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BMC Musculoskeletal Disorders

Clinical rheumatology and osteoporosis

Section edited by Jasvinder Singh

This section concerns all aspects of research into osteoporosis and rheumatic diseases, where the primary focus relates specifically to a component(s) of the musculoskeletal system

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  1. Content type: Research article

    Since persistence to first biological disease modifying anti-rheumatic drugs (bDMARDs) is far from ideal in rheumatoid arthritis (RA) patients, many do receive a second and/or third bDMARD treatment. However, ...

    Authors: Thomas Wilke, Sabrina Mueller, Sze Chim Lee, Istvan Majer and Marieke Heisen

    Citation: BMC Musculoskeletal Disorders 2017 18:332

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  2. Content type: Research article

    Axial spondyloarthritis (ax-SpA) is a chronic inflammatory disease of the spine causing pain, stiffness, loss in physical function, and fatigue. Therefore, the physical and psychological burden of having this ...

    Authors: Gudrun Rohde, Kari Hansen Berg, Anne Prøven and Glenn Haugeberg

    Citation: BMC Musculoskeletal Disorders 2017 18:328

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  3. Content type: Research article

    This study evaluated the effect of early anti-tumor necrosis factor (TNF) therapy in patients with severe rheumatoid arthritis (RA) on the subsequent risk of total knee replacement (TKR) surgery.

    Authors: Ying-Chou Chen, Wen-Chan Chiu, Tien-Tsai Cheng, Han-Ming Lai, Shan-Fu Yu, Ben Yu-Jih Su, Chung-Yuan Hsu, Chi-Hua Ko and Jia-Feng Chen

    Citation: BMC Musculoskeletal Disorders 2017 18:326

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  4. Content type: Research article

    RA patients who eventually dropped out of treatment and out of the health care system had potentially disastrous consequences for their health-related quality-of-life outcomes. Objectives of the study were to ...

    Authors: Irazú Contreras-Yáñez and Virginia Pascual-Ramos

    Citation: BMC Musculoskeletal Disorders 2017 18:321

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  5. Content type: Research article

    The standard dose of rituximab used in rheumatoid arthritis (RA) is 1000 mg but recent studies have shown that low dose (500 mg) is also effective. Efficacy of low dose rituximab in rheumatoid arthritis (RA) r...

    Authors: Harindu Wijesinghe, Priyadharshini Galappatthy, Rajiva de Silva, Suranjith L. Seneviratne, Ushagowry Saravanamuttu, Preethi Udagama, Melanie Hart, Peter Kelleher, Upul Senerath, Rohini Fernandopulle, Lilani P. Weerasekera and Lalith S. Wijayaratne

    Citation: BMC Musculoskeletal Disorders 2017 18:310

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  6. Content type: Study protocol

    Psoriatic arthritis (PsA) is a chronic inflammatory arthritis which impacts significantly on the quality of life and work capacity of affected individuals. Recent evidence has shown that early control of infla...

    Authors: Gabriele De Marco, Philip Helliwell, Dennis McGonagle, Paul Emery, Laura C. Coates, Elizabeth M. A. Hensor and Helena Marzo-Ortega

    Citation: BMC Musculoskeletal Disorders 2017 18:303

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  7. Content type: Research article

    Disease-related foot pathology is recognised to have a significant impact on mobility and functional capacity in the majority of patients with rheumatoid arthritis (RA). The forefoot is widely affected and the...

    Authors: Heidi J Siddle, Richard J Hodgson, Elizabeth M A Hensor, Andrew J Grainger, Anthony C Redmond, Richard J Wakefield and Philip S Helliwell

    Citation: BMC Musculoskeletal Disorders 2017 18:308

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  8. Content type: Research article

    ONO-5334 is a cathepsin K inhibitor that induced bone mineral density (BMD) gain in a phase II study in postmenopausal osteoporosis patients. Even though the antiresorptive effect could only be monitored in th...

    Authors: Makoto Tanaka, Yoshitaka Hashimoto, Chihiro Hasegawa, Steve Deacon and Richard Eastell

    Citation: BMC Musculoskeletal Disorders 2017 18:267

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  9. Content type: Research article

    When people first experience symptoms of rheumatoid arthritis (RA) they often delay seeking medical attention resulting in delayed diagnosis and treatment. This research assesses behaviours people might engage...

    Authors: Gwenda Simons, Sophie Lumley, Marie Falahee, Kanta Kumar, Christian D. Mallen, Rebecca J. Stack and Karim Raza

    Citation: BMC Musculoskeletal Disorders 2017 18:258

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  10. Content type: Research article

    Patients with rheumatoid arthritis (RA) demonstrate reduced aerobic capacity, excess cardiovascular risk, mobility limitations and are less physically active than their healthy peers. Physical activity may dec...

    Authors: Thomas Quinn, Michelle Frits BS, Johan von Heideken, Christine Iannaccone, Nancy A. Shadick, Michael Weinblatt and Maura D. Iversen

    Citation: BMC Musculoskeletal Disorders 2017 18:234

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  11. Content type: Research article

    Systemic sclerosis (SSc) is a chronic connective-tissue disease responsible for reduced life expectancy, disability and a decreased quality of life. In order to optimize patients-physicians relationship and ca...

    Authors: Luc Mouthon, Sophie Alami, Anne-Sophie Boisard, Benjamin Chaigne, Eric Hachulla and Serge Poiraudeau

    Citation: BMC Musculoskeletal Disorders 2017 18:230

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  12. Content type: Research article

    Viscosupplementation is a symptomatic treatment of the knee osteoarthritis based on the intra-articular injection of hyaluronic acid (IAHA). Although many studies have investigated its effect on symptoms, few ...

    Authors: Yves Henrotin, Francis Berenbaum, Xavier Chevalier, Marc Marty, Pascal Richette and François Rannou

    Citation: BMC Musculoskeletal Disorders 2017 18:222

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  13. Content type: Research article

    Rheumatoid arthritis (RA) patients carry a high risk of cardiovascular morbidity and mortality. The excess of cardiovascular disease cannot be entirely explained by traditional risk factors and the immune syst...

    Authors: Francesca Romana Spinelli, Arbi Pecani, Francesco Ciciarello, Tania Colasanti, Manuela Di Franco, Francesca Miranda, Fabrizio Conti, Guido Valesini and Cristiano Alessandri

    Citation: BMC Musculoskeletal Disorders 2017 18:214

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    The Erratum to this article has been published in BMC Musculoskeletal Disorders 2017 18:263

  14. Content type: Research article

    There have been no previous report of hand joint destruction prevalence in Chinese rheumatoid arthritis (RA) patients. Therefore, the aim of this study was to investigate the prevalence and potential factors o...

    Authors: Lijuan Zhang, Jing Wang, Qiuxiang Zhang, Ting Fu, Rulan Yin, Ze Wang, Liren Li, Xianhua Wu and Zhifeng Gu

    Citation: BMC Musculoskeletal Disorders 2017 18:211

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    The Erratum to this article has been published in BMC Musculoskeletal Disorders 2017 18:231

  15. Content type: Research article

    The Multidimensional Daily Diary of Fatigue-Fibromyalgia-17 instrument (MDF-Fibro-17) has been developed for use in fibromyalgia (FM) clinical studies and includes 5 domains: Global Fatigue Experience, Cogniti...

    Authors: Y. Li, S. Morris, J. Cole, S. Dube’, J. A. M. Smith, C. Burbridge, T. Symonds, S. Hudgens and W. Wang

    Citation: BMC Musculoskeletal Disorders 2017 18:198

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  16. Content type: Research article

    Fibromyalgia (FM), a disorder characterized by chronic widespread pain and tenderness, affects greater than five million individuals in the United States alone. Patients experience multiple symptoms in additio...

    Authors: S. Morris, Y. Li, J.A.M. Smith, S. Dube’, C. Burbridge and T. Symonds

    Citation: BMC Musculoskeletal Disorders 2017 18:195

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  17. Content type: Research article

    The Stanford Health Assessment Questionnaire-Disability Index (HAQ) is widely used to measure functional ability in persons with Rheumatoid Arthritis (RA). The instrument was developed with limited involvement...

    Authors: David Ebbevi, Anna Essén and Helena Hvitfeldt Forsberg

    Citation: BMC Musculoskeletal Disorders 2017 18:189

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  18. Content type: Research article

    The primary purpose of this study is to assess the existing evidence on the cost-effectiveness of surgical interventions for the management of knee and hip osteoarthritis by systematically reviewing published ...

    Authors: Hanin Kamaruzaman, Philip Kinghorn and Raymond Oppong

    Citation: BMC Musculoskeletal Disorders 2017 18:183

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  19. Content type: Research article

    Denosumab treatment for up to 8 years in the FREEDOM study and Extension was associated with low fracture incidence. It was not clear whether subjects who discontinued during the study conduct had a higher ris...

    Authors: Jonathan D. Adachi, Henry G. Bone, Nadia S. Daizadeh, Paula Dakin, Socrates Papapoulos, Peyman Hadji, Chris Recknor, Michael A. Bolognese, Andrea Wang, Celia J. F. Lin, Rachel B. Wagman and Serge Ferrari

    Citation: BMC Musculoskeletal Disorders 2017 18:174

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