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Pathophysiology of musculoskeletal disorders

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

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  1. Previous research has described a neuroprotective effect of IGF-I, supporting neuronal survival, axon growth and proliferation of muscle cells. Therefore, the association between IGF-I concentration, muscle hi...

    Authors: Stefanie Jarmusch, Lisa Baber, Martin Bidlingmaier, Uta Ferrari, Fabian Hofmeister, Stefan Hintze, Stefan Mehaffey, Peter Meinke, Carl Neuerburg, Benedikt Schoser, Fabiana Tanganelli and Michael Drey

    Citation: BMC Musculoskeletal Disorders 2021 22:807

    Content type: Research article

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  2. Dysregulation of the OPG/RANK/RANKL signalling pathway is a key step in the occurrence of steroid-induced osteonecrosis of the femoral head (ONFH). This study aims to understand the degree of methylation of the O...

    Authors: Menghu Sun, Yuju Cao, Xiaolong Yang, Feimeng An, Huiqiang Wu and Jianzhong Wang

    Citation: BMC Musculoskeletal Disorders 2021 22:599

    Content type: Research article

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  3. Macrophages and inflammatory cytokines play important roles in bone fracture healing. However, the expression patterns of macrophages and inflammatory cytokines during fracture healing under the condition of p...

    Authors: Lin Chen, Shao Cheng, Kanghui Sun, Jing Wang, Xinhua Liu, Yongjian Zhao, Junjie Yang, Dongfeng Zhao, Chunchun Xue, Yuren Tao, Shitian Zhao, Hao Zhang, Sheng Lu, Qi Shi, Yongjun Wang and Bing Shu

    Citation: BMC Musculoskeletal Disorders 2021 22:494

    Content type: Research article

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  4. Osteomyelitis (OM) in the jaw is an inflammatory disease of osseous tissue that begins in the medullary space and progressively expands to the cortical portion of the bone, the Haversian system, the periosteum...

    Authors: Buyanbileg Sodnom-Ish, Mi Young Eo, Mi Hyun Seo, Jong Ho Lee and Soung Min Kim

    Citation: BMC Musculoskeletal Disorders 2021 22:469

    Content type: Research article

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  5. Damage to sensory input is an underlying pathology of chronic ankle instability (CAI). Therefore, it is necessary to evaluate the sensory function of patients with CAI. The present study quantitatively evaluat...

    Authors: Ran Zhang, Xi Zhang, Yaping Chen and Weiqun Song

    Citation: BMC Musculoskeletal Disorders 2021 22:453

    Content type: Research article

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  6. Schnitzler’s syndrome (SchS) is a rare autoinflammatory syndrome with diagnostic challenge and be characterized by chronic urticaria, a monoclonal gammopath, periodic fever and bone pain. In addition to the mo...

    Authors: Yuya Fujita, Tomoyuki Asano, Akira Sakai, Natsumi Norikawa, Toshiyuki Yamamoto, Haruki Matsumoto, Shuzo Sato, Jumpei Temmoku, Makiko Yashiro-Furuya, Naoki Matsuoka, Hiroshi Watanabe and Kiyoshi Migita

    Citation: BMC Musculoskeletal Disorders 2021 22:257

    Content type: Case report

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  7. Hyaluronic acid (HA) is the major extracellular matrix glycosaminoglycan with a reduced synovial fluid (SF) concentration in arthropathies. Cell-derived extracellular vesicles (EV) have also been proposed to c...

    Authors: Anne-Mari Mustonen, Janne Capra, Kirsi Rilla, Petri Lehenkari, Sanna Oikari, Tommi Kääriäinen, Antti Joukainen, Heikki Kröger, Tommi Paakkonen, Johanna Matilainen and Petteri Nieminen

    Citation: BMC Musculoskeletal Disorders 2021 22:247

    Content type: Research article

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  8. Mechanical overload applied on the articular cartilage may play an important role in the pathogenesis of osteoarthritis. However, the mechanism of chondrocyte mechanotransduction is not fully understood. The p...

    Authors: Yuki Takeda, Yasuo Niki, Yusuke Fukuhara, Yoshitsugu Fukuda, Kazuhiko Udagawa, Masayuki Shimoda, Toshiyuki Kikuchi, Shu Kobayashi, Kengo Harato, Takeshi Miyamoto, Morio Matsumoto and Masaya Nakamura

    Citation: BMC Musculoskeletal Disorders 2021 22:238

    Content type: Research article

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  9. In osteoarthritis (OA), cartilage matrix is lost gradually despite enhanced matrix synthesis by chondrocytes. This paradox may be explained, at least partly, by reduced chondrocyte anabolism in degenerated are...

    Authors: Nobuho Tanaka, Hirotaka Tsuno, Satoru Ohashi, Mitsuyasu Iwasawa, Hiroshi Furukawa, Tomohiro Kato and Naoshi Fukui

    Citation: BMC Musculoskeletal Disorders 2021 22:231

    Content type: Research article

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  10. The nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome signaling pathway is a highlighted topic in the field of inflammation. However, there is little resear...

    Authors: Mengying Jia, Yaoguang Lv, Yingjie Xu and Zhongcheng Gong

    Citation: BMC Musculoskeletal Disorders 2021 22:229

    Content type: Research article

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  11. In this study, we investigated whether substance P (SP) or calcitonin gene-related peptide (CGRP) expression is associated with tendon degeneration in patients with lateral epicondylitis.

    Authors: Soo-Hong Han, Hyung Kyung Kim, Yoon Jang, Hyeon Hae Lee, Jeongbae Rhie, Donghun Han, Jongbeom Oh and Soonchul Lee

    Citation: BMC Musculoskeletal Disorders 2021 22:210

    Content type: Research article

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  12. Fibromyalgia (FM) patients are likely to differ from healthy controls in muscle activity and in reactivity to experimental stress.

    Authors: Teemu Zetterman, Ritva Markkula, Juhani V. Partanen, Teemu Miettinen, Ann-Mari Estlander and Eija Kalso

    Citation: BMC Musculoskeletal Disorders 2021 22:183

    Content type: Research article

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  13. This study aimed to investigate the effect of abnormal Core binding factor-β expression on proliferation, differentiation and apoptosis of chondrocytes, and elucidate the relationship between Core binding fact...

    Authors: Guangdi Li, Mi Zhang, Yuan Huang, Jiafei Yang, Lianghong Dong, Hao Shi, Long Li, Riguang Liu and Jiangwei Li

    Citation: BMC Musculoskeletal Disorders 2021 22:174

    Content type: Research article

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  14. Altered knee muscle activity in children with asymptomatic Generalized Joint Hypermobility (GJH) is reported during isometric contraction, static and dynamic balance tasks and jumping, but has not been studied...

    Authors: Helene Nikolajsen, Birgit Juul-Kristensen, Peter Fjeldstad Hendriksen and Bente Rona Jensen

    Citation: BMC Musculoskeletal Disorders 2021 22:170

    Content type: Research article

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  15. Acromioclavicular joint (ACJ) dislocation is a relatively common shoulder injury. For the treatment of cases of severe ACJ dislocation (Rockwood type III–V), hook plate fixation is an easy-to-master and minima...

    Authors: Yu-Ta Chen, Kuan-Ting Wu, Shun-Wun Jhan, Shan-Ling Hsu, Hao-Chen Liu, Ching-Jen Wang, Jih-Yang Ko and Wen-Yi Chou

    Citation: BMC Musculoskeletal Disorders 2021 22:127

    Content type: Research article

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  16. Joint Hypermobility Syndrome (JHS) is a Heritable Disorder of Connective tissue characterised by joint laxity and chronic widespread arthralgia. People with JHS exhibit a range of other symptoms including bala...

    Authors: Alexander Vernon Bates, Alison McGregor and Caroline M. Alexander

    Citation: BMC Musculoskeletal Disorders 2021 22:123

    Content type: Research article

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  17. In a prior randomized trial, we demonstrated that participants receiving spinal manipulative therapy at a pain-sensitive segment instead of a stiff segment experienced increased mechanical pressure pain thresh...

    Authors: Casper Glissmann Nim, Gregory Neil Kawchuk, Berit Schiøttz-Christensen and Søren O’Neill

    Citation: BMC Musculoskeletal Disorders 2021 22:23

    Content type: Research article

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  18. An important complication of pyogenic spondylitis is aneurysms in the adjacent arteries. There are reports of abdominal aortic or iliac aneurysms, but there are few reports describing infected aneurysms of the...

    Authors: Takahiro Furukawa, Keisuke Masuda, Hideki Shigematsu, Masato Tanaka, Akinori Okuda, Sachiko Kawasaki, Yuma Suga, Yusuke Yamamoto and Yasuhito Tanaka

    Citation: BMC Musculoskeletal Disorders 2021 22:22

    Content type: Case report

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  19. Epidural fibrosis is one of the aetiologies of pain following a spinal revision surgery. It is reported that the specific members of the mitogen – activated protein kinases (MAPK) family might mediate neuropat...

    Authors: Meiling Quan, Won-Ha Hwang, Jae-Hoon Kim and Young-Yul Kim

    Citation: BMC Musculoskeletal Disorders 2021 22:16

    Content type: Research article

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  20. Guillain-Barré syndrome (GBS) is the most common and serious acute paralytic neuropathy and is usually caused by infection. It is thought to be the result of an aberrant response of the immune system. To our k...

    Authors: Jian Chen, Jian-xiong Ma, Cai-hong Zuo, Qing Zhang, Heng-ting Chen and Xin-long Ma

    Citation: BMC Musculoskeletal Disorders 2021 22:8

    Content type: Case report

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  21. Although morphological improvement of femoral trochlea has been investigated in children with patellar dislocation after surgery, whether the patellar shape changed under the same condition is still unknown. T...

    Authors: Jinghui Niu, Qi Qi, Kuo Hao, Wei Lin, Kang Piao and Fei Wang

    Citation: BMC Musculoskeletal Disorders 2020 21:833

    Content type: Research article

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  22. Open and closed fractures can be associated with posttraumatic or postoperative soft tissue defects caused by initial trauma, operative procedures, or infections. This study evaluated the postoperative outcome...

    Authors: Emrah Aydogan, Stefan Langer, Christoph Josten, Johannes Karl Maria Fakler and Ralf Henkelmann

    Citation: BMC Musculoskeletal Disorders 2020 21:799

    Content type: Research article

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  23. To investigate if cartilage related biomarkers in synovial fluid are associated with knee cartilage status 20 years after an anterior cruciate ligament (ACL) injury.

    Authors: Paul Neuman, Staffan Larsson, L. Stefan Lohmander and André Struglics

    Citation: BMC Musculoskeletal Disorders 2020 21:798

    Content type: Research article

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  24. Osteoarthritis, rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, all have one clear common denominator; an altered turnover of bone. However, this may be more complex than a simple change...

    Authors: Christian S. Thudium, Signe Holm Nielsen, Samra Sardar, Ali Mobasheri, Willem Evert van Spil, Rik Lories, Kim Henriksen, Anne-Christine Bay-Jensen and Morten A. Karsdal

    Citation: BMC Musculoskeletal Disorders 2020 21:789

    Content type: Review

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  25. Dysferlinopathies are a group of muscle disorders causing muscle weakness and absence or low levels of dysferlin, a type-II transmembrane protein and the causative gene of these dystrophies. Dysferlin is impli...

    Authors: Esther Fernández-Simón, Cinta Lleixà, Xavier Suarez-Calvet, Jordi Diaz-Manera, Isabel Illa, Eduard Gallardo and Noemí de Luna

    Citation: BMC Musculoskeletal Disorders 2020 21:784

    Content type: Research article

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  26. Septic arthritis of digits needs urgent treatment. When treatments delayed or insufficient, patients may be referred to the upper-level hospital due to uncontrolled infection. We reviewed the treatment history...

    Authors: Sang Ho Kwak, Jung Yun Bae, Youngkwang Oh, Hyo Seok Jang, Tae Young Ahn and Sang Hyun Lee

    Citation: BMC Musculoskeletal Disorders 2020 21:780

    Content type: Research article

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  27. The hip abductors are crucial in maintaining pelvic stability. Tears in these tendons are common and often debilitating. There is uncertainty regarding both the histological and macroscopic features of hip abd...

    Authors: Mark F. Zhu, Brittany Smith, Sanjeev Krishna, David S. Musson, Peter R. Riordan, Sue R. McGlashan, Jillian Cornish and Jacob T. Munro

    Citation: BMC Musculoskeletal Disorders 2020 21:778

    Content type: Research article

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  28. Due to its unique arrangement, the deep and superficial fibers of the multifidus may have differential roles for maintaining spine stabilization and lumbar posture; the superficial multifidus is responsible fo...

    Authors: Jennifer Padwal, David B. Berry, James C. Hubbard, Vinko Zlomislic, R. Todd Allen, Steven R. Garfin, Samuel R. Ward and Bahar Shahidi

    Citation: BMC Musculoskeletal Disorders 2020 21:764

    Content type: Research article

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  29. Percutaneous endoscopic decompression (PED) is considered a minimally invasive and safe procedure in lumbar degenerative disease. Few authors report the success of PED for thoracic spinal stenosis (TSS) with t...

    Authors: Xiao-Kang Cheng, Fu-Cheng Bian, Zhao-Yu Liu, Feng-Kai Yang and Bin Chen

    Citation: BMC Musculoskeletal Disorders 2020 21:717

    Content type: Research article

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  30. Vascular injury is a very rare complication following arthroscopic knee surgery. This is the first report of pseudoaneurysm at the saphenous branch of the descending genicular artery complicating semitendinosu...

    Authors: Chung-Wei Ho, Shih-Han Lee, Shen-Han Wu, Chun-Yu Lin, Chian-Her Lee and Jia-Lin Wu

    Citation: BMC Musculoskeletal Disorders 2020 21:697

    Content type: Case report

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  31. Subcutaneous adipose tissue represents an abundant source of multipotent adult stem cells named as Adipose-derived stem cells (ADSCs). With a cell sheet approach, ADSCs survive longer, and can be delivered in ...

    Authors: Tomoharu Takagi, Tamon Kabata, Katsuhiro Hayashi, Xiang Fang, Yoshitomo Kajino, Daisuke Inoue, Takaaki Ohmori, Takuro Ueno, Junya Yoshitani, Ken Ueoka, Yuki Yamamuro and Hiroyuki Tsuchiya

    Citation: BMC Musculoskeletal Disorders 2020 21:691

    Content type: Research article

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  32. The objective of this cross-sectional case-control study was to determine the prevalence and size of marginal and subarticular osteophytes in patients with osteoarthritis (OA), and to compare these to that of ...

    Authors: Rasmus Klose-Jensen, Andreas Wiggers Nielsen, Louise Brøndt Hartlev, Jesper Skovhus Thomsen, Lene Warner Thorup Boel, Mogens Laursen, Kresten Krarup Keller and Ellen-Margrethe Hauge

    Citation: BMC Musculoskeletal Disorders 2020 21:653

    Content type: Research article

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  33. Modic changes (MC) in the lumbar spine are considered one potential etiological factor behind low back pain (LBP). Multiple risk factors for MC have been suggested, including male gender, smoking and factors a...

    Authors: Marella Modarress Julin, Jesperi Saukkonen, Petteri Oura, Maisa Niemelä, Juho-Antti Junno, Juhani Määttä, Jaakko Niinimäki, Timo Jämsä, Raija Korpelainen and Jaro Karppinen

    Citation: BMC Musculoskeletal Disorders 2020 21:630

    Content type: Research article

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  34. Among common findings in osteoporotic vertebral compression fractures (OVCFs), the intravertebral cleft (IVC) is usually considered a benign lesion. The current study was aimed to present a rare case of verteb...

    Authors: Liang Dong, Chunke Dong, Yuting Zhu and Hongyu Wei

    Citation: BMC Musculoskeletal Disorders 2020 21:619

    Content type: Case report

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  35. Tendon adhesion is one of the most common clinical problems, which poses a considerable challenge to orthopedics doctors. Quercetin (QUE) as a popular drug at present, it has various biological functions, incl...

    Authors: Yuan Liang, Keteng Xu, Pei Zhang, Jiale Zhang, Pengtao Chen, Jinshan He, Yongchao Fang, Yuelai Zhou, Jingcheng Wang and Jianzhong Bai

    Citation: BMC Musculoskeletal Disorders 2020 21:608

    Content type: Research article

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  36. Limb girdle muscular dystrophy type 2Y (LGMD2Y) is a rare subgroup of limb girdle muscular dystrophy featuring limb-girdle weakness, tendon contracture and cardiac involvement. It is caused by the mutation of ...

    Authors: Xuelin Feng, Jinlang Wu, Wenbiao Xian, Bing Liao, Songjie Liao, Xiaoli Yao and Weixi Zhang

    Citation: BMC Musculoskeletal Disorders 2020 21:588

    Content type: Case report

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  37. Gorham-Stout disease (GSD) is a rare disease characterized by bone lesions and osteolysis. Therapy usually involves surgical resection. Sirolimus (Rapamycin) is used in some patients with GSD but the efficacy ...

    Authors: Yu Liang, Ruicheng Tian, Jing Wang, Yuhua Shan, Hongxiang Gao, Chenjie Xie, Jingjing Li, Min Xu and Song Gu

    Citation: BMC Musculoskeletal Disorders 2020 21:577

    Content type: Case report

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  38. The prognostic value of Neutrophil-to-Lymphocyte Ratio (NLR) for the outcome of acute cervical traumatic spinal cord injury (tSCI) patients has rarely been studied by now throughout the world.

    Authors: Jian-Lan Zhao, Song-Tao Lai, Zhuo-Ying Du, Jian Xu, Yi-Rui Sun, Qiang Yuan, Xing Wu, Zhi-Qi Li, Jin Hu and Rong Xie

    Citation: BMC Musculoskeletal Disorders 2020 21:548

    Content type: Research article

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  39. Transient osteoporosis of the hip (TOH) is a rare and temporary clinical condition characterised by bone marrow edema (BME), severe pain, and functional limitation. It commonly occurs in middle-aged men or in ...

    Authors: Marco Paoletta, Antimo Moretti, Sara Liguori, Matteo Bertone, Giuseppe Toro and Giovanni Iolascon

    Citation: BMC Musculoskeletal Disorders 2020 21:543

    Content type: Case report

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  40. The differentiation of human stromal (mesenchymal) stem cells (hMSCs) is a critical procedure for the development of osteoblast. SNHG14 is a newly discovered lncRNA that has been barely studied. Our preliminar...

    Authors: Mingchang Du, Bo Wu, Shiwen Fan, Ye Liu, Xu Ma and Xun Fu

    Citation: BMC Musculoskeletal Disorders 2020 21:525

    Content type: Research article

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  41. Elderly patients with hip fractures often have multiple medical comorbidities, and vitamin D deficiency is common in this population. Accumulating evidence links low vitamin D levels to various comorbidities. ...

    Authors: Ing How Moo, Carmen Jia Wen Kam, Eric Wei Liang Cher, Bryan Ce Jie Peh, Chung Ean Lo, David Thai Chong Chua, Ngai Nung Lo, Tet Sen Howe and Joyce Suang Bee Koh

    Citation: BMC Musculoskeletal Disorders 2020 21:524

    Content type: Research article

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  42. Bone tumors are often treated with intralesional curettage. High-speed burring, an adjuvant therapy, was performed to maximize the tumor cell killing; however, tumor recurrence might still occur, which may be ...

    Authors: Pai-Han Wang, Chia-Lun Wu, Chao-Ming Chen, Jir-You Wang, Po-Kuei Wu and Wei-Ming Chen

    Citation: BMC Musculoskeletal Disorders 2020 21:507

    Content type: Research article

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  43. Previous research indicated that nitric oxide synthase (NOS) is the key molecule for S-nitrosylation of ryanodine receptor 1 (RyR1) in DMD model mice (mdx mice) and that both neuronal NOS (nNOS) and inducible NOS...

    Authors: Ken’ichiro Nogami, Yusuke Maruyama, Ahmed Elhussieny, Fusako Sakai-Takemura, Jun Tanihata, Jun-ichi Kira, Yuko Miyagoe-Suzuki and Shin’ichi Takeda

    Citation: BMC Musculoskeletal Disorders 2020 21:479

    Content type: Research article

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  44. Adolescent idiopathic scoliosis (AIS) has been associated with diminished postural stability and a greater prevalence of back pain. Currently, the literature is lacking information on the effect of spinal fusi...

    Authors: Maxime St-Georges, Alisson R. Teles, Oded Rabau, Neil Saran, Jean A. Ouellet and Catherine E. Ferland

    Citation: BMC Musculoskeletal Disorders 2020 21:466

    Content type: Research article

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  45. Pelvic obliquity (PO) is common in individuals with cerebral palsy (CP). The prevalence of PO in a population of children with CP and its associations with scoliosis, hip displacement and asymmetric range of h...

    Authors: Gunnar Hägglund

    Citation: BMC Musculoskeletal Disorders 2020 21:464

    Content type: Research article

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