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Pathophysiology of musculoskeletal disorders

Section edited by Ali Mobasheri

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

Page 1 of 6

  1. Content type: Research article

    Axial spondyloarthritis (axSpA) is characterized by significant bone loss caused by dysregulation of physiological bone turnover, possibly resulting from intensified differentiation of osteoclasts. The aim of ...

    Authors: Mariusz Korkosz, Marcin Czepiel, Zofia Guła, Małgorzata Stec, Kazimierz Węglarczyk, Magdalena Rutkowska-Zapała, Anna Gruca, Marzena Lenart, Jarosław Baran, Jerzy Gąsowski, Przemysław Błyszczuk and Maciej Siedlar

    Citation: BMC Musculoskeletal Disorders 2018 19:434

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  2. Content type: Research article

    Studies have shown that cytokines play a role in bone remodeling.

    Authors: Ana Maria Baptista Menezes, Paula Duarte Oliveira, Helen Gonçalves, Isabel O. Oliveira, Maria Cecilia F. Assunção, Luciana Tovo-Rodrigues, Gustavo Dias Ferreira and Fernando César Wehrmeister

    Citation: BMC Musculoskeletal Disorders 2018 19:427

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  3. Content type: Research article

    Tendon disorders are common and lead to significant disability and pain. Our knowledge of the ‘tennis elbow’, the ‘jumpers knee’, and Achilles tendinosis has increased over the years, but changes in denervated...

    Authors: Roine El-Habta, Jialin Chen, Jessica Pingel and Ludvig J. Backman

    Citation: BMC Musculoskeletal Disorders 2018 19:426

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  4. Content type: Research article

    Proteomics is an emerging field in the study of joint disease. Our two aims with this pilot analysis were to compare healthy human knee articular cartilage with meniscus, two tissues both known to become affec...

    Authors: Elin Folkesson, Aleksandra Turkiewicz, Martin Englund and Patrik Önnerfjord

    Citation: BMC Musculoskeletal Disorders 2018 19:416

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  5. Content type: Research article

    Myofascial trigger points (MTrPs) are hyperirritable areas in the fascia of the affected muscle, possibly related to mitochondrial impairment. They can result in pain and hypoxic areas within the muscle. This ...

    Authors: Michael J. Fischer, Gergo Horvath, Martin Krismer, Erich Gnaiger, Georg Goebel and Dominik H. Pesta

    Citation: BMC Musculoskeletal Disorders 2018 19:388

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  6. Content type: Research article

    Cyclops nodule formation is a serious complication after anterior cruciate ligament (ACL) reconstruction. The purpose of our study was to investigate whether an increase in thymol turbidity test (TTT) values i...

    Authors: Yuya Kodama, Takayuki Furumatsu, Tomohito Hino, Yusuke Kamatsuki, Yoshiki Okazaki, Shin Masuda, Yuki Okazaki and Toshifumi Ozaki

    Citation: BMC Musculoskeletal Disorders 2018 19:367

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  7. Content type: Research article

    The phenotypes of osteoarthritis (OA) consist of cartilage extracellular matrix (ECM) metabolism disorder and the breakdown of cartilage homeostasis, which are induced by pro-inflammatory factors and oxidative...

    Authors: Jianli Xue, Zixin Min, Zhuqing Xia, Bin Cheng, Binshang Lan, Fujun Zhang, Yan Han, Kunzheng Wang and Jian Sun

    Citation: BMC Musculoskeletal Disorders 2018 19:355

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  8. Content type: Research article

    Fibroblast behavior and cell-matrix interactions of cells from normal and idiopathic carpal tunnel syndrome (CTS) subsynovial connective tissue (SSCT) with and without Triamcinolone Acetonide (TA) were compare...

    Authors: Tai-Hua Yang, Anne Gingery, Andrew R. Thoreson, Dirk R. Larson, Chunfeng Zhao and Peter C. Amadio

    Citation: BMC Musculoskeletal Disorders 2018 19:342

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  9. Content type: Research article

    To explore and evaluate the predictive value of preoperative Neutrophil-lymphocyte ratio (NLR) on the recurrence of pigmented villonodular synovitis (PVNS) of the knee joint treated by arthroscopic surgery com...

    Authors: Guanglei Zhao, Jin Wang, Jun Xia, Yibing Wei, Siqun Wang, Gangyong Huang, Feiyan Chen, Jie Chen, Jingsheng Shi and Yuanqing Yang

    Citation: BMC Musculoskeletal Disorders 2018 19:339

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  10. Content type: Research article

    Formation of lamellar bone in non-osseus tissue is a pathological process called heterotopic ossification. It is the aim of this study to analyse the morphology and immunological status of patients with hetero...

    Authors: Klemens Trieb, Andreas Meryk, Sascha Senck, Erin Naismith and Beatrix Grubeck-Loebenstein

    Citation: BMC Musculoskeletal Disorders 2018 19:327

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  11. Content type: Research article

    The age-related osteoporosis is an increasing risk severely threatening the live quality of aged people. Human parathyroid hormone (hPTH) is applied to the therapy of osteoporosis successfully, however, the me...

    Authors: Wei Li, Liang Yuan, Guojun Tong, Youhua He, Yue Meng, Song Hao, Jianting Chen, Jun Guo, Richard Bringhurst and Dehong Yang

    Citation: BMC Musculoskeletal Disorders 2018 19:311

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  12. Content type: Research article

    Pain in osteoarthritis (OA) remains poorly understood. Different types of somatosensory alterations exist in OA including hyperesthesia and increased sensitivity to painful stimuli as well as those of decrease...

    Authors: Anisha B. Dua, Tuhina Neogi, Rachel A. Mikolaitis, Joel A. Block and Najia Shakoor

    Citation: BMC Musculoskeletal Disorders 2018 19:307

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  13. Content type: Research article

    The major complaint of knee osteoarthritis (OA) is persistent pain. Unlike acute inflammatory pain, persistent pain is usually difficult to manage since its pathology is not fully understood. To elucidate the ...

    Authors: Takashi Hoshino, Kunikazu Tsuji, Hiroaki Onuma, Mio Udo, Hiroko Ueki, Masako Akiyama, Kahaer Abula, Hiroki Katagiri, Kazumasa Miyatake, Toshihumi Watanabe, Ichiro Sekiya, Hideyuki Koga and Takeshi Muneta

    Citation: BMC Musculoskeletal Disorders 2018 19:291

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  14. Content type: Research article

    Knee osteoarthritis (KOA) is the most common form of chronic degenerative joint disease worldwide. Its incidence has increased in recent years. Aberrant expression profile of lncRNAs in damaged bone and cartil...

    Authors: Kejie Wang, Minjie Chu, Wenge Ding and Qing Jiang

    Citation: BMC Musculoskeletal Disorders 2018 19:284

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  15. Content type: Research article

    Injury prevalence data commonly indicate trends of higher rates of work-related musculoskeletal disorders in older workers over their younger counterparts, and for females more than males. The purpose of this ...

    Authors: John D. Collins and Leonard O’Sullivan

    Citation: BMC Musculoskeletal Disorders 2018 19:280

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  16. Content type: Research article

    The aims of this study were to analyse the serum concentrations of clusterin (CLU) in patients with hand osteoarthritis (OA) and in healthy controls, to compare CLU levels between patients with erosive and non...

    Authors: Tereza Kropáčková, Olga Šléglová, Olga Růžičková, Jiří Vencovský, Karel Pavelka and Ladislav Šenolt

    Citation: BMC Musculoskeletal Disorders 2018 19:264

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  17. Content type: Research article

    Although aneurysmal bone cysts (ABCs) are benign tumours, they have the potential to be locally aggressive. Various treatment approaches, such as en bloc resection, open curettage, radiotherapy, sclerotherapy,...

    Authors: Hisaki Aiba, Masaaki Kobayashi, Yuko Waguri-Nagaya, Hideyuki Goto, Jun Mizutani, Satoshi Yamada, Hideki Okamoto, Masahiro Nozaki, Hiroto Mitsui, Shinji Miwa, Makoto Kobayashi, Kojiro Endo, Shiro Saito, Taeko Goto and Takanobu Otsuka

    Citation: BMC Musculoskeletal Disorders 2018 19:268

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  18. Content type: Research article

    Mesenchymal stromal cells (MSC) have shown promising results in the treatment of tendinopathy in equine medicine, making this therapeutic approach seem favorable for translation to human medicine. Having demon...

    Authors: A. B. Ahrberg, C. Horstmeier, D. Berner, W. Brehm, C. Gittel, A. Hillmann, C. Josten, G. Rossi, S. Schubert, K. Winter and J. Burk

    Citation: BMC Musculoskeletal Disorders 2018 19:230

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  19. Content type: Research article

    Bone structure and strength are rapidly lost during conditions of decreased mechanical loading, and aged bones have a diminished ability to adapt to increased mechanical loading. This is a concern for older pa...

    Authors: Hailey C. Cunningham, Daniel W. D. West, Leslie M. Baehr, Franklin D. Tarke, Keith Baar, Sue C. Bodine and Blaine A. Christiansen

    Citation: BMC Musculoskeletal Disorders 2018 19:223

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  20. Content type: Research article

    To evaluate synchrotron radiation-based Fourier transform infrared microspectroscopy (SR-FTIR) as a tool for quantitative mapping of the content and distribution of the extracellular matrix in decellularized f...

    Authors: Yongchun Zhou, Can Chen, Zhu Guo, Shanshan Xie, Jianzhong Hu and Hongbin Lu

    Citation: BMC Musculoskeletal Disorders 2018 19:220

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  21. Content type: Correspondence

    Recent reported results by Fang et al. published in BMC Musculoskeletal Disorders have added to the weight of evidence supporting association between gluteal pain and lumbar disc hernia. Their clinical finding...

    Authors: Yu Wang, Jin Yang, Yuqing Yan, Lifeng Zhang, Chuan Guo, Zhiyu Peng and Qingquan Kong

    Citation: BMC Musculoskeletal Disorders 2018 19:214

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  22. Content type: Research article

    Research suggests that vascular endothelial growth factor (VEGF) levels in the synovial fluid of knee osteoarthritis (KOA) patients are positively correlated with KOA severity. The relationship between synovia...

    Authors: Shotaro Takano, Kentaro Uchida, Gen Inoue, Toshihide Matsumoto, Jun Aikawa, Dai Iwase, Manabu Mukai, Masayuki Miyagi and Masashi Takaso

    Citation: BMC Musculoskeletal Disorders 2018 19:204

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  23. Content type: Research article

    The anterior cruciate ligament (ACL) is responsible for braking forward movement of the tibia relative to the femur and for tibial rotation. After ACL injury, this braking performance deteriorates, inducing ab...

    Authors: Yuichi Nishikawa, Takanori Kokubun, Naohiko Kanemura, Tetsuya Takahashi, Masayasu Matsumoto, Hirofumi Maruyama and Kiyomi Takayanagi

    Citation: BMC Musculoskeletal Disorders 2018 19:175

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  24. Content type: Research article

    Autologous chondrocyte implantation (ACI) is a therapy for articular cartilage and osteochondral lesions that relies on notch- or trochlea-derived primary chondrocytes. An alternative cell source for ACI could...

    Authors: Matthias Aurich, Gunther O. Hofmann, Florian Gras and Bernd Rolauffs

    Citation: BMC Musculoskeletal Disorders 2018 19:168

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  25. Content type: Research article

    It was indicated that inhibition of PPARγ probably represents a novel therapy for steroid-related osteonecrosis. In this study, we investigated the preventive effects of PPARγ inhibition on steroid-related ost...

    Authors: Na Yuan, Jia Li, Meng Li, Wenchen Ji, Zhaogang Ge, Lihong Fan and Kunzheng Wang

    Citation: BMC Musculoskeletal Disorders 2018 19:129

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  26. Content type: Research article

    Tendon is a commonly injured soft musculoskeletal tissue, however, poor healing potential and ineffective treatment strategies result in persistent injuries and tissue that is unable to perform its normal phys...

    Authors: Katie Joanna Lee, Peter David Clegg, Eithne Josephine Comerford and Elizabeth Gail Canty-Laird

    Citation: BMC Musculoskeletal Disorders 2018 19:116

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  27. Content type: Research article

    Steroid therapy, a key therapy for inflammatory, allergic, and immunological disorders, is often associated with steroid myopathy as one of the side effects. Steroid therapy is considered the first-line therap...

    Authors: Takashi Nawata, Makoto Kubo, Takafumi Nomura, Keiji Oishi, Kosaku Shiragami, Tadayoshi Ikegami, Munemasa Okada, Shigeki Kobayashi and Masafumi Yano

    Citation: BMC Musculoskeletal Disorders 2018 19:93

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  28. Content type: Research article

    Mobilization of mesenchymal stem cells (MSCs) from the synovium was revealed using a “suspended synovium culture model” of osteoarthritis (OA). The pathology of rheumatoid arthritis (RA) differs from that of O...

    Authors: Yuji Kohno, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Koji Otabe, Hideyuki Koga, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa and Ichiro Sekiya

    Citation: BMC Musculoskeletal Disorders 2018 19:78

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  29. Content type: Research article

    Inflammation is associated with the onset and progression of osteoarthritis in multiple joints. It is well known that mechanical properties differ between different joints, however, it remains unknown if the i...

    Authors: Guomin Ren, Ian Lutz, Pamela Railton, J. Preston Wiley, Jenelle McAllister, James Powell and Roman J. Krawetz

    Citation: BMC Musculoskeletal Disorders 2018 19:39

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  30. Content type: Research article

    Microendoscopic foraminotomy has been reported to be effective for the treatment of cervical radiculopathy, using outcome measurement scores such as the neck disability index (NDI) and numerical rating scale (...

    Authors: Juichi Tonosu, Hirohiko Inanami, Hiroyuki Oka, Yuichi Takano, Hisashi Koga, Yohei Yuzawa, Ryutaro Shiboi, Yasushi Oshima, Satoshi Baba, Sakae Tanaka and Ko Matsudaira

    Citation: BMC Musculoskeletal Disorders 2018 19:30

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  31. Content type: Research article

    Chondrosarcoma is the second most common primary malignant bone tumor. Because of their heterogeneity, with differences in invasive and metastatic behavior, it is important to identify biological markers that ...

    Authors: Dominik Malcherczyk, Thomas J. Heyse, Bilal F. El-Zayat, Vanessa Kunzke, Roland Moll, Susanne Fuchs-Winkelmann and Jürgen R. J. Paletta

    Citation: BMC Musculoskeletal Disorders 2018 19:9

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  32. Content type: Research article

    Greater age and body mass index are strong risk factors for osteoarthritis (OA). Older and overweight individuals may be more susceptible to OA because these factors alter tissue turnover in menisci, articular...

    Authors: Alina C. Stout, Mary F. Barbe, Charles B. Eaton, Mamta Amin, Fatimah Al-Eid, Lori Lyn Price, Bing Lu, Grace H. Lo, Ming Zhang, Jincheng Pang, Timothy E. McAlindon and Jeffrey B. Driban

    Citation: BMC Musculoskeletal Disorders 2018 19:1

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  33. Content type: Research article

    The objective of this study was to evaluate the extent of stromal cell-derived factor-1’s (SDF-1) involvement in the pathogenesis of idiopathic versus post-traumatic OA by comparing differences in synovial mem...

    Authors: Nathan P. Thomas, Wesley J. Wu, Braden C. Fleming, Fangyuan Wei, Qian Chen and Lei Wei

    Citation: BMC Musculoskeletal Disorders 2017 18:556

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  34. Content type: Research article

    Transplanting myogenic cells and scaffolds for tissue engineering in skeletal muscle have shown inconsistent results. One of the limiting factors is neovascularization at the recipient site. Low intensity shoc...

    Authors: Lise K. Hansen, Henrik D. Schrøder, Lars Lund, Karthikeyan Rajagopal, Vrisha Maduri and Jeeva Sellathurai

    Citation: BMC Musculoskeletal Disorders 2017 18:557

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  35. Content type: Research article

    Studies have investigated the correlation between tumor necrosis factor related apoptosis-inducing ligand (TRAIL) gene polymorphisms and the susceptibility and severity of intervertebral disc degeneration (IDD...

    Authors: Qi-ling Yuan, Liang Liu, Yong-song Cai and Yin-gang Zhang

    Citation: BMC Musculoskeletal Disorders 2017 18:555

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  36. Content type: Research article

    Some reports have shown that intermittent parathyroid hormone (PTH) (1–34) treatment for patients with delayed union or nonunion have led to successful healing. In this study, we investigated whether systemic ...

    Authors: Yohei Kumabe, Sang Yang Lee, Takahiro Waki, Takashi Iwakura, Shunsuke Takahara, Michio Arakura, Yu Kuroiwa, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda and Takahiro Niikura

    Citation: BMC Musculoskeletal Disorders 2017 18:545

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  37. Content type: Research article

    TNF-alpha is suggested to be involved in muscle damage and muscle inflammation (myositis). In order to evaluate whether TNF-alpha is involved in the myositis that occurs in response to muscle overuse, the aim ...

    Authors: Lina Renström, Per Stål, Yafeng Song and Sture Forsgren

    Citation: BMC Musculoskeletal Disorders 2017 18:498

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  38. Content type: Research article

    Blunt trauma is the most frequent mechanism of injury in multiple trauma, commonly resulting from road traffic collisions or falls. Two of the most frequent injuries in patients with multiple trauma are chest ...

    Authors: Stefanie Fitschen-Oestern, Sebastian Lippross, Tim Klueter, Matthias Weuster, Deike Varoga, Mersedeh Tohidnezhad, Thomas Pufe, Stefan Rose-John, Hagen Andruszkow, Frank Hildebrand, Nadine Steubesand, Andreas Seekamp and Claudia Neunaber

    Citation: BMC Musculoskeletal Disorders 2017 18:468

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  39. Content type: Research article

    Glucocorticoid-associated osteonecrosis is an intractable condition, making the establishment of preventative strategies of particular importance. Recently various studies using mesenchymal stem cells (MSC) ha...

    Authors: Shusuke Ueda, Miyako Shimasaki, Toru Ichiseki, Yoshimichi Ueda, Masanobu Tsuchiya, Ayumi Kaneuji and Norio Kawahara

    Citation: BMC Musculoskeletal Disorders 2017 18:480

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  41. Content type: Research article

    ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteins play an important pathological role in matrix degeneration. Aggrecan degradation is a significant and critical event in early-stag...

    Authors: Takuya Tajima, Tomohisa Sekimoto, Nami Yamaguchi, Noboru Taniguchi, Syuji Kurogi, Masugi Maruyama and Etsuo Chosa

    Citation: BMC Musculoskeletal Disorders 2017 18:449

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  42. Content type: Research article

    p21(WAF1/CIP1/SDI1), a cyclin dependent kinase inhibitor has been shown to influence cell proliferation, differentiation and apoptosis; but more recently, p21 has been implicated in tissue repair. Studies on p21(

    Authors: Priyatha Premnath, Britta Jorgenson, Ricarda Hess, Pankaj Tailor, Dante Louie, Jaymi Taiani, Steven Boyd and Roman Krawetz

    Citation: BMC Musculoskeletal Disorders 2017 18:435

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  43. Content type: Research article

    Rotator cuff (RTC) tears are a common clinical problem resulting in adverse changes to the muscle, but there is limited information comparing histopathology to contractile function. This study assessed suprasp...

    Authors: Ana P. Valencia, Shama R. Iyer, Espen E. Spangenburg, Mohit N. Gilotra and Richard M. Lovering

    Citation: BMC Musculoskeletal Disorders 2017 18:436

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  44. Content type: Research article

    The aim was to investigate whether resident chondrocytes in human articular cartilage and in subculture express vitamin D receptor (VDR) and the enzyme that hydroxylates the prohormone 25(OH)D3 to the active horm...

    Authors: Ann Kristin Hansen, Yngve Figenschau and Inigo Zubiaurre-Martinez

    Citation: BMC Musculoskeletal Disorders 2017 18:432

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  45. Content type: Research article

    Nerve growth factor (NGF) is not only an important factor in nerve growth but also a major contributor to the production of inflammation. It has been reported that inhibiting NGF could reduce several types of ...

    Authors: Masayuki Miyagi, Tetsuhiro Ishikawa, Hiroto Kamoda, Miyako Suzuki, Gen Inoue, Yoshihiro Sakuma, Yasuhiro Oikawa, Sumihisa Orita, Kentaro Uchida, Kazuhisa Takahashi, Masashi Takaso and Seiji Ohtori

    Citation: BMC Musculoskeletal Disorders 2017 18:428

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  46. Content type: Research article

    Osteoarthritis research has been most commonly performed in the setting of the articular cartilage of the knee. To the best of our knowledge, no studies have evaluated the role of adiponectin in osteoarthritis...

    Authors: Qi Lai, Yuan Liu, Leitao Huang, Xuqiang Liu, Xionglong Yu, Qiang Wang, Runsheng Guo, Jianghao Zhu, Hanxiong Cheng, Min Dai and Bin Zhang

    Citation: BMC Musculoskeletal Disorders 2017 18:427

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  47. Content type: Research article

    Significant amount of bone mass is lost during the process of aging due to an imbalance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption in bone marrow microenvironment, which...

    Authors: Xia Chen, Junsong Chen, Dongliang Xu, Shuangxia Zhao, Huaidong Song and Yongde Peng

    Citation: BMC Musculoskeletal Disorders 2017 18:423

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  48. Content type: Case report

    Pure exercise intolerance associated with exclusive affection of skeletal muscle is a very rare phenotype of patients with mitochondrial myopathy. Moreover, the exercise intolerance in these rare patients is y...

    Authors: Patrick Soldath, Karen Lindhardt Madsen, Astrid Emilie Buch, Morten Duno, Flemming Wibrand and John Vissing

    Citation: BMC Musculoskeletal Disorders 2017 18:419

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  49. Content type: Case report

    At present, there are no registered products for the treatment of subchondral Bone Marrow Edema Lesion (BML) and associated knee pain. Patients who do not respond to current anti-inflammatory therapies are lef...

    Authors: Matthew J. Sampson, Margie Kabbani, Ravi Krishnan, Michael Nganga, Annika Theodoulou and Jeganath Krishnan

    Citation: BMC Musculoskeletal Disorders 2017 18:396

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  50. Content type: Research article

    Subchondral osteopenia is important for the pathophysiology of osteoarthritis (OA). Although previous studies suggest that plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, is related to...

    Authors: Akihiro Moritake, Naoyuki Kawao, Kiyotaka Okada, Kohei Tatsumi, Masayoshi Ishida, Katsumi Okumoto, Osamu Matsuo, Masao Akagi and Hiroshi Kaji

    Citation: BMC Musculoskeletal Disorders 2017 18:392

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