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Clinical rheumatology and osteoporosis

This section concerns all aspects of research into osteoporosis and rheumatic diseases, where the primary focus relates specifically to a component(s) of the musculoskeletal system

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  1. Knee osteoarthritis is a major cause of pain and disability. Pain control is poor, with most patients remaining in moderate to severe pain. This may be because central causes of pain, a common contributor to k...

    Authors: Anita E. Wluka, Donna M. Urquhart, Andrew J. Teichtahl, Sultana Monira Hussain, Andrew Forbes, Carolyn Arnold, Yuanyuan Wang and Flavia M. Cicuttini

    Citation: BMC Musculoskeletal Disorders 2021 22:826

    Content type: Study protocol

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  2. Osteoporosis and cardiovascular diseases (CVDs) are 2 major public health problems. Osteoporosis and CVDs may be linked but the association between lipid profile and osteoporosis is still controversial. The pu...

    Authors: Bo Kan, Qianqian Zhao, Lijuan Wang, Shanshan Xue, Hanqing Cai and Shuman Yang

    Citation: BMC Musculoskeletal Disorders 2021 22:759

    Content type: Research article

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  3. Shifts in treatment strategies for rheumatoid arthritis (RA) have made ambulatory care more labour-intensive. These developments have prompted innovative care models, including mobile health (mHealth) applicat...

    Authors: Michaël Doumen, René Westhovens, Sofia Pazmino, Delphine Bertrand, Veerle Stouten, Claudia Neys, Nelly Creten, Els Van Laeken, Patrick Verschueren and Diederik De Cock

    Citation: BMC Musculoskeletal Disorders 2021 22:746

    Content type: Research article

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  4. Varus deformity of the knee is a common pathological characteristic in knee osteoarthritis (KOA), and not enough attention has been given to the relationship between knee varus deformity and the state of syste...

    Authors: Cheng Zhang, Zhikun Zhuang, Xiaojun Chen, Keda Li, Tianye Lin, Fengxiang Pang, Ying Zhang, Wei He and Qiushi Wei

    Citation: BMC Musculoskeletal Disorders 2021 22:694

    Content type: Research article

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  5. Despite having higher bone mineral density (BMD) values, type 2 diabetes mellitus (T2DM) patients are at increased risk of fracture. Trabecular bone score (TBS) obtained by evaluating bone microarchitecture mi...

    Authors: Negar Delbari, Alireza Rajaei, Mahbobeh Oroei, Arman Ahmadzadeh and Faraneh Farsad

    Citation: BMC Musculoskeletal Disorders 2021 22:582

    Content type: Research article

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  6. The 2013 Malaysian Clinical Practice Guidelines on the Management of Osteoarthritis (OA) recommend a linear step-up approach to manage knee OA. However, patients with knee OA often require a multimodal approac...

    Authors: Swan Sim Yeap, Syamsul Rizal Abu Amin, Hazlyna Baharuddin, Kar Chai Koh, Joon Kiong Lee, Verna Kar Mun Lee, Nor Hamdan Mohamad Yahaya, Cheh Chin Tai and Maw Pin Tan

    Citation: BMC Musculoskeletal Disorders 2021 22:514

    Content type: Research article

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  7. To evaluate the effect of treatment on serum bone biomarkers and explore whether serum bone biomarkers are associated with therapeutic response in rheumatoid arthritis (RA) patients treated with abatacept.

    Authors: Shin-ya Kawashiri, Yushiro Endo, Ayako Nishino, Momoko Okamoto, Sosuke Tsuji, Ayuko Takatani, Toshimasa Shimizu, Remi Sumiyoshi, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Toshiyuki Aramaki, Yukitaka Ueki…

    Citation: BMC Musculoskeletal Disorders 2021 22:506

    Content type: Research article

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  8. Single 6 ml Hylan G-F 20 injection, is indicated for knee osteoarthritis patients who have failed to respond to non-pharmacologic therapy and/or simple analgesics. To obtain more thorough understanding of the ...

    Authors: Yan Ke, Wenxue Jiang, Yongsheng Xu, Yajun Chen, Qingsong Zhang, Qingyun Xue, Jianhao Lin, Wilson Ngai, Gaowei Nian, Mir Sohail Fazeli, Yao Xie and Zhenan Zhu

    Citation: BMC Musculoskeletal Disorders 2021 22:428

    Content type: Research article

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  9. We aimed to determine the efficacy and safety of multiple doses of intravenous tranexamic acid (IV-TXA) on perioperative blood loss in patients with rheumatoid arthritis (RA) who had undergone primary unilater...

    Authors: Bing-xin Kang, Hui Xu, Chen-xin Gao, Sheng Zhong, Jing Zhang, Jun Xie, Song-tao Sun, Ying-hui Ma, Xi-rui Xu, Chi Zhao, Wei-tao Zhai, Lian-bo Xiao and Xiao-jun Gao

    Citation: BMC Musculoskeletal Disorders 2021 22:425

    Content type: Research article

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  10. Knee osteoarthritis (KOA) is increasingly more prevalent and significant number of patients require knee arthroplasty. Although knee arthroplasty is generally successful, it takes months to recover physical fu...

    Authors: Sunghye Kim, Fang-Chi Hsu, Leanne Groban, Jeff Williamson and Stephen Messier

    Citation: BMC Musculoskeletal Disorders 2021 22:388

    Content type: Research article

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  11. Blocking of the Tumor Necrosis Factor (TNF) activity is a successful therapeutic approach for 50–60% of rheumatoid arthritis (RA) patients. However, there are yet no biomarkers to stratify patients for anti-TN...

    Authors: Antonio Julià, María López-Lasanta, Francisco Blanco, Antonio Gómez, Isabel Haro, Antonio Juan Mas, Alba Erra, Ma Luz García Vivar, Jordi Monfort, Simón Sánchez-Fernández, Isidoro González, Mercedes Alperi, Raúl Castellanos-Moreira, Antonio Fernández-Nebro, César Díaz-Torné, Núria Palau…

    Citation: BMC Musculoskeletal Disorders 2021 22:372

    Content type: Research article

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  12. Arthritis, regardless of cause, has significant physical, social and psychological impacts on patients. We aimed to identify the non-healthcare needs perceived by patients with inflammatory arthritis (IA) and ...

    Authors: Jessica L. Fairley, Maheeka Seneviwickrama, Sabrina Yeh, Shane Anthony, Louisa Chou, Flavia M. Cicuttini, Kaye Sullivan, Andrew M. Briggs and Anita E. Wluka

    Citation: BMC Musculoskeletal Disorders 2021 22:341

    Content type: Research article

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  13. Giant cell tumor of bone is a benign, locally aggressive neoplasm. Surgical resection is the preferred treatment method. However, for cases in which resection poses an increased risk to the patient, denosumab ...

    Authors: Andrew Chandler, Meredith K. Bartelstein, Tomohiro Fujiwara, Cristina R. Antonescu, John H. Healey and Max Vaynrub

    Citation: BMC Musculoskeletal Disorders 2021 22:320

    Content type: Case report

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  14. The aim was to describe the population of patients with moderate rheumatoid arthritis (RA) in the United Kingdom and the burden of disease from the perspectives of the patient, caregiver, and health service.

    Authors: James Galloway, Julie Edwards, Shweta Bhagat, Ben Parker, Ai Lyn Tan, James Maxwell, Mike Wallington, Sophee Blanthorn-Hazell, Claire Bellamy and Zoe Cole

    Citation: BMC Musculoskeletal Disorders 2021 22:277

    Content type: Research article

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  15. Ankylosing spondylitis (AS) is a chronic autoimmune disease affecting the sacroiliac joint. To date, few studies have examined the association between long non-coding RNAs (lncRNAs) and AS pathogenesis. As suc...

    Authors: Dan Huang, Jian Liu, Lei Wan, Yanyan Fang, Yan Long, Ying Zhang and Bingxi Bao

    Citation: BMC Musculoskeletal Disorders 2021 22:272

    Content type: Research article

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  16. Altered circulating levels and genetic variation of B-type natriuretic peptide (BNP), has been associated with lower bone mineral density (BMD) values and incidence of osteoporosis in peritoneal dialysis patie...

    Authors: Pan Chen, Pijun Yan, Qin Wan, Zhihong Zhang, Yong Xu, Ying Miao and Jun Yang

    Citation: BMC Musculoskeletal Disorders 2021 22:261

    Content type: Research article

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  17. Placebo can have a significant therapeutic effect in patients with hand osteoarthritis (OA). This aim of the study is to identify factors associated with a clinically meaningful placebo response in patients wi...

    Authors: Jin Kyun Park, Se Han Ahn, Kichul Shin, Yun Jong Lee, Yeong Wook Song and Eun Bong Lee

    Citation: BMC Musculoskeletal Disorders 2021 22:244

    Content type: Research article

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  18. Pain is the principal symptom in knee osteoarthritis (OA). Current non-operative treatment options have only moderate effects and often patients experience persistent pain or side-effects. Novel advances in th...

    Authors: Niels-Peter Brøchner Nygaard, Carsten Koch-Jensen, Henrik Bjarke Vægter, Niels Wedderkopp, Morten Blichfeldt-Eckhardt and Bibi Gram

    Citation: BMC Musculoskeletal Disorders 2021 22:228

    Content type: Study protocol

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  19. The secondary fracture prevention gap in the osteoporosis field has been previously described as a ‘crisis’. Closing this gap is increasingly important in the context of accumulating evidence showing that an i...

    Authors: Jonathan D. Adachi, Jacques P. Brown, Emil Schemitsch, Jean-Eric Tarride, Vivien Brown, Alan D. Bell, Maureen Reiner, Millicent Packalen, Ponda Motsepe-Ditshego, Natasha Burke and Lubomira Slatkovska

    Citation: BMC Musculoskeletal Disorders 2021 22:224

    Content type: Research article

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  20. L-carnitine decreases oxidation and inflammation by reducing the fatty acid in plasma and using oxygen in ATP synthesis. As such, knee osteoarthritis (KOA) can be improved by reducing apoptotic chondrocytes. T...

    Authors: Farnaz Baghban, Mahdieh Hosseinzadeh, Hassan Mozaffari-Khosravi, Ali Dehghan and Hossein Fallahzadeh

    Citation: BMC Musculoskeletal Disorders 2021 22:195

    Content type: Research article

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  21. Aim of this multicenter, observational, cross-sectional study was to evaluate health-related quality of life (HRQoL) and treatment satisfaction of current medications in Chinese knee OA patients.

    Authors: Qingyun Xue, Huibin Long, Jianhao Lin, Dongping Du, Jin Zhou, Jinwei Chen, Shu li, Yanlei Zhang, Yan Cheng, Xiao Ma and Zhiyi Zhang

    Citation: BMC Musculoskeletal Disorders 2021 22:178

    Content type: Research article

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  22. In dermatomyostis (DM) patients, inflammation, reduced activity, and medication have a negative impact on the musculoskeletal system. Several endocrine factors are involved in muscle growth and bone turnover.

    Authors: Katharina Kerschan-Schindl, Wolfgang Gruther, Ursula Föger-Samwald, Christine Bangert, Stefan Kudlacek and Peter Pietschmann

    Citation: BMC Musculoskeletal Disorders 2021 22:150

    Content type: Research article

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  23. In clinically amyopathic dermatomyositis, the hallmark cutaneous manifestations are the key to diagnosis. We report a case of clinically amyopathic dermatomyositis which presented with facial edema as the sole...

    Authors: Doo-Ho Lim, Min Wook So, Yeon Mee Kim, Ji Hwa Ryu, Jae Ha Lee, Chan Sun Park, Seong-Ho Kim and Sunggun Lee

    Citation: BMC Musculoskeletal Disorders 2021 22:117

    Content type: Case report

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  24. Recent studies are lacking reports on mortality after non-hip fractures in adults aged > 65.

    Authors: Jacques P. Brown, Jonathan D. Adachi, Emil Schemitsch, Jean-Eric Tarride, Vivien Brown, Alan Bell, Maureen Reiner, Thiago Oliveira, Ponda Motsepe-Ditshego, Natasha Burke and Lubomira Slatkovska

    Citation: BMC Musculoskeletal Disorders 2021 22:105

    Content type: Research article

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  25. Skeletal manifestations are predominant in psoriatic arthritis (PsA). The aim of this cross-sectional, case-control study is the complex assessment of areal and volumetric bone mineral density (BMD), fracture ...

    Authors: Zsófia Pethő, Edit Kalina, Zoltán Pap, Katalin Hodosi, Rebeka Falcsik, Ádám Balogh, Zoltán Szekanecz and Harjit Pal Bhattoa

    Citation: BMC Musculoskeletal Disorders 2021 22:70

    Content type: Research article

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  26. Primary hyperparathyroidism (PHPT) is a common endocrinopathy that may increase fracture risk and decrease bone mineral density (BMD). Some patients develop distal renal tubular acidification dysfunction under...

    Authors: Wangna Tang, Hongwei Jia, Baoping Wang, Yun Chai, Tong Liu, Hao Wang and Chenlin Dai

    Citation: BMC Musculoskeletal Disorders 2021 22:69

    Content type: Research article

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  27. Long non-coding RNA (lncRNA) has been implicated in the progression of osteoarthritis (OA). This study was aimed to explore the role and molecular mechanism of lncRNA HOXA terminal transcriptional RNA (HOTTIP)...

    Authors: Xianwei He, Kun Gao, Shuaihua Lu and Rongbo Wu

    Citation: BMC Musculoskeletal Disorders 2021 22:67

    Content type: Research article

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  28. Recent research has suggested that cardiotrophin-like cytokine factor 1 (CLCF1) may be an important regulator of bone homeostasis. Furthermore, a whole gene chip analysis suggested that the expression levels o...

    Authors: Xuan Chen, Jianyang Li, Yunjin Ye, Jingwen Huang, Lihua Xie, Juan Chen, Shengqiang Li, Sainan Chen and Jirong Ge

    Citation: BMC Musculoskeletal Disorders 2021 22:62

    Content type: Research article

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  29. Obstructive sleep apnea (OSA) is prevalent in individuals with Osteogenesis imperfecta (OI). To date, no study has investigated treatment of OSA in adult individuals with OI using positive airway pressure (PAP...

    Authors: Heidi Arponen, Adel Bachour, Leif Bäck, Helena Valta, Antti Mäkitie, Outi Mäkitie and Janna Waltimo-Sirén

    Citation: BMC Musculoskeletal Disorders 2021 22:61

    Content type: Research article

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  30. First metatarsophalangeal (MTP) joint osteoarthritis (OA) is a painful and debilitating condition affecting nearly one in 10 people aged over 50 years. Non-drug, non-surgical treatments are recommended by OA c...

    Authors: Kade L. Paterson, Rana S. Hinman, Ben R. Metcalf, Sarah E. Jones, Hylton B. Menz, Shannon E. Munteanu, Jessica Kasza and Kim L. Bennell

    Citation: BMC Musculoskeletal Disorders 2020 21:830

    Content type: Study protocol

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  31. It is mechanically plausible that osteoporosis leads to more severe peripheral fractures, but studies investigating associations between BMD and radiographically verified complexity of distal radius fractures ...

    Authors: Anja M. Hjelle, Jan-Erik Gjertsen, Ellen M. Apalset, Roy M. Nilsen, Anja Lober, Grethe S. Tell and Pawel Mielnik

    Citation: BMC Musculoskeletal Disorders 2020 21:811

    Content type: Research article

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  32. Bisphosphonate (BP) therapy has been associated with atypical femur fracture (AFF). However, the threshold of treatment duration leading to increased AFF risk is unclear. In a retrospective cohort of older wom...

    Authors: Joan C. Lo, Romain S. Neugebauer, Bruce Ettinger, Malini Chandra, Rita L. Hui, Susan M. Ott, Christopher D. Grimsrud and Monika A. Izano

    Citation: BMC Musculoskeletal Disorders 2020 21:801

    Content type: Research article

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  33. Several risk assessments have been developed to evaluate fall risk in older adults, but it has not been conclusively established which of these tools is most effective for assessing fall risk in this vulnerabl...

    Authors: Nitchanant Kitcharanant, Ekasame Vanitcharoenkul and Aasis Unnanuntana

    Citation: BMC Musculoskeletal Disorders 2020 21:757

    Content type: Research article

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  34. Sequential therapy from bone-forming medication to resorptive agents is reportedly effective for patients with severe osteoporosis. The objective of this study is to determine the impact of implementing short-...

    Authors: Chan Ho Park, Jun-Il Yoo, Chang Hyun Choi and You-Sung Suh

    Citation: BMC Musculoskeletal Disorders 2020 21:751

    Content type: Research article

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  35. Globally, osteoarthritis (OA) is the third condition associated with disability. There is still poor treatment in OA but science holds the key to finding better treatments and a cure. It is essential to learn ...

    Authors: Marianna Vitaloni, Angie Botto-van Bemden, Rosa Sciortino, Xavier Carné, Maritza Quintero, Pedro Santos-Moreno, Rolando Espinosa, Oscar Rillo, Jordi Monfort, Francisco de Abajo, Elizabeth Oswald, Marco Matucci, Patrick du Souich, Ingrid Möller, Montserrat Romera Baures, Arlene Vinci…

    Citation: BMC Musculoskeletal Disorders 2020 21:727

    Content type: Research article

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  36. The 2013 American Academy of Orthopaedic Surgeons (AAOS) guidelines made strong recommendations against intraarticular hyaluronic acid (IAHA) for patients with knee osteoarthritis (OA), as evidence supporting ...

    Authors: Charles D. Hummer, Felix Angst, Wilson Ngai, Craig Whittington, Sophie S. Yoon, Lionel Duarte, Colleen Manitt and Emil Schemitsch

    Citation: BMC Musculoskeletal Disorders 2020 21:702

    Content type: Research article

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  37. Low back pain is common and a significant number of patients experience chronic low back pain. Current treatment options offer small to moderate effects. Patients with vertebral bone marrow lesions visualized ...

    Authors: Elisabeth Gjefsen, Lars Christian Haugli Bråten, Guro Løvik Goll, Monica Wigemyr, Nils Bolstad, Morten Valberg, Elina Iordanova Schistad, Gunn Hege Marchand, Fredrik Granviken, Kaja Kristine Selmer, Anne Froholdt, Anne Julsrud Haugen, Magnhild Hammersland Dagestad, Nils Vetti, Gunnstein Bakland, Benedicte Alexandra Lie…

    Citation: BMC Musculoskeletal Disorders 2020 21:698

    Content type: Study protocol

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  38. Osteoporosis affects elderly patients of both sexes. It is characterized by an increased fracture risk due to defective remodeling of the bone microarchitecture. It affects in particular postmenopausal women d...

    Authors: K. Jäckle, J. P. Kolb, A. F. Schilling, C. Schlickewei, M. Amling, J. M. Rueger and W. Lehmann

    Citation: BMC Musculoskeletal Disorders 2020 21:693

    Content type: Research article

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  39. Inflammatory diseases are chronic autoimmune systemic autoimmune diseases, which may increase the risk of prosthetic joint infection (PJI) after total joint arthroplasty (TJA). However, to our best knowledge, ...

    Authors: Qiao Jiang, Jun Fu, Wei Chai, Li-Bo Hao, Yong-Gang Zhou, Chi Xu and Ji-Ying Chen

    Citation: BMC Musculoskeletal Disorders 2020 21:681

    Content type: Research article

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  40. To investigate the frequency of pain among subjects with advanced radiographic knee osteoarthritis (OA) defined as Kellgren–Lawrence (KL) grade 4 and clinical features associated with pain.

    Authors: Kyeong Min Son, Jeong Im Hong, Dong-Hyun Kim, Dae-Gyu Jang, Michel D. Crema and Hyun Ah Kim

    Citation: BMC Musculoskeletal Disorders 2020 21:640

    Content type: Research article

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  41. Chronic low back pain (cLBP) results in significant physical, psycho-social and socioeconomic burden. Identifying efficient and reliable patient reported outcome measures is critical for research and clinical pur...

    Authors: Rabih Nayfe, Matthieu Chansard, Linda S. Hynan, Eric M. Mortensen, Thiru Annaswamy, Liana Fraenkel and Una E. Makris

    Citation: BMC Musculoskeletal Disorders 2020 21:598

    Content type: Research article

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  42. Bone cement leakage causes severe complication following percutaneous vertebroplasty. This study probed the diffusion and leakage status of bone cement injected within diverged time duration, so as to find the...

    Authors: Meiyong Wang and Qunhua Jin

    Citation: BMC Musculoskeletal Disorders 2020 21:589

    Content type: Research article

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  43. Melanocortin receptor (MCR) agonists have anti-inflammatory and immunomodulatory properties mediated by receptors expressed on cells relevant to arthritis. Repository corticotropin injection (RCI; Acthar® Gel)...

    Authors: Dima A. Decker, Paul Higgins, Kyle Hayes, Chris Bollinger, Patrice Becker and Dale Wright

    Citation: BMC Musculoskeletal Disorders 2020 21:586

    Content type: Research article

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  44. Recently, an increasing number of studies have focused on the extra-gastrointestinal effects of Helicobacter pylori (H. pylori), including metabolic syndrome, fatty liver, and rheumatic and skin diseases. Oste...

    Authors: Jing-Wei Wang, Feng-Xiao Dong, Hui Su, Licun Zhu, Sujun Shao and Hong Liu

    Citation: BMC Musculoskeletal Disorders 2020 21:559

    Content type: Research article

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  45. Numerous comparative studies of surgical procedures have focused on clinical and radiographical outcomes, as well as the effect of bone fragility on the outcome of spinal surgery; however, insights concerning ...

    Authors: Tetsuro Ohba, Hiroshi Yokomichi, Kensuke Koyama, Nobuki Tanaka, Kotaro Oda and Hirotaka Haro

    Citation: BMC Musculoskeletal Disorders 2020 21:528

    Content type: Research article

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  46. Osteoporosis is a metabolic bone disorder characterized by deterioration in the quantity and quality of bone tissue, with a consequent increase susceptibility to fracture.

    Authors: Chin-Chean Wong, Jeng-Hao Liao, Shi-Yuan Sheu, Po-Yu Lin, Chih-Hwa Chen and Tzong-Fu Kuo

    Citation: BMC Musculoskeletal Disorders 2020 21:527

    Content type: Research article

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  47. Patients with rheumatoid arthritis (RA) who have undergone total knee arthroplasty are at increased risk of requiring a blood transfusion. This study is designed to compare the effects of preemptive antifibrin...

    Authors: Yiting Lei, Jiacheng Liu, Xi Liang, Ning Hu, Fuxing Pei and Wei Huang

    Citation: BMC Musculoskeletal Disorders 2020 21:465

    Content type: Study protocol

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  48. Osteoporosis (OP) is one of the commonly seen bone diseases with low bone mineral densities and trauma fractures. Accumulative studies have demonstrated that the occurrence of OP is closely related to osteocla...

    Authors: Yingfeng Yu, Peiquan Yao, Zhikun Wang and Wenwei Xie

    Citation: BMC Musculoskeletal Disorders 2020 21:456

    Content type: Research article

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