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Pathophysiology of musculoskeletal disorders

Section edited by Ali Mobasheri

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

Page 1 of 8

  1. Pelvic obliquity (PO) is common in individuals with cerebral palsy (CP). The prevalence of PO in a population of children with CP and its associations with scoliosis, hip displacement and asymmetric range of h...

    Authors: Gunnar Hägglund

    Citation: BMC Musculoskeletal Disorders 2020 21:464

    Content type: Research article

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  2. Clinical treatment of osteosarcoma suffers from high recurrence rate. Therefore, is of great clinical values to develop predictive markers for recurrent osteosarcoma. Cervical carcinoma high-expressed lncRNA 1...

    Authors: Zhi Zhang, Tao Yu and Wei Geng

    Citation: BMC Musculoskeletal Disorders 2020 21:462

    Content type: Research article

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  3. Randomised trials on antibiotic treatment for patients with chronic low back pain and vertebral endplate changes visible on MRI (Modic changes) have shown mixed results. A possible explanation might be a real ...

    Authors: Lars Christian Haugli Bråten, Lars Grøvle, Ansgar Espeland, Are Hugo Pripp, Margreth Grotle, Christian Helllum, Anne Julsrud Haugen, Anne Froholdt, Mads Peder Rolfsen, Øystein Petter Nygaard, Olav Lutro, Per Martin Kristoffersen, Audny Anke, Elina Iordanova Schistad, Jan Sture Skouen, Jens Ivar Brox…

    Citation: BMC Musculoskeletal Disorders 2020 21:458

    Content type: Research article

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  4. Clinically, skeletal muscle ischemia/reperfusion injury is a life-threatening syndrome that is often caused by skeletal muscle damage and is characterized by oxidative stress and inflammatory responses. Biloba...

    Authors: Ying Li, Jiliang Jiang, Liangcheng Tong, Tingting Gao, Lei Bai, Qing Xue, Jianxin Xing, Qin Wang, Haoran Lyu, Min Cai and Zhongyang Sun

    Citation: BMC Musculoskeletal Disorders 2020 21:449

    Content type: Research article

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  5. The optimal treatment of osteoporosis after reconstruction surgery for osteoporotic vertebral fractures (OVF) remains unclear. In this multicentre retrospective study, we investigated the effects of typically ...

    Authors: Atsuyuki Kawabata, Toshitaka Yoshii, Takashi Hirai, Shuta Ushio, Takashi Kaito, Tomoya Yamashita, Hiroyasu Fujiwara, Yukitaka Nagamoto, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Hidetomi Terai, Koji Tamai, Atsushi Tagami, Syuta Yamada, Shinji Adachi…

    Citation: BMC Musculoskeletal Disorders 2020 21:420

    Content type: Research article

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  6. Multiple primary tumors, especially quadruple primary neoplasms is extremely rare. Fibrous dysplasia (FD), osteosarcoma (OS), and giant cell tumor of bone (GCTB) are three bone tumors with low incidence while ...

    Authors: Zhiqing Zhao, Kunkun Sun, Taiqiang Yan, Ran Wei and Wei Guo

    Citation: BMC Musculoskeletal Disorders 2020 21:394

    Content type: Case report

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  7. Age-dependent male osteoporosis remains a poorly studied medical problem despite its significance. It is estimated that at least 1 of 5 men will suffer from osteoporotic consequences. Given that multiple mecha...

    Authors: Omnia Ameen, Rania I. Yassien and Yahya M. Naguib

    Citation: BMC Musculoskeletal Disorders 2020 21:375

    Content type: Research article

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  8. Lumbar spinal stenosis (LSS) is a common degenerative disease, which can lead to neurological dysfunction and requires surgical treatment. In the previous study, we used H&E staining and immunohistochemistry t...

    Authors: Wei Hu, Yidong Liu, Shunli Kan, Tengfei Zhang, Zehua Jiang and Rusen Zhu

    Citation: BMC Musculoskeletal Disorders 2020 21:359

    Content type: Research article

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  9. To examine the associations between hip muscle cross-sectional area and hip pain and function in community-based individuals with mild-to-moderate hip osteoarthritis.

    Authors: Waruna L. Peiris, Flavia M. Cicuttini, Maria Constantinou, Abbas Yaqobi, Sultana Monira Hussain, Anita E. Wluka, Donna Urquhart, Rod Barrett, Ben Kennedy and Yuanyuan Wang

    Citation: BMC Musculoskeletal Disorders 2020 21:316

    Content type: Research article

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  10. Animal studies have reported an increase in pelvic floor muscle stiffness during pregnancy, which might be a protective process against perineal trauma at delivery. Our main objective is to describe the change...

    Authors: Bertrand Gachon, Xavier Fritel, Fabrice Pierre and Antoine Nordez

    Citation: BMC Musculoskeletal Disorders 2020 21:305

    Content type: Study protocol

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  11. Shockwave therapy (SWT) is a commonly used intervention for a number of musculoskeletal conditions with varying clinical outcomes. However, the capacity of SWT to influence pathophysiological processes and the...

    Authors: Hani Al-Abbad, Sophie Allen, Susan Morris, Jackie Reznik, Erik Biros, Bruce Paulik and Anthony Wright

    Citation: BMC Musculoskeletal Disorders 2020 21:275

    Content type: Research article

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  12. Haemophilic arthropathy is a chronic and debilitating joint disease caused by recurrent spontaneous joint bleeds in patients with haemophilia. Understanding how characteristics of individual joint bleeds relat...

    Authors: K. K. Vøls, M. Kjelgaard-Hansen, C. D. Ley, A. K. Hansen and M. Petersen

    Citation: BMC Musculoskeletal Disorders 2020 21:241

    Content type: Research article

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  13. Klippel-Feil syndrome (KFS) represents a rare anomaly characterized by congenital fusion of the cervical vertebrae. The underlying molecular etiology remains largely unknown because of the genetic and phenotyp...

    Authors: Ziquan Li, Sen Zhao, Siyi Cai, Yuanqiang Zhang, Lianlei Wang, Yuchen Niu, Xiaoxin Li, Jianhua Hu, Jingdan Chen, Shengru Wang, Huizi Wang, Gang Liu, Ye Tian, Zhihong Wu, Terry Jianguo Zhang, Yipeng Wang…

    Citation: BMC Musculoskeletal Disorders 2020 21:220

    Content type: Research article

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  14. Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare disorder marked by painful, recurrent flare-ups and heterotopic ossification (HO) in soft and connective tissues, which can be idiopathic or provoke...

    Authors: Sukhmani Singh, Joseph Kidane, Kelly L. Wentworth, Daria Motamedi, Saam Morshed, Andrew E. Schober and Edward C. Hsiao

    Citation: BMC Musculoskeletal Disorders 2020 21:204

    Content type: Case report

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  15. Rotator cuff tendon tears are typically degenerative and usually affect the region of tendon insertion on bone. The remnant torn tendon is degenerative and may not be an ideal source for progenitor cells for c...

    Authors: Mandeep S. Virk, Wei Luo, Katie J. Sikes, Jun Li, Anna Plaas and Brian J. Cole

    Citation: BMC Musculoskeletal Disorders 2020 21:194

    Content type: Research article

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  16. The association between fibromyalgia and irritable bowel syndrome is well-established. Alterations in the composition and diversity of the gut microbiome in irritable bowel syndrome have been reported, however...

    Authors: Sharon Erdrich, Jason A. Hawrelak, Stephen P. Myers and Joanna E. Harnett

    Citation: BMC Musculoskeletal Disorders 2020 21:181

    Content type: Research article

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  17. It is known that Fas ligand (FasL) is involved in the development of intervertebral disc degeneration (IDD). A recent study reported that lncRNA MAGI2-AS3 up-regulated the expression of FasL to promote breast ...

    Authors: Shuting Cui, Zizhen Liu, Bin Tang, Zhizhen Wang and Baojian Li

    Citation: BMC Musculoskeletal Disorders 2020 21:149

    Content type: Research article

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  18. Low back pain (LBP) is one of the greatest contributors to disability in the world and there is growing interest on the role of biomarkers in LBP. To purpose of this review was to analyze available evidence on...

    Authors: Patrick Morris, Kareem Ali, Mackenzie Merritt, Joey Pelletier and Luciana G Macedo

    Citation: BMC Musculoskeletal Disorders 2020 21:142

    Content type: Research article

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  19. Osteoporosis is a worldwide severe bone disease. This study aimed to evaluate the effect of polyphyllin VII on the genesis of osteoclasts from bone marrow macrophages (BMMs) and its potentiality as a therapeut...

    Authors: Long Zhou, Hanyi Song, Yiqi Zhang, Zhaozhou Ren, Minghe Li and Qin Fu

    Citation: BMC Musculoskeletal Disorders 2020 21:112

    Content type: Research article

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  20. Inflammatory mediators in the synovial fluid (SF) play critical roles in the initiation and development of pain in knee osteoarthritis (KOA). However, data for inflammatory marker expression are conflicting, a...

    Authors: Li Li, Zhenxing Li, Yuyan Li, Xi Hu, Yu Zhang and Pei Fan

    Citation: BMC Musculoskeletal Disorders 2020 21:99

    Content type: Research article

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  21. This article systematically reviews the current evidence regarding inflammation in Tendinopathy with the aim to increase understanding of a potential common pathophysiology.

    Authors: George Jomaa, Cheuk-Kin Kwan, Sai-Chuen Fu, Samuel Ka-Kin Ling, Kai-Ming Chan, Patrick Shu-Hang Yung and Christer Rolf

    Citation: BMC Musculoskeletal Disorders 2020 21:78

    Content type: Research article

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  22. The leptin receptor-deficient knockout (db/db) mouse is a well-established model for studying type II diabetes mellitus (T2DM). T2DM is an important risk factor of intervertebral disc degeneration (IVDD). Alth...

    Authors: Xinhua Li, Xiaoming Liu, Yiru Wang, Fuming Cao, Zhaoxiong Chen, Zhouyang Hu, Bin Yu, Hang Feng, Zhaoyu Ba, Tao Liu, Haoxi Li, Bei Jiang, Yufeng Huang, Lijun Li and Desheng Wu

    Citation: BMC Musculoskeletal Disorders 2020 21:77

    Content type: Research article

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  23. Musculoskeletal disorders can result from prolonged repetitive and/or forceful movements. Performance of an upper extremity high repetition high force task increases serum pro-inflammatory cytokines and upper ...

    Authors: Tianqi Tenchi Gao Smith, Ann E. Barr-Gillespie, David M. Klyne, Michelle Y. Harris, Mamta Amin, Ryan W. Paul, Geneva E. Cruz, Huaqing Zhao, Sean Gallagher and Mary F. Barbe

    Citation: BMC Musculoskeletal Disorders 2020 21:57

    Content type: Research article

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  24. Osteonecrosis of the femoral head (ONFH) is a common disease that greatly affects the quality of life of patients. Repair of the necrotic area is key to successful treatment. Currently, the combination of stem...

    Authors: Zhan Yu Wu, Qi Sun, Ming Liu, Brian E. Grottkau, Zhi Xu He, Qiang Zou and Chuan Ye

    Citation: BMC Musculoskeletal Disorders 2020 21:55

    Content type: Research article

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  25. Calf muscle strain and Achilles tendon injuries are common in many sports. For the treatment of muscular and tendinous injuries, one of the newer approaches in sports medicine is capacitive-resistive electric ...

    Authors: Carlos López-de-Celis, César Hidalgo-García, Albert Pérez-Bellmunt, Pablo Fanlo-Mazas, Vanessa González-Rueda, José Miguel Tricás-Moreno, Sara Ortiz and Jacobo Rodríguez-Sanz

    Citation: BMC Musculoskeletal Disorders 2020 21:46

    Content type: Research article

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  26. Peripheral nerve injury causes limb muscle/bone atrophy, leading to chronic pain. However, the mechanisms underlying muscle/bone atrophy after peripheral nerve injury remain unknown. It was recently reported t...

    Authors: Nobuhiro Shimada, Asuka Sakata, Takashi Igarashi, Mamoru Takeuchi and Satoshi Nishimura

    Citation: BMC Musculoskeletal Disorders 2020 21:44

    Content type: Research article

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  27. There is some limited evidence for the presence of viruses in herniated disc material including a previous case series that claimed to provide “unequivocal evidence of the presence of herpes virus DNA in inter...

    Authors: B. F. Walker, A. J. Armson, M. A. O’Dea, J. R. White, C. R. P. Lind and P. R. Woodland

    Citation: BMC Musculoskeletal Disorders 2020 21:27

    Content type: Research article

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  28. Bone mineral density of the humeral head is an independent determining factor for postoperative rotator cuff tendon healing. Bisphosphonates, which are commonly used to treat osteoporosis, have raised concerns...

    Authors: Chang-Meen Sung, Ra Jeong Kim, Young-Sool Hah, Ji-Yong Gwark and Hyung Bin Park

    Citation: BMC Musculoskeletal Disorders 2020 21:19

    Content type: Research article

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  29. The CHD7 (chromosome domain helicase DNA binding protein 7) gene has been associated with familial idiopathic scoliosis (IS) in families of European descent. The CHD7 single-nucleotide polymorphisms have never be...

    Authors: Karolina Borysiak, Piotr Janusz, Mirosław Andrusiewicz, Małgorzata Chmielewska, Mateusz Kozinoga, Tomasz Kotwicki and Małgorzata Kotwicka

    Citation: BMC Musculoskeletal Disorders 2020 21:18

    Content type: Research article

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  30. Rad is the prototypic member of a subfamily of Ras-related small G-proteins and is highly expressed in the skeletal muscle of patients with type II diabetes. Our previous microarray analysis suggested that Rad...

    Authors: Takahiro Oda, Takahiro Niikura, Tomoaki Fukui, Michio Arakura, Keisuke Oe, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita and Ryosuke Kuroda

    Citation: BMC Musculoskeletal Disorders 2019 20:602

    Content type: Research article

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  31. Fibroblast-like synoviocytes (FLS) are essential cellular components in inflammatory joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). Despite the growing use of FLS isolated from OA an...

    Authors: Wei Huang, Linlin Zhang, Chao Cheng, Wenshan Shan, Ruixiang Ma, Zongsheng Yin and Chen Zhu

    Citation: BMC Musculoskeletal Disorders 2019 20:591

    Content type: Research article

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  32. Recent reports indicate that oxidative stress induced by reactive oxygen species is associated with the pathobiology of neurodegenerative disorders that involve neuronal cell apoptosis. Here we conducted a cro...

    Authors: Hiroshi Takahashi, Yasuchika Aoki, Junya Saito, Arata Nakajima, Masato Sonobe, Yorikazu Akatsu, Shinji Taniguchi, Manabu Yamada, Keita Koyama, Yuki Akiyama, Yasuhiro Shiga, Kazuhide Inage, Sumihisa Orita, Yawara Eguchi, Satoshi Maki, Takeo Furuya…

    Citation: BMC Musculoskeletal Disorders 2019 20:589

    Content type: Research article

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  33. LBP is a common and serious problem affecting vast populations of the world. However, only few studies on LBP in sub-Saharan Africa have been conducted. Studies report that LBP and pelvic angle are interrelate...

    Authors: Masataka Tatsumi, Egfrid Michael Mkoba, Yusuke Suzuki, Yuu Kajiwara, Hala Zeidan, Keiko Harada, Tsubasa Bitoh, Yuichi Nishida, Kengo Nakai, Kanako Shimoura and Tomoki Aoyama

    Citation: BMC Musculoskeletal Disorders 2019 20:584

    Content type: Research article

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  34. The meniscus plays a vital role in the normal biomechanics of the knee. However, it is not well studied at the molecular level. The purpose of this study was to determine whether molecular and pathological cha...

    Authors: Yi Long, Jingping Xie, Zhi-Qi Zhang, Ziji Zhang, Fangang Meng and Aishan He

    Citation: BMC Musculoskeletal Disorders 2019 20:577

    Content type: Research article

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  35. Degenerative intervertebral disc (IVD) disease can cause lower back pain. However, the change of lactic acid content during disc degeneration process still unclear. The objective of this study was to investiga...

    Authors: Jinhui Shi, Xichao Zhou, Zhen Wang, Swamy Kurra, Junjie Niu and Huilin Yang

    Citation: BMC Musculoskeletal Disorders 2019 20:551

    Content type: Research article

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  36. It is theorized that neck pain may cause reduced postural control due to the known physiological connection between the receptors in the cervical spine and the vestibular system. The purpose of this study was ...

    Authors: Mari K. Knapstad, Frederik K. Goplen, Tove Ask, Jan S. Skouen and Stein Helge G. Nordahl

    Citation: BMC Musculoskeletal Disorders 2019 20:528

    Content type: Research article

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  37. Adolescent idiopathic scoliosis (AIS) which characterized by complex three-dimensional deformity of spine has been difficult to cure because of the unknown etiopathology and uncertainty of progression. Nowaday...

    Authors: Jiong Li, Longjie Wang, Guanteng Yang, Yunjia Wang, Chaofeng Guo, Shaohua Liu, Qile Gao and Hongqi Zhang

    Citation: BMC Musculoskeletal Disorders 2019 20:479

    Content type: Research article

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  38. One of the characteristics of lumbar spinal stenosis (LSS) is elastin degradation and fibrosis in the ligamentum flavum (LF). However, the biochemical factors that cause these histologic changes is unclear. P1...

    Authors: Wei Hu, Shunli Kan, Guang Liu, Zegang Cao and Rusen Zhu

    Citation: BMC Musculoskeletal Disorders 2019 20:458

    Content type: Research article

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  39. Mesenchymal chondrosarcoma (MCS) is a rare malignant variant of chondrosarcoma with a high tendency of recurrence and metastasis. Intradural extramedullary spinal MCS is exceedingly rare and usually found in p...

    Authors: Chih-Wei Chen, I-Hsin Chen, Ming-Hsiao Hu, Jen-Chieh Lee, Hsuan-Ying Huang, Ruey-Long Hong and Shu-Hua Yang

    Citation: BMC Musculoskeletal Disorders 2019 20:408

    Content type: Case report

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  40. Using mass spectrometry, we evaluated the metabolic profiles of patients who had rotator cuff tears with shoulder stiffness, or shoulder stiffness only, and compared these with samples from a control group.

    Authors: Hyo-Jin Lee, Oak-Kee Hong, Dong-Ho Kwak and Yang-Soo Kim

    Citation: BMC Musculoskeletal Disorders 2019 20:364

    Content type: Research article

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  41. There are only a few published case reports of irreducible Galeazzi fracture-dislocation, and patients in these studies had undergone reduction by open surgical methods. Arthroscopy for the distal radioulnar j...

    Authors: Masayoshi Iwamae, Koichi Yano, Yasunori Kaneshiro and Hideki Sakanaka

    Citation: BMC Musculoskeletal Disorders 2019 20:354

    Content type: Case report

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  42. The relationship between spinal alignment and skeletal muscle mass (SMM) has attracted attention in recent years. Sagittal alignment is known to deteriorate with age, but it is not known whether this is relate...

    Authors: Akihiko Hiyama, Hiroyuki Katoh, Daisuke Sakai, Masahiro Tanaka, Masato Sato and Masahiko Watanabe

    Citation: BMC Musculoskeletal Disorders 2019 20:352

    Content type: Research article

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  43. Female patients are more likely to have tendon injuries than males, especially those who has a higher concentration of relaxin. Previous studies have demonstrated that relaxin attenuates extracellular matrix (...

    Authors: Tianpeng Xu, Jiaxiang Bai, Menglei Xu, Binqing Yu, Jiayi Lin, Xiaobin Guo, Yu Liu, Di Zhang, Kai Yan, Dan Hu, Yuefeng Hao and Dechun Geng

    Citation: BMC Musculoskeletal Disorders 2019 20:349

    Content type: Research article

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  44. Impaired lumbar artery flow has been reported in clinical and epidemiological studies to be associated with low back pain and lumbar disc degeneration. However, it has not been experimentally demonstrated that...

    Authors: Takao Imanishi, Koji Akeda, Koichiro Murata and Akihiro Sudo

    Citation: BMC Musculoskeletal Disorders 2019 20:347

    Content type: Research article

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  45. Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, w...

    Authors: Katherine A. Staines, Ekele Ikpegbu, Anna E. Törnqvist, Scott Dillon, Behzad Javaheri, Anish K. Amin, Dylan N. Clements, David J. Buttle, Andrew A. Pitsillides and Colin Farquharson

    Citation: BMC Musculoskeletal Disorders 2019 20:344

    Content type: Research article

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