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Clinical rheumatology and osteoporosis

This section concerns all aspects of research into osteoporosis and rheumatic diseases, where the primary focus relates specifically to a component(s) of the musculoskeletal system

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  1. Fibroblast proliferation is a common manifestation of chronic inflammatory diseases, including rheumatoid arthritis (RA), Crohn’s disease and ulcerative colitis, etc. To alleviate patient suffering, the mechan...

    Authors: Zheng-de Xi, Chang-yi Xie and Ye-bin Xi

    Citation: BMC Musculoskeletal Disorders 2016 17:43

    Content type: Research article

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  2. Little is known on how well targeted treatment, for instance targeting towards low DAS, is implemented in clinical practice. Our aim was to evaluate treatment adjustments in response to DAS in RA patients in c...

    Authors: Emilia Gvozdenović, Ron Wolterbeek, Désirée van der Heijde, Tom Huizinga, Cornelia Allaart and Robert Landewé

    Citation: BMC Musculoskeletal Disorders 2016 17:33

    Content type: Research article

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  3. Trabecular bone score (TBS), which has been proposed to be used in complementary with bone mineral density (BMD) to improve the assessment of fracture risk, is negatively associated with body mass index (BMI)....

    Authors: Sasithorn Amnuaywattakorn, Chanika Sritara, Chirawat Utamakul, Wichana Chamroonrat, Arpakorn Kositwattanarerk, Kanungnij Thamnirat and Boonsong Ongphiphadhanakul

    Citation: BMC Musculoskeletal Disorders 2016 17:17

    Content type: Research article

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  4. Primary Sjögren syndrome (pSS) is a common autoimmune condition which primarily affects epithelial tissue, often including the kidney causing either tubulointerstitial nephritis (TIN) or more rarely, an immune...

    Authors: Rhys D. R. Evans, Christopher M. Laing, Coziana Ciurtin and Stephen B. Walsh

    Citation: BMC Musculoskeletal Disorders 2016 17:2

    Content type: Research article

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  5. To investigate and compare the impact of primary hip (THA) and knee (TKA) arthroplasty on quality of life in patients with osteoarthritis, to determine patients’ satisfaction with total joint arthroplasty, and...

    Authors: Zoe H. Dailiana, Ippolyti Papakostidou, Sokratis Varitimidis, Lycurgos Liaropoulos, Elias Zintzaras, Theofilos Karachalios, Emmanuel Michelinakis and Konstantinos N. Malizos

    Citation: BMC Musculoskeletal Disorders 2015 16:366

    Content type: Research article

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  6. Recommendations for rheumatology nursing management of chronic inflammatory arthritis (CIA) from European League Against Rheumatism (EULAR) states that nurses should take part in the monitoring patients’ disea...

    Authors: Ingrid Larsson, Bengt Fridlund, Barbro Arvidsson, Annika Teleman, Petra Svedberg and Stefan Bergman

    Citation: BMC Musculoskeletal Disorders 2015 16:354

    Content type: Research article

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  7. Antibodies to citrullinated proteins (ACPA) occur years before RA diagnosis. Porphyromonas gingivalis expresses its own peptidylarginine deiminase (PPAD), and is a proposed aetiological factor for the ACPA respon...

    Authors: Benjamin A. Fisher, Alison J. Cartwright, Anne-Marie Quirke, Paola de Pablo, Dora Romaguera, Salvatore Panico, Amalia Mattiello, Diana Gavrila, Carmen Navarro, Carlotta Sacerdote, Paolo Vineis, Rosario Tumino, David F. Lappin, Danae Apazidou, Shauna Culshaw, Jan Potempa…

    Citation: BMC Musculoskeletal Disorders 2015 16:331

    Content type: Research article

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    The Erratum to this article has been published in BMC Musculoskeletal Disorders 2016 17:62

  8. To measure circulating anti-citrullinated peptide antibodies (ACPA) and cytokines pre- and 6 months post-therapy as a strategy to predict and optimize responses to traditional disease-modifying antirheumatic d...

    Authors: Mahmood M. T. M. Ally, Bridget Hodkinson, Pieter W. A. Meyer, Eustasius Musenge, Gregory R. Tintinger, Mohammed Tikly and Ronald Anderson

    Citation: BMC Musculoskeletal Disorders 2015 16:130

    Content type: Research article

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  9. Osteoarthritis is thought to be the most prevalent chronic and disabling joint disease in animals and humans and its treatment is a major orthopaedic challenge because there is no ideal drug treatment to prese...

    Authors: María Permuy, David Guede, Mónica López-Peña, Fernando Muñoz, José-Ramón Caeiro and Antonio González-Cantalapiedra

    Citation: BMC Musculoskeletal Disorders 2015 16:120

    Content type: Research article

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  10. A survey was conducted to evaluate whether a steady improvement in the quality of life of Rheumatoid Arthritis (RA) patients as frequently reported in clinical studies, does actually occur. The focus of this s...

    Authors: Rudolf Puchner, Hans Peter Brezinschek, Josef Fritz, Manfred Herold, Monika Mustak, Thomas Nothnagl, Stephan E Puchner, Andrea Studnicka-Benke and Burkhard F Leeb

    Citation: BMC Musculoskeletal Disorders 2015 16:109

    Content type: Research article

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  11. Ankylosing spondylitis (AS) is an inflammatory disease with documented elevated cardiovascular (CV) risk due to systemic inflammation and a higher prevalence of CV risk factors. CV risk management (CV-RM) coul...

    Authors: Sjoerd C Heslinga, Inge A Van den Oever, Alper M Van Sijl, Mike J Peters, Irene E Van der Horst-Bruinsma, Yvo M Smulders and Michael T Nurmohamed

    Citation: BMC Musculoskeletal Disorders 2015 16:80

    Content type: Research article

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  12. To investigate whether a modified Rheumatoid Arthritis Disease Activity Index-5 could be applied as a routine assessment tool for psoriatic arthritis (PsA) patients.

    Authors: Burkhard F Leeb, Pia M Haindl, Hans-Peter Brezinschek, Harsono T H Mai, Christoph Deutsch and Bernhard Rintelen

    Citation: BMC Musculoskeletal Disorders 2015 16:73

    Content type: Research article

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  13. Since the reference value is the core factor of the T-score calculation, it has a significant impact on the prevalence of osteoporosis. The purpose of this study was to determine the effects of using the Korea...

    Authors: Sungwha Lee, Moon-Gi Choi, Jaemyung Yu, Ohk-Hyun Ryu, Hyung Joon Yoo, Sung-Hee Ihm, Doo-Man Kim, Eun-Gyung Hong, Kyutae Park, Myungjin Choi and Hyunhee Choi

    Citation: BMC Musculoskeletal Disorders 2015 16:69

    Content type: Research article

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  14. Studies have evaluated the concomitant use of hyaluronan (HA) with steroids, anti-inflammatory drugs and analgesic agents in an attempt to magnify the extent and duration of pain relief due to knee osteoarthri...

    Authors: Robert J Petrella, Pieter J Emans, Julia Alleyne, Frank Dellaert, Dawn P Gill and Marcee Maroney

    Citation: BMC Musculoskeletal Disorders 2015 16:57

    Content type: Research article

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  15. Vitamin D displays immunomodulatory activities and has been proposed as a potential player in the pathogenesis of rheumatoid arthritis (RA). A negative association between serum 25(OH) vitamin D levels and RA ...

    Authors: Manuela Di Franco, Ilaria Barchetta, Cristina Iannuccelli, Maria Chiara Gerardi, Silvia Frisenda, Fulvia Ceccarelli, Guido Valesini and Maria Gisella Cavallo

    Citation: BMC Musculoskeletal Disorders 2015 16:53

    Content type: Research article

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  16. Our objective was to evaluate the effect of background biological disease-modifying anti-rheumatic drugs (bDMARDs) and/or corticosteroids (CS) on response to nonsteroidal anti-inflammatory drugs (NSAIDs) in rh...

    Authors: Tore K Kvien, Maria Greenwald, Paul M Peloso, Hongwei Wang, Anish Mehta and Arnold Gammaitoni

    Citation: BMC Musculoskeletal Disorders 2015 16:26

    Content type: Research article

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  17. We performed a meta-analysis to evaluate the effect of anti–tumor necrosis factor (TNF) therapy on the frequency of extra–articular manifestations (EAMs) in patients with ankylosing spondylitis (AS).

    Authors: Dan Wu, Ying-Ying Guo, Nan-Nan Xu, Shuai Zhao, Lin-Xin Hou, Ting Jiao and Ning Zhang

    Citation: BMC Musculoskeletal Disorders 2015 16:19

    Content type: Research article

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  18. Rheumatoid Arthritis (RA) is one of the most common autoimmune diseases, affecting approximately 1% of the UK adult population. Patients suffer considerable pain, stiffness and swelling and can sustain various...

    Authors: Nuria C Navarro Coy, Sarah Brown, Ailsa Bosworth, Claire T Davies, Paul Emery, Colin C Everett, Catherine Fernandez, Janine C Gray, Suzanne Hartley, Claire Hulme, Anne-Maree Keenan, Christopher McCabe, Anthony Redmond, Catherine Reynolds, David Scott, Linda D Sharples…

    Citation: BMC Musculoskeletal Disorders 2014 15:452

    Content type: Study protocol

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  19. To investigate the risk of hepatitis B virus (HBV) reactivation in rheumatoid arthritis (RA) patients with HBV carrier state during treatment of disease-modifying antirheumatic drugs (DMARDs) and the use of an...

    Authors: Ying-Qian Mo, An-Qi Liang, Jian-Da Ma, Le-Feng Chen, Dong-Hui Zheng, H Ralph Schumacher and Lie Dai

    Citation: BMC Musculoskeletal Disorders 2014 15:449

    Content type: Research article

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  20. The Patient and PRovider Interventions for Managing Osteoarthritis (OA) in Primary Care (PRIMO) study is one of the first health services trials targeting OA in a multi-site, primary care network. This multi-s...

    Authors: Kelli D Allen, Hayden B Bosworth, Ranee Chatterjee, Cynthia J Coffman, Leonor Corsino, Amy S Jeffreys, Eugene Z Oddone, Catherine Stanwyck, William S Yancy Jr and Rowena J Dolor

    Citation: BMC Musculoskeletal Disorders 2014 15:413

    Content type: Research article

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  21. Rheumatoid arthritis (RA) is a chronic autoimmune condition that results in pain and disability. Patients with RA have a decreased functional ability and are forced into a sedentary lifestyle and as such, thes...

    Authors: Alessandra Prioreschi, Mohammed Tikly and Joanne A McVeigh

    Citation: BMC Musculoskeletal Disorders 2014 15:403

    Content type: Study protocol

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  22. The treat-to-target (T2T) approach to the care of patients with rheumatoid arthritis involves using validated metrics to measure disease activity, frequent follow-up visits for patients with moderate to high d...

    Authors: Leslie R Harrold, George W Reed, J Timothy Harrington, Christine J Barr, Katherine C Saunders, Allan Gibofsky, Jeffrey D Greenberg, Ani John, Jenny Devenport and Joel M Kremer

    Citation: BMC Musculoskeletal Disorders 2014 15:389

    Content type: Study protocol

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  23. Based on questionnaire criteria, the sensorimotor disorder restless legs syndrome (RLS) has been reported to have a higher prevalence in rheumatoid arthritis (RA) patients than in the general population. There...

    Authors: Regina M Taylor-Gjevre, John A Gjevre and Bindu V Nair

    Citation: BMC Musculoskeletal Disorders 2014 15:378

    Content type: Research article

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  24. Pelubiprofen is a prodrug of 2-arylpropionic acid with relatively selective effects on cyclooxygenase-2 activity. The aim of this study was to compare the efficacy and safety profiles of pelubiprofen with thos...

    Authors: In Ah Choi, Han-Joo Baek, Chul-Soo Cho, Yeon-Ah Lee, Won Tae Chung, Young Eun Park, Yun Jong Lee, Yong-Beom Park, Jisoo Lee, Shin-Seok Lee, Wan-Hee Yoo, Jung-Soo Song, Seong Wook Kang, Hyun Ah Kim and Yeong Wook Song

    Citation: BMC Musculoskeletal Disorders 2014 15:375

    Content type: Research article

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  25. We explored psychometric properties of the Osteoporosis Assessment Questionnaire 2.0 in terms of reliability, validity, and responsiveness with generic, clinical, demographic, and preference-based data collect...

    Authors: Wei Shen, Russel Burge, April N Naegeli, Jeremy Shih, Jahangir Alam, Deborah T Gold and Stuart Silverman

    Citation: BMC Musculoskeletal Disorders 2014 15:374

    Content type: Research article

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  26. The erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are two commonly used measures of inflammation in rheumatoid arthritis (RA). As current RA treatment guidelines strongly emphasize early an...

    Authors: Liseth Siemons, Peter M ten Klooster, Harald E Vonkeman, Piet LCM van Riel, Cees AW Glas and Mart AFJ van de Laar

    Citation: BMC Musculoskeletal Disorders 2014 15:368

    Content type: Research article

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  27. A Moroccan model for the FRAX tool to determine the absolute risk of osteoporotic fracture at 10 years has been established recently. The study aimed to assess the discriminative capacity of FRAX in identifyin...

    Authors: Abdellah El Maghraoui, Siham Sadni, Nabil Jbili, Asmaa Rezqi, Aziza Mounach and Imad Ghozlani

    Citation: BMC Musculoskeletal Disorders 2014 15:365

    Content type: Research article

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  28. The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore ...

    Authors: Hilde Haugedal Nordal, Johan G Brun, Anne-Kristine Halse, Roland Jonsson, Magne K Fagerhol and Hilde Berner Hammer

    Citation: BMC Musculoskeletal Disorders 2014 15:335

    Content type: Research article

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  29. Involvement of patients in decision-making about medication is currently being advocated. This study examined (the concordance between) inflammatory arthritis patients’ preferred and perceived involvement in d...

    Authors: Ingrid Nota, Constance HC Drossaert, Erik Taal, Harald E Vonkeman and Mart AFJ van de Laar

    Citation: BMC Musculoskeletal Disorders 2014 15:333

    Content type: Research article

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  30. Biologic drugs are expensive treatments used in rheumatoid arthritis (RA). Switching among them is common practice in patients who have had an inadequate response or intolerable adverse events. The National In...

    Authors: Tim Blake, Vijay Rao, Tahir Hashmi, Nicola Erb, Sheila Catherine O’Reilly, Shireen Shaffu, Karen Obrenovic and Jon Packham

    Citation: BMC Musculoskeletal Disorders 2014 15:290

    Content type: Research article

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  31. Osteoporosis is a well-known extra articular manifestation in rheumatoid arthritis (RA). Biologic disease modifying anti rheumatic drugs (DMARDs) has been shown to be superior to synthetic DMARDs to reduce bon...

    Authors: Glenn Haugeberg, Knut Bjørn Helgetveit, Øystein Førre, Torhild Garen, Hege Sommerseth and Anne Prøven

    Citation: BMC Musculoskeletal Disorders 2014 15:289

    Content type: Research article

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  32. Psoriatic arthritis (PsA) disease activities at baseline may determine physical function over time. There is no longitudinal data on course of physical function in PsA patients from Asia. We aim to describe va...

    Authors: Ying-Ying Leung, Kwok-Wah Ho, Edmund K Li, Martin Li, Lai-Wa Kwok, Priscilla C Wong, Tena K Li, Tracy Y Zhu, Emily W Kun and Lai-Shan Tam

    Citation: BMC Musculoskeletal Disorders 2014 15:284

    Content type: Research article

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  33. Arthritis pain is reported as one of the most common reasons for persons using medical herbal cannabis in North America. “Severe arthritis” is the condition justifying legal use of cannabis in over half of all...

    Authors: Mary-Ann Fitzcharles, Peter A Ste-Marie, Daniel J Clauw, Shahin Jamal, Jacob Karsh, Sharon LeClercq, Jason J McDougall, Yoram Shir, Kam Shojania and Zach Walsh

    Citation: BMC Musculoskeletal Disorders 2014 15:258

    Content type: Research article

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  34. Vitamin D is essential for calcium metabolism, Vitamin D deficiency can precipitate osteoporosis, cause muscle weakness and increase the risk of fracture. The aim of this study was to assess the prevalence of ...

    Authors: Jawl-Shan Hwang, Keh-Sung Tsai, Yuh-Min Cheng, Wen-Jer Chen, Shih-Te Tu, Ko-Hsiu Lu, Sheng-Mou Hou, Shu-Hua Yang, Henrich Cheng, Hung Jen Lai, Sharon Lei and Jung-Fu Chen

    Citation: BMC Musculoskeletal Disorders 2014 15:257

    Content type: Research article

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  35. KIR genes coding for natural killer cell immunoglobulin-like receptors, KIR, influence the effector and regulatory function of NK cells as well as some subpopulations of T lymphocytes (e.g. CD4+CD28-KIR+) depend...

    Authors: Edyta Majorczyk, Andrzej Pawlik, Daria Gendosz and Piotr Kuśnierczyk

    Citation: BMC Musculoskeletal Disorders 2014 15:256

    Content type: Research article

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  36. Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease mediated by T cells. The aim of the present study was to investigate the therapeutic efficacy of synthetic peptides (HP-R1, HP-R2 and HP-R3)...

    Authors: Xiao-Lian Shi, Li-Ping Wang, Xuan Feng, Dan-Dan Fan, Wei-Jin Zang, Bing Wang and Jun Zhou

    Citation: BMC Musculoskeletal Disorders 2014 15:253

    Content type: Research article

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  37. Rheumatoid arthritis (RA) is a chronic autoinflammatory joint disease which leads to the destruction of joints and disability of the patients. Anti-tumour necrosis factor (anti-TNF) drugs can halt radiological...

    Authors: Péter Juhász, Ádám Mester, Anna-Julianna Biró, Gábor Héjj and Gyula Poór

    Citation: BMC Musculoskeletal Disorders 2014 15:251

    Content type: Research article

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  38. To address both the growing burden of joint disease and the gaps in medical access in developing nations, medical relief organizations have begun to launch programs to perform total joint replacement (TJR) on ...

    Authors: Scott A Elman, Yan Dong, Derek S Stenquist, Roya Ghazinouri, Luis Alcantara, Jamie E Collins, Carolyn Beagan, Thomas S Thornhill and Jeffrey N Katz

    Citation: BMC Musculoskeletal Disorders 2014 15:207

    Content type: Research article

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  39. The aim of this study was to examine the clinical characteristics of rheumatoid arthritis (RA) patients who underwent cervical spine surgery using a multicenter observational database.

    Authors: Shurei Sugita, Hirotaka Chikuda, Yuho Kadono, Hiroshi Ohtsu, Katsushi Takeshita, Jinju Nishino, Shigeto Tohma and Sakae Tanaka

    Citation: BMC Musculoskeletal Disorders 2014 15:203

    Content type: Research article

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  40. Rituximab is a B cell depleting anti-CD20 monoclonal antibody. CD20 is not expressed on mature plasma cells and accordingly rituximab does not have immediate effects on immunoglobulin levels. However, after ri...

    Authors: Helena Marco, Rona M Smith, Rachel B Jones, Mary-Jane Guerry, Fausta Catapano, Stella Burns, Afzal N Chaudhry, Kenneth GC Smith and David RW Jayne

    Citation: BMC Musculoskeletal Disorders 2014 15:178

    Content type: Research article

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  41. As recommended in the current prescribing information, rituximab infusions in patients with rheumatoid arthritis (RA) take 4.25 hours for the first infusion and 3.25 hours for subsequent infusions, which is a ...

    Authors: Charles H Pritchard, Maria W Greenwald, Joel M Kremer, Norman B Gaylis, William Rigby, Steve Zlotnick, Carol Chung, Birgit Jaber and William Reiss

    Citation: BMC Musculoskeletal Disorders 2014 15:177

    Content type: Research article

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  42. Gout and hyperuricaemia may be associated with increased cardiovascular risk, but analyses in different populations show conflicting results. This study investigates the impact of serum uric acid, inflammation...

    Authors: Inger L Meek, Harald E Vonkeman and Mart AFJ van de Laar

    Citation: BMC Musculoskeletal Disorders 2014 15:174

    Content type: Research article

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  43. Comparative effectiveness research has recently attracted considerable attention. The C omparative E ffectiveness R egistry to study T herapies for A rthritis and I nflammatory Con ditions (CERTAIN) is an ongoing...

    Authors: Dimitrios A Pappas, Joel M Kremer, George Reed, Jeffrey D Greenberg and Jeffrey R Curtis

    Citation: BMC Musculoskeletal Disorders 2014 15:113

    Content type: Study protocol

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  44. Self-management of arthritis requires informed, activated patients to manage its physical and psychosocial consequences. Patient activation and self-management can be enhanced through the use of cognitive-beha...

    Authors: Emma Dures, Sarah Hewlett, Nicholas Ambler, Remona Jenkins, Joyce Clarke and Rachael Gooberman-Hill

    Citation: BMC Musculoskeletal Disorders 2014 15:108

    Content type: Research article

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  45. To measure the use, satisfaction and impact of a web portal which provides patients with rheumatoid arthritis home access to their electronic medical records (EMR).

    Authors: Rosalie van der Vaart, Constance HC Drossaert, Erik Taal, K Wiepke Drossaers-Bakker, Harald E Vonkeman and Mart AFJ van de Laar

    Citation: BMC Musculoskeletal Disorders 2014 15:102

    Content type: Research article

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  46. Matrix metalloproteinase-3 (MMP-3) plays an important role in the pathology of rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Measurement of active MMP-3 in clinical samples could provide informati...

    Authors: Shu Sun, Anne-Christine Bay-Jensen, Morten A Karsdal, Anne Sofie Siebuhr, Qinlong Zheng, Walter P Maksymowych, Thorbjørn G Christiansen and Kim Henriksen

    Citation: BMC Musculoskeletal Disorders 2014 15:93

    Content type: Research article

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  47. Subacromial impingement syndrome is the most frequent cause of shoulder problems which themselves affect 1 in 3 adults. Management commonly includes exercise and corticosteroid injection. However, the few exis...

    Authors: Edward Roddy, Irena Zwierska, Elaine M Hay, Sue Jowett, Martyn Lewis, Kay Stevenson, Danielle van der Windt and Nadine E Foster

    Citation: BMC Musculoskeletal Disorders 2014 15:81

    Content type: Study protocol

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