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BMC Musculoskeletal Disorders

Pathophysiology of musculoskeletal disorders

Section edited by Ali Mobasheri

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

Page 1 of 13

  1. Content type: Research article

    Mesenchymal stromal cells (MSC) have shown promising results in the treatment of tendinopathy in equine medicine, making this therapeutic approach seem favorable for translation to human medicine. Having demon...

    Authors: A. B. Ahrberg, C. Horstmeier, D. Berner, W. Brehm, C. Gittel, A. Hillmann, C. Josten, G. Rossi, S. Schubert, K. Winter and J. Burk

    Citation: BMC Musculoskeletal Disorders 2018 19:230

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  2. Content type: Research article

    Bone structure and strength are rapidly lost during conditions of decreased mechanical loading, and aged bones have a diminished ability to adapt to increased mechanical loading. This is a concern for older pa...

    Authors: Hailey C. Cunningham, Daniel W. D. West, Leslie M. Baehr, Franklin D. Tarke, Keith Baar, Sue C. Bodine and Blaine A. Christiansen

    Citation: BMC Musculoskeletal Disorders 2018 19:223

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  3. Content type: Research article

    To evaluate synchrotron radiation-based Fourier transform infrared microspectroscopy (SR-FTIR) as a tool for quantitative mapping of the content and distribution of the extracellular matrix in decellularized f...

    Authors: Yongchun Zhou, Can Chen, Zhu Guo, Shanshan Xie, Jianzhong Hu and Hongbin Lu

    Citation: BMC Musculoskeletal Disorders 2018 19:220

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  4. Content type: Correspondence

    Recent reported results by Fang et al. published in BMC Musculoskeletal Disorders have added to the weight of evidence supporting association between gluteal pain and lumbar disc hernia. Their clinical finding...

    Authors: Yu Wang, Jin Yang, Yuqing Yan, Lifeng Zhang, Chuan Guo, Zhiyu Peng and Qingquan Kong

    Citation: BMC Musculoskeletal Disorders 2018 19:214

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  5. Content type: Research article

    Research suggests that vascular endothelial growth factor (VEGF) levels in the synovial fluid of knee osteoarthritis (KOA) patients are positively correlated with KOA severity. The relationship between synovia...

    Authors: Shotaro Takano, Kentaro Uchida, Gen Inoue, Toshihide Matsumoto, Jun Aikawa, Dai Iwase, Manabu Mukai, Masayuki Miyagi and Masashi Takaso

    Citation: BMC Musculoskeletal Disorders 2018 19:204

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  6. Content type: Research article

    The anterior cruciate ligament (ACL) is responsible for braking forward movement of the tibia relative to the femur and for tibial rotation. After ACL injury, this braking performance deteriorates, inducing ab...

    Authors: Yuichi Nishikawa, Takanori Kokubun, Naohiko Kanemura, Tetsuya Takahashi, Masayasu Matsumoto, Hirofumi Maruyama and Kiyomi Takayanagi

    Citation: BMC Musculoskeletal Disorders 2018 19:175

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  7. Content type: Research article

    Autologous chondrocyte implantation (ACI) is a therapy for articular cartilage and osteochondral lesions that relies on notch- or trochlea-derived primary chondrocytes. An alternative cell source for ACI could...

    Authors: Matthias Aurich, Gunther O. Hofmann, Florian Gras and Bernd Rolauffs

    Citation: BMC Musculoskeletal Disorders 2018 19:168

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  8. Content type: Research article

    It was indicated that inhibition of PPARγ probably represents a novel therapy for steroid-related osteonecrosis. In this study, we investigated the preventive effects of PPARγ inhibition on steroid-related ost...

    Authors: Na Yuan, Jia Li, Meng Li, Wenchen Ji, Zhaogang Ge, Lihong Fan and Kunzheng Wang

    Citation: BMC Musculoskeletal Disorders 2018 19:129

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  9. Content type: Research article

    Tendon is a commonly injured soft musculoskeletal tissue, however, poor healing potential and ineffective treatment strategies result in persistent injuries and tissue that is unable to perform its normal phys...

    Authors: Katie Joanna Lee, Peter David Clegg, Eithne Josephine Comerford and Elizabeth Gail Canty-Laird

    Citation: BMC Musculoskeletal Disorders 2018 19:116

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  10. Content type: Research article

    Steroid therapy, a key therapy for inflammatory, allergic, and immunological disorders, is often associated with steroid myopathy as one of the side effects. Steroid therapy is considered the first-line therap...

    Authors: Takashi Nawata, Makoto Kubo, Takafumi Nomura, Keiji Oishi, Kosaku Shiragami, Tadayoshi Ikegami, Munemasa Okada, Shigeki Kobayashi and Masafumi Yano

    Citation: BMC Musculoskeletal Disorders 2018 19:93

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  11. Content type: Research article

    Mobilization of mesenchymal stem cells (MSCs) from the synovium was revealed using a “suspended synovium culture model” of osteoarthritis (OA). The pathology of rheumatoid arthritis (RA) differs from that of O...

    Authors: Yuji Kohno, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Koji Otabe, Hideyuki Koga, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa and Ichiro Sekiya

    Citation: BMC Musculoskeletal Disorders 2018 19:78

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  12. Content type: Research article

    Inflammation is associated with the onset and progression of osteoarthritis in multiple joints. It is well known that mechanical properties differ between different joints, however, it remains unknown if the i...

    Authors: Guomin Ren, Ian Lutz, Pamela Railton, J. Preston Wiley, Jenelle McAllister, James Powell and Roman J. Krawetz

    Citation: BMC Musculoskeletal Disorders 2018 19:39

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  13. Content type: Research article

    Microendoscopic foraminotomy has been reported to be effective for the treatment of cervical radiculopathy, using outcome measurement scores such as the neck disability index (NDI) and numerical rating scale (...

    Authors: Juichi Tonosu, Hirohiko Inanami, Hiroyuki Oka, Yuichi Takano, Hisashi Koga, Yohei Yuzawa, Ryutaro Shiboi, Yasushi Oshima, Satoshi Baba, Sakae Tanaka and Ko Matsudaira

    Citation: BMC Musculoskeletal Disorders 2018 19:30

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  14. Content type: Research article

    Chondrosarcoma is the second most common primary malignant bone tumor. Because of their heterogeneity, with differences in invasive and metastatic behavior, it is important to identify biological markers that ...

    Authors: Dominik Malcherczyk, Thomas J. Heyse, Bilal F. El-Zayat, Vanessa Kunzke, Roland Moll, Susanne Fuchs-Winkelmann and Jürgen R. J. Paletta

    Citation: BMC Musculoskeletal Disorders 2018 19:9

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  15. Content type: Research article

    Greater age and body mass index are strong risk factors for osteoarthritis (OA). Older and overweight individuals may be more susceptible to OA because these factors alter tissue turnover in menisci, articular...

    Authors: Alina C. Stout, Mary F. Barbe, Charles B. Eaton, Mamta Amin, Fatimah Al-Eid, Lori Lyn Price, Bing Lu, Grace H. Lo, Ming Zhang, Jincheng Pang, Timothy E. McAlindon and Jeffrey B. Driban

    Citation: BMC Musculoskeletal Disorders 2018 19:1

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  16. Content type: Research article

    The objective of this study was to evaluate the extent of stromal cell-derived factor-1’s (SDF-1) involvement in the pathogenesis of idiopathic versus post-traumatic OA by comparing differences in synovial mem...

    Authors: Nathan P. Thomas, Wesley J. Wu, Braden C. Fleming, Fangyuan Wei, Qian Chen and Lei Wei

    Citation: BMC Musculoskeletal Disorders 2017 18:556

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  17. Content type: Research article

    Transplanting myogenic cells and scaffolds for tissue engineering in skeletal muscle have shown inconsistent results. One of the limiting factors is neovascularization at the recipient site. Low intensity shoc...

    Authors: Lise K. Hansen, Henrik D. Schrøder, Lars Lund, Karthikeyan Rajagopal, Vrisha Maduri and Jeeva Sellathurai

    Citation: BMC Musculoskeletal Disorders 2017 18:557

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  18. Content type: Research article

    Studies have investigated the correlation between tumor necrosis factor related apoptosis-inducing ligand (TRAIL) gene polymorphisms and the susceptibility and severity of intervertebral disc degeneration (IDD...

    Authors: Qi-ling Yuan, Liang Liu, Yong-song Cai and Yin-gang Zhang

    Citation: BMC Musculoskeletal Disorders 2017 18:555

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  19. Content type: Research article

    Some reports have shown that intermittent parathyroid hormone (PTH) (1–34) treatment for patients with delayed union or nonunion have led to successful healing. In this study, we investigated whether systemic ...

    Authors: Yohei Kumabe, Sang Yang Lee, Takahiro Waki, Takashi Iwakura, Shunsuke Takahara, Michio Arakura, Yu Kuroiwa, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda and Takahiro Niikura

    Citation: BMC Musculoskeletal Disorders 2017 18:545

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  20. Content type: Research article

    TNF-alpha is suggested to be involved in muscle damage and muscle inflammation (myositis). In order to evaluate whether TNF-alpha is involved in the myositis that occurs in response to muscle overuse, the aim ...

    Authors: Lina Renström, Per Stål, Yafeng Song and Sture Forsgren

    Citation: BMC Musculoskeletal Disorders 2017 18:498

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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