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Clinical rheumatology and osteoporosis

This section concerns all aspects of research into osteoporosis and rheumatic diseases, where the primary focus relates specifically to a component(s) of the musculoskeletal system

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  1. Poor adherence with oral bisphosphonates (BPs) can mitigate their therapeutic benefit for osteoporosis and is a significant clinical burden. Most previous studies regarding adherence with oral BPs have focused...

    Authors: Ji-Heh Park, Eun-Kyoung Park, Dong-Wan Koo, Shinwon Lee, Sun-Hee Lee, Geun-Tae Kim and Seung-Geun Lee

    Citation: BMC Musculoskeletal Disorders 2017 18:152

    Content type: Research article

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  2. Teriparatide (recombinant human parathyroid hormone 1–34) is increasingly used for the treatment of severe osteoporosis because it stimulates bone formation and may potentially enhance fracture healing. The ob...

    Authors: Akira Iwata, Masahiro Kanayama, Fumihiro Oha, Tomoyuki Hashimoto and Norimasa Iwasaki

    Citation: BMC Musculoskeletal Disorders 2017 18:148

    Content type: Research article

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  3. A patient- and surgeon-Delphi-derived Outcome Measures in Rheumatology (OMERACT) draft core domain set for total joint arthroplasty (TJR) trials was recently developed. Our objective was to obtain further pati...

    Authors: Jasvinder A. Singh, Michelle Dowsey and Peter F. Choong

    Citation: BMC Musculoskeletal Disorders 2017 18:111

    Content type: Research article

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  4. The cementoma is a common disease of the dental root apex, which generally occurs in the maxilla and the mandible, but the cementoma occurring in the long bone is rare. Moreover, the incidence of cementoma in ...

    Authors: Xiaona Li, Zhigang Peng, Mahrukh Latif, Abhinav Kumar, Wei Chen and Zekun Zhang

    Citation: BMC Musculoskeletal Disorders 2017 18:103

    Content type: Case report

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  5. Clinical symptoms of rheumatoid arthritis (RA) improve in the course of the day, as can synovitis activity, reported via doppler ultrasound (US). The aim of the study was to establish whether the Color Doppler...

    Authors: Hakim Lazaar, Agnes Lhoste-Trouilloud, Bruno Pereira, Marion Couderc, Sylvain Mathieu and Martin Soubrier

    Citation: BMC Musculoskeletal Disorders 2017 18:98

    Content type: Research article

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  6. Today, patients are expected to take an active role in the form of self-management. Given the burden of a rheumatic disorder, the patients cannot be expected to self-manage on their own. In order to develop se...

    Authors: Janet M.J. Been-Dahmen, Margot J. Walter, Jolanda Dwarswaard, Johanna M.W. Hazes, AnneLoes van Staa and Erwin Ista

    Citation: BMC Musculoskeletal Disorders 2017 18:84

    Content type: Research article

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  7. We have previously described the association between rheumatoid arthritis (RA) prevalence and the two mutY Homolog (E. coli) (MUTYH) SNPs (rs3219463 and rs3219476) among the Taiwanese population. This present ...

    Authors: Shih-Yin Chen, Hsin-Han Chen, Yu-Chuen Huang, Shih-Ping Liu, Ying-Ju Lin, Sui-Foon Lo, Yuan-Yen Chang, Hui-Wen Lin, Chung-Ming Huang and Fuu-Jen Tsai

    Citation: BMC Musculoskeletal Disorders 2017 18:69

    Content type: Research article

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  8. Osteoporosis and osteoporotic fractures remain significant public health challenges worldwide. Recently the concept of frailty in relation to osteoporosis in the elderly has been increasingly accepted, with em...

    Authors: Guowei Li, Lehana Thabane, Alexandra Papaioannou, George Ioannidis, Mitchell A. H. Levine and Jonathan D. Adachi

    Citation: BMC Musculoskeletal Disorders 2017 18:46

    Content type: Review

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  9. Intra-articular corticosteroid injections (IACI) are effective treatments for pain in knee osteoarthritis (KOA) but treatment response varies. There is uncertainty as to whether structural factors such as accu...

    Authors: G. Hirsch, T. W. O’Neill, G. Kitas, A. Sinha and R. Klocke

    Citation: BMC Musculoskeletal Disorders 2017 18:44

    Content type: Research article

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  10. The Internet is increasingly used to access health information, although the quality of information varies. The aim of this study was to evaluate the readability, and quality of websites about polymyalgia rheu...

    Authors: Arani Vivekanantham, Joanne Protheroe, Sara Muller and Samantha Hider

    Citation: BMC Musculoskeletal Disorders 2017 18:43

    Content type: Research article

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  11. Interstitial lung disease (ILD) is frequently associated with rheumatoid arthritis (RA), and is designated RA-associated ILD (RA-ILD). RA-ILD has a large impact on the prognosis of RA. Here, we investigated th...

    Authors: Shomi Oka, Hiroshi Furukawa, Kota Shimada, Atsushi Hashimoto, Akiko Komiya, Naoshi Fukui, Naoyuki Tsuchiya and Shigeto Tohma

    Citation: BMC Musculoskeletal Disorders 2017 18:21

    Content type: Research article

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  12. Destructive spondyloarthropathy (DSA) is one of the major complications in patients undergoing long-term hemodialysis. To the best of our knowledge, an epidural abscess occurring at the level of preexisting ce...

    Authors: Jun-Seok Lee, Ji-Hyun Ryu, Jong-Tae Park and Ki-Won Kim

    Citation: BMC Musculoskeletal Disorders 2017 18:11

    Content type: Case report

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  13. Well-designed studies of complications and readmission rates in patients undergoing total hip arthroplasty (THA) with osteonecrosis are lacking. Our objective was to examine if a diagnosis of osteonecrosis was...

    Authors: Jasvinder A. Singh, Jason Chen, Maria C. S. Inacio, Robert S. Namba and Elizabeth W. Paxton

    Citation: BMC Musculoskeletal Disorders 2017 18:8

    Content type: Research article

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  14. In our current economic climate of scarce resources there is a lot of debate around the best - and most efficient - way of delivering care, which points patients towards the right physician at the earliest opp...

    Authors: R. Puchner, R. Hochreiter, H. Pieringer and A. Vavrovsky

    Citation: BMC Musculoskeletal Disorders 2017 18:7

    Content type: Research article

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  15. To identify predictive factors of response to viscosupplementation (VS) in patients with hip osteoarthritis (HOA).

    Authors: Florent Eymard, Bernard Maillet, Henri Lellouche, Sylvie Mellac-Ducamp, Olivier Brocq, Damien Loeuille, Xavier Chevalier and Thierry Conrozier

    Citation: BMC Musculoskeletal Disorders 2017 18:3

    Content type: Research article

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  16. The aim of this study was to assess the efficacy of choline-stabilized orthosilicic acid (ch-OSA) in patients with symptomatic knee osteoarthritis (OA).

    Authors: Piet Geusens, Karel Pavelka, Jozef Rovensky, Johan Vanhoof, Nathalie Demeester, Mario Calomme and Dirk Vanden Berghe

    Citation: BMC Musculoskeletal Disorders 2017 18:2

    Content type: Research article

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  17. Rheumatoid arthritis (RA) is a long term condition that requires early treatment to control symptoms and improve long-term outcomes. Lack of response to RA treatments is not only a waste of healthcare resource...

    Authors: Kanta Kumar, Sarah Peters and Anne Barton

    Citation: BMC Musculoskeletal Disorders 2016 17:460

    Content type: Research article

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  18. Fragility fractures are one of the leading causes for disability in old people. The main underlying mechanisms are osteoporosis and falls. Evidence-based measures to prevent either falls or fractures are avail...

    Authors: Kilian Rapp, Karin Kampe, Patrick Roigk, Hella Kircheisen, Clemens Becker, Ivonne Lindlbauer, Hans-Helmut König, Dietrich Rothenbacher and Gisela Büchele

    Citation: BMC Musculoskeletal Disorders 2016 17:458

    Content type: Study protocol

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  19. The purpose of this study was to test the hypothesis that a health and wellness coaching (HWC)-based intervention for fibromyalgia (FM) would result in sustained improvements in health and quality of life, and...

    Authors: Kevin V. Hackshaw, Marcal Plans-Pujolras, Luis E. Rodriguez-Saona, Margaret A. Moore, Erika K. Jackson, Gary A. Sforzo and C. A. Tony Buffington

    Citation: BMC Musculoskeletal Disorders 2016 17:457

    Content type: Research article

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  20. Although disease-modifying anti-rheumatic drugs (DMARDs) are the cornerstone of treatment for inflammatory rheumatic diseases, medication adherence to DMARDs is often suboptimal. Effective interventions to imp...

    Authors: Marieke Voshaar, Johanna Vriezekolk, Sandra van Dulmen, Bart van den Bemt and Mart van de Laar

    Citation: BMC Musculoskeletal Disorders 2016 17:442

    Content type: Research article

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  21. Patients with rheumatoid arthritis (RA) spend a high proportion of their waking time in sedentary behaviour (SB) and have an increased risk of cardiovascular disease. Reduction of SB and increase in light inte...

    Authors: T. Thomsen, M. Aadahl, N. Beyer, M. L. Hetland, K. Løppenthin, J. Midtgaard, R. Christensen and B. A. Esbensen

    Citation: BMC Musculoskeletal Disorders 2016 17:434

    Content type: Research article

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  22. To develop Singapore Chinese and English versions of the Psoriatic Arthritis Quality of Life (PsAQoL) scale that were equivalent to and met the same psychometric and acceptability standards as the original UK ...

    Authors: Ying Ying Leung, Julian Thumboo, Matthew Rouse and Stephen P. McKenna

    Citation: BMC Musculoskeletal Disorders 2016 17:432

    Content type: Research article

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  23. This study evaluated two doses of etoricoxib (60 and 90 mg) vs. naproxen 1000 mg in subjects with ankylosing spondylitis (AS).

    Authors: Eva Balazcs, Joachim Sieper, Kara Bickham, Anish Mehta, Nancy Frontera, Paul Stryszak, Zoran Popmihajlov and Paul M. Peloso

    Citation: BMC Musculoskeletal Disorders 2016 17:426

    Content type: Research article

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  24. Knee Osteoarthritis (KOA) is a heterogeneous pathology characterized by a complex and multifactorial nature. It has been hypothesised that these differences are due to the existence of underlying phenotypes re...

    Authors: A. Dell’Isola, R. Allan, S. L. Smith, S. S. P. Marreiros and M. Steultjens

    Citation: BMC Musculoskeletal Disorders 2016 17:425

    Content type: Research article

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  25. The aim of this study was to investigate the effects of chondroitin sulfate (CS) on the serum levels of Coll2-1 in patients with knee OA.

    Authors: Ingrid Möller, Myriam Gharbi, Helena Martinez Serrano, Marta Herrero Barbero, Josep Verges Milano and Yves Henrotin

    Citation: BMC Musculoskeletal Disorders 2016 17:416

    Content type: Research article

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  26. In patients with rheumatoid arthritis (RA) clinical measures of disease activity may not reliably discriminate between patients with active inflammatory disease and those with concomitant fibromyalgia (FM). Re...

    Authors: Aneela N. Mian, Khaldoun Chaabo, Julekha Wajed, Sujith Subesinghe, Nicola J. Gullick, Bruce Kirkham and Toby Garrood

    Citation: BMC Musculoskeletal Disorders 2016 17:404

    Content type: Research article

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  27. In 2004, we initiated an inception cohort of patients with recent-onset rheumatoid arthritis (RA). Hand function was incorporated into evaluations from 2014 onward. The objectives were to examine hand function...

    Authors: Ana K. Romero-Guzmán, Víctor M. Menchaca-Tapia, Irazú Contreras-Yáñez and Virginia Pascual-Ramos

    Citation: BMC Musculoskeletal Disorders 2016 17:392

    Content type: Research article

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  28. The distal radius is the most common osteoporotic fracture site occurring in postmenopausal women. Finite element (FE) modeling is a non-invasive mathematical technique that can estimate bone strength using in...

    Authors: C. E. Kawalilak, S. A. Kontulainen, M. A. Amini, J. L. Lanovaz, W. P. Olszynski and J. D. Johnston

    Citation: BMC Musculoskeletal Disorders 2016 17:389

    Content type: Research article

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  29. Several measurements are often used in daily clinical practice in the assessment of Ankylosing Spondylitis (AS) patients. The Assessment in SpondyloArthiritis International Society (ASAS) recommend in its core...

    Authors: J. Calvo-Gutiérrez, J. L. Garrido-Castro, C. González-Navas, M. C. Castro-Villegas, R. Ortega-Castro, C. López-Medina, P. Font-Ugalde, A. Escudero-Contreras and E. Collantes-Estévez

    Citation: BMC Musculoskeletal Disorders 2016 17:382

    Content type: Research article

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  30. Undiagnosed, or diagnosed and untreated osteoporosis (OP) increases the likelihood that falls result in hip fractures, decreased quality of life (QOL), and significant medical expenditures among older adults. ...

    Authors: Stephanie W. Edmonds, Peter Cram, Yiyue Lou, Michael P. Jones, Douglas W. Roblin, Kenneth G. Saag, Nicole C. Wright and Fredric D. Wolinsky

    Citation: BMC Musculoskeletal Disorders 2016 17:369

    Content type: Research article

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  31. Osteoporosis and osteoporotic fractures are widely known as complications of rheumatoid arthritis. Kyphoplasty (KP) is known as an effective treatment modality for reducing pain and correcting kyphotic deformi...

    Authors: Jihoon Shim, Kwanghyun Lee, Hunchul Kim, Byungjik Kang, Haewon Jeong and Chang-Nam Kang

    Citation: BMC Musculoskeletal Disorders 2016 17:365

    Content type: Research article

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  32. Methotrexate (MTX) is standard treatment for RA. Absorption is better in subcutaneous MTX (scMTX), which may impact speed of onset. In RA, earlier time to remission improves long-term results. Our objectives w...

    Authors: Anna O’Connor, Carter Thorne, Hyeon Kang, Diane Tin and Janet E. Pope

    Citation: BMC Musculoskeletal Disorders 2016 17:364

    Content type: Research article

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  33. To investigate the effect of baseline clinical characteristics and glucocorticoid treatment on temporal artery biopsy (TAB) findings in patients with giant cell arteritis (GCA).

    Authors: Karin Jakobsson, Lennart Jacobsson, Aladdin J. Mohammad, Jan-Åke Nilsson, Kenneth Warrington, Eric L. Matteson and Carl Turesson

    Citation: BMC Musculoskeletal Disorders 2016 17:363

    Content type: Research article

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  34. African Americans bear a disproportionate burden of osteoarthritis (OA), with higher prevalence rates, more severe pain, and more functional limitations. One key barrier to addressing these disparities has bee...

    Authors: Leah A. Schrubbe, Scott G. Ravyts, Bernadette C. Benas, Lisa C. Campbell, Crystal W. Cené, Cynthia J. Coffman, Alexander H. Gunn, Francis J. Keefe, Caroline T. Nagle, Eugene Z. Oddone, Tamara J. Somers, Catherine L. Stanwyck, Shannon S. Taylor and Kelli D. Allen

    Citation: BMC Musculoskeletal Disorders 2016 17:359

    Content type: Study protocol

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  35. Anti-Tumor Necrosis Factor (TNF) therapies are able to control rheumatoid arthritis (RA) disease activity and limit structural damage. Yet no predictive factor of response to anti-TNF has been identified. Meta...

    Authors: Zuzana Tatar, Carole Migne, Melanie Petera, Philippe Gaudin, Thierry Lequerre, Hubert Marotte, Jacques Tebib, Estelle Pujos Guillot and Martin Soubrier

    Citation: BMC Musculoskeletal Disorders 2016 17:353

    Content type: Research article

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  36. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint structural deterioration. Driven by recent expectations that patients in clinical trials randomized to placebo ...

    Authors: Jeroen P. Jansen, Maria-Cecilia Vieira, John D. Bradley, Joseph C. Cappelleri, Samuel H. Zwillich and Gene V. Wallenstein

    Citation: BMC Musculoskeletal Disorders 2016 17:348

    Content type: Research article

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  37. To report the predictive value of nail-fold capillaroscopy (NFC) patterns of vasculopathy for systemic sclerosis (Scleroderma; SSc) in an unselected cohort of patients with Raynaud’s phenomenon (RP).

    Authors: Lesley-Anne Bissell, Giuseppina Abignano, Paul Emery, Francesco Del Galdo and Maya H. Buch

    Citation: BMC Musculoskeletal Disorders 2016 17:342

    Content type: Research article

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  38. The concerns about the development of adverse events (AEs) in elderly RA patients as a result of age-related changes in drug metabolism and the presence of comorbid illnesses are emphasizing due to increasing ...

    Authors: Soo-Kyung Cho, Yoon-Kyoung Sung, Dam Kim, Soyoung Won, Chan-Bum Choi, Tae-Hwan Kim, Jae-Bum Jun, Dae-Hyun Yoo and Sang-Cheol Bae

    Citation: BMC Musculoskeletal Disorders 2016 17:333

    Content type: Research article

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  39. Case reports have linked adult hypophosphatasia as a possible cause of atypical femur fractures (AFF) associated with bisphosphonate use. Adult hypophosphatasia is an asymptomatic genetic condition which resul...

    Authors: Timothy Bhattacharyya, Smita Jha, Hongying Wang, Daniel L. Kastner and Elaine F. Remmers

    Citation: BMC Musculoskeletal Disorders 2016 17:332

    Content type: Research article

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  40. Treatment with non-steroidal anti-inflammatory drugs (NSAID) is a common component of treatment regimens for rheumatoid arthritis (RA). Etoricoxib is a COX-2 selective NSAID that has demonstrated efficacy in t...

    Authors: Kara Bickham, Alan J. Kivitz, Anish Mehta, Nancy Frontera, Sandhya Shah, Paul Stryszak, Zoran Popmihajlov and Paul M. Peloso

    Citation: BMC Musculoskeletal Disorders 2016 17:331

    Content type: Research article

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  41. There is evidence that postmenopausal women with rheumatoid arthritis (RA) on glucocorticoid (GC) therapy and bisphosphonate (BP) have an increased risk for atypical subtrochanteric and atypical diaphyseal fem...

    Authors: Rahel Meinen, Inna Galli-Lysak, Peter M. Villiger and Daniel Aeberli

    Citation: BMC Musculoskeletal Disorders 2016 17:324

    Content type: Research article

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  42. Infections are a common complication of RA with associated morbidity and mortality. The aetiology of increased risk is complex and multifactorial. Despite this, strategies to mitigate against risk of infection...

    Authors: Sujith Subesinghe, Andrew Ian Rutherford, Fowzia Ibrahim, Helen Harris and James Galloway

    Citation: BMC Musculoskeletal Disorders 2016 17:322

    Content type: Research article

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  43. Juvenile idiopathic arthritis (JIA) refers to a number of rare chronic inflammatory diseases. Although JIA imposes a significant societal burden, limited data are available on the cost of JIA. The study’s obje...

    Authors: Aris Angelis, Panos Kanavos, Julio López-Bastida, Renata Linertová and Pedro Serrano-Aguilar

    Citation: BMC Musculoskeletal Disorders 2016 17:321

    Content type: Research article

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  44. Accelerated knee osteoarthritis may be a unique subset of knee osteoarthritis, which is associated with greater knee pain and disability. Identifying risk factors for accelerated knee osteoarthritis is vital t...

    Authors: Jeffrey B. Driban, Alina C. Stout, Jeffrey Duryea, Grace H. Lo, William F. Harvey, Lori Lyn Price, Robert J. Ward, Charles B. Eaton, Mary F. Barbe, Bing Lu and Timothy E. McAlindon

    Citation: BMC Musculoskeletal Disorders 2016 17:299

    Content type: Research article

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  45. Glucocorticoids (GCs), such as prednisone, are the standard of care for several inflammatory and immunologically mediated diseases, but their chronic systemic administration is severely limited by serious adve...

    Authors: Dona L. Fleishaker, Arnab Mukherjee, Fredrick S. Whaley, Shanthini Daniel and Bernhardt G. Zeiher

    Citation: BMC Musculoskeletal Disorders 2016 17:293

    Content type: Research article

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  46. Patients with painful knee osteoarthritis (OA) demonstrate hyperalgesia and altered pain-modulatory responses. While some prior work has demonstrated cross-sectional associations between laboratory and clinica...

    Authors: Robert R. Edwards, Andrew J. Dolman, Marc. O. Martel, Patrick H. Finan, Asimina Lazaridou, Marise Cornelius and Ajay D. Wasan

    Citation: BMC Musculoskeletal Disorders 2016 17:284

    Content type: Research article

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  47. Osteoporosis is a well-known complication of ankylosing spondylitis (AS). However, data about body composition modifications and muscle performance showed conflicting results. The aim of the study was to deter...

    Authors: Abdellah El Maghraoui, François Bertin Ebo’o, Siham Sadni, Abderrahim Majjad, Toufik Hamza and Aziza Mounach

    Citation: BMC Musculoskeletal Disorders 2016 17:268

    Content type: Research article

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  48. The National Institute for Health and Care Excellence’s Osteoarthritis (OA) guidelines recommended that future research should consider the benefits of combination therapies in people with OA across multiple j...

    Authors: Andrew Finney, Emma Healey, Joanne L. Jordan, Sarah Ryan and Krysia S. Dziedzic

    Citation: BMC Musculoskeletal Disorders 2016 17:266

    Content type: Research article

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