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Pathophysiology of musculoskeletal disorders

Section edited by Ali Mobasheri

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

Page 1 of 7

  1. Content type: Research article

    One of the characteristics of lumbar spinal stenosis (LSS) is elastin degradation and fibrosis in the ligamentum flavum (LF). However, the biochemical factors that cause these histologic changes is unclear. P1...

    Authors: Wei Hu, Shunli Kan, Guang Liu, Zegang Cao and Rusen Zhu

    Citation: BMC Musculoskeletal Disorders 2019 20:458

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  2. Content type: Case report

    Mesenchymal chondrosarcoma (MCS) is a rare malignant variant of chondrosarcoma with a high tendency of recurrence and metastasis. Intradural extramedullary spinal MCS is exceedingly rare and usually found in p...

    Authors: Chih-Wei Chen, I-Hsin Chen, Ming-Hsiao Hu, Jen-Chieh Lee, Hsuan-Ying Huang, Ruey-Long Hong and Shu-Hua Yang

    Citation: BMC Musculoskeletal Disorders 2019 20:408

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  3. Content type: Research article

    Using mass spectrometry, we evaluated the metabolic profiles of patients who had rotator cuff tears with shoulder stiffness, or shoulder stiffness only, and compared these with samples from a control group.

    Authors: Hyo-Jin Lee, Oak-Kee Hong, Dong-Ho Kwak and Yang-Soo Kim

    Citation: BMC Musculoskeletal Disorders 2019 20:364

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  4. Content type: Case report

    There are only a few published case reports of irreducible Galeazzi fracture-dislocation, and patients in these studies had undergone reduction by open surgical methods. Arthroscopy for the distal radioulnar j...

    Authors: Masayoshi Iwamae, Koichi Yano, Yasunori Kaneshiro and Hideki Sakanaka

    Citation: BMC Musculoskeletal Disorders 2019 20:354

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  5. Content type: Research article

    The relationship between spinal alignment and skeletal muscle mass (SMM) has attracted attention in recent years. Sagittal alignment is known to deteriorate with age, but it is not known whether this is relate...

    Authors: Akihiko Hiyama, Hiroyuki Katoh, Daisuke Sakai, Masahiro Tanaka, Masato Sato and Masahiko Watanabe

    Citation: BMC Musculoskeletal Disorders 2019 20:352

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  6. Content type: Research article

    Female patients are more likely to have tendon injuries than males, especially those who has a higher concentration of relaxin. Previous studies have demonstrated that relaxin attenuates extracellular matrix (...

    Authors: Tianpeng Xu, Jiaxiang Bai, Menglei Xu, Binqing Yu, Jiayi Lin, Xiaobin Guo, Yu Liu, Di Zhang, Kai Yan, Dan Hu, Yuefeng Hao and Dechun Geng

    Citation: BMC Musculoskeletal Disorders 2019 20:349

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  7. Content type: Research article

    Impaired lumbar artery flow has been reported in clinical and epidemiological studies to be associated with low back pain and lumbar disc degeneration. However, it has not been experimentally demonstrated that...

    Authors: Takao Imanishi, Koji Akeda, Koichiro Murata and Akihiro Sudo

    Citation: BMC Musculoskeletal Disorders 2019 20:347

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  8. Content type: Research article

    Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, w...

    Authors: Katherine A. Staines, Ekele Ikpegbu, Anna E. Törnqvist, Scott Dillon, Behzad Javaheri, Anish K. Amin, Dylan N. Clements, David J. Buttle, Andrew A. Pitsillides and Colin Farquharson

    Citation: BMC Musculoskeletal Disorders 2019 20:344

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  9. Content type: Research article

    Previous basic research and clinical studies examined the effects of mesenchymal stem cells (MSCs) on regeneration and maintenance of articular cartilage. However, our pilot study suggested that MSCs are more ...

    Authors: Takumi Sakamoto, Tsuyoshi Miyazaki, Shuji Watanabe, Ai Takahashi, Kazuya Honjoh, Hideaki Nakajima, Hisashi Oki, Yasuo Kokubo and Akihiko Matsumine

    Citation: BMC Musculoskeletal Disorders 2019 20:335

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  10. Content type: Research article

    The aetiology of bone marrow oedema-like abnormalities (BMOA) seen on magnetic resonance imaging (MRI) is as yet not fully understood. The current study aimed to investigate the potential of projection radiogr...

    Authors: Christine J. Heales, Ian R. Summers, Jonathan Fulford, Karen M. Knapp and C. Peter Winlove

    Citation: BMC Musculoskeletal Disorders 2019 20:330

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  11. Content type: Research article

    Oestrogen-deficiency induced by menopause is associated with reduced bone density and primary osteoporosis, resulting in an increased risk of fracture. While the exact etiology of menopause-induced primary ost...

    Authors: Fraser L. Collins, Michael D. Stone, Jane Turton, Laura R. McCabe, Eddie C. Y. Wang and Anwen S. Williams

    Citation: BMC Musculoskeletal Disorders 2019 20:326

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  12. Content type: Research article

    Synovial mesenchymal stem cells (MSCs) are an attractive cell source for cartilage and meniscus regeneration. The optimum cryopreservation medium has not been determined, but dimethylsulfoxide (DMSO) should be...

    Authors: Ryota Fujisawa, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga and Ichiro Sekiya

    Citation: BMC Musculoskeletal Disorders 2019 20:316

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  13. Content type: Research article

    The incidence of proximal humeral fractures (PHF) increased by more than 30% over the last decade, which is accompanied by an increased number of operations. However, the evidence on operative vs. non-operativ...

    Authors: Corinna Nerz, Lars Schwickert, Sabine Schölch, Katharina Gordt, Philip-Christian Nolte, Inga Kröger, Peter Augat and Clemens Becker

    Citation: BMC Musculoskeletal Disorders 2019 20:315

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  14. Content type: Research article

    People who have had anterior cruciate ligament reconstruction (ACLR) are at a high risk of developing tibiofemoral joint (TFJ) osteoarthritis (OA), with concomitant meniscal injury elevating this risk. This st...

    Authors: Xinyang Wang, Kim L. Bennell, Yuanyuan Wang, Tim V. Wrigley, Ans Van Ginckel, Karine Fortin, David J. Saxby, Flavia M. Cicuttini, David G. Lloyd, Christopher J. Vertullo, Julian A. Feller, Tim Whitehead, Price Gallie and Adam L. Bryant

    Citation: BMC Musculoskeletal Disorders 2019 20:312

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  15. Content type: Case report

    A vitamin A derivative, 13-cis-retinoic acid (isotretinoin), has been administered to treat several types of pediatric cancer and has improved survival rates in patients despite being known to induce premature...

    Authors: Masatake Matsuoka, Tomohiro Onodera, Tokifumi Majima, Koji Iwasaki, Daisuke Takahashi, Eiji Kondo and Norimasa Iwasaki

    Citation: BMC Musculoskeletal Disorders 2019 20:287

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  16. Content type: Research article

    McH-lpr/lpr-RA1 mice are a new strain of mice which spontaneously develop destructive arthritis and enthesitis in the ankle. There is no published data that drug treatment has been trialed on these mice. This ...

    Authors: Takuya Izumiyama, Yu Mori, Shiro Mori, Naoko Mori, Tetsuya Kodama and Eiji Itoi

    Citation: BMC Musculoskeletal Disorders 2019 20:286

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  17. Content type: Study protocol

    Musculoskeletal injuries (MSKIs) are common in military trainees and present a considerable threat to occupational fitness, deployability, and overall military readiness. Despite the negative effects of MSKIs ...

    Authors: Julie M. Hughes, Stephen A. Foulis, Kathryn M. Taylor, Katelyn I. Guerriere, Leila A. Walker, Amy F. Hand, Kristin L. Popp, Erin Gaffney-Stomberg, Kristin J. Heaton, Marilyn A. Sharp, Tyson L. Grier, Keith G. Hauret, Bruce H. Jones, Mary L. Bouxsein, James P. McClung, Ronald W. Matheny Jr…

    Citation: BMC Musculoskeletal Disorders 2019 20:282

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  18. Content type: Research article

    Understanding interactions between bone and muscle based on endocrine factors may help elucidate the relationship between osteoporosis and sarcopenia. However, whether the abundance or activity of these endocr...

    Authors: Kenta Moriwaki, Hiromi Matsumoto, Shinji Tanishima, Chika Tanimura, Mari Osaki, Hideki Nagashima and Hiroshi Hagino

    Citation: BMC Musculoskeletal Disorders 2019 20:276

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  19. Content type: Research article

    A considerable number of patients with whiplash-associated disorders (WAD) report variable and indefinite symptoms involving the whole body, despite there being no evidence of direct injuries to organs other t...

    Authors: Takayoshi Matsui, Makoto Iwata, Yuzo Endo, Nobuyuki Shitara, Shuntaro Hojo, Hideoki Fukuoka, Kazuhiro Hara and Hiroshi Kawaguchi

    Citation: BMC Musculoskeletal Disorders 2019 20:251

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  20. Content type: Research article

    Musculoskeletal (MSK) pain represents a considerable worldwide healthcare burden. This study aimed to gain consensus from practitioners who work with MSK pain patients, on the most appropriate primary care tre...

    Authors: Joanne Protheroe, Benjamin Saunders, Bernadette Bartlam, Kate M. Dunn, Vince Cooper, Paul Campbell, Jonathan C. Hill, Stephanie Tooth, Christian D. Mallen, Elaine M. Hay and Nadine E. Foster

    Citation: BMC Musculoskeletal Disorders 2019 20:271

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  21. Content type: Study protocol

    Low back pain (LBP) is a ubiquitous, heterogeneous disorder that affects most people at some point in their lives. The efficient management of LBP remains elusive, with direct and indirect costs attributed to ...

    Authors: Mehul J. Desai, Holly Jonely, Meagan Blackburn, Sangeeth Wanasinghage, Sidrah Sheikh and Rod S. Taylor

    Citation: BMC Musculoskeletal Disorders 2019 20:249

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  22. Content type: Research article

    Although the pathogenesis of adolescent idiopathic scoliosis (AIS) remains unclear, there are little evidences of the pathogenesis in patients with thoracolumbar/lumbar AIS. The purpose of this study was to id...

    Authors: Hiroto Makino, Shoji Seki, Isao Kitajima, Hiraku Motomura, Makiko Nogami, Yasuhito Yahara, Naoko Ejiri and Tomoatsu Kimura

    Citation: BMC Musculoskeletal Disorders 2019 20:247

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  23. Content type: Research article

    Accelerated knee osteoarthritis (AKOA) is characterized by more pain, impaired physical function, and greater likelihood to receive a joint replacement compared to individuals who develop the typical gradual o...

    Authors: Matthew S. Harkey, Julie E. Davis, Bing Lu, Lori Lyn Price, Robert J. Ward, James W. MacKay, Charles B. Eaton, Grace H. Lo, Mary F. Barbe, Ming Zhang, Jincheng Pang, Alina C. Stout, Timothy E. McAlindon and Jeffrey B. Driban

    Citation: BMC Musculoskeletal Disorders 2019 20:241

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  24. Content type: Research article

    A detailed evaluation focusing on the fibrocartilage layers in the anterior cruciate ligament (ACL) insertion is necessary to consider regeneration of the insertion. This study examined the development of the ...

    Authors: Hirotaka Mutsuzaki, Hiromi Nakajima, Maika Someji and Masataka Sakane

    Citation: BMC Musculoskeletal Disorders 2019 20:233

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  25. Content type: Research article

    In osteoarthritis (OA), cartilage matrix is lost despite vigorous chondrocyte anabolism. In this study, we attempted to determine whether altered matrix synthesis is involved in this paradox in disease progres...

    Authors: Nobuho Tanaka, Toshiyuki Tashiro, Yozo Katsuragawa, Motoji Sawabe, Hiroshi Furukawa and Naoshi Fukui

    Citation: BMC Musculoskeletal Disorders 2019 20:232

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  26. Content type: Research article

    The expression of the receptor activator of nuclear factor kappa B (RANK) /RANK ligand (RANKL) /osteoprotegerin (OPG) system and its association with the progression of intervertebral disc (IVD) degeneration h...

    Authors: Tomohiko Sano, Koji Akeda, Junichi Yamada, Norihiko Takegami, Takao Sudo and Akihiro Sudo

    Citation: BMC Musculoskeletal Disorders 2019 20:225

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  27. Content type: Research article

    Low back pain (LBP) is a common complaint in the elderly Japanese population. Although previous studies showed that height loss was associated with LBP, it remains unclear whether LBP is associated with body c...

    Authors: Takeshi Endo, Takafumi Abe, Kenju Akai, Tsunetaka Kijima, Miwako Takeda, Masayuki Yamasaki, Minoru Isomura, Toru Nabika and Shozo Yano

    Citation: BMC Musculoskeletal Disorders 2019 20:207

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  28. Content type: Research article

    Nerve growth factor (NGF) contributes to pain in knee osteoarthritis (KOA) patients. Transforming growth factor-beta (TGF-β) stimulates NGF expression in chondrocytes from KOA patients. However, the correlatio...

    Authors: Shotaro Takano, Kentaro Uchida, Makoto Itakura, Dai Iwase, Jun Aikawa, Gen Inoue, Manabu Mukai, Masayuki Miyagi, Kosuke Murata, Hiroyuki Sekiguchi and Masashi Takaso

    Citation: BMC Musculoskeletal Disorders 2019 20:204

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  29. Content type: Research article

    There is increasing interest in the role of pro-inflammatory cytokines in the pathogenesis of sciatica and whether these could be potential targets for treatment. We sought to investigate serum biomarker level...

    Authors: Samantha L. Hider, Kika Konstantinou, Elaine M. Hay, John Glossop and Derek L. Mattey

    Citation: BMC Musculoskeletal Disorders 2019 20:202

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  30. Content type: Research article

    We have reported that a single intra-articular injection of diclofenac etalhyaluronate (SI-613) exerted a potent and long-lasting analgesic effect in experimental arthritis models. In the present study, we inv...

    Authors: Tomochika Kisukeda, Junichi Onaya and Keiji Yoshioka

    Citation: BMC Musculoskeletal Disorders 2019 20:201

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  31. Content type: Research article

    Chronic inflammation with aging contributes to sarcopenia. Previous studies have suggested that the accumulation of adipose tissue in skeletal muscle, referred to as intermuscular adipose tissue (IMAT), increa...

    Authors: Ryo Tazawa, Kentaro Uchida, Hisako Fujimaki, Masayuki Miyagi, Gen Inoue, Hiroyuki Sekiguchi, Kosuke Murata, Ken Takata, Ayumu Kawakubo and Masashi Takaso

    Citation: BMC Musculoskeletal Disorders 2019 20:199

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  32. Content type: Review

    We live in a world with an ever-increasing ageing population. Studying healthy ageing and reducing the socioeconomic impact of age-related diseases is a key research priority for the industrialised and develop...

    Authors: Rebecca Lewis, Constanza B. Gómez Álvarez, Margaret Rayman, Susan Lanham-New, Anthony Woolf and Ali Mobasheri

    Citation: BMC Musculoskeletal Disorders 2019 20:164

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  33. Content type: Research article

    This systematic review focusses on inflammation as an underlying pathogenic mechanism in sciatica. We addressed two questions in particular: (1) what inflammatory biomarkers have been identified in patients wi...

    Authors: Maarten J. Jungen, Bastiaan C. ter Meulen, Tim van Osch, Henry C. Weinstein and Raymond W. J. G. Ostelo

    Citation: BMC Musculoskeletal Disorders 2019 20:156

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  34. Content type: Research article

    Surgical treatment is mainly used for atlantoaxial tuberculosis with neurological damage. However, the anatomic structure around the atlantoaxial joint is complex, and the position of vertebral body is deep, w...

    Authors: Biao Wang, Rongan Shang, Tong Yang, Haiping Zhang, Huimin Hu, Wei Hu and Dingjun Hao

    Citation: BMC Musculoskeletal Disorders 2019 20:148

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  35. Content type: Study protocol

    Adhesive capsulitis (AC) is a disabling and poorly understood pathological condition of the shoulder joint. The current study aims to increase our understanding of the pathogenesis, diagnosis and clinical outc...

    Authors: Richard S. Page, Sean L. McGee, Kevin Eng, Graeme Brown, Sally Beattie, Fiona Collier and Stephen D. Gill

    Citation: BMC Musculoskeletal Disorders 2019 20:145

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  36. Content type: Research article

    Dupuytren’s disease (DD) is a progressive, debilitating condition of the hand that can eventually cause contractures of the affected fingers. Transforming growth factor- β1 (TGF-β1) has been reported to play a...

    Authors: Chaoming Zhou, Yael Zeldin, Mark E. Baratz, Sandeep Kathju and Latha Satish

    Citation: BMC Musculoskeletal Disorders 2019 20:135

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  37. Content type: Research article

    The synovial membrane adjacent to the articular cartilage is home to synovial mesenchymal progenitor cell (sMPC) populations that have the ability to undergo chondrogenesis. While it has been hypothesized that...

    Authors: Asmaa Affan, Nedaa Al-Jezani, Pamela Railton, James N. Powell and Roman J. Krawetz

    Citation: BMC Musculoskeletal Disorders 2019 20:125

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  38. Content type: Research article

    Aging impairs tendon healing and is a potential risk factor for chronic tendinitis. During normal aging, tendons undergo structural and biomechanical degenerative changes, accompanied by a reduction in the num...

    Authors: Yasuhiro Ueda, Atsuyuki Inui, Yutaka Mifune, Fumiaki Takase, Takeshi Kataoka, Takashi Kurosawa, Kohei Yamaura, Takeshi Kokubu and Ryosuke Kuroda

    Citation: BMC Musculoskeletal Disorders 2019 20:120

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  39. Content type: Research article

    Locomotive syndrome (LS) is associated with weakness and loss of function in the musculoskeletal organs. We aimed to determine the association between LS components and blood parameters in middle-aged and elde...

    Authors: Toshinori Yoshihara, Hayao Ozaki, Takashi Nakagata, Toshiharu Natsume, Tomoharu Kitada, Yoshihiko Ishihara, Shuji Sawada, Masayoshi Ishibashi, Hiroyuki Kobayashi, Shuichi Machida and Hisashi Naito

    Citation: BMC Musculoskeletal Disorders 2019 20:104

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  40. Content type: Research article

    Myotonic dystrophy type 1 (DM1) is a neuromuscular disease characterized by multisystemic involvements including a progressive loss of maximal muscle strength and muscle wasting. Poor lower-limb strength is an...

    Authors: Marie-Pier Roussel, Marika Morin, Cynthia Gagnon and Elise Duchesne

    Citation: BMC Musculoskeletal Disorders 2019 20:101

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    The Correction to this article has been published in BMC Musculoskeletal Disorders 2019 20:244

  41. Content type: Research article

    The objective of this study was to use confocal fluorescence recovery after photobleaching (FRAP) to examine the specific and dose-dependent effect of proteoglycan 4 (PRG4) on hyaluronan (HA) solutions of diff...

    Authors: Adam K. Bloom, Michael L. Samsom, Suresh C. Regmi, Bridgett L. Steele and Tannin A. Schmidt

    Citation: BMC Musculoskeletal Disorders 2019 20:93

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  42. Content type: Case report

    The incidence of bilateral corticosteroid-induced osteonecrosis of the femoral head (ONFH) is high. Although the precise mechanism of corticosteroid-induced ONFH development is unclear, hepatic enzyme abnormal...

    Authors: Hirokazu Shimizu, Tomohiro Shimizu, Daisuke Takahashi, Tsuyoshi Asano, Ryuta Arai, Yasunari Takakuwa and Norimasa Iwasaki

    Citation: BMC Musculoskeletal Disorders 2019 20:88

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  43. Content type: Case report

    Gorham’s disease (GSD) is a rare osteolytic disease with unclear etiology, and no known prevention or effective treatment. Here we report a new surgical treatment for a case of GSD in September 2017.

    Authors: Linjie Feng, Yaoping Wu, Xiangqian Yu and Wenguo Zhao

    Citation: BMC Musculoskeletal Disorders 2019 20:73

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  44. Content type: Research article

    Preclinical osteoarthritis models where damage occurs spontaneously may better reflect the initiation and development of human osteoarthritis. The aim was to assess the commercial pig as a model of spontaneous...

    Authors: Mhairi A. Macfadyen, Zoe Daniel, Sara Kelly, Tim Parr, John M. Brameld, Andrew J. Murton and Simon W. Jones

    Citation: BMC Musculoskeletal Disorders 2019 20:70

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  45. Content type: Study protocol

    There is insufficient knowledge of pathophysiological parameters to understand the mechanism behind prolonged whiplash associated disorders (WAD), and it is not known whether or not changes can be restored by ...

    Authors: Anneli Peolsson, Anette Karlsson, Bijar Ghafouri, Tino Ebbers, Maria Engström, Margaretha Jönsson, Karin Wåhlén, Thobias Romu, Magnus Borga, Eythor Kristjansson, Hilla Sarig Bahat, Dmitry German, Peter Zsigmond and Gunnel Peterson

    Citation: BMC Musculoskeletal Disorders 2019 20:51

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  46. Content type: Research article

    Osteoarthritis (OA) is a common joint disease in aging societies, which is accompanied by chronic inflammation and degeneration of the joint structure. Inflammation of the infrapatellar fat pad (IFP) and synov...

    Authors: Kei Inomata, Kunikazu Tsuji, Hiroaki Onuma, Takashi Hoshino, Mio Udo, Masako Akiyama, Yusuke Nakagawa, Hiroki Katagiri, Kazumasa Miyatake, Ichiro Sekiya, Takeshi Muneta and Hideyuki Koga

    Citation: BMC Musculoskeletal Disorders 2019 20:8

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  47. Content type: Case report

    Nodular fasciitis is a benign proliferation of myofibroblasts that usually arises in subcutaneous tissues of the trunk, neck, head, and upper extremities of young adults. It is not reported to arise in the joi...

    Authors: Wei Wang, Yiting Huang, Changxing Wang, Jianqiao Hong, Chiyuan Ma, Nong Lin, Zhaoming Ye, Shiyuan Yan and Haobo Wu

    Citation: BMC Musculoskeletal Disorders 2019 20:5

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  48. Content type: Research article

    Osteoarthritis is a degradative joint disease found in humans and commercial swine which can develop from a number of factors, including prior joint trauma. An impact injury model was developed to deliver in v...

    Authors: R. S. McCulloch, P. L. Mente, A. T. O’Nan and M. S. Ashwell

    Citation: BMC Musculoskeletal Disorders 2018 19:449

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  49. Content type: Research article

    Axial spondyloarthritis (axSpA) is characterized by significant bone loss caused by dysregulation of physiological bone turnover, possibly resulting from intensified differentiation of osteoclasts. The aim of ...

    Authors: Mariusz Korkosz, Marcin Czepiel, Zofia Guła, Małgorzata Stec, Kazimierz Węglarczyk, Magdalena Rutkowska-Zapała, Anna Gruca, Marzena Lenart, Jarosław Baran, Jerzy Gąsowski, Przemysław Błyszczuk and Maciej Siedlar

    Citation: BMC Musculoskeletal Disorders 2018 19:434

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