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Clinical rheumatology and osteoporosis

This section concerns all aspects of research into osteoporosis and rheumatic diseases, where the primary focus relates specifically to a component(s) of the musculoskeletal system

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  1. Content type: Research article

    Rheumatologists increasingly perform ultrasound (US) imaging to aid diagnosis and management decisions. There is a need to determine the role of US in facilitating early diagnosis of inflammatory arthritis. Th...

    Authors: Stephen Kelly, Brian Davidson, Sarah Keidel, Stephan Gadola, Claire Gorman, Gary Meenagh and Piero Reynolds

    Citation: BMC Musculoskeletal Disorders 2017 18:487

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  2. Content type: Research article

    Osteoarthritis (OA) of the trapeziometacarpal joint (TMJ) is a disabling condition with a significant impact on quality of life. The optimal management of hand OA requires a combination of non-pharmacological ...

    Authors: Sara Tenti, Nicola Antonio Pascarelli, Stefano Giannotti, Mauro Galeazzi, Nicola Giordano and Antonella Fioravanti

    Citation: BMC Musculoskeletal Disorders 2017 18:444

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  3. Content type: Study protocol

    Several drugs have become available for the treatment of osteoporosis. However, screening and treatment of patients with a high fracture risk is currently not recommended in the Netherlands, because the effect...

    Authors: P. J. M. Elders, T. Merlijn, K. M. A. Swart, W. van Hout, B. C. van der Zwaard, C. Niemeijer, M. W. Heymans, A. A. van der Heijden, F. Rutters, H. E. van der Horst, P. Lips, J. C. Netelenbos and N. M. van Schoor

    Citation: BMC Musculoskeletal Disorders 2017 18:424

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  4. Content type: Research article

    Use of conservative treatment modalities in osteoarthritis (OA) is suboptimal, which appears to be partly due to patients’ beliefs about treatments. The aim of this study was to develop a research instrument a...

    Authors: Ellen M. H. Selten, Johanna E. Vriezekolk, Henk J. Schers, Marc W. Nijhof, Willemijn H. van der Laan, Roelien G. van der Meulen-Dilling, Rinie Geenen and Cornelia H. M. van den Ende

    Citation: BMC Musculoskeletal Disorders 2017 18:402

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  5. Content type: Research article

    During the course of rheumatoid arthritis (RA), patients have profound negative effects on their patient-reported-outcomes (PRO); in addition, the impact of sustained remission (SR) on PROs may differ for each...

    Authors: Irazú Contreras-Yáñez, Guillermo Guaracha-Basañez, Daniel Ruiz-Domínguez and Virginia Pascual-Ramos

    Citation: BMC Musculoskeletal Disorders 2017 18:379

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  6. Content type: Research article

    Investigate the prevalence and risk factors of low bone mineral density (BMD) in patients with axial spondyloarthritis as well as investigating the prevalence of vertebral fractures.

    Authors: Sandrine Malochet-Guinamand, Bruno Pereira, Zuzana Tatar, Anne Tournadre, Anna Moltó, Maxime Dougados and Martin Soubrier

    Citation: BMC Musculoskeletal Disorders 2017 18:357

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  7. Content type: Research article

    To cross-culturally adapt and validate the Singapore Chinese and Singapore English versions of the Ankylosing Spondylitis Quality of Life (ASQoL) scales.

    Authors: Ying Ying Leung, Weixian Lee, Nai Lee Lui, Matthew Rouse, Stephen P. McKenna and Julian Thumboo

    Citation: BMC Musculoskeletal Disorders 2017 18:353

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  8. Content type: Research article

    We examined the effectiveness and tolerability of transdermal buprenorphine (TDB) treatment in real-world setting in Asian patients with musculoskeletal pain.

    Authors: Do Heum Yoon, Seong-Il Bin, Simon Kin-Cheong Chan, Chun Kee Chung, Yong In, Hyoungmin Kim, Juan Javier Lichauco, Chi Chiu Mok, Young-Wan Moon, Tony Kwun-Tung Ng, Ester Gonzales Penserga, Dong Ah Shin, Dora You and Hanlim Moon

    Citation: BMC Musculoskeletal Disorders 2017 18:337

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  9. Content type: Research article

    Since persistence to first biological disease modifying anti-rheumatic drugs (bDMARDs) is far from ideal in rheumatoid arthritis (RA) patients, many do receive a second and/or third bDMARD treatment. However, ...

    Authors: Thomas Wilke, Sabrina Mueller, Sze Chim Lee, Istvan Majer and Marieke Heisen

    Citation: BMC Musculoskeletal Disorders 2017 18:332

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  10. Content type: Research article

    Axial spondyloarthritis (ax-SpA) is a chronic inflammatory disease of the spine causing pain, stiffness, loss in physical function, and fatigue. Therefore, the physical and psychological burden of having this ...

    Authors: Gudrun Rohde, Kari Hansen Berg, Anne Prøven and Glenn Haugeberg

    Citation: BMC Musculoskeletal Disorders 2017 18:328

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  11. Content type: Research article

    This study evaluated the effect of early anti-tumor necrosis factor (TNF) therapy in patients with severe rheumatoid arthritis (RA) on the subsequent risk of total knee replacement (TKR) surgery.

    Authors: Ying-Chou Chen, Wen-Chan Chiu, Tien-Tsai Cheng, Han-Ming Lai, Shan-Fu Yu, Ben Yu-Jih Su, Chung-Yuan Hsu, Chi-Hua Ko and Jia-Feng Chen

    Citation: BMC Musculoskeletal Disorders 2017 18:326

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  12. Content type: Research article

    RA patients who eventually dropped out of treatment and out of the health care system had potentially disastrous consequences for their health-related quality-of-life outcomes. Objectives of the study were to ...

    Authors: Irazú Contreras-Yáñez and Virginia Pascual-Ramos

    Citation: BMC Musculoskeletal Disorders 2017 18:321

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  13. Content type: Research article

    The standard dose of rituximab used in rheumatoid arthritis (RA) is 1000 mg but recent studies have shown that low dose (500 mg) is also effective. Efficacy of low dose rituximab in rheumatoid arthritis (RA) r...

    Authors: Harindu Wijesinghe, Priyadharshini Galappatthy, Rajiva de Silva, Suranjith L. Seneviratne, Ushagowry Saravanamuttu, Preethi Udagama, Melanie Hart, Peter Kelleher, Upul Senerath, Rohini Fernandopulle, Lilani P. Weerasekera and Lalith S. Wijayaratne

    Citation: BMC Musculoskeletal Disorders 2017 18:310

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  14. Content type: Study protocol

    Psoriatic arthritis (PsA) is a chronic inflammatory arthritis which impacts significantly on the quality of life and work capacity of affected individuals. Recent evidence has shown that early control of infla...

    Authors: Gabriele De Marco, Philip Helliwell, Dennis McGonagle, Paul Emery, Laura C. Coates, Elizabeth M. A. Hensor and Helena Marzo-Ortega

    Citation: BMC Musculoskeletal Disorders 2017 18:303

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  15. Content type: Research article

    Disease-related foot pathology is recognised to have a significant impact on mobility and functional capacity in the majority of patients with rheumatoid arthritis (RA). The forefoot is widely affected and the...

    Authors: Heidi J Siddle, Richard J Hodgson, Elizabeth M A Hensor, Andrew J Grainger, Anthony C Redmond, Richard J Wakefield and Philip S Helliwell

    Citation: BMC Musculoskeletal Disorders 2017 18:308

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  16. Content type: Research article

    ONO-5334 is a cathepsin K inhibitor that induced bone mineral density (BMD) gain in a phase II study in postmenopausal osteoporosis patients. Even though the antiresorptive effect could only be monitored in th...

    Authors: Makoto Tanaka, Yoshitaka Hashimoto, Chihiro Hasegawa, Steve Deacon and Richard Eastell

    Citation: BMC Musculoskeletal Disorders 2017 18:267

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  17. Content type: Research article

    When people first experience symptoms of rheumatoid arthritis (RA) they often delay seeking medical attention resulting in delayed diagnosis and treatment. This research assesses behaviours people might engage...

    Authors: Gwenda Simons, Sophie Lumley, Marie Falahee, Kanta Kumar, Christian D. Mallen, Rebecca J. Stack and Karim Raza

    Citation: BMC Musculoskeletal Disorders 2017 18:258

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  18. Content type: Research article

    Patients with rheumatoid arthritis (RA) demonstrate reduced aerobic capacity, excess cardiovascular risk, mobility limitations and are less physically active than their healthy peers. Physical activity may dec...

    Authors: Thomas Quinn, Michelle Frits BS, Johan von Heideken, Christine Iannaccone, Nancy A. Shadick, Michael Weinblatt and Maura D. Iversen

    Citation: BMC Musculoskeletal Disorders 2017 18:234

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  19. Content type: Research article

    Systemic sclerosis (SSc) is a chronic connective-tissue disease responsible for reduced life expectancy, disability and a decreased quality of life. In order to optimize patients-physicians relationship and ca...

    Authors: Luc Mouthon, Sophie Alami, Anne-Sophie Boisard, Benjamin Chaigne, Eric Hachulla and Serge Poiraudeau

    Citation: BMC Musculoskeletal Disorders 2017 18:230

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  20. Content type: Research article

    Viscosupplementation is a symptomatic treatment of the knee osteoarthritis based on the intra-articular injection of hyaluronic acid (IAHA). Although many studies have investigated its effect on symptoms, few ...

    Authors: Yves Henrotin, Francis Berenbaum, Xavier Chevalier, Marc Marty, Pascal Richette and François Rannou

    Citation: BMC Musculoskeletal Disorders 2017 18:222

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