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Clinical rheumatology and osteoporosis

This section concerns all aspects of research into osteoporosis and rheumatic diseases, where the primary focus relates specifically to a component(s) of the musculoskeletal system

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  1. Content type: Research article

    Accelerated knee osteoarthritis may be a unique subset of knee osteoarthritis, which is associated with greater knee pain and disability. Identifying risk factors for accelerated knee osteoarthritis is vital t...

    Authors: Jeffrey B. Driban, Alina C. Stout, Jeffrey Duryea, Grace H. Lo, William F. Harvey, Lori Lyn Price, Robert J. Ward, Charles B. Eaton, Mary F. Barbe, Bing Lu and Timothy E. McAlindon

    Citation: BMC Musculoskeletal Disorders 2016 17:299

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  2. Content type: Research article

    Glucocorticoids (GCs), such as prednisone, are the standard of care for several inflammatory and immunologically mediated diseases, but their chronic systemic administration is severely limited by serious adve...

    Authors: Dona L. Fleishaker, Arnab Mukherjee, Fredrick S. Whaley, Shanthini Daniel and Bernhardt G. Zeiher

    Citation: BMC Musculoskeletal Disorders 2016 17:293

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  3. Content type: Research article

    Patients with painful knee osteoarthritis (OA) demonstrate hyperalgesia and altered pain-modulatory responses. While some prior work has demonstrated cross-sectional associations between laboratory and clinica...

    Authors: Robert R. Edwards, Andrew J. Dolman, Marc. O. Martel, Patrick H. Finan, Asimina Lazaridou, Marise Cornelius and Ajay D. Wasan

    Citation: BMC Musculoskeletal Disorders 2016 17:284

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  4. Content type: Research article

    Osteoporosis is a well-known complication of ankylosing spondylitis (AS). However, data about body composition modifications and muscle performance showed conflicting results. The aim of the study was to deter...

    Authors: Abdellah El Maghraoui, François Bertin Ebo’o, Siham Sadni, Abderrahim Majjad, Toufik Hamza and Aziza Mounach

    Citation: BMC Musculoskeletal Disorders 2016 17:268

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  5. Content type: Research article

    The National Institute for Health and Care Excellence’s Osteoarthritis (OA) guidelines recommended that future research should consider the benefits of combination therapies in people with OA across multiple j...

    Authors: Andrew Finney, Emma Healey, Joanne L. Jordan, Sarah Ryan and Krysia S. Dziedzic

    Citation: BMC Musculoskeletal Disorders 2016 17:266

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  6. Content type: Research article

    The FRAX® tool estimates the risk of a fragility fracture among the population and many countries have been evaluating its performance among their populations since its creation in 2007.

    Authors: Rafael Azagra, Marta Zwart, Gloria Encabo, Amada Aguyé, Juan Carlos Martin-Sánchez, Nuria Puchol-Ruiz, Paula Gabriel-Escoda, Sergio Ortiz-Alinque, Emilio Gené, Milagros Iglesias, David Moriña, Miguel Angel Diaz-Herrera, Mireia Utzet and Josep Maria Manresa

    Citation: BMC Musculoskeletal Disorders 2016 17:262

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  7. Content type: Research article

    Both gravitational loading and the forces generated by muscle contraction have direct effects on serum markers of bone metabolism. The object of this study was to examine the direct effects of a single session...

    Authors: Gabriella Császárné Gombos, Viktória Bajsz, Emese Pék, Béla Schmidt, Eszter Sió, Bálint Molics and József Betlehem

    Citation: BMC Musculoskeletal Disorders 2016 17:254

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  8. Content type: Research article

    Gel-200 is a cross-linked hyaluronate single-injection device for treatment of osteoarthritis pain in the knee. This report summarizes new analyses of the safety of retreatment with Gel-200 from the 13-week, p...

    Authors: Vibeke Strand, Sooyeol Lim and Junko Takamura

    Citation: BMC Musculoskeletal Disorders 2016 17:240

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  9. Content type: Research article

    Patients with rheumatoid arthritis (RA), including those treated with biologics, are at increased risk of some vaccine-preventable infections. We evaluated the antibody response to standard 23-valent pneumococ...

    Authors: Rieke Alten, Clifton O. Bingham III, Stanley B. Cohen, Jeffrey R. Curtis, Sheila Kelly, Dennis Wong and Mark C. Genovese

    Citation: BMC Musculoskeletal Disorders 2016 17:231

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  10. Content type: Research article

    This study aimed to assess the accuracy of the Short-Form Health Survey (SF-36) mental health subscale (MH) and mental component summary (MCS) scores in identifying the presence of probable major depressive or...

    Authors: Faith Matcham, Sam Norton, Sophia Steer and Matthew Hotopf

    Citation: BMC Musculoskeletal Disorders 2016 17:224

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  11. Content type: Research article

    Advanced osteoarthritis and total joint replacement (TJR) recovery are painful experiences and often prompt opioid use in developed countries. Physicians participating in the philanthropic medical mission Oper...

    Authors: Amy Yu, Christopher A. Devine, Rachel G. Kasdin, Mónica Orizondo, Wendy Perdomo, Aileen M. Davis, Laura M. Bogart and Jeffrey N. Katz

    Citation: BMC Musculoskeletal Disorders 2016 17:211

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  12. Content type: Research article

    Activated platelets release serotonin that binds 5-HT2B receptor on fibroblasts leading to fibroblast activation. Clopidogrel, an inhibitor of ADP-dependent platelet activation prevents fibrosis in animal models ...

    Authors: Konstantinos Ntelis, Vasileios Gkizas, Alexandra Filippopoulou, Periclis Davlouros, Dimitrios Alexopoulos, Andrew P. Andonopoulos and Dimitrios Daoussis

    Citation: BMC Musculoskeletal Disorders 2016 17:213

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  13. Content type: Research article

    Interleukin-17 plays important role in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to examine the associations between polymorphisms in the IL17A and IL17F genes and RA.

    Authors: Andrzej Pawlik, Daniel Kotrych, Damian Malinowski, Violetta Dziedziejko, Michal Czerewaty and Krzysztof Safranow

    Citation: BMC Musculoskeletal Disorders 2016 17:208

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  14. Content type: Research article

    Peptidylarginine deiminase type 4 (PADI4) has been identified as a susceptibility gene for rheumatoid arthritis (RA) by genome-wide association studies. PADI4 is highly expressed in the bone marrow, macrophage...

    Authors: Akari Suzuki, Yuta Kochi, Hirofumi Shoda, Yu Seri, Keishi Fujio, Tetsuji Sawada, Ryo Yamada and Kazuhiko Yamamoto

    Citation: BMC Musculoskeletal Disorders 2016 17:205

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  15. Content type: Research article

    Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed for elderly patients, particularly after a hip fracture. However, we are not clear about the effect of NSAIDs on the risk of a second hi...

    Authors: Po-Yao Chuang, Shih-Hsun Shen, Tien-Yu Yang, Tsan-Wen Huang and Kuo-Chin Huang

    Citation: BMC Musculoskeletal Disorders 2016 17:201

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  16. Content type: Research article

    A substantial portion of women diagnosed with osteoporosis (OP) do not initiate pharmacotherapy to reduce fracture risk. In clinical practice, gastrointestinal (GI) events have been linked with OP therapy disc...

    Authors: Bernard Cortet, Ankita Modi, Jackson Tang, Chun-Po Steve Fan, Shiva Sajjan and Jessica Papadopoulos Weaver

    Citation: BMC Musculoskeletal Disorders 2016 17:195

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  17. Content type: Research article

    We examined the effects of fat deposition on radiographic osteoarthritis (OA) to determine the role of obesity in the pathogenesis of radiographic OA.

    Authors: Lihui Wen, Ji-Hyoun Kang, Yi-Rang Yim, Ji-Eun Kim, Jeong-Won Lee, Kyung-Eun Lee, Dong-Jin Park, Tae-Jong Kim, Yong-Wook Park, Sun-Seog Kweon, Young-Hoon Lee, Yong-Woon Yun, Min-Ho Shin and Shin-Seok Lee

    Citation: BMC Musculoskeletal Disorders 2016 17:192

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  18. Content type: Research article

    Previous studies showed that among persons with radiographic knee OA, periarticular lesions were significantly more common among participants with knee pain than those without. However, data were derived mostl...

    Authors: In Je Kim, Dong Hyun Kim, Yeoung Wook Song, Ali Guermazi, Michel D. Crema, David J. Hunter, Young-Il Seo and Hyun Ah Kim

    Citation: BMC Musculoskeletal Disorders 2016 17:186

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  19. Content type: Research article

    Adjacent fracture of the cemented vertebrae result from crushed fragile trabeculae during follow-up, suggesting impaired bone marrow integrity. This study aimed to determine if anti-osteoporotic therapy can de...

    Authors: Ying-Chou Chen and Wei-Che Lin

    Citation: BMC Musculoskeletal Disorders 2016 17:151

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  20. Content type: Research article

    The advent of Internet and World Wide Web has created new perspectives toward interaction between patients and healthcare professionals. Telemonitoring patients with rheumatoid arthritis (RA) is an emerging co...

    Authors: Fausto Salaffi, Marina Carotti, Alessandro Ciapetti, Marco Di Carlo, Stefania Gasparini, Sonia Farah and Marwin Gutierrez

    Citation: BMC Musculoskeletal Disorders 2016 17:146

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  21. Content type: Research article

    The mechanism for hip pain has been unclear because of a lack of experimental animal models. We aimed to establish an intra-articular injection technique to the rat hip and to document the effect of intra-arti...

    Authors: Shuichi Miyamoto, Junichi Nakamura, Seiji Ohtori, Sumihisa Orita, Takanori Omae, Takayuki Nakajima, Takane Suzuki and Kazuhisa Takahashi

    Citation: BMC Musculoskeletal Disorders 2016 17:132

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  22. Content type: Research article

    Self-management of inflammatory arthritis (IA) requires patients to address the impact of symptoms, treatment, and the psychosocial consequences of a long term condition. There are several possible mechanisms ...

    Authors: Emma Dures, Sarah Hewlett, Nicholas Ambler, Remona Jenkins, Joyce Clarke and Rachael Gooberman-Hill

    Citation: BMC Musculoskeletal Disorders 2016 17:129

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  23. Content type: Research article

    To evaluate the clinical outcomes of a group of patients affected by knee osteoarthritis (OA) treated with MD-Knee (Guna S.p.a., Milan, Italy) versus a group of patients treated with sodium hyaluronate.

    Authors: Luis Severino Martin Martin, Umberto Massafra, Emanuele Bizzi and Alberto Migliore

    Citation: BMC Musculoskeletal Disorders 2016 17:94

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  24. Content type: Research article

    Dual-energy computed tomography (DECT) is a new diagnostic tool for gout, but its sensitivity has not been established. Our goal was to assess the sensitivity of DECT for the detection of monosodium urate (MSU...

    Authors: Alan N. Baer, Tracie Kurano, Uma J. Thakur, Gaurav K. Thawait, Matthew K. Fuld, Janet W. Maynard, Mara McAdams-DeMarco, Elliot K. Fishman and John A. Carrino

    Citation: BMC Musculoskeletal Disorders 2016 17:91

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  25. Content type: Research article

    The aim of this review was to qualitatively synthesise studies that have investigated characteristics of the first metatarsophalangeal joint (1st MTP) in gout and to undertake a meta-analysis to estimate the aver...

    Authors: Sarah Stewart, Nicola Dalbeth, Alain C. Vandal and Keith Rome

    Citation: BMC Musculoskeletal Disorders 2016 17:69

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  26. Content type: Case report

    Zoledronic acid-induced uveitis (ZAIU) is rare but severe, and has been recently considered part of an acute phase reaction. Only 15 cases have been reported since 2005. Here we describe a case with macular ed...

    Authors: Yiming Tian, Rui Wang, Lianyuan Liu, Chunming Ma, Qiang Lu and Fuzai Yin

    Citation: BMC Musculoskeletal Disorders 2016 17:72

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  27. Content type: Research article

    Improvements in knee osteoarthritis (OA) symptoms with platelet-rich plasma (PRP) have been attributed to its ability to modify intra-articular inflammatory processes. Photo-activation of peripheral blood also...

    Authors: Kade L. Paterson, Melissa Nicholls, Kim L. Bennell and Dan Bates

    Citation: BMC Musculoskeletal Disorders 2016 17:67

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  28. Content type: Study protocol

    Rheumatoid arthritis (RA) is a chronic inflammatory arthritis, with significant impact on quality of life and functional status. Whilst biologic disease modifying anti-rheumatic drugs (bDMARD) such as tumour n...

    Authors: Raluca B. Dumitru, Sarah Horton, Richard Hodgson, Richard J. Wakefield, Elizabeth M. A. Hensor, Paul Emery and Maya H. Buch

    Citation: BMC Musculoskeletal Disorders 2016 17:61

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  29. Content type: Erratum

    Authors: Benjamin A. Fisher, Alison J. Cartwright, Anne-Marie Quirke, Paola de Pablo, Dora Romaguera, Salvatore Panico, Amalia Mattiello, Diana Gavrila, Carmen Navarro, Carlotta Sacerdote, Paolo Vineis, Rosario Tumino, David F. Lappin, Danae Apatzidou, Shauna Culshaw, Jan Potempa…

    Citation: BMC Musculoskeletal Disorders 2016 17:62

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    The original article was published in BMC Musculoskeletal Disorders 2015 16:331

  30. Content type: Research article

    Fatigue is a prominent symptom in persons with rheumatoid arthritis (RA). Although this symptom has been described to vary in duration and frequency little is known about fluctuations in fatigue over time and ...

    Authors: Caroline Feldthusen, Anna Grimby-Ekman, Helena Forsblad-d’Elia, Lennart Jacobsson and Kaisa Mannerkorpi

    Citation: BMC Musculoskeletal Disorders 2016 17:59

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  31. Content type: Research article

    Rheumatoid arthritis (RA) treatment paradigms have shifted over the last two decades. There has been increasing emphasis on combination disease modifying anti-rheumatic drug (DMARD) therapy, newer biologic the...

    Authors: Aneela N Mian, Fowzia Ibrahim, Ian C Scott, Sardar Bahadur, Maria Filkova, Louise Pollard, Sophia Steer, Gabrielle H Kingsley, David L Scott and James Galloway

    Citation: BMC Musculoskeletal Disorders 2016 17:44

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  32. Content type: Research article

    Fibroblast proliferation is a common manifestation of chronic inflammatory diseases, including rheumatoid arthritis (RA), Crohn’s disease and ulcerative colitis, etc. To alleviate patient suffering, the mechan...

    Authors: Zheng-de Xi, Chang-yi Xie and Ye-bin Xi

    Citation: BMC Musculoskeletal Disorders 2016 17:43

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  33. Content type: Research article

    Little is known on how well targeted treatment, for instance targeting towards low DAS, is implemented in clinical practice. Our aim was to evaluate treatment adjustments in response to DAS in RA patients in c...

    Authors: Emilia Gvozdenović, Ron Wolterbeek, Désirée van der Heijde, Tom Huizinga, Cornelia Allaart and Robert Landewé

    Citation: BMC Musculoskeletal Disorders 2016 17:33

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  34. Content type: Research article

    Trabecular bone score (TBS), which has been proposed to be used in complementary with bone mineral density (BMD) to improve the assessment of fracture risk, is negatively associated with body mass index (BMI)....

    Authors: Sasithorn Amnuaywattakorn, Chanika Sritara, Chirawat Utamakul, Wichana Chamroonrat, Arpakorn Kositwattanarerk, Kanungnij Thamnirat and Boonsong Ongphiphadhanakul

    Citation: BMC Musculoskeletal Disorders 2016 17:17

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  35. Content type: Research article

    Primary Sjögren syndrome (pSS) is a common autoimmune condition which primarily affects epithelial tissue, often including the kidney causing either tubulointerstitial nephritis (TIN) or more rarely, an immune...

    Authors: Rhys D. R. Evans, Christopher M. Laing, Coziana Ciurtin and Stephen B. Walsh

    Citation: BMC Musculoskeletal Disorders 2016 17:2

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  36. Content type: Research article

    To investigate and compare the impact of primary hip (THA) and knee (TKA) arthroplasty on quality of life in patients with osteoarthritis, to determine patients’ satisfaction with total joint arthroplasty, and...

    Authors: Zoe H. Dailiana, Ippolyti Papakostidou, Sokratis Varitimidis, Lycurgos Liaropoulos, Elias Zintzaras, Theofilos Karachalios, Emmanuel Michelinakis and Konstantinos N. Malizos

    Citation: BMC Musculoskeletal Disorders 2015 16:366

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  37. Content type: Research article

    Recommendations for rheumatology nursing management of chronic inflammatory arthritis (CIA) from European League Against Rheumatism (EULAR) states that nurses should take part in the monitoring patients’ disea...

    Authors: Ingrid Larsson, Bengt Fridlund, Barbro Arvidsson, Annika Teleman, Petra Svedberg and Stefan Bergman

    Citation: BMC Musculoskeletal Disorders 2015 16:354

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  38. Content type: Research article

    Antibodies to citrullinated proteins (ACPA) occur years before RA diagnosis. Porphyromonas gingivalis expresses its own peptidylarginine deiminase (PPAD), and is a proposed aetiological factor for the ACPA respon...

    Authors: Benjamin A. Fisher, Alison J. Cartwright, Anne-Marie Quirke, Paola de Pablo, Dora Romaguera, Salvatore Panico, Amalia Mattiello, Diana Gavrila, Carmen Navarro, Carlotta Sacerdote, Paolo Vineis, Rosario Tumino, David F. Lappin, Danae Apazidou, Shauna Culshaw, Jan Potempa…

    Citation: BMC Musculoskeletal Disorders 2015 16:331

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    The Erratum to this article has been published in BMC Musculoskeletal Disorders 2016 17:62

  39. Content type: Research article

    To measure circulating anti-citrullinated peptide antibodies (ACPA) and cytokines pre- and 6 months post-therapy as a strategy to predict and optimize responses to traditional disease-modifying antirheumatic d...

    Authors: Mahmood M. T. M. Ally, Bridget Hodkinson, Pieter W. A. Meyer, Eustasius Musenge, Gregory R. Tintinger, Mohammed Tikly and Ronald Anderson

    Citation: BMC Musculoskeletal Disorders 2015 16:130

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  40. Content type: Research article

    Osteoarthritis is thought to be the most prevalent chronic and disabling joint disease in animals and humans and its treatment is a major orthopaedic challenge because there is no ideal drug treatment to prese...

    Authors: María Permuy, David Guede, Mónica López-Peña, Fernando Muñoz, José-Ramón Caeiro and Antonio González-Cantalapiedra

    Citation: BMC Musculoskeletal Disorders 2015 16:120

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  41. Content type: Research article

    A survey was conducted to evaluate whether a steady improvement in the quality of life of Rheumatoid Arthritis (RA) patients as frequently reported in clinical studies, does actually occur. The focus of this s...

    Authors: Rudolf Puchner, Hans Peter Brezinschek, Josef Fritz, Manfred Herold, Monika Mustak, Thomas Nothnagl, Stephan E Puchner, Andrea Studnicka-Benke and Burkhard F Leeb

    Citation: BMC Musculoskeletal Disorders 2015 16:109

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  42. Content type: Research article

    Ankylosing spondylitis (AS) is an inflammatory disease with documented elevated cardiovascular (CV) risk due to systemic inflammation and a higher prevalence of CV risk factors. CV risk management (CV-RM) coul...

    Authors: Sjoerd C Heslinga, Inge A Van den Oever, Alper M Van Sijl, Mike J Peters, Irene E Van der Horst-Bruinsma, Yvo M Smulders and Michael T Nurmohamed

    Citation: BMC Musculoskeletal Disorders 2015 16:80

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  43. Content type: Research article

    To investigate whether a modified Rheumatoid Arthritis Disease Activity Index-5 could be applied as a routine assessment tool for psoriatic arthritis (PsA) patients.

    Authors: Burkhard F Leeb, Pia M Haindl, Hans-Peter Brezinschek, Harsono T H Mai, Christoph Deutsch and Bernhard Rintelen

    Citation: BMC Musculoskeletal Disorders 2015 16:73

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  44. Content type: Research article

    Since the reference value is the core factor of the T-score calculation, it has a significant impact on the prevalence of osteoporosis. The purpose of this study was to determine the effects of using the Korea...

    Authors: Sungwha Lee, Moon-Gi Choi, Jaemyung Yu, Ohk-Hyun Ryu, Hyung Joon Yoo, Sung-Hee Ihm, Doo-Man Kim, Eun-Gyung Hong, Kyutae Park, Myungjin Choi and Hyunhee Choi

    Citation: BMC Musculoskeletal Disorders 2015 16:69

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  45. Content type: Research article

    Studies have evaluated the concomitant use of hyaluronan (HA) with steroids, anti-inflammatory drugs and analgesic agents in an attempt to magnify the extent and duration of pain relief due to knee osteoarthri...

    Authors: Robert J Petrella, Pieter J Emans, Julia Alleyne, Frank Dellaert, Dawn P Gill and Marcee Maroney

    Citation: BMC Musculoskeletal Disorders 2015 16:57

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  46. Content type: Research article

    Vitamin D displays immunomodulatory activities and has been proposed as a potential player in the pathogenesis of rheumatoid arthritis (RA). A negative association between serum 25(OH) vitamin D levels and RA ...

    Authors: Manuela Di Franco, Ilaria Barchetta, Cristina Iannuccelli, Maria Chiara Gerardi, Silvia Frisenda, Fulvia Ceccarelli, Guido Valesini and Maria Gisella Cavallo

    Citation: BMC Musculoskeletal Disorders 2015 16:53

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  47. Content type: Research article

    Our objective was to evaluate the effect of background biological disease-modifying anti-rheumatic drugs (bDMARDs) and/or corticosteroids (CS) on response to nonsteroidal anti-inflammatory drugs (NSAIDs) in rh...

    Authors: Tore K Kvien, Maria Greenwald, Paul M Peloso, Hongwei Wang, Anish Mehta and Arnold Gammaitoni

    Citation: BMC Musculoskeletal Disorders 2015 16:26

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  48. Content type: Research article

    We performed a meta-analysis to evaluate the effect of anti–tumor necrosis factor (TNF) therapy on the frequency of extra–articular manifestations (EAMs) in patients with ankylosing spondylitis (AS).

    Authors: Dan Wu, Ying-Ying Guo, Nan-Nan Xu, Shuai Zhao, Lin-Xin Hou, Ting Jiao and Ning Zhang

    Citation: BMC Musculoskeletal Disorders 2015 16:19

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