Pathophysiology of musculoskeletal disorders

Section edited by Ali Mobasheri

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

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  1. Case report

    Pure exercise intolerance and ophthalmoplegia associated with the m.12,294G > A mutation in the MT-TL2 gene: a case report

    Pure exercise intolerance associated with exclusive affection of skeletal muscle is a very rare phenotype of patients with mitochondrial myopathy. Moreover, the exercise intolerance in these rare patients is y...

    Patrick Soldath, Karen Lindhardt Madsen, Astrid Emilie Buch, Morten Duno, Flemming Wibrand and John Vissing

    BMC Musculoskeletal Disorders 2017 18:419

    Published on: 19 October 2017

  2. Case report

    Improved clinical outcome measures of knee pain and function with concurrent resolution of subchondral Bone Marrow Edema Lesion and joint effusion in an osteoarthritic patient following Pentosan Polysulphate Sodium treatment: a case report

    At present, there are no registered products for the treatment of subchondral Bone Marrow Edema Lesion (BML) and associated knee pain. Patients who do not respond to current anti-inflammatory therapies are lef...

    Matthew J. Sampson, Margie Kabbani, Ravi Krishnan, Michael Nganga, Annika Theodoulou and Jeganath Krishnan

    BMC Musculoskeletal Disorders 2017 18:396

    Published on: 12 September 2017

  3. Research article

    Neuroimmune expression in hip osteoarthritis: a systematic review

    Neuroimmune axis is central in the physiopathology of hip osteoarthritis (OA), but its specific pathways are still unclear. This systematic review aims to assess the nervous and immune system profile of patien...

    Manuel Ribeiro da Silva, Daniela Linhares, Daniel Marques Vasconcelos, Cecilia Juliana Alves, Nuno Neves, Gilberto Costa and Meriem Lamghari

    BMC Musculoskeletal Disorders 2017 18:394

    Published on: 11 September 2017

  4. Research article

    Plasminogen activator inhibitor-1 deficiency enhances subchondral osteopenia after induction of osteoarthritis in mice

    Subchondral osteopenia is important for the pathophysiology of osteoarthritis (OA). Although previous studies suggest that plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, is related to...

    Akihiro Moritake, Naoyuki Kawao, Kiyotaka Okada, Kohei Tatsumi, Masayoshi Ishida, Katsumi Okumoto, Osamu Matsuo, Masao Akagi and Hiroshi Kaji

    BMC Musculoskeletal Disorders 2017 18:392

    Published on: 11 September 2017

  5. Research article

    Effects of hyaluronic acid combined with anti-inflammatory drugs compared with hyaluronic acid alone, in clinical trials and experiments in osteoarthritis: a systematic review and meta-analysis

    The objectives are to compare the efficacy of intra-articular hyaluronic acid (IA-HA) alone and in combination with anti-inflammatory drugs (IA-HA + AI), corticosteroids (CS) or non-steroidal anti-inflammatory...

    Thippaporn Euppayo, Veerasak Punyapornwithaya, Siriwadee Chomdej, Siriwan Ongchai and Korakot Nganvongpanit

    BMC Musculoskeletal Disorders 2017 18:387

    Published on: 6 September 2017

  6. Research article

    Effects of dietary gelatin hydrolysates on bone mineral density in magnesium-deficient rats

    The major types of commercially available gelatin hydrolysates are prepared from mammals or fish. Dietary gelatin hydrolysates from mammals were reported to improve bone mineral density (BMD) in some animal mo...

    Teruyuki Noma, Satoshi Takasugi, Miho Shioyama, Taketo Yamaji, Hiroyuki Itou, Yoshio Suzuki, Keishoku Sakuraba and Keisuke Sawaki

    BMC Musculoskeletal Disorders 2017 18:385

    Published on: 5 September 2017

  7. Research article

    Analysis of DNA methylation in chondrocytes in rats with knee osteoarthritis

    Knee osteoarthritis (KOA) is a degenerative knee disease commonly found in the ageing population. DNA methylation works with histone acetylation to participate in aging. Alterations of DNA methylation may invo...

    Xinxin Wang, Dezhi Tang, Peng Shen, Hao Xu, Hongfu Qiu, Tao Wu and Xiang Gao

    BMC Musculoskeletal Disorders 2017 18:377

    Published on: 31 August 2017

  8. Research article

    Chitosan in viscosupplementation: in vivo effect on rabbit subchondral bone

    To investigate the effect of intra-articular injection of Chitosan (Cs) added to hyaluronic acid (HA) on subchondral bone during osteoarthritis (OA), microarchitectural parameters and mineral density were meas...

    R. Rieger, C. Boulocher, S. Kaderli and T. Hoc

    BMC Musculoskeletal Disorders 2017 18:350

    Published on: 15 August 2017

  9. Research article

    Gene expression profiling in patients with polymyalgia rheumatica before and after symptom-abolishing glucocorticoid treatment

    The pathophysiology, including the impact of gene expression, of polymyalgia rheumatica (PMR) remains elusive. We profiled the gene expression in muscle tissue in PMR patients before and after glucocorticoid t...

    Frederik Flindt Kreiner, Rehannah Borup, Finn Cilius Nielsen, Peter Schjerling and Henrik Galbo

    BMC Musculoskeletal Disorders 2017 18:341

    Published on: 7 August 2017

  10. Research article

    Hip preserving surgery with concentrated autologous bone marrow aspirate transplantation for the treatment of asymptomatic osteonecrosis of the femoral head: retrospective review of clinical and radiological outcomes at 6 years postoperatively

    We had previously established concentrated autologous bone marrow aspirate transplantation (CABMAT), a one-step, low-invasive, joint-preserving surgical technique for treating osteonecrosis of the femoral head...

    Yohei Tomaru, Tomokazu Yoshioka, Hisashi Sugaya, Katsuya Aoto, Hiroshi Wada, Hiroshi Akaogi, Masashi Yamazaki and Hajime Mishima

    BMC Musculoskeletal Disorders 2017 18:292

    Published on: 6 July 2017

  11. Research article

    Altered somatosensory profile according to quantitative sensory testing in patients with degenerative lumbar spine disorders scheduled for surgery

    Somatosensory profiling in affected and non-affected body regions can strengthen our insight regarding the underlying pain mechanisms, which can be valuable in treatment decision making and to improve outcomes...

    Yvonne Lindbäck, Hans Tropp, Paul Enthoven, Björn Gerdle, Allan Abbott and Birgitta Öberg

    BMC Musculoskeletal Disorders 2017 18:264

    Published on: 17 June 2017

  12. Research article

    The mitochondrial inhibitor oligomycin induces an inflammatory response in the rat knee joint

    Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether intra-articular admi...

    Carlos Vaamonde-García, Jesús Loureiro, Marta N. Valcárcel-Ares, Romina R. Riveiro-Naveira, Olalla Ramil-Gómez, Laura Hermida-Carballo, Alberto Centeno, Rosa Meijide-Failde, Francisco J. Blanco and María J. López-Armada

    BMC Musculoskeletal Disorders 2017 18:254

    Published on: 12 June 2017

  13. Research article

    Factors influencing treatment success of negative pressure wound therapy in patients with postoperative infections after Osteosynthetic fracture fixation

    Negative Pressure Wound Therapy (NPWT) is being increasingly used to treat postoperative infections after osteosynthetic fracture fixation. The aim of the present study was to analyze the influence of epidemio...

    Kaywan Izadpanah, Stephanie Hansen, Julia Six-Merker, Peter Helwig, Norbert P Südkamp and Hagen Schmal

    BMC Musculoskeletal Disorders 2017 18:247

    Published on: 7 June 2017

  14. Research article

    Early anti-inflammatory intervention ameliorates axial disease in the proteoglycan-induced spondylitis mouse model of ankylosing spondylitis

    Ankylosing spondylitis (AS) is characterised by immune-mediated arthritis and osteoproliferation, ultimately leading to joint ankylosis. Whether inflammation is necessary for osteoproliferation is controversia...

    Hsu-Wen Tseng, Tibor T. Glant, Matthew A. Brown, Tony J. Kenna, Gethin P. Thomas and Allison R. Pettit

    BMC Musculoskeletal Disorders 2017 18:228

    Published on: 30 May 2017

  15. Research article

    Glutamate signaling through the NMDA receptor reduces the expression of scleraxis in plantaris tendon derived cells

    A body of evidence demonstrating changes to the glutaminergic system in tendinopathy has recently emerged. This hypothesis was further tested by studying the effects of glutamate on the tenocyte phenotype, and...

    Christoph Spang, Ludvig J. Backman, Sandrine Le Roux, Jialin Chen and Patrik Danielson

    BMC Musculoskeletal Disorders 2017 18:218

    Published on: 25 May 2017

  16. Research article

    Immunogenicity and immunomodulatory effects of the human chondrocytes, hChonJ

    Invossa™ (TissueGene-C) is a cell and gene therapy for osteoarthritis. It is composed of primary human chondrocytes (hChonJ cells) and irradiated human chondrocytes modified to express TGF-β1 (hChonJb#7 cells)...

    Chae-Lyul Lim, Yeon-Ju Lee, Jong-Ho Cho, Heonsik Choi, Bumsup Lee, Myung Chul Lee and Sujeong Kim

    BMC Musculoskeletal Disorders 2017 18:199

    Published on: 18 May 2017

  17. Research article

    Mucin 1, a signal transduction membrane-bound mucin, is present in human disc tissue and is downregulated in vitro by exposure to IL-1ß or TNF-α

    Back pain and disc degeneration have a growing socioeconomic healthcare impact. Mucin 1 (MUC1) is a transmembrane glycoprotein whose extracellular and intracellular domains participate in cellular signaling. L...

    Helen E. Gruber, Jane A. Ingram, Gretchen L. Hoelscher, Emilio Marrero and Edward N. Hanley Jr

    BMC Musculoskeletal Disorders 2017 18:182

    Published on: 8 May 2017

  18. Research article

    Return to sports after plate fixation of humeral head fractures 65 cases with minimum 24-month follow-up

    Humeral head fractures requiring surgical intervention are severe injuries, which might affect the return to sports and daily activities. We hypothesize that athletic patients will be constrained regarding the...

    Philipp Ahrens, Frank Martetschläger, Sebastian Siebenlist, Johann Attenberger, Moritz Crönlein, Peter Biberthaler, Ulrich Stöckle and Gunther H. Sandmann

    BMC Musculoskeletal Disorders 2017 18:173

    Published on: 26 April 2017

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