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Clinical rheumatology and osteoporosis

This section concerns all aspects of research into osteoporosis and rheumatic diseases, where the primary focus relates specifically to a component(s) of the musculoskeletal system

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  1. To cross-culturally adapt and validate the Singapore Chinese and Singapore English versions of the Ankylosing Spondylitis Quality of Life (ASQoL) scales.

    Authors: Ying Ying Leung, Weixian Lee, Nai Lee Lui, Matthew Rouse, Stephen P. McKenna and Julian Thumboo

    Citation: BMC Musculoskeletal Disorders 2017 18:353

    Content type: Research article

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  2. We examined the effectiveness and tolerability of transdermal buprenorphine (TDB) treatment in real-world setting in Asian patients with musculoskeletal pain.

    Authors: Do Heum Yoon, Seong-Il Bin, Simon Kin-Cheong Chan, Chun Kee Chung, Yong In, Hyoungmin Kim, Juan Javier Lichauco, Chi Chiu Mok, Young-Wan Moon, Tony Kwun-Tung Ng, Ester Gonzales Penserga, Dong Ah Shin, Dora You and Hanlim Moon

    Citation: BMC Musculoskeletal Disorders 2017 18:337

    Content type: Research article

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  3. Since persistence to first biological disease modifying anti-rheumatic drugs (bDMARDs) is far from ideal in rheumatoid arthritis (RA) patients, many do receive a second and/or third bDMARD treatment. However, ...

    Authors: Thomas Wilke, Sabrina Mueller, Sze Chim Lee, Istvan Majer and Marieke Heisen

    Citation: BMC Musculoskeletal Disorders 2017 18:332

    Content type: Research article

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  4. Axial spondyloarthritis (ax-SpA) is a chronic inflammatory disease of the spine causing pain, stiffness, loss in physical function, and fatigue. Therefore, the physical and psychological burden of having this ...

    Authors: Gudrun Rohde, Kari Hansen Berg, Anne Prøven and Glenn Haugeberg

    Citation: BMC Musculoskeletal Disorders 2017 18:328

    Content type: Research article

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  5. This study evaluated the effect of early anti-tumor necrosis factor (TNF) therapy in patients with severe rheumatoid arthritis (RA) on the subsequent risk of total knee replacement (TKR) surgery.

    Authors: Ying-Chou Chen, Wen-Chan Chiu, Tien-Tsai Cheng, Han-Ming Lai, Shan-Fu Yu, Ben Yu-Jih Su, Chung-Yuan Hsu, Chi-Hua Ko and Jia-Feng Chen

    Citation: BMC Musculoskeletal Disorders 2017 18:326

    Content type: Research article

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  6. RA patients who eventually dropped out of treatment and out of the health care system had potentially disastrous consequences for their health-related quality-of-life outcomes. Objectives of the study were to ...

    Authors: Irazú Contreras-Yáñez and Virginia Pascual-Ramos

    Citation: BMC Musculoskeletal Disorders 2017 18:321

    Content type: Research article

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  7. The standard dose of rituximab used in rheumatoid arthritis (RA) is 1000 mg but recent studies have shown that low dose (500 mg) is also effective. Efficacy of low dose rituximab in rheumatoid arthritis (RA) r...

    Authors: Harindu Wijesinghe, Priyadharshini Galappatthy, Rajiva de Silva, Suranjith L. Seneviratne, Ushagowry Saravanamuttu, Preethi Udagama, Melanie Hart, Peter Kelleher, Upul Senerath, Rohini Fernandopulle, Lilani P. Weerasekera and Lalith S. Wijayaratne

    Citation: BMC Musculoskeletal Disorders 2017 18:310

    Content type: Research article

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  8. Disease-related foot pathology is recognised to have a significant impact on mobility and functional capacity in the majority of patients with rheumatoid arthritis (RA). The forefoot is widely affected and the...

    Authors: Heidi J Siddle, Richard J Hodgson, Elizabeth M A Hensor, Andrew J Grainger, Anthony C Redmond, Richard J Wakefield and Philip S Helliwell

    Citation: BMC Musculoskeletal Disorders 2017 18:308

    Content type: Research article

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  9. Psoriatic arthritis (PsA) is a chronic inflammatory arthritis which impacts significantly on the quality of life and work capacity of affected individuals. Recent evidence has shown that early control of infla...

    Authors: Gabriele De Marco, Philip Helliwell, Dennis McGonagle, Paul Emery, Laura C. Coates, Elizabeth M. A. Hensor and Helena Marzo-Ortega

    Citation: BMC Musculoskeletal Disorders 2017 18:303

    Content type: Study protocol

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  10. ONO-5334 is a cathepsin K inhibitor that induced bone mineral density (BMD) gain in a phase II study in postmenopausal osteoporosis patients. Even though the antiresorptive effect could only be monitored in th...

    Authors: Makoto Tanaka, Yoshitaka Hashimoto, Chihiro Hasegawa, Steve Deacon and Richard Eastell

    Citation: BMC Musculoskeletal Disorders 2017 18:267

    Content type: Research article

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  11. When people first experience symptoms of rheumatoid arthritis (RA) they often delay seeking medical attention resulting in delayed diagnosis and treatment. This research assesses behaviours people might engage...

    Authors: Gwenda Simons, Sophie Lumley, Marie Falahee, Kanta Kumar, Christian D. Mallen, Rebecca J. Stack and Karim Raza

    Citation: BMC Musculoskeletal Disorders 2017 18:258

    Content type: Research article

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  12. Patients with rheumatoid arthritis (RA) demonstrate reduced aerobic capacity, excess cardiovascular risk, mobility limitations and are less physically active than their healthy peers. Physical activity may dec...

    Authors: Thomas Quinn, Michelle Frits BS, Johan von Heideken, Christine Iannaccone, Nancy A. Shadick, Michael Weinblatt and Maura D. Iversen

    Citation: BMC Musculoskeletal Disorders 2017 18:234

    Content type: Research article

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  13. Systemic sclerosis (SSc) is a chronic connective-tissue disease responsible for reduced life expectancy, disability and a decreased quality of life. In order to optimize patients-physicians relationship and ca...

    Authors: Luc Mouthon, Sophie Alami, Anne-Sophie Boisard, Benjamin Chaigne, Eric Hachulla and Serge Poiraudeau

    Citation: BMC Musculoskeletal Disorders 2017 18:230

    Content type: Research article

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  14. Viscosupplementation is a symptomatic treatment of the knee osteoarthritis based on the intra-articular injection of hyaluronic acid (IAHA). Although many studies have investigated its effect on symptoms, few ...

    Authors: Yves Henrotin, Francis Berenbaum, Xavier Chevalier, Marc Marty, Pascal Richette and François Rannou

    Citation: BMC Musculoskeletal Disorders 2017 18:222

    Content type: Research article

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  15. Rheumatoid arthritis (RA) patients carry a high risk of cardiovascular morbidity and mortality. The excess of cardiovascular disease cannot be entirely explained by traditional risk factors and the immune syst...

    Authors: Francesca Romana Spinelli, Arbi Pecani, Francesco Ciciarello, Tania Colasanti, Manuela Di Franco, Francesca Miranda, Fabrizio Conti, Guido Valesini and Cristiano Alessandri

    Citation: BMC Musculoskeletal Disorders 2017 18:214

    Content type: Research article

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    The Erratum to this article has been published in BMC Musculoskeletal Disorders 2017 18:263

  16. There have been no previous report of hand joint destruction prevalence in Chinese rheumatoid arthritis (RA) patients. Therefore, the aim of this study was to investigate the prevalence and potential factors o...

    Authors: Lijuan Zhang, Jing Wang, Qiuxiang Zhang, Ting Fu, Rulan Yin, Ze Wang, Liren Li, Xianhua Wu and Zhifeng Gu

    Citation: BMC Musculoskeletal Disorders 2017 18:211

    Content type: Research article

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    The Erratum to this article has been published in BMC Musculoskeletal Disorders 2017 18:231

  17. The Multidimensional Daily Diary of Fatigue-Fibromyalgia-17 instrument (MDF-Fibro-17) has been developed for use in fibromyalgia (FM) clinical studies and includes 5 domains: Global Fatigue Experience, Cogniti...

    Authors: Y. Li, S. Morris, J. Cole, S. Dube’, J. A. M. Smith, C. Burbridge, T. Symonds, S. Hudgens and W. Wang

    Citation: BMC Musculoskeletal Disorders 2017 18:198

    Content type: Research article

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  18. Fibromyalgia (FM), a disorder characterized by chronic widespread pain and tenderness, affects greater than five million individuals in the United States alone. Patients experience multiple symptoms in additio...

    Authors: S. Morris, Y. Li, J.A.M. Smith, S. Dube’, C. Burbridge and T. Symonds

    Citation: BMC Musculoskeletal Disorders 2017 18:195

    Content type: Research article

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  19. The Stanford Health Assessment Questionnaire-Disability Index (HAQ) is widely used to measure functional ability in persons with Rheumatoid Arthritis (RA). The instrument was developed with limited involvement...

    Authors: David Ebbevi, Anna Essén and Helena Hvitfeldt Forsberg

    Citation: BMC Musculoskeletal Disorders 2017 18:189

    Content type: Research article

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  20. The primary purpose of this study is to assess the existing evidence on the cost-effectiveness of surgical interventions for the management of knee and hip osteoarthritis by systematically reviewing published ...

    Authors: Hanin Kamaruzaman, Philip Kinghorn and Raymond Oppong

    Citation: BMC Musculoskeletal Disorders 2017 18:183

    Content type: Research article

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  21. Denosumab treatment for up to 8 years in the FREEDOM study and Extension was associated with low fracture incidence. It was not clear whether subjects who discontinued during the study conduct had a higher ris...

    Authors: Jonathan D. Adachi, Henry G. Bone, Nadia S. Daizadeh, Paula Dakin, Socrates Papapoulos, Peyman Hadji, Chris Recknor, Michael A. Bolognese, Andrea Wang, Celia J. F. Lin, Rachel B. Wagman and Serge Ferrari

    Citation: BMC Musculoskeletal Disorders 2017 18:174

    Content type: Research article

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  22. Remission is arguably the ultimate therapeutic goal in rheumatoid arthritis (RA). Applying modern strategies, clinical remission can be achieved in a substantial number of patients with early RA (ERA). Even in...

    Authors: Philipp Sewerin, Stefan Vordenbaeumen, Annika Hoyer, Ralph Brinks, Christian Buchbender, Falk Miese, Christoph Schleich, Sabine Klein, Matthias Schneider and Benedikt Ostendorf

    Citation: BMC Musculoskeletal Disorders 2017 18:163

    Content type: Research article

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  23. Poor adherence with oral bisphosphonates (BPs) can mitigate their therapeutic benefit for osteoporosis and is a significant clinical burden. Most previous studies regarding adherence with oral BPs have focused...

    Authors: Ji-Heh Park, Eun-Kyoung Park, Dong-Wan Koo, Shinwon Lee, Sun-Hee Lee, Geun-Tae Kim and Seung-Geun Lee

    Citation: BMC Musculoskeletal Disorders 2017 18:152

    Content type: Research article

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  24. Teriparatide (recombinant human parathyroid hormone 1–34) is increasingly used for the treatment of severe osteoporosis because it stimulates bone formation and may potentially enhance fracture healing. The ob...

    Authors: Akira Iwata, Masahiro Kanayama, Fumihiro Oha, Tomoyuki Hashimoto and Norimasa Iwasaki

    Citation: BMC Musculoskeletal Disorders 2017 18:148

    Content type: Research article

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  25. A patient- and surgeon-Delphi-derived Outcome Measures in Rheumatology (OMERACT) draft core domain set for total joint arthroplasty (TJR) trials was recently developed. Our objective was to obtain further pati...

    Authors: Jasvinder A. Singh, Michelle Dowsey and Peter F. Choong

    Citation: BMC Musculoskeletal Disorders 2017 18:111

    Content type: Research article

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  26. The cementoma is a common disease of the dental root apex, which generally occurs in the maxilla and the mandible, but the cementoma occurring in the long bone is rare. Moreover, the incidence of cementoma in ...

    Authors: Xiaona Li, Zhigang Peng, Mahrukh Latif, Abhinav Kumar, Wei Chen and Zekun Zhang

    Citation: BMC Musculoskeletal Disorders 2017 18:103

    Content type: Case report

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  27. Clinical symptoms of rheumatoid arthritis (RA) improve in the course of the day, as can synovitis activity, reported via doppler ultrasound (US). The aim of the study was to establish whether the Color Doppler...

    Authors: Hakim Lazaar, Agnes Lhoste-Trouilloud, Bruno Pereira, Marion Couderc, Sylvain Mathieu and Martin Soubrier

    Citation: BMC Musculoskeletal Disorders 2017 18:98

    Content type: Research article

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  28. Today, patients are expected to take an active role in the form of self-management. Given the burden of a rheumatic disorder, the patients cannot be expected to self-manage on their own. In order to develop se...

    Authors: Janet M.J. Been-Dahmen, Margot J. Walter, Jolanda Dwarswaard, Johanna M.W. Hazes, AnneLoes van Staa and Erwin Ista

    Citation: BMC Musculoskeletal Disorders 2017 18:84

    Content type: Research article

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  29. We have previously described the association between rheumatoid arthritis (RA) prevalence and the two mutY Homolog (E. coli) (MUTYH) SNPs (rs3219463 and rs3219476) among the Taiwanese population. This present ...

    Authors: Shih-Yin Chen, Hsin-Han Chen, Yu-Chuen Huang, Shih-Ping Liu, Ying-Ju Lin, Sui-Foon Lo, Yuan-Yen Chang, Hui-Wen Lin, Chung-Ming Huang and Fuu-Jen Tsai

    Citation: BMC Musculoskeletal Disorders 2017 18:69

    Content type: Research article

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  30. Osteoporosis and osteoporotic fractures remain significant public health challenges worldwide. Recently the concept of frailty in relation to osteoporosis in the elderly has been increasingly accepted, with em...

    Authors: Guowei Li, Lehana Thabane, Alexandra Papaioannou, George Ioannidis, Mitchell A. H. Levine and Jonathan D. Adachi

    Citation: BMC Musculoskeletal Disorders 2017 18:46

    Content type: Review

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  31. Intra-articular corticosteroid injections (IACI) are effective treatments for pain in knee osteoarthritis (KOA) but treatment response varies. There is uncertainty as to whether structural factors such as accu...

    Authors: G. Hirsch, T. W. O’Neill, G. Kitas, A. Sinha and R. Klocke

    Citation: BMC Musculoskeletal Disorders 2017 18:44

    Content type: Research article

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  32. The Internet is increasingly used to access health information, although the quality of information varies. The aim of this study was to evaluate the readability, and quality of websites about polymyalgia rheu...

    Authors: Arani Vivekanantham, Joanne Protheroe, Sara Muller and Samantha Hider

    Citation: BMC Musculoskeletal Disorders 2017 18:43

    Content type: Research article

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  33. Interstitial lung disease (ILD) is frequently associated with rheumatoid arthritis (RA), and is designated RA-associated ILD (RA-ILD). RA-ILD has a large impact on the prognosis of RA. Here, we investigated th...

    Authors: Shomi Oka, Hiroshi Furukawa, Kota Shimada, Atsushi Hashimoto, Akiko Komiya, Naoshi Fukui, Naoyuki Tsuchiya and Shigeto Tohma

    Citation: BMC Musculoskeletal Disorders 2017 18:21

    Content type: Research article

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  34. Destructive spondyloarthropathy (DSA) is one of the major complications in patients undergoing long-term hemodialysis. To the best of our knowledge, an epidural abscess occurring at the level of preexisting ce...

    Authors: Jun-Seok Lee, Ji-Hyun Ryu, Jong-Tae Park and Ki-Won Kim

    Citation: BMC Musculoskeletal Disorders 2017 18:11

    Content type: Case report

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  35. Well-designed studies of complications and readmission rates in patients undergoing total hip arthroplasty (THA) with osteonecrosis are lacking. Our objective was to examine if a diagnosis of osteonecrosis was...

    Authors: Jasvinder A. Singh, Jason Chen, Maria C. S. Inacio, Robert S. Namba and Elizabeth W. Paxton

    Citation: BMC Musculoskeletal Disorders 2017 18:8

    Content type: Research article

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  36. In our current economic climate of scarce resources there is a lot of debate around the best - and most efficient - way of delivering care, which points patients towards the right physician at the earliest opp...

    Authors: R. Puchner, R. Hochreiter, H. Pieringer and A. Vavrovsky

    Citation: BMC Musculoskeletal Disorders 2017 18:7

    Content type: Research article

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  37. To identify predictive factors of response to viscosupplementation (VS) in patients with hip osteoarthritis (HOA).

    Authors: Florent Eymard, Bernard Maillet, Henri Lellouche, Sylvie Mellac-Ducamp, Olivier Brocq, Damien Loeuille, Xavier Chevalier and Thierry Conrozier

    Citation: BMC Musculoskeletal Disorders 2017 18:3

    Content type: Research article

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  38. The aim of this study was to assess the efficacy of choline-stabilized orthosilicic acid (ch-OSA) in patients with symptomatic knee osteoarthritis (OA).

    Authors: Piet Geusens, Karel Pavelka, Jozef Rovensky, Johan Vanhoof, Nathalie Demeester, Mario Calomme and Dirk Vanden Berghe

    Citation: BMC Musculoskeletal Disorders 2017 18:2

    Content type: Research article

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  39. Rheumatoid arthritis (RA) is a long term condition that requires early treatment to control symptoms and improve long-term outcomes. Lack of response to RA treatments is not only a waste of healthcare resource...

    Authors: Kanta Kumar, Sarah Peters and Anne Barton

    Citation: BMC Musculoskeletal Disorders 2016 17:460

    Content type: Research article

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  40. Fragility fractures are one of the leading causes for disability in old people. The main underlying mechanisms are osteoporosis and falls. Evidence-based measures to prevent either falls or fractures are avail...

    Authors: Kilian Rapp, Karin Kampe, Patrick Roigk, Hella Kircheisen, Clemens Becker, Ivonne Lindlbauer, Hans-Helmut König, Dietrich Rothenbacher and Gisela Büchele

    Citation: BMC Musculoskeletal Disorders 2016 17:458

    Content type: Study protocol

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  41. The purpose of this study was to test the hypothesis that a health and wellness coaching (HWC)-based intervention for fibromyalgia (FM) would result in sustained improvements in health and quality of life, and...

    Authors: Kevin V. Hackshaw, Marcal Plans-Pujolras, Luis E. Rodriguez-Saona, Margaret A. Moore, Erika K. Jackson, Gary A. Sforzo and C. A. Tony Buffington

    Citation: BMC Musculoskeletal Disorders 2016 17:457

    Content type: Research article

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  42. Although disease-modifying anti-rheumatic drugs (DMARDs) are the cornerstone of treatment for inflammatory rheumatic diseases, medication adherence to DMARDs is often suboptimal. Effective interventions to imp...

    Authors: Marieke Voshaar, Johanna Vriezekolk, Sandra van Dulmen, Bart van den Bemt and Mart van de Laar

    Citation: BMC Musculoskeletal Disorders 2016 17:442

    Content type: Research article

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  43. Patients with rheumatoid arthritis (RA) spend a high proportion of their waking time in sedentary behaviour (SB) and have an increased risk of cardiovascular disease. Reduction of SB and increase in light inte...

    Authors: T. Thomsen, M. Aadahl, N. Beyer, M. L. Hetland, K. Løppenthin, J. Midtgaard, R. Christensen and B. A. Esbensen

    Citation: BMC Musculoskeletal Disorders 2016 17:434

    Content type: Research article

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  44. To develop Singapore Chinese and English versions of the Psoriatic Arthritis Quality of Life (PsAQoL) scale that were equivalent to and met the same psychometric and acceptability standards as the original UK ...

    Authors: Ying Ying Leung, Julian Thumboo, Matthew Rouse and Stephen P. McKenna

    Citation: BMC Musculoskeletal Disorders 2016 17:432

    Content type: Research article

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  45. This study evaluated two doses of etoricoxib (60 and 90 mg) vs. naproxen 1000 mg in subjects with ankylosing spondylitis (AS).

    Authors: Eva Balazcs, Joachim Sieper, Kara Bickham, Anish Mehta, Nancy Frontera, Paul Stryszak, Zoran Popmihajlov and Paul M. Peloso

    Citation: BMC Musculoskeletal Disorders 2016 17:426

    Content type: Research article

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  46. Knee Osteoarthritis (KOA) is a heterogeneous pathology characterized by a complex and multifactorial nature. It has been hypothesised that these differences are due to the existence of underlying phenotypes re...

    Authors: A. Dell’Isola, R. Allan, S. L. Smith, S. S. P. Marreiros and M. Steultjens

    Citation: BMC Musculoskeletal Disorders 2016 17:425

    Content type: Research article

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  47. The aim of this study was to investigate the effects of chondroitin sulfate (CS) on the serum levels of Coll2-1 in patients with knee OA.

    Authors: Ingrid Möller, Myriam Gharbi, Helena Martinez Serrano, Marta Herrero Barbero, Josep Verges Milano and Yves Henrotin

    Citation: BMC Musculoskeletal Disorders 2016 17:416

    Content type: Research article

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  48. In patients with rheumatoid arthritis (RA) clinical measures of disease activity may not reliably discriminate between patients with active inflammatory disease and those with concomitant fibromyalgia (FM). Re...

    Authors: Aneela N. Mian, Khaldoun Chaabo, Julekha Wajed, Sujith Subesinghe, Nicola J. Gullick, Bruce Kirkham and Toby Garrood

    Citation: BMC Musculoskeletal Disorders 2016 17:404

    Content type: Research article

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