemistry t...

    Authors: Wei Hu, Yidong Liu, Shunli Kan, Tengfei Zhang, Zehua Jiang and Rusen Zhu

    Citation: BMC Musculoskeletal Disorders 2020 21:359

    Content type: Research article

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  33. To examine the associations between hip muscle cross-sectional area and hip pain and function in community-based individuals with mild-to-moderate hip osteoarthritis.

    Authors: Waruna L. Peiris, Flavia M. Cicuttini, Maria Constantinou, Abbas Yaqobi, Sultana Monira Hussain, Anita E. Wluka, Donna Urquhart, Rod Barrett, Ben Kennedy and Yuanyuan Wang

    Citation: BMC Musculoskeletal Disorders 2020 21:316

    Content type: Research article

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  34. Animal studies have reported an increase in pelvic floor muscle stiffness during pregnancy, which might be a protective process against perineal trauma at delivery. Our main objective is to describe the change...

    Authors: Bertrand Gachon, Xavier Fritel, Fabrice Pierre and Antoine Nordez

    Citation: BMC Musculoskeletal Disorders 2020 21:305

    Content type: Study protocol

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  35. Shockwave therapy (SWT) is a commonly used intervention for a number of musculoskeletal conditions with varying clinical outcomes. However, the capacity of SWT to influence pathophysiological processes and the...

    Authors: Hani Al-Abbad, Sophie Allen, Susan Morris, Jackie Reznik, Erik Biros, Bruce Paulik and Anthony Wright

    Citation: BMC Musculoskeletal Disorders 2020 21:275

    Content type: Research article

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  36. Haemophilic arthropathy is a chronic and debilitating joint disease caused by recurrent spontaneous joint bleeds in patients with haemophilia. Understanding how characteristics of individual joint bleeds relat...

    Authors: K. K. Vøls, M. Kjelgaard-Hansen, C. D. Ley, A. K. Hansen and M. Petersen

    Citation: BMC Musculoskeletal Disorders 2020 21:241

    Content type: Research article

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  37. Klippel-Feil syndrome (KFS) represents a rare anomaly characterized by congenital fusion of the cervical vertebrae. The underlying molecular etiology remains largely unknown because of the genetic and phenotyp...

    Authors: Ziquan Li, Sen Zhao, Siyi Cai, Yuanqiang Zhang, Lianlei Wang, Yuchen Niu, Xiaoxin Li, Jianhua Hu, Jingdan Chen, Shengru Wang, Huizi Wang, Gang Liu, Ye Tian, Zhihong Wu, Terry Jianguo Zhang, Yipeng Wang…

    Citation: BMC Musculoskeletal Disorders 2020 21:220

    Content type: Research article

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  38. Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare disorder marked by painful, recurrent flare-ups and heterotopic ossification (HO) in soft and connective tissues, which can be idiopathic or provoke...

    Authors: Sukhmani Singh, Joseph Kidane, Kelly L. Wentworth, Daria Motamedi, Saam Morshed, Andrew E. Schober and Edward C. Hsiao

    Citation: BMC Musculoskeletal Disorders 2020 21:204

    Content type: Case report

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  39. Rotator cuff tendon tears are typically degenerative and usually affect the region of tendon insertion on bone. The remnant torn tendon is degenerative and may not be an ideal source for progenitor cells for c...

    Authors: Mandeep S. Virk, Wei Luo, Katie J. Sikes, Jun Li, Anna Plaas and Brian J. Cole

    Citation: BMC Musculoskeletal Disorders 2020 21:194

    Content type: Research article

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  40. The association between fibromyalgia and irritable bowel syndrome is well-established. Alterations in the composition and diversity of the gut microbiome in irritable bowel syndrome have been reported, however...

    Authors: Sharon Erdrich, Jason A. Hawrelak, Stephen P. Myers and Joanna E. Harnett

    Citation: BMC Musculoskeletal Disorders 2020 21:181

    Content type: Research article

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  41. It is known that Fas ligand (FasL) is involved in the development of intervertebral disc degeneration (IDD). A recent study reported that lncRNA MAGI2-AS3 up-regulated the expression of FasL to promote breast ...

    Authors: Shuting Cui, Zizhen Liu, Bin Tang, Zhizhen Wang and Baojian Li

    Citation: BMC Musculoskeletal Disorders 2020 21:149

    Content type: Research article

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  42. Low back pain (LBP) is one of the greatest contributors to disability in the world and there is growing interest on the role of biomarkers in LBP. To purpose of this review was to analyze available evidence on...

    Authors: Patrick Morris, Kareem Ali, Mackenzie Merritt, Joey Pelletier and Luciana G Macedo

    Citation: BMC Musculoskeletal Disorders 2020 21:142

    Content type: Research article

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  43. Osteoporosis is a worldwide severe bone disease. This study aimed to evaluate the effect of polyphyllin VII on the genesis of osteoclasts from bone marrow macrophages (BMMs) and its potentiality as a therapeut...

    Authors: Long Zhou, Hanyi Song, Yiqi Zhang, Zhaozhou Ren, Minghe Li and Qin Fu

    Citation: BMC Musculoskeletal Disorders 2020 21:112

    Content type: Research article

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  44. Inflammatory mediators in the synovial fluid (SF) play critical roles in the initiation and development of pain in knee osteoarthritis (KOA). However, data for inflammatory marker expression are conflicting, a...

    Authors: Li Li, Zhenxing Li, Yuyan Li, Xi Hu, Yu Zhang and Pei Fan

    Citation: BMC Musculoskeletal Disorders 2020 21:99

    Content type: Research article

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  45. This article systematically reviews the current evidence regarding inflammation in Tendinopathy with the aim to increase understanding of a potential common pathophysiology.

    Authors: George Jomaa, Cheuk-Kin Kwan, Sai-Chuen Fu, Samuel Ka-Kin Ling, Kai-Ming Chan, Patrick Shu-Hang Yung and Christer Rolf

    Citation: BMC Musculoskeletal Disorders 2020 21:78

    Content type: Research article

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  46. The leptin receptor-deficient knockout (db/db) mouse is a well-established model for studying type II diabetes mellitus (T2DM). T2DM is an important risk factor of intervertebral disc degeneration (IVDD). Alth...

    Authors: Xinhua Li, Xiaoming Liu, Yiru Wang, Fuming Cao, Zhaoxiong Chen, Zhouyang Hu, Bin Yu, Hang Feng, Zhaoyu Ba, Tao Liu, Haoxi Li, Bei Jiang, Yufeng Huang, Lijun Li and Desheng Wu

    Citation: BMC Musculoskeletal Disorders 2020 21:77

    Content type: Research article

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  47. Musculoskeletal disorders can result from prolonged repetitive and/or forceful movements. Performance of an upper extremity high repetition high force task increases serum pro-inflammatory cytokines and upper ...

    Authors: Tianqi Tenchi Gao Smith, Ann E. Barr-Gillespie, David M. Klyne, Michelle Y. Harris, Mamta Amin, Ryan W. Paul, Geneva E. Cruz, Huaqing Zhao, Sean Gallagher and Mary F. Barbe

    Citation: BMC Musculoskeletal Disorders 2020 21:57

    Content type: Research article

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  48. Osteonecrosis of the femoral head (ONFH) is a common disease that greatly affects the quality of life of patients. Repair of the necrotic area is key to successful treatment. Currently, the combination of stem...

    Authors: Zhan Yu Wu, Qi Sun, Ming Liu, Brian E. Grottkau, Zhi Xu He, Qiang Zou and Chuan Ye

    Citation: BMC Musculoskeletal Disorders 2020 21:55

    Content type: Research article

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  49. Calf muscle strain and Achilles tendon injuries are common in many sports. For the treatment of muscular and tendinous injuries, one of the newer approaches in sports medicine is capacitive-resistive electric ...

    Authors: Carlos López-de-Celis, César Hidalgo-García, Albert Pérez-Bellmunt, Pablo Fanlo-Mazas, Vanessa González-Rueda, José Miguel Tricás-Moreno, Sara Ortiz and Jacobo Rodríguez-Sanz

    Citation: BMC Musculoskeletal Disorders 2020 21:46

    Content type: Research article

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  50. Peripheral nerve injury causes limb muscle/bone atrophy, leading to chronic pain. However, the mechanisms underlying muscle/bone atrophy after peripheral nerve injury remain unknown. It was recently reported t...

    Authors: Nobuhiro Shimada, Asuka Sakata, Takashi Igarashi, Mamoru Takeuchi and Satoshi Nishimura

    Citation: BMC Musculoskeletal Disorders 2020 21:44

    Content type: Research article

    Published on:

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BMC Musculoskeletal Disorders

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