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Clinical rheumatology and osteoporosis

This section concerns all aspects of research into osteoporosis and rheumatic diseases, where the primary focus relates specifically to a component(s) of the musculoskeletal system

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  1. In 2004, we initiated an inception cohort of patients with recent-onset rheumatoid arthritis (RA). Hand function was incorporated into evaluations from 2014 onward. The objectives were to examine hand function...

    Authors: Ana K. Romero-Guzmán, Víctor M. Menchaca-Tapia, Irazú Contreras-Yáñez and Virginia Pascual-Ramos

    Citation: BMC Musculoskeletal Disorders 2016 17:392

    Content type: Research article

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  2. The distal radius is the most common osteoporotic fracture site occurring in postmenopausal women. Finite element (FE) modeling is a non-invasive mathematical technique that can estimate bone strength using in...

    Authors: C. E. Kawalilak, S. A. Kontulainen, M. A. Amini, J. L. Lanovaz, W. P. Olszynski and J. D. Johnston

    Citation: BMC Musculoskeletal Disorders 2016 17:389

    Content type: Research article

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  3. Several measurements are often used in daily clinical practice in the assessment of Ankylosing Spondylitis (AS) patients. The Assessment in SpondyloArthiritis International Society (ASAS) recommend in its core...

    Authors: J. Calvo-Gutiérrez, J. L. Garrido-Castro, C. González-Navas, M. C. Castro-Villegas, R. Ortega-Castro, C. López-Medina, P. Font-Ugalde, A. Escudero-Contreras and E. Collantes-Estévez

    Citation: BMC Musculoskeletal Disorders 2016 17:382

    Content type: Research article

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  4. Undiagnosed, or diagnosed and untreated osteoporosis (OP) increases the likelihood that falls result in hip fractures, decreased quality of life (QOL), and significant medical expenditures among older adults. ...

    Authors: Stephanie W. Edmonds, Peter Cram, Yiyue Lou, Michael P. Jones, Douglas W. Roblin, Kenneth G. Saag, Nicole C. Wright and Fredric D. Wolinsky

    Citation: BMC Musculoskeletal Disorders 2016 17:369

    Content type: Research article

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  5. Osteoporosis and osteoporotic fractures are widely known as complications of rheumatoid arthritis. Kyphoplasty (KP) is known as an effective treatment modality for reducing pain and correcting kyphotic deformi...

    Authors: Jihoon Shim, Kwanghyun Lee, Hunchul Kim, Byungjik Kang, Haewon Jeong and Chang-Nam Kang

    Citation: BMC Musculoskeletal Disorders 2016 17:365

    Content type: Research article

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  6. Methotrexate (MTX) is standard treatment for RA. Absorption is better in subcutaneous MTX (scMTX), which may impact speed of onset. In RA, earlier time to remission improves long-term results. Our objectives w...

    Authors: Anna O’Connor, Carter Thorne, Hyeon Kang, Diane Tin and Janet E. Pope

    Citation: BMC Musculoskeletal Disorders 2016 17:364

    Content type: Research article

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  7. To investigate the effect of baseline clinical characteristics and glucocorticoid treatment on temporal artery biopsy (TAB) findings in patients with giant cell arteritis (GCA).

    Authors: Karin Jakobsson, Lennart Jacobsson, Aladdin J. Mohammad, Jan-Åke Nilsson, Kenneth Warrington, Eric L. Matteson and Carl Turesson

    Citation: BMC Musculoskeletal Disorders 2016 17:363

    Content type: Research article

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  8. African Americans bear a disproportionate burden of osteoarthritis (OA), with higher prevalence rates, more severe pain, and more functional limitations. One key barrier to addressing these disparities has bee...

    Authors: Leah A. Schrubbe, Scott G. Ravyts, Bernadette C. Benas, Lisa C. Campbell, Crystal W. Cené, Cynthia J. Coffman, Alexander H. Gunn, Francis J. Keefe, Caroline T. Nagle, Eugene Z. Oddone, Tamara J. Somers, Catherine L. Stanwyck, Shannon S. Taylor and Kelli D. Allen

    Citation: BMC Musculoskeletal Disorders 2016 17:359

    Content type: Study protocol

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  9. Anti-Tumor Necrosis Factor (TNF) therapies are able to control rheumatoid arthritis (RA) disease activity and limit structural damage. Yet no predictive factor of response to anti-TNF has been identified. Meta...

    Authors: Zuzana Tatar, Carole Migne, Melanie Petera, Philippe Gaudin, Thierry Lequerre, Hubert Marotte, Jacques Tebib, Estelle Pujos Guillot and Martin Soubrier

    Citation: BMC Musculoskeletal Disorders 2016 17:353

    Content type: Research article

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  10. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint structural deterioration. Driven by recent expectations that patients in clinical trials randomized to placebo ...

    Authors: Jeroen P. Jansen, Maria-Cecilia Vieira, John D. Bradley, Joseph C. Cappelleri, Samuel H. Zwillich and Gene V. Wallenstein

    Citation: BMC Musculoskeletal Disorders 2016 17:348

    Content type: Research article

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  11. To report the predictive value of nail-fold capillaroscopy (NFC) patterns of vasculopathy for systemic sclerosis (Scleroderma; SSc) in an unselected cohort of patients with Raynaud’s phenomenon (RP).

    Authors: Lesley-Anne Bissell, Giuseppina Abignano, Paul Emery, Francesco Del Galdo and Maya H. Buch

    Citation: BMC Musculoskeletal Disorders 2016 17:342

    Content type: Research article

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  12. The concerns about the development of adverse events (AEs) in elderly RA patients as a result of age-related changes in drug metabolism and the presence of comorbid illnesses are emphasizing due to increasing ...

    Authors: Soo-Kyung Cho, Yoon-Kyoung Sung, Dam Kim, Soyoung Won, Chan-Bum Choi, Tae-Hwan Kim, Jae-Bum Jun, Dae-Hyun Yoo and Sang-Cheol Bae

    Citation: BMC Musculoskeletal Disorders 2016 17:333

    Content type: Research article

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  13. Case reports have linked adult hypophosphatasia as a possible cause of atypical femur fractures (AFF) associated with bisphosphonate use. Adult hypophosphatasia is an asymptomatic genetic condition which resul...

    Authors: Timothy Bhattacharyya, Smita Jha, Hongying Wang, Daniel L. Kastner and Elaine F. Remmers

    Citation: BMC Musculoskeletal Disorders 2016 17:332

    Content type: Research article

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  14. Treatment with non-steroidal anti-inflammatory drugs (NSAID) is a common component of treatment regimens for rheumatoid arthritis (RA). Etoricoxib is a COX-2 selective NSAID that has demonstrated efficacy in t...

    Authors: Kara Bickham, Alan J. Kivitz, Anish Mehta, Nancy Frontera, Sandhya Shah, Paul Stryszak, Zoran Popmihajlov and Paul M. Peloso

    Citation: BMC Musculoskeletal Disorders 2016 17:331

    Content type: Research article

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  15. There is evidence that postmenopausal women with rheumatoid arthritis (RA) on glucocorticoid (GC) therapy and bisphosphonate (BP) have an increased risk for atypical subtrochanteric and atypical diaphyseal fem...

    Authors: Rahel Meinen, Inna Galli-Lysak, Peter M. Villiger and Daniel Aeberli

    Citation: BMC Musculoskeletal Disorders 2016 17:324

    Content type: Research article

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  16. Infections are a common complication of RA with associated morbidity and mortality. The aetiology of increased risk is complex and multifactorial. Despite this, strategies to mitigate against risk of infection...

    Authors: Sujith Subesinghe, Andrew Ian Rutherford, Fowzia Ibrahim, Helen Harris and James Galloway

    Citation: BMC Musculoskeletal Disorders 2016 17:322

    Content type: Research article

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  17. Juvenile idiopathic arthritis (JIA) refers to a number of rare chronic inflammatory diseases. Although JIA imposes a significant societal burden, limited data are available on the cost of JIA. The study’s obje...

    Authors: Aris Angelis, Panos Kanavos, Julio López-Bastida, Renata Linertová and Pedro Serrano-Aguilar

    Citation: BMC Musculoskeletal Disorders 2016 17:321

    Content type: Research article

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  18. Accelerated knee osteoarthritis may be a unique subset of knee osteoarthritis, which is associated with greater knee pain and disability. Identifying risk factors for accelerated knee osteoarthritis is vital t...

    Authors: Jeffrey B. Driban, Alina C. Stout, Jeffrey Duryea, Grace H. Lo, William F. Harvey, Lori Lyn Price, Robert J. Ward, Charles B. Eaton, Mary F. Barbe, Bing Lu and Timothy E. McAlindon

    Citation: BMC Musculoskeletal Disorders 2016 17:299

    Content type: Research article

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  19. Glucocorticoids (GCs), such as prednisone, are the standard of care for several inflammatory and immunologically mediated diseases, but their chronic systemic administration is severely limited by serious adve...

    Authors: Dona L. Fleishaker, Arnab Mukherjee, Fredrick S. Whaley, Shanthini Daniel and Bernhardt G. Zeiher

    Citation: BMC Musculoskeletal Disorders 2016 17:293

    Content type: Research article

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  20. Patients with painful knee osteoarthritis (OA) demonstrate hyperalgesia and altered pain-modulatory responses. While some prior work has demonstrated cross-sectional associations between laboratory and clinica...

    Authors: Robert R. Edwards, Andrew J. Dolman, Marc. O. Martel, Patrick H. Finan, Asimina Lazaridou, Marise Cornelius and Ajay D. Wasan

    Citation: BMC Musculoskeletal Disorders 2016 17:284

    Content type: Research article

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  21. Osteoporosis is a well-known complication of ankylosing spondylitis (AS). However, data about body composition modifications and muscle performance showed conflicting results. The aim of the study was to deter...

    Authors: Abdellah El Maghraoui, François Bertin Ebo’o, Siham Sadni, Abderrahim Majjad, Toufik Hamza and Aziza Mounach

    Citation: BMC Musculoskeletal Disorders 2016 17:268

    Content type: Research article

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  22. The National Institute for Health and Care Excellence’s Osteoarthritis (OA) guidelines recommended that future research should consider the benefits of combination therapies in people with OA across multiple j...

    Authors: Andrew Finney, Emma Healey, Joanne L. Jordan, Sarah Ryan and Krysia S. Dziedzic

    Citation: BMC Musculoskeletal Disorders 2016 17:266

    Content type: Research article

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  23. The FRAX® tool estimates the risk of a fragility fracture among the population and many countries have been evaluating its performance among their populations since its creation in 2007.

    Authors: Rafael Azagra, Marta Zwart, Gloria Encabo, Amada Aguyé, Juan Carlos Martin-Sánchez, Nuria Puchol-Ruiz, Paula Gabriel-Escoda, Sergio Ortiz-Alinque, Emilio Gené, Milagros Iglesias, David Moriña, Miguel Angel Diaz-Herrera, Mireia Utzet and Josep Maria Manresa

    Citation: BMC Musculoskeletal Disorders 2016 17:262

    Content type: Research article

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  24. Both gravitational loading and the forces generated by muscle contraction have direct effects on serum markers of bone metabolism. The object of this study was to examine the direct effects of a single session...

    Authors: Gabriella Császárné Gombos, Viktória Bajsz, Emese Pék, Béla Schmidt, Eszter Sió, Bálint Molics and József Betlehem

    Citation: BMC Musculoskeletal Disorders 2016 17:254

    Content type: Research article

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  25. Gel-200 is a cross-linked hyaluronate single-injection device for treatment of osteoarthritis pain in the knee. This report summarizes new analyses of the safety of retreatment with Gel-200 from the 13-week, p...

    Authors: Vibeke Strand, Sooyeol Lim and Junko Takamura

    Citation: BMC Musculoskeletal Disorders 2016 17:240

    Content type: Research article

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  26. Patients with rheumatoid arthritis (RA), including those treated with biologics, are at increased risk of some vaccine-preventable infections. We evaluated the antibody response to standard 23-valent pneumococ...

    Authors: Rieke Alten, Clifton O. Bingham III, Stanley B. Cohen, Jeffrey R. Curtis, Sheila Kelly, Dennis Wong and Mark C. Genovese

    Citation: BMC Musculoskeletal Disorders 2016 17:231

    Content type: Research article

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  27. This study aimed to assess the accuracy of the Short-Form Health Survey (SF-36) mental health subscale (MH) and mental component summary (MCS) scores in identifying the presence of probable major depressive or...

    Authors: Faith Matcham, Sam Norton, Sophia Steer and Matthew Hotopf

    Citation: BMC Musculoskeletal Disorders 2016 17:224

    Content type: Research article

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  28. Activated platelets release serotonin that binds 5-HT2B receptor on fibroblasts leading to fibroblast activation. Clopidogrel, an inhibitor of ADP-dependent platelet activation prevents fibrosis in animal models ...

    Authors: Konstantinos Ntelis, Vasileios Gkizas, Alexandra Filippopoulou, Periclis Davlouros, Dimitrios Alexopoulos, Andrew P. Andonopoulos and Dimitrios Daoussis

    Citation: BMC Musculoskeletal Disorders 2016 17:213

    Content type: Research article

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  29. Advanced osteoarthritis and total joint replacement (TJR) recovery are painful experiences and often prompt opioid use in developed countries. Physicians participating in the philanthropic medical mission Oper...

    Authors: Amy Yu, Christopher A. Devine, Rachel G. Kasdin, Mónica Orizondo, Wendy Perdomo, Aileen M. Davis, Laura M. Bogart and Jeffrey N. Katz

    Citation: BMC Musculoskeletal Disorders 2016 17:211

    Content type: Research article

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  30. Interleukin-17 plays important role in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to examine the associations between polymorphisms in the IL17A and IL17F genes and RA.

    Authors: Andrzej Pawlik, Daniel Kotrych, Damian Malinowski, Violetta Dziedziejko, Michal Czerewaty and Krzysztof Safranow

    Citation: BMC Musculoskeletal Disorders 2016 17:208

    Content type: Research article

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  31. Peptidylarginine deiminase type 4 (PADI4) has been identified as a susceptibility gene for rheumatoid arthritis (RA) by genome-wide association studies. PADI4 is highly expressed in the bone marrow, macrophage...

    Authors: Akari Suzuki, Yuta Kochi, Hirofumi Shoda, Yu Seri, Keishi Fujio, Tetsuji Sawada, Ryo Yamada and Kazuhiko Yamamoto

    Citation: BMC Musculoskeletal Disorders 2016 17:205

    Content type: Research article

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  32. Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed for elderly patients, particularly after a hip fracture. However, we are not clear about the effect of NSAIDs on the risk of a second hi...

    Authors: Po-Yao Chuang, Shih-Hsun Shen, Tien-Yu Yang, Tsan-Wen Huang and Kuo-Chin Huang

    Citation: BMC Musculoskeletal Disorders 2016 17:201

    Content type: Research article

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  33. A substantial portion of women diagnosed with osteoporosis (OP) do not initiate pharmacotherapy to reduce fracture risk. In clinical practice, gastrointestinal (GI) events have been linked with OP therapy disc...

    Authors: Bernard Cortet, Ankita Modi, Jackson Tang, Chun-Po Steve Fan, Shiva Sajjan and Jessica Papadopoulos Weaver

    Citation: BMC Musculoskeletal Disorders 2016 17:195

    Content type: Research article

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  34. We examined the effects of fat deposition on radiographic osteoarthritis (OA) to determine the role of obesity in the pathogenesis of radiographic OA.

    Authors: Lihui Wen, Ji-Hyoun Kang, Yi-Rang Yim, Ji-Eun Kim, Jeong-Won Lee, Kyung-Eun Lee, Dong-Jin Park, Tae-Jong Kim, Yong-Wook Park, Sun-Seog Kweon, Young-Hoon Lee, Yong-Woon Yun, Min-Ho Shin and Shin-Seok Lee

    Citation: BMC Musculoskeletal Disorders 2016 17:192

    Content type: Research article

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  35. Previous studies showed that among persons with radiographic knee OA, periarticular lesions were significantly more common among participants with knee pain than those without. However, data were derived mostl...

    Authors: In Je Kim, Dong Hyun Kim, Yeoung Wook Song, Ali Guermazi, Michel D. Crema, David J. Hunter, Young-Il Seo and Hyun Ah Kim

    Citation: BMC Musculoskeletal Disorders 2016 17:186

    Content type: Research article

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  36. Adjacent fracture of the cemented vertebrae result from crushed fragile trabeculae during follow-up, suggesting impaired bone marrow integrity. This study aimed to determine if anti-osteoporotic therapy can de...

    Authors: Ying-Chou Chen and Wei-Che Lin

    Citation: BMC Musculoskeletal Disorders 2016 17:151

    Content type: Research article

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  37. The advent of Internet and World Wide Web has created new perspectives toward interaction between patients and healthcare professionals. Telemonitoring patients with rheumatoid arthritis (RA) is an emerging co...

    Authors: Fausto Salaffi, Marina Carotti, Alessandro Ciapetti, Marco Di Carlo, Stefania Gasparini, Sonia Farah and Marwin Gutierrez

    Citation: BMC Musculoskeletal Disorders 2016 17:146

    Content type: Research article

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  38. The mechanism for hip pain has been unclear because of a lack of experimental animal models. We aimed to establish an intra-articular injection technique to the rat hip and to document the effect of intra-arti...

    Authors: Shuichi Miyamoto, Junichi Nakamura, Seiji Ohtori, Sumihisa Orita, Takanori Omae, Takayuki Nakajima, Takane Suzuki and Kazuhisa Takahashi

    Citation: BMC Musculoskeletal Disorders 2016 17:132

    Content type: Research article

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  39. Self-management of inflammatory arthritis (IA) requires patients to address the impact of symptoms, treatment, and the psychosocial consequences of a long term condition. There are several possible mechanisms ...

    Authors: Emma Dures, Sarah Hewlett, Nicholas Ambler, Remona Jenkins, Joyce Clarke and Rachael Gooberman-Hill

    Citation: BMC Musculoskeletal Disorders 2016 17:129

    Content type: Research article

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  40. To evaluate the clinical outcomes of a group of patients affected by knee osteoarthritis (OA) treated with MD-Knee (Guna S.p.a., Milan, Italy) versus a group of patients treated with sodium hyaluronate.

    Authors: Luis Severino Martin Martin, Umberto Massafra, Emanuele Bizzi and Alberto Migliore

    Citation: BMC Musculoskeletal Disorders 2016 17:94

    Content type: Research article

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  41. Dual-energy computed tomography (DECT) is a new diagnostic tool for gout, but its sensitivity has not been established. Our goal was to assess the sensitivity of DECT for the detection of monosodium urate (MSU...

    Authors: Alan N. Baer, Tracie Kurano, Uma J. Thakur, Gaurav K. Thawait, Matthew K. Fuld, Janet W. Maynard, Mara McAdams-DeMarco, Elliot K. Fishman and John A. Carrino

    Citation: BMC Musculoskeletal Disorders 2016 17:91

    Content type: Research article

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  42. Zoledronic acid-induced uveitis (ZAIU) is rare but severe, and has been recently considered part of an acute phase reaction. Only 15 cases have been reported since 2005. Here we describe a case with macular ed...

    Authors: Yiming Tian, Rui Wang, Lianyuan Liu, Chunming Ma, Qiang Lu and Fuzai Yin

    Citation: BMC Musculoskeletal Disorders 2016 17:72

    Content type: Case report

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  43. The aim of this review was to qualitatively synthesise studies that have investigated characteristics of the first metatarsophalangeal joint (1st MTP) in gout and to undertake a meta-analysis to estimate the aver...

    Authors: Sarah Stewart, Nicola Dalbeth, Alain C. Vandal and Keith Rome

    Citation: BMC Musculoskeletal Disorders 2016 17:69

    Content type: Research article

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  44. Improvements in knee osteoarthritis (OA) symptoms with platelet-rich plasma (PRP) have been attributed to its ability to modify intra-articular inflammatory processes. Photo-activation of peripheral blood also...

    Authors: Kade L. Paterson, Melissa Nicholls, Kim L. Bennell and Dan Bates

    Citation: BMC Musculoskeletal Disorders 2016 17:67

    Content type: Research article

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  45. Authors: Benjamin A. Fisher, Alison J. Cartwright, Anne-Marie Quirke, Paola de Pablo, Dora Romaguera, Salvatore Panico, Amalia Mattiello, Diana Gavrila, Carmen Navarro, Carlotta Sacerdote, Paolo Vineis, Rosario Tumino, David F. Lappin, Danae Apatzidou, Shauna Culshaw, Jan Potempa…

    Citation: BMC Musculoskeletal Disorders 2016 17:62

    Content type: Erratum

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    The original article was published in BMC Musculoskeletal Disorders 2015 16:331

  46. Rheumatoid arthritis (RA) is a chronic inflammatory arthritis, with significant impact on quality of life and functional status. Whilst biologic disease modifying anti-rheumatic drugs (bDMARD) such as tumour n...

    Authors: Raluca B. Dumitru, Sarah Horton, Richard Hodgson, Richard J. Wakefield, Elizabeth M. A. Hensor, Paul Emery and Maya H. Buch

    Citation: BMC Musculoskeletal Disorders 2016 17:61

    Content type: Study protocol

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  47. Fatigue is a prominent symptom in persons with rheumatoid arthritis (RA). Although this symptom has been described to vary in duration and frequency little is known about fluctuations in fatigue over time and ...

    Authors: Caroline Feldthusen, Anna Grimby-Ekman, Helena Forsblad-d’Elia, Lennart Jacobsson and Kaisa Mannerkorpi

    Citation: BMC Musculoskeletal Disorders 2016 17:59

    Content type: Research article

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  48. Rheumatoid arthritis (RA) treatment paradigms have shifted over the last two decades. There has been increasing emphasis on combination disease modifying anti-rheumatic drug (DMARD) therapy, newer biologic the...

    Authors: Aneela N Mian, Fowzia Ibrahim, Ian C Scott, Sardar Bahadur, Maria Filkova, Louise Pollard, Sophia Steer, Gabrielle H Kingsley, David L Scott and James Galloway

    Citation: BMC Musculoskeletal Disorders 2016 17:44

    Content type: Research article

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