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Section edited by Ali Mobasheri
This section concerns all aspects of the pathophysiology of musculoskeletal disorders.
Research article
To investigate the effect of intra-articular injection of Chitosan (Cs) added to hyaluronic acid (HA) on subchondral bone during osteoarthritis (OA), microarchitectural parameters and mineral density were meas...
BMC Musculoskeletal Disorders 2017 18:350
Published on: 15 August 2017
Research article
The pathophysiology, including the impact of gene expression, of polymyalgia rheumatica (PMR) remains elusive. We profiled the gene expression in muscle tissue in PMR patients before and after glucocorticoid t...
BMC Musculoskeletal Disorders 2017 18:341
Published on: 7 August 2017
Research article
We had previously established concentrated autologous bone marrow aspirate transplantation (CABMAT), a one-step, low-invasive, joint-preserving surgical technique for treating osteonecrosis of the femoral head...
BMC Musculoskeletal Disorders 2017 18:292
Published on: 6 July 2017
Research article
Somatosensory profiling in affected and non-affected body regions can strengthen our insight regarding the underlying pain mechanisms, which can be valuable in treatment decision making and to improve outcomes...
BMC Musculoskeletal Disorders 2017 18:264
Published on: 17 June 2017
Research article
Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether intra-articular admi...
BMC Musculoskeletal Disorders 2017 18:254
Published on: 12 June 2017
Research article
Negative Pressure Wound Therapy (NPWT) is being increasingly used to treat postoperative infections after osteosynthetic fracture fixation. The aim of the present study was to analyze the influence of epidemio...
BMC Musculoskeletal Disorders 2017 18:247
Published on: 7 June 2017
Research article
Leptin plays an important role in mediating chondrogenesis of limb growth plate. Previous studies suggest that bone structures and development of spine and limb are different. The expression of Ob-Rb, the gene...
BMC Musculoskeletal Disorders 2017 18:235
Published on: 31 May 2017
Research article
Ankylosing spondylitis (AS) is characterised by immune-mediated arthritis and osteoproliferation, ultimately leading to joint ankylosis. Whether inflammation is necessary for osteoproliferation is controversia...
BMC Musculoskeletal Disorders 2017 18:228
Published on: 30 May 2017
Research article
A body of evidence demonstrating changes to the glutaminergic system in tendinopathy has recently emerged. This hypothesis was further tested by studying the effects of glutamate on the tenocyte phenotype, and...
BMC Musculoskeletal Disorders 2017 18:218
Published on: 25 May 2017
Research article
Invossa™ (TissueGene-C) is a cell and gene therapy for osteoarthritis. It is composed of primary human chondrocytes (hChonJ cells) and irradiated human chondrocytes modified to express TGF-β1 (hChonJb#7 cells)...
BMC Musculoskeletal Disorders 2017 18:199
Published on: 18 May 2017
Research article
Joint inflammation causes meniscus degeneration and can exacerbate post-traumatic meniscus injuries by extracellular matrix degradation, cellular de-differentiation and cell death. The aim of this study was to...
BMC Musculoskeletal Disorders 2017 18:197
Published on: 16 May 2017
Research article
Back pain and disc degeneration have a growing socioeconomic healthcare impact. Mucin 1 (MUC1) is a transmembrane glycoprotein whose extracellular and intracellular domains participate in cellular signaling. L...
BMC Musculoskeletal Disorders 2017 18:182
Published on: 8 May 2017
Research article
Humeral head fractures requiring surgical intervention are severe injuries, which might affect the return to sports and daily activities. We hypothesize that athletic patients will be constrained regarding the...
BMC Musculoskeletal Disorders 2017 18:173
Published on: 26 April 2017
Research article
Degenerative lumbar spinal stenosis (DLSS) is a common health problem in the elderly and usually associated with three-joint complex degeneration. Schmorl’s nodes (SNs) are described as vertical herniation of ...
BMC Musculoskeletal Disorders 2017 18:164
Published on: 20 April 2017
Research article
Detailed pain mapping of extent and distribution in individuals with patellofemoral pain (PFP) within and around a complex structure such as the knee has yet to be explored.
BMC Musculoskeletal Disorders 2017 18:160
Published on: 18 April 2017
Technical advance
Accelerometric analysis of gait abnormalities in golden retriever muscular dystrophy (GRMD) dogs is of limited sensitivity, and produces highly complex data. The use of discriminant analysis may enable simpler...
BMC Musculoskeletal Disorders 2017 18:153
Published on: 12 April 2017
Research article
Evidence is lacking on whether fat infiltration in the multifidus muscles affects outcomes after total disc replacement (TDR) surgery and if it develops after surgery. The aims of this study were 1) to investi...
BMC Musculoskeletal Disorders 2017 18:145
Published on: 4 April 2017
Research article
Human-beta defensins (HBD) belong to the family of acute phase peptides and hold a broad antimicrobial spectrum that includes gram-positive and gram-negative bacteria. HBD are up-regulated after severe injurie...
BMC Musculoskeletal Disorders 2017 18:100
Published on: 7 March 2017
Research article
Facet tropism is the angular asymmetry between the left and right facet joint orientation. Although debatable, facet tropism was suggested to be associated with disc degeneration, facet degeneration and degene...
BMC Musculoskeletal Disorders 2017 18:86
Published on: 20 February 2017
Case report
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by renal phosphate wasting, hypophosphatemia, reduction of 1,25-dihydroxyl vitamin D, and bone calcification disorders. Tumors a...
BMC Musculoskeletal Disorders 2017 18:79
Published on: 13 February 2017
