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Clinical rheumatology and osteoporosis

This section concerns all aspects of research into osteoporosis and rheumatic diseases, where the primary focus relates specifically to a component(s) of the musculoskeletal system

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  1. The treat-to-target (T2T) approach to the care of patients with rheumatoid arthritis involves using validated metrics to measure disease activity, frequent follow-up visits for patients with moderate to high d...

    Authors: Leslie R Harrold, George W Reed, J Timothy Harrington, Christine J Barr, Katherine C Saunders, Allan Gibofsky, Jeffrey D Greenberg, Ani John, Jenny Devenport and Joel M Kremer

    Citation: BMC Musculoskeletal Disorders 2014 15:389

    Content type: Study protocol

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  2. Based on questionnaire criteria, the sensorimotor disorder restless legs syndrome (RLS) has been reported to have a higher prevalence in rheumatoid arthritis (RA) patients than in the general population. There...

    Authors: Regina M Taylor-Gjevre, John A Gjevre and Bindu V Nair

    Citation: BMC Musculoskeletal Disorders 2014 15:378

    Content type: Research article

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  3. Pelubiprofen is a prodrug of 2-arylpropionic acid with relatively selective effects on cyclooxygenase-2 activity. The aim of this study was to compare the efficacy and safety profiles of pelubiprofen with thos...

    Authors: In Ah Choi, Han-Joo Baek, Chul-Soo Cho, Yeon-Ah Lee, Won Tae Chung, Young Eun Park, Yun Jong Lee, Yong-Beom Park, Jisoo Lee, Shin-Seok Lee, Wan-Hee Yoo, Jung-Soo Song, Seong Wook Kang, Hyun Ah Kim and Yeong Wook Song

    Citation: BMC Musculoskeletal Disorders 2014 15:375

    Content type: Research article

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  4. We explored psychometric properties of the Osteoporosis Assessment Questionnaire 2.0 in terms of reliability, validity, and responsiveness with generic, clinical, demographic, and preference-based data collect...

    Authors: Wei Shen, Russel Burge, April N Naegeli, Jeremy Shih, Jahangir Alam, Deborah T Gold and Stuart Silverman

    Citation: BMC Musculoskeletal Disorders 2014 15:374

    Content type: Research article

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  5. The erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are two commonly used measures of inflammation in rheumatoid arthritis (RA). As current RA treatment guidelines strongly emphasize early an...

    Authors: Liseth Siemons, Peter M ten Klooster, Harald E Vonkeman, Piet LCM van Riel, Cees AW Glas and Mart AFJ van de Laar

    Citation: BMC Musculoskeletal Disorders 2014 15:368

    Content type: Research article

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  6. A Moroccan model for the FRAX tool to determine the absolute risk of osteoporotic fracture at 10 years has been established recently. The study aimed to assess the discriminative capacity of FRAX in identifyin...

    Authors: Abdellah El Maghraoui, Siham Sadni, Nabil Jbili, Asmaa Rezqi, Aziza Mounach and Imad Ghozlani

    Citation: BMC Musculoskeletal Disorders 2014 15:365

    Content type: Research article

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  7. The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore ...

    Authors: Hilde Haugedal Nordal, Johan G Brun, Anne-Kristine Halse, Roland Jonsson, Magne K Fagerhol and Hilde Berner Hammer

    Citation: BMC Musculoskeletal Disorders 2014 15:335

    Content type: Research article

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  8. Involvement of patients in decision-making about medication is currently being advocated. This study examined (the concordance between) inflammatory arthritis patients’ preferred and perceived involvement in d...

    Authors: Ingrid Nota, Constance HC Drossaert, Erik Taal, Harald E Vonkeman and Mart AFJ van de Laar

    Citation: BMC Musculoskeletal Disorders 2014 15:333

    Content type: Research article

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  9. Biologic drugs are expensive treatments used in rheumatoid arthritis (RA). Switching among them is common practice in patients who have had an inadequate response or intolerable adverse events. The National In...

    Authors: Tim Blake, Vijay Rao, Tahir Hashmi, Nicola Erb, Sheila Catherine O’Reilly, Shireen Shaffu, Karen Obrenovic and Jon Packham

    Citation: BMC Musculoskeletal Disorders 2014 15:290

    Content type: Research article

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  10. Osteoporosis is a well-known extra articular manifestation in rheumatoid arthritis (RA). Biologic disease modifying anti rheumatic drugs (DMARDs) has been shown to be superior to synthetic DMARDs to reduce bon...

    Authors: Glenn Haugeberg, Knut Bjørn Helgetveit, Øystein Førre, Torhild Garen, Hege Sommerseth and Anne Prøven

    Citation: BMC Musculoskeletal Disorders 2014 15:289

    Content type: Research article

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  11. Psoriatic arthritis (PsA) disease activities at baseline may determine physical function over time. There is no longitudinal data on course of physical function in PsA patients from Asia. We aim to describe va...

    Authors: Ying-Ying Leung, Kwok-Wah Ho, Edmund K Li, Martin Li, Lai-Wa Kwok, Priscilla C Wong, Tena K Li, Tracy Y Zhu, Emily W Kun and Lai-Shan Tam

    Citation: BMC Musculoskeletal Disorders 2014 15:284

    Content type: Research article

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  12. Arthritis pain is reported as one of the most common reasons for persons using medical herbal cannabis in North America. “Severe arthritis” is the condition justifying legal use of cannabis in over half of all...

    Authors: Mary-Ann Fitzcharles, Peter A Ste-Marie, Daniel J Clauw, Shahin Jamal, Jacob Karsh, Sharon LeClercq, Jason J McDougall, Yoram Shir, Kam Shojania and Zach Walsh

    Citation: BMC Musculoskeletal Disorders 2014 15:258

    Content type: Research article

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  13. Vitamin D is essential for calcium metabolism, Vitamin D deficiency can precipitate osteoporosis, cause muscle weakness and increase the risk of fracture. The aim of this study was to assess the prevalence of ...

    Authors: Jawl-Shan Hwang, Keh-Sung Tsai, Yuh-Min Cheng, Wen-Jer Chen, Shih-Te Tu, Ko-Hsiu Lu, Sheng-Mou Hou, Shu-Hua Yang, Henrich Cheng, Hung Jen Lai, Sharon Lei and Jung-Fu Chen

    Citation: BMC Musculoskeletal Disorders 2014 15:257

    Content type: Research article

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  14. KIR genes coding for natural killer cell immunoglobulin-like receptors, KIR, influence the effector and regulatory function of NK cells as well as some subpopulations of T lymphocytes (e.g. CD4+CD28-KIR+) depend...

    Authors: Edyta Majorczyk, Andrzej Pawlik, Daria Gendosz and Piotr Kuśnierczyk

    Citation: BMC Musculoskeletal Disorders 2014 15:256

    Content type: Research article

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  15. Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease mediated by T cells. The aim of the present study was to investigate the therapeutic efficacy of synthetic peptides (HP-R1, HP-R2 and HP-R3)...

    Authors: Xiao-Lian Shi, Li-Ping Wang, Xuan Feng, Dan-Dan Fan, Wei-Jin Zang, Bing Wang and Jun Zhou

    Citation: BMC Musculoskeletal Disorders 2014 15:253

    Content type: Research article

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  16. Rheumatoid arthritis (RA) is a chronic autoinflammatory joint disease which leads to the destruction of joints and disability of the patients. Anti-tumour necrosis factor (anti-TNF) drugs can halt radiological...

    Authors: Péter Juhász, Ádám Mester, Anna-Julianna Biró, Gábor Héjj and Gyula Poór

    Citation: BMC Musculoskeletal Disorders 2014 15:251

    Content type: Research article

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  17. To address both the growing burden of joint disease and the gaps in medical access in developing nations, medical relief organizations have begun to launch programs to perform total joint replacement (TJR) on ...

    Authors: Scott A Elman, Yan Dong, Derek S Stenquist, Roya Ghazinouri, Luis Alcantara, Jamie E Collins, Carolyn Beagan, Thomas S Thornhill and Jeffrey N Katz

    Citation: BMC Musculoskeletal Disorders 2014 15:207

    Content type: Research article

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  18. The aim of this study was to examine the clinical characteristics of rheumatoid arthritis (RA) patients who underwent cervical spine surgery using a multicenter observational database.

    Authors: Shurei Sugita, Hirotaka Chikuda, Yuho Kadono, Hiroshi Ohtsu, Katsushi Takeshita, Jinju Nishino, Shigeto Tohma and Sakae Tanaka

    Citation: BMC Musculoskeletal Disorders 2014 15:203

    Content type: Research article

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  19. Rituximab is a B cell depleting anti-CD20 monoclonal antibody. CD20 is not expressed on mature plasma cells and accordingly rituximab does not have immediate effects on immunoglobulin levels. However, after ri...

    Authors: Helena Marco, Rona M Smith, Rachel B Jones, Mary-Jane Guerry, Fausta Catapano, Stella Burns, Afzal N Chaudhry, Kenneth GC Smith and David RW Jayne

    Citation: BMC Musculoskeletal Disorders 2014 15:178

    Content type: Research article

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  20. As recommended in the current prescribing information, rituximab infusions in patients with rheumatoid arthritis (RA) take 4.25 hours for the first infusion and 3.25 hours for subsequent infusions, which is a ...

    Authors: Charles H Pritchard, Maria W Greenwald, Joel M Kremer, Norman B Gaylis, William Rigby, Steve Zlotnick, Carol Chung, Birgit Jaber and William Reiss

    Citation: BMC Musculoskeletal Disorders 2014 15:177

    Content type: Research article

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  21. Gout and hyperuricaemia may be associated with increased cardiovascular risk, but analyses in different populations show conflicting results. This study investigates the impact of serum uric acid, inflammation...

    Authors: Inger L Meek, Harald E Vonkeman and Mart AFJ van de Laar

    Citation: BMC Musculoskeletal Disorders 2014 15:174

    Content type: Research article

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  22. Comparative effectiveness research has recently attracted considerable attention. The C omparative E ffectiveness R egistry to study T herapies for A rthritis and I nflammatory Con ditions (CERTAIN) is an ongoing...

    Authors: Dimitrios A Pappas, Joel M Kremer, George Reed, Jeffrey D Greenberg and Jeffrey R Curtis

    Citation: BMC Musculoskeletal Disorders 2014 15:113

    Content type: Study protocol

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  23. Self-management of arthritis requires informed, activated patients to manage its physical and psychosocial consequences. Patient activation and self-management can be enhanced through the use of cognitive-beha...

    Authors: Emma Dures, Sarah Hewlett, Nicholas Ambler, Remona Jenkins, Joyce Clarke and Rachael Gooberman-Hill

    Citation: BMC Musculoskeletal Disorders 2014 15:108

    Content type: Research article

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  24. To measure the use, satisfaction and impact of a web portal which provides patients with rheumatoid arthritis home access to their electronic medical records (EMR).

    Authors: Rosalie van der Vaart, Constance HC Drossaert, Erik Taal, K Wiepke Drossaers-Bakker, Harald E Vonkeman and Mart AFJ van de Laar

    Citation: BMC Musculoskeletal Disorders 2014 15:102

    Content type: Research article

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  25. Matrix metalloproteinase-3 (MMP-3) plays an important role in the pathology of rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Measurement of active MMP-3 in clinical samples could provide informati...

    Authors: Shu Sun, Anne-Christine Bay-Jensen, Morten A Karsdal, Anne Sofie Siebuhr, Qinlong Zheng, Walter P Maksymowych, Thorbjørn G Christiansen and Kim Henriksen

    Citation: BMC Musculoskeletal Disorders 2014 15:93

    Content type: Research article

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  26. Subacromial impingement syndrome is the most frequent cause of shoulder problems which themselves affect 1 in 3 adults. Management commonly includes exercise and corticosteroid injection. However, the few exis...

    Authors: Edward Roddy, Irena Zwierska, Elaine M Hay, Sue Jowett, Martyn Lewis, Kay Stevenson, Danielle van der Windt and Nadine E Foster

    Citation: BMC Musculoskeletal Disorders 2014 15:81

    Content type: Study protocol

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  27. This meta-analysis assessed the efficacy of duloxetine versus other oral treatments used after failure of acetaminophen for management of patients with osteoarthritis.

    Authors: Julie Myers, Ronald C Wielage, Baoguang Han, Karen Price, James Gahn, Marie-Ange Paget and Michael Happich

    Citation: BMC Musculoskeletal Disorders 2014 15:76

    Content type: Research article

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  28. The health belief model (HBM) is the most commonly used conceptual framework for evaluating osteoporosis health belief and behaviors. The purpose of this study was to develop and evaluate the psychometric prop...

    Authors: Atoosa Soleymanian, Shamsaddin Niknami, Ebrahim Hajizadeh, Davoud Shojaeizadeh and Ali Montazeri

    Citation: BMC Musculoskeletal Disorders 2014 15:61

    Content type: Research article

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  29. The study is aimed to evaluate body composition and bone status in adolescent and adult patients with active juvenile idiopathic arthritis (JIA) untreated with tumor necrosis factor alpha inhibitors.

    Authors: Kristyna Brabnikova Maresova, Katerina Jarosova, Karel Pavelka and Jan J Stepan

    Citation: BMC Musculoskeletal Disorders 2014 15:51

    Content type: Research article

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  30. Poor sleep is prevalent in patients with systemic inflammatory disorders, including rheumatoid arthritis, and, in addition to fatigue, pain, depression and inflammation, is associated with an increased risk of...

    Authors: Katrine Løppenthin, Bente Appel Esbensen, Poul Jennum, Mikkel Østergaard, Jesper Frank Christensen, Tanja Thomsen, Julie Schjerbech Bech and Julie Midtgaard

    Citation: BMC Musculoskeletal Disorders 2014 15:49

    Content type: Study protocol

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  31. To validate physical activity estimates by the Sensewear Pro3 activity monitor compared with indirect calorimetry during simulated free living in patients diagnosed with osteoarthritis of the hip pre or post t...

    Authors: Andreas Hermann, Mathias Ried-Larsen, Andreas Kryger Jensen, René Holst, Lars Bo Andersen, Søren Overgaard and Anders Holsgaard-Larsen

    Citation: BMC Musculoskeletal Disorders 2014 15:43

    Content type: Research article

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  32. The economic assessment of treatment options in a chronic and severe disease like Psoriatic Arthritis (PsA) is crucial to estimate the burden of costs. In particular, the impact of new costly medications such ...

    Authors: Ennio Lubrano and Antonio Spadaro

    Citation: BMC Musculoskeletal Disorders 2014 15:25

    Content type: Commentary

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  33. Primary Sjögren’s Syndrome (PSS) mainly affects women (9:1 female:male ratio) and is one of the commonest autoimmune diseases with a prevalence of 0.1 – 0.6% of adult women. For patients with PSS there is curr...

    Authors: Sarah Brown, Nuria Navarro Coy, Costantino Pitzalis, Paul Emery, Sue Pavitt, Janine Gray, Claire Hulme, Frances Hall, Robert Busch, Pete Smith, Luke Dawson, Michele Bombardieri, Ng Wan-fai, Colin Pease, Elizabeth Price, Nurhan Sutcliffe…

    Citation: BMC Musculoskeletal Disorders 2014 15:21

    Content type: Study protocol

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  34. Discontinuation of rheumatoid arthritis (RA) treatment for lack or loss of initial response, tolerability issues, or development of antibodies against the therapeutic agent remains a challenge in clinical prac...

    Authors: Hubert G Nüßlein, Rieke Alten, Mauro Galeazzi, Hanns-Martin Lorenz, Dimitrios Boumpas, Michael T Nurmohamed, William G Bensen, Gerd R Burmester, Hans-Hartmut Peter, Franz Rainer, Karel Pavelka, Melanie Chartier, Coralie Poncet, Christiane Rauch and Manuela Le Bars

    Citation: BMC Musculoskeletal Disorders 2014 15:14

    Content type: Research article

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  35. Inclusion/exclusion criteria and baseline characteristics are essential for assessing the applicability of trial results to a given patient and the comparability of study populations for meta-analyses. This De...

    Authors: Lukas M Wildi, Anita Hensel, Maria Wertli, Beat A Michel and Johann Steurer

    Citation: BMC Musculoskeletal Disorders 2013 14:369

    Content type: Research article

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  36. Although typically a late feature of gout, tophi may present early in the course of disease. The aim of this study was to identify factors associated with the presence of early tophaceous disease.

    Authors: Nicola Dalbeth, Meaghan E House, Anne Horne and William J Taylor

    Citation: BMC Musculoskeletal Disorders 2013 14:363

    Content type: Research article

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  37. Where health economic studies are frequently performed using modelling, with input from randomized controlled trials and best guesses, we used real-life data to analyse the cost-effectiveness and cost-utility ...

    Authors: Marloes Vermeer, Wietske Kievit, Hillechiena H Kuper, Louise MA Braakman-Jansen, Hein J Bernelot Moens, Theo R Zijlstra, Alfons A den Broeder, Piet LCM van Riel, Jaap Fransen and Mart AFJ van de Laar

    Citation: BMC Musculoskeletal Disorders 2013 14:350

    Content type: Research article

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  38. Selective and reversible inhibitors of human Cathepsin K (CatK), including odanacatib (ODN), have been developed as potential therapeutics for the treatment of osteoporosis. Inhibitors of human CatK show signi...

    Authors: Brenda L Pennypacker, Renata M Oballa, Sonia Levesque, Donald B Kimmel and Le T Duong

    Citation: BMC Musculoskeletal Disorders 2013 14:344

    Content type: Research article

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  39. Knowledge of factors that contribute to non-persistence with disease modifying anti-rheumatic drugs (NP) is essential to improve rheumatoid arthritis (RA) outcomes. Aims of the study were to investigate patien...

    Authors: Virginia Pascual-Ramos and Irazú Contreras-Yáñez

    Citation: BMC Musculoskeletal Disorders 2013 14:336

    Content type: Research article

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  40. This meta-analysis was conducted to determine the efficacy, safety and tolerability of tofacitinib in the treatment of rheumatoid arthritis in patients with an inadequate response or intolerance to at least on...

    Authors: Asres Berhan

    Citation: BMC Musculoskeletal Disorders 2013 14:332

    Content type: Research article

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  41. The discovery of a fetal cells transfer to the mother is a phenomenon with multiple implications for autoimmunity and tolerance. The prevalence and meaning of the feto-maternal microchimerism (MC) in rheumatic...

    Authors: Marianne Kekow, Maria Barleben, Susanne Drynda, Sibylle Jakubiczka, Jörn Kekow and Thomas Brune

    Citation: BMC Musculoskeletal Disorders 2013 14:325

    Content type: Research article

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  42. Moderate loads with knee loading enhance bone formation, but its effects on the maintenance of the knee are not well understood. In this study, we examined the effects of knee loading on the activity of matrix...

    Authors: Kazunori Hamamura, Ping Zhang, Liming Zhao, Joon W Shim, Andy Chen, Todd R Dodge, Qiaoqiao Wan, Han Shih, Sungsoo Na, Chien-Chi Lin, Hui Bin Sun and Hiroki Yokota

    Citation: BMC Musculoskeletal Disorders 2013 14:312

    Content type: Research article

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  43. Lateral epicondylalgia (LE) defines a condition of varying degrees of pain near the lateral epicondyle. Studies on the management of LE indicated unexplained variations in the use of pharmacologic, non-pharmac...

    Authors: Francisco Minaya-Muñoz, Francesc Medina-Mirapeix and Fermin Valera-Garrido

    Citation: BMC Musculoskeletal Disorders 2013 14:310

    Content type: Research article

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  44. Individual studies have reported different results regarding the association of HLA alleles with RA in Chinese populations. This study was performed to systematically summarize results on the association of HL...

    Authors: Meng Yang, Xiaocong Kuang, Jianmin Li, Yanbin Pan, Meile Tan, Binzhu Lu, Qiumei Cheng, Lingyan Wu and Guodong Pang

    Citation: BMC Musculoskeletal Disorders 2013 14:307

    Content type: Research article

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  45. Preliminary, mostly uncontrolled studies suggest that dose reduction or discontinuation of tumour necrosis factor blockers can be achieved in a relevant proportion of patients with RA without loss of disease c...

    Authors: Alfons A den Broeder, Noortje van Herwaarden, Aatke van der Maas, Frank HJ van den Hoogen, Johannes W Bijlsma, Ronald F van Vollenhoven and Bart JF van den Bemt

    Citation: BMC Musculoskeletal Disorders 2013 14:299

    Content type: Study protocol

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  46. Tofacitinib is a disease-modifying antirheumatic drug (DMARD) which was recently approved by US Food and Drug Administration (FDA). There are several randomised clinical trials (RCTs) that have investigated th...

    Authors: Ying He, Angel YS Wong, Esther W Chan, Wallis CY Lau, Kenneth KC Man, Celine SL Chui, Alan J Worsley and Ian CK Wong

    Citation: BMC Musculoskeletal Disorders 2013 14:298

    Content type: Research article

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  47. Taking DMARDs as prescribed is an essential part of self-management for patients with Rheumatoid Arthritis. To date, the Compliance Questionnaire for Rheumatology (CQR) is the only self-report adherence measur...

    Authors: Lyndsay D Hughes, John Done and Adam Young

    Citation: BMC Musculoskeletal Disorders 2013 14:286

    Content type: Research article

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  48. The access to healthcare and treatment by rheumatoid arthritis (RA) patients, particularly to biologics, differs significantly among European countries.

    Authors: Pedro A Laires, Rui Mesquita, Luís Veloso, Ana Paula Martins, Rui Cernadas and João Eurico Fonseca

    Citation: BMC Musculoskeletal Disorders 2013 14:279

    Content type: Research article

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  49. There is limited evidence on non-pharmacological interventions for gout. The aim of the study was to determine whether a footwear intervention can reduce foot pain and musculoskeletal disability in people with...

    Authors: Keith Rome, Sarah Stewart, Alain C Vandal, Peter Gow, Peter McNair and Nicola Dalbeth

    Citation: BMC Musculoskeletal Disorders 2013 14:278

    Content type: Research article

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