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Clinical rheumatology and osteoporosis

This section concerns all aspects of research into osteoporosis and rheumatic diseases, where the primary focus relates specifically to a component(s) of the musculoskeletal system

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  1. Vitamin D (VD) insufficiency or deficiency is a frequent comorbidity in Chinese women with postmenopausal osteoporosis (PMO). The present study aimed to investigate 25-hydroxyvitamin D [25(OH) D] improvement a...

    Authors: Er-Yuan Liao, Zhen-Lin Zhang, Wei-Bo Xia, Hua Lin, Qun Cheng, Li Wang, Yong-Qiang Hao, De-Cai Chen, Hai Tang, Yong-De Peng, Li You, Liang He, Zhao-Heng Hu, Chun-Li Song, Fang Wei, Jue Wang…

    Citation: BMC Musculoskeletal Disorders 2018 19:210

    Content type: Research article

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  2. Dutasteride is a potent inhibitor of 5-alpha reductase enzymes that reduces concentrations of dihydrotestosterone to a greater extent than finasteride. Whether this has adverse implications for bone health is ...

    Authors: Tony Antoniou, Erin M. Macdonald, Zhan Yao, Tara Gomes, Mina Tadrous, Joanne M.-W. Ho, Muhammad M. Mamdani and David N. Juurlink

    Citation: BMC Musculoskeletal Disorders 2018 19:160

    Content type: Research article

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  3. Osteoarthritis (OA) is the most common joint disorder worldwide and one of the leading causes of disability in the elderly. We have investigated the novel sodium hyaluronate derivative chemically linked with d...

    Authors: Keiji Yoshioka, Tomochika Kisukeda, Ryoji Zuinen, Yosuke Yasuda and Kenji Miyamoto

    Citation: BMC Musculoskeletal Disorders 2018 19:157

    Content type: Research article

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  4. Knowledge on prevalence of osteoporosis stratifying for socioeconomic background is insufficient in Germany. Little is known in Europe about other diseases that go along with it although these aspects are impo...

    Authors: Marie-Therese Puth, Manuela Klaschik, Matthias Schmid, Klaus Weckbecker and Eva Münster

    Citation: BMC Musculoskeletal Disorders 2018 19:144

    Content type: Research article

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  5. Several studies looking into the association between insulin-like growth factor-1 (IGF-1) gene polymorphisms and osteoporosis predisposition have been conducted among Chinese population with conflicting outcom...

    Authors: Shu-tao Gao, Zheng-tao Lv, Chuan-kun Zhou, Chao Mao and Wei-bin Sheng

    Citation: BMC Musculoskeletal Disorders 2018 19:141

    Content type: Research article

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  6. To increase the uptake of key clinical recommendations for non-surgical management of knee osteoarthritis (OA) and improve patient outcomes, we developed a new model of service delivery (PARTNER model) and an ...

    Authors: David J. Hunter, Rana S. Hinman, Jocelyn L. Bowden, Thorlene Egerton, Andrew M. Briggs, Stephen J. Bunker, Jessica Kasza, Andrew B. Forbes, Simon D. French, Marie Pirotta, Deborah J. Schofield, Nicholas A. Zwar and Kim L. Bennell

    Citation: BMC Musculoskeletal Disorders 2018 19:132

    Content type: Study protocol

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    The Correction to this article has been published in BMC Musculoskeletal Disorders 2018 19:443

  7. Inflammatory back pain is a condition characterized by inflammation of the sacroiliac joints and lower spine. It is frequently seen in patients with spondyloarthropathies like ankylosing spondylitis, psoriatic...

    Authors: Safi Alqatari, Roberta Visevic, Nina Marshall, John Ryan and Grainne Murphy

    Citation: BMC Musculoskeletal Disorders 2018 19:126

    Content type: Case report

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  8. Osteoporotic vertebral fractures are common, and are associated with reduced functioning and health related quality of life. The primary aims of this randomized controlled trial are to examine the immediate an...

    Authors: Brita Stanghelle, Hege Bentzen, Lora Giangregorio, Are Hugo Pripp and Astrid Bergland

    Citation: BMC Musculoskeletal Disorders 2018 19:100

    Content type: Study protocol

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  9. The prevalence of hand osteoarthritis (HOA) has been reported to be higher amongst women over 50 years old (66%) compared to men of the same age (34%). Although exercise therapy has been shown effective in red...

    Authors: Paulette Guitard, Lucie Brosseau, George A. Wells, Nicole Paquet, Gail Paterson, Karine Toupin-April, Sabrina Cavallo, Sibel Z. Aydin, Guillaume Léonard and Gino De Angelis

    Citation: BMC Musculoskeletal Disorders 2018 19:56

    Content type: Study protocol

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  10. Impaired bone quality is associated with poor outcome of spinal surgery. The aim of the study was to assess the bone mineral status of patients scheduled to undergo spinal surgery and to report frequencies of ...

    Authors: Tobias Schmidt, Katharina Ebert, Tim Rolvien, Nicola Oehler, Jens Lohmann, Luca Papavero, Ralph Kothe, Michael Amling, Florian Barvencik and Haider Mussawy

    Citation: BMC Musculoskeletal Disorders 2018 19:53

    Content type: Research article

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  11. Dupuytren’s disease (DD) is a common and progressive, fibroproliferative disorder of the palmar and digital fascia of the hand. Various treatments have been recommended for advanced disease or to retard progre...

    Authors: Melina Dritsaki, Oliver Rivero-Arias, Alastair Gray, Catherine Ball and Jagdeep Nanchahal

    Citation: BMC Musculoskeletal Disorders 2018 19:34

    Content type: Research article

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  12. The roles of C-reactive protein (CRP) and cartilage oligomeric matrix protein (COMP) in knee osteoarthritis (KOA) remain controversial, thus the present study is aimed to explore the relationships between CRP,...

    Authors: Junfeng Zhang

    Citation: BMC Musculoskeletal Disorders 2018 19:22

    Content type: Research article

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  13. Pain is the principal clinical symptom of osteoarthritis (OA), and development of safe and effective analgesics for OA pain is needed. Drug development of new analgesics for OA pain is impaired by substantial ...

    Authors: Asger Reinstrup Bihlet, Inger Byrjalsen, Anne-Christine Bay-Jensen, Jeppe Ragnar Andersen, Claus Christiansen, Bente Juel Riis, Ivo Valter, Morten A. Karsdal and Marc C. Hochberg

    Citation: BMC Musculoskeletal Disorders 2018 19:17

    Content type: Research article

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  14. Associations between adipokines and bone mineral density (BMD) in knee osteoarthritis (OA) remain indistinct. The aim of this study was to investigate the cross-sectional associations between serum levels of a...

    Authors: Juan Wu, Jianhua Xu, Kang Wang, Qicui Zhu, Jingyu Cai, Jiale Ren, Shuang Zheng and Changhai Ding

    Citation: BMC Musculoskeletal Disorders 2018 19:16

    Content type: Research article

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  15. Intra-articular hyaluronic acid (IA-HA) is a common therapy used to treat knee pain and suppress knee inflammation in knee osteoarthritis (OA), typically prescribed in regimens ranging from a single injection ...

    Authors: Andrew Concoff, Parag Sancheti, Faizan Niazi, Peter Shaw and Jeffrey Rosen

    Citation: BMC Musculoskeletal Disorders 2017 18:542

    Content type: Research article

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  16. Despite the widely known benefits of exercise and physical activity, adherence rates to these activities are poor. Understanding exercise facilitators, barriers, and preferences may provide an opportunity to p...

    Authors: Isabel B. Rodrigues, Jonathan D. Adachi, Karen A. Beattie and Joy C. MacDermid

    Citation: BMC Musculoskeletal Disorders 2017 18:540

    Content type: Research article

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  17. We used High Resolution – peripheral Quantitative CT (HR-pQCT) imaging to examine peri-articular bone quality in early rheumatoid arthritis (RA) and explore whether bone quality improved over 12-months in indi...

    Authors: Lynne M. Feehan, Linda L. Li and Heather A. McKay

    Citation: BMC Musculoskeletal Disorders 2017 18:521

    Content type: Research article

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  18. The Lower Limb Assessment Score (LLAS) has only been validated in a paediatric population. The aim of this study was to validate the use of the LLAS in an adult population by: i) evaluating its ability to disc...

    Authors: Kaitlin J. Meyer, Cliffton Chan, Luke Hopper and Leslie L. Nicholson

    Citation: BMC Musculoskeletal Disorders 2017 18:514

    Content type: Research article

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  19. Oscarvit (OSC) is an in-house preparation consisting of calcium, magnesium, phosphorus, strontium, Vitamin D, and eggshell membrane hydrolysate containing naturally occurring glycosaminoglycans and sulfated gl...

    Authors: Tibor Görögh, Elgar S. Quabius, Alexander Georgitsis, Markus Hoffmann and Sebastian Lippross

    Citation: BMC Musculoskeletal Disorders 2017 18:500

    Content type: Research article

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  20. Social media is increasingly used by patients to source information for managing chronic disease. The aim of this study was to understand patient information needs about gout by a content analysis of questions...

    Authors: Christina Derksen, Anna Serlachius, Keith J. Petrie and Nicola Dalbeth

    Citation: BMC Musculoskeletal Disorders 2017 18:488

    Content type: Research article

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  21. Rheumatologists increasingly perform ultrasound (US) imaging to aid diagnosis and management decisions. There is a need to determine the role of US in facilitating early diagnosis of inflammatory arthritis. Th...

    Authors: Stephen Kelly, Brian Davidson, Sarah Keidel, Stephan Gadola, Claire Gorman, Gary Meenagh and Piero Reynolds

    Citation: BMC Musculoskeletal Disorders 2017 18:487

    Content type: Research article

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  22. Osteoarthritis (OA) of the trapeziometacarpal joint (TMJ) is a disabling condition with a significant impact on quality of life. The optimal management of hand OA requires a combination of non-pharmacological ...

    Authors: Sara Tenti, Nicola Antonio Pascarelli, Stefano Giannotti, Mauro Galeazzi, Nicola Giordano and Antonella Fioravanti

    Citation: BMC Musculoskeletal Disorders 2017 18:444

    Content type: Research article

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  23. Several drugs have become available for the treatment of osteoporosis. However, screening and treatment of patients with a high fracture risk is currently not recommended in the Netherlands, because the effect...

    Authors: P. J. M. Elders, T. Merlijn, K. M. A. Swart, W. van Hout, B. C. van der Zwaard, C. Niemeijer, M. W. Heymans, A. A. van der Heijden, F. Rutters, H. E. van der Horst, P. Lips, J. C. Netelenbos and N. M. van Schoor

    Citation: BMC Musculoskeletal Disorders 2017 18:424

    Content type: Study protocol

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  24. Use of conservative treatment modalities in osteoarthritis (OA) is suboptimal, which appears to be partly due to patients’ beliefs about treatments. The aim of this study was to develop a research instrument a...

    Authors: Ellen M. H. Selten, Johanna E. Vriezekolk, Henk J. Schers, Marc W. Nijhof, Willemijn H. van der Laan, Roelien G. van der Meulen-Dilling, Rinie Geenen and Cornelia H. M. van den Ende

    Citation: BMC Musculoskeletal Disorders 2017 18:402

    Content type: Research article

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  25. During the course of rheumatoid arthritis (RA), patients have profound negative effects on their patient-reported-outcomes (PRO); in addition, the impact of sustained remission (SR) on PROs may differ for each...

    Authors: Irazú Contreras-Yáñez, Guillermo Guaracha-Basañez, Daniel Ruiz-Domínguez and Virginia Pascual-Ramos

    Citation: BMC Musculoskeletal Disorders 2017 18:379

    Content type: Research article

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  26. Investigate the prevalence and risk factors of low bone mineral density (BMD) in patients with axial spondyloarthritis as well as investigating the prevalence of vertebral fractures.

    Authors: Sandrine Malochet-Guinamand, Bruno Pereira, Zuzana Tatar, Anne Tournadre, Anna Moltó, Maxime Dougados and Martin Soubrier

    Citation: BMC Musculoskeletal Disorders 2017 18:357

    Content type: Research article

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  27. To cross-culturally adapt and validate the Singapore Chinese and Singapore English versions of the Ankylosing Spondylitis Quality of Life (ASQoL) scales.

    Authors: Ying Ying Leung, Weixian Lee, Nai Lee Lui, Matthew Rouse, Stephen P. McKenna and Julian Thumboo

    Citation: BMC Musculoskeletal Disorders 2017 18:353

    Content type: Research article

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  28. We examined the effectiveness and tolerability of transdermal buprenorphine (TDB) treatment in real-world setting in Asian patients with musculoskeletal pain.

    Authors: Do Heum Yoon, Seong-Il Bin, Simon Kin-Cheong Chan, Chun Kee Chung, Yong In, Hyoungmin Kim, Juan Javier Lichauco, Chi Chiu Mok, Young-Wan Moon, Tony Kwun-Tung Ng, Ester Gonzales Penserga, Dong Ah Shin, Dora You and Hanlim Moon

    Citation: BMC Musculoskeletal Disorders 2017 18:337

    Content type: Research article

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  29. Since persistence to first biological disease modifying anti-rheumatic drugs (bDMARDs) is far from ideal in rheumatoid arthritis (RA) patients, many do receive a second and/or third bDMARD treatment. However, ...

    Authors: Thomas Wilke, Sabrina Mueller, Sze Chim Lee, Istvan Majer and Marieke Heisen

    Citation: BMC Musculoskeletal Disorders 2017 18:332

    Content type: Research article

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  30. Axial spondyloarthritis (ax-SpA) is a chronic inflammatory disease of the spine causing pain, stiffness, loss in physical function, and fatigue. Therefore, the physical and psychological burden of having this ...

    Authors: Gudrun Rohde, Kari Hansen Berg, Anne Prøven and Glenn Haugeberg

    Citation: BMC Musculoskeletal Disorders 2017 18:328

    Content type: Research article

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  31. This study evaluated the effect of early anti-tumor necrosis factor (TNF) therapy in patients with severe rheumatoid arthritis (RA) on the subsequent risk of total knee replacement (TKR) surgery.

    Authors: Ying-Chou Chen, Wen-Chan Chiu, Tien-Tsai Cheng, Han-Ming Lai, Shan-Fu Yu, Ben Yu-Jih Su, Chung-Yuan Hsu, Chi-Hua Ko and Jia-Feng Chen

    Citation: BMC Musculoskeletal Disorders 2017 18:326

    Content type: Research article

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  32. RA patients who eventually dropped out of treatment and out of the health care system had potentially disastrous consequences for their health-related quality-of-life outcomes. Objectives of the study were to ...

    Authors: Irazú Contreras-Yáñez and Virginia Pascual-Ramos

    Citation: BMC Musculoskeletal Disorders 2017 18:321

    Content type: Research article

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  33. The standard dose of rituximab used in rheumatoid arthritis (RA) is 1000 mg but recent studies have shown that low dose (500 mg) is also effective. Efficacy of low dose rituximab in rheumatoid arthritis (RA) r...

    Authors: Harindu Wijesinghe, Priyadharshini Galappatthy, Rajiva de Silva, Suranjith L. Seneviratne, Ushagowry Saravanamuttu, Preethi Udagama, Melanie Hart, Peter Kelleher, Upul Senerath, Rohini Fernandopulle, Lilani P. Weerasekera and Lalith S. Wijayaratne

    Citation: BMC Musculoskeletal Disorders 2017 18:310

    Content type: Research article

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  34. Disease-related foot pathology is recognised to have a significant impact on mobility and functional capacity in the majority of patients with rheumatoid arthritis (RA). The forefoot is widely affected and the...

    Authors: Heidi J Siddle, Richard J Hodgson, Elizabeth M A Hensor, Andrew J Grainger, Anthony C Redmond, Richard J Wakefield and Philip S Helliwell

    Citation: BMC Musculoskeletal Disorders 2017 18:308

    Content type: Research article

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  35. Psoriatic arthritis (PsA) is a chronic inflammatory arthritis which impacts significantly on the quality of life and work capacity of affected individuals. Recent evidence has shown that early control of infla...

    Authors: Gabriele De Marco, Philip Helliwell, Dennis McGonagle, Paul Emery, Laura C. Coates, Elizabeth M. A. Hensor and Helena Marzo-Ortega

    Citation: BMC Musculoskeletal Disorders 2017 18:303

    Content type: Study protocol

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  36. ONO-5334 is a cathepsin K inhibitor that induced bone mineral density (BMD) gain in a phase II study in postmenopausal osteoporosis patients. Even though the antiresorptive effect could only be monitored in th...

    Authors: Makoto Tanaka, Yoshitaka Hashimoto, Chihiro Hasegawa, Steve Deacon and Richard Eastell

    Citation: BMC Musculoskeletal Disorders 2017 18:267

    Content type: Research article

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  37. When people first experience symptoms of rheumatoid arthritis (RA) they often delay seeking medical attention resulting in delayed diagnosis and treatment. This research assesses behaviours people might engage...

    Authors: Gwenda Simons, Sophie Lumley, Marie Falahee, Kanta Kumar, Christian D. Mallen, Rebecca J. Stack and Karim Raza

    Citation: BMC Musculoskeletal Disorders 2017 18:258

    Content type: Research article

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  38. Patients with rheumatoid arthritis (RA) demonstrate reduced aerobic capacity, excess cardiovascular risk, mobility limitations and are less physically active than their healthy peers. Physical activity may dec...

    Authors: Thomas Quinn, Michelle Frits BS, Johan von Heideken, Christine Iannaccone, Nancy A. Shadick, Michael Weinblatt and Maura D. Iversen

    Citation: BMC Musculoskeletal Disorders 2017 18:234

    Content type: Research article

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  39. Systemic sclerosis (SSc) is a chronic connective-tissue disease responsible for reduced life expectancy, disability and a decreased quality of life. In order to optimize patients-physicians relationship and ca...

    Authors: Luc Mouthon, Sophie Alami, Anne-Sophie Boisard, Benjamin Chaigne, Eric Hachulla and Serge Poiraudeau

    Citation: BMC Musculoskeletal Disorders 2017 18:230

    Content type: Research article

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  40. Viscosupplementation is a symptomatic treatment of the knee osteoarthritis based on the intra-articular injection of hyaluronic acid (IAHA). Although many studies have investigated its effect on symptoms, few ...

    Authors: Yves Henrotin, Francis Berenbaum, Xavier Chevalier, Marc Marty, Pascal Richette and François Rannou

    Citation: BMC Musculoskeletal Disorders 2017 18:222

    Content type: Research article

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  41. Rheumatoid arthritis (RA) patients carry a high risk of cardiovascular morbidity and mortality. The excess of cardiovascular disease cannot be entirely explained by traditional risk factors and the immune syst...

    Authors: Francesca Romana Spinelli, Arbi Pecani, Francesco Ciciarello, Tania Colasanti, Manuela Di Franco, Francesca Miranda, Fabrizio Conti, Guido Valesini and Cristiano Alessandri

    Citation: BMC Musculoskeletal Disorders 2017 18:214

    Content type: Research article

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    The Erratum to this article has been published in BMC Musculoskeletal Disorders 2017 18:263

  42. There have been no previous report of hand joint destruction prevalence in Chinese rheumatoid arthritis (RA) patients. Therefore, the aim of this study was to investigate the prevalence and potential factors o...

    Authors: Lijuan Zhang, Jing Wang, Qiuxiang Zhang, Ting Fu, Rulan Yin, Ze Wang, Liren Li, Xianhua Wu and Zhifeng Gu

    Citation: BMC Musculoskeletal Disorders 2017 18:211

    Content type: Research article

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    The Erratum to this article has been published in BMC Musculoskeletal Disorders 2017 18:231

  43. The Multidimensional Daily Diary of Fatigue-Fibromyalgia-17 instrument (MDF-Fibro-17) has been developed for use in fibromyalgia (FM) clinical studies and includes 5 domains: Global Fatigue Experience, Cogniti...

    Authors: Y. Li, S. Morris, J. Cole, S. Dube’, J. A. M. Smith, C. Burbridge, T. Symonds, S. Hudgens and W. Wang

    Citation: BMC Musculoskeletal Disorders 2017 18:198

    Content type: Research article

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  44. Fibromyalgia (FM), a disorder characterized by chronic widespread pain and tenderness, affects greater than five million individuals in the United States alone. Patients experience multiple symptoms in additio...

    Authors: S. Morris, Y. Li, J.A.M. Smith, S. Dube’, C. Burbridge and T. Symonds

    Citation: BMC Musculoskeletal Disorders 2017 18:195

    Content type: Research article

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  45. The Stanford Health Assessment Questionnaire-Disability Index (HAQ) is widely used to measure functional ability in persons with Rheumatoid Arthritis (RA). The instrument was developed with limited involvement...

    Authors: David Ebbevi, Anna Essén and Helena Hvitfeldt Forsberg

    Citation: BMC Musculoskeletal Disorders 2017 18:189

    Content type: Research article

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  46. The primary purpose of this study is to assess the existing evidence on the cost-effectiveness of surgical interventions for the management of knee and hip osteoarthritis by systematically reviewing published ...

    Authors: Hanin Kamaruzaman, Philip Kinghorn and Raymond Oppong

    Citation: BMC Musculoskeletal Disorders 2017 18:183

    Content type: Research article

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  47. Denosumab treatment for up to 8 years in the FREEDOM study and Extension was associated with low fracture incidence. It was not clear whether subjects who discontinued during the study conduct had a higher ris...

    Authors: Jonathan D. Adachi, Henry G. Bone, Nadia S. Daizadeh, Paula Dakin, Socrates Papapoulos, Peyman Hadji, Chris Recknor, Michael A. Bolognese, Andrea Wang, Celia J. F. Lin, Rachel B. Wagman and Serge Ferrari

    Citation: BMC Musculoskeletal Disorders 2017 18:174

    Content type: Research article

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  48. Remission is arguably the ultimate therapeutic goal in rheumatoid arthritis (RA). Applying modern strategies, clinical remission can be achieved in a substantial number of patients with early RA (ERA). Even in...

    Authors: Philipp Sewerin, Stefan Vordenbaeumen, Annika Hoyer, Ralph Brinks, Christian Buchbender, Falk Miese, Christoph Schleich, Sabine Klein, Matthias Schneider and Benedikt Ostendorf

    Citation: BMC Musculoskeletal Disorders 2017 18:163

    Content type: Research article

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  49. Poor adherence with oral bisphosphonates (BPs) can mitigate their therapeutic benefit for osteoporosis and is a significant clinical burden. Most previous studies regarding adherence with oral BPs have focused...

    Authors: Ji-Heh Park, Eun-Kyoung Park, Dong-Wan Koo, Shinwon Lee, Sun-Hee Lee, Geun-Tae Kim and Seung-Geun Lee

    Citation: BMC Musculoskeletal Disorders 2017 18:152

    Content type: Research article

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