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Clinical rheumatology and osteoporosis

This section concerns all aspects of research into osteoporosis and rheumatic diseases, where the primary focus relates specifically to a component(s) of the musculoskeletal system

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  1. Content type: Research article

    Previous studies suggest that RA activity is sensitive to seasonal changes. This study explored the influence of season on RA activity, particularly the distribution of affected joints, using a nationwide data...

    Authors: Hiroaki Mori, Tetsuji Sawada, Susumu Nishiyama, Kota Shimada, Koichiro Tahara, Haeru Hayashi, Eri Kato, Mayu Tago, Toshihiro Matsui and Shigeto Tohma

    Citation: BMC Musculoskeletal Disorders 2019 20:30

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  2. Content type: Research article

    This study examines the association of both pain severity and within-person pain variability with physical activity (PA) in older adults with osteoarthritis (OA).

    Authors: Erik J. Timmermans, Elisa J. de Koning, Natasja M. van Schoor, Suzan van der Pas, Michael D. Denkinger, Elaine M. Dennison, Stefania Maggi, Nancy L. Pedersen, Ángel Otero, Richard Peter, Cyrus Cooper, Paola Siviero, Maria Victoria Castell, Florian Herbolsheimer, Mark Edwards, Federica Limongi…

    Citation: BMC Musculoskeletal Disorders 2019 20:12

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  3. Content type: Research article

    Rheumatoid arthritis (RA) is a chronic and refractory autoimmune joint disease. Fibroblast-like synoviocytes (FLS) produce inflammatory cytokines and are involved in the migration and invasion of panuus tissue...

    Authors: Jing Wu, Yuan Qu, Yu-Ping Zhang, Jia-Xin Deng and Qing-Hong Yu

    Citation: BMC Musculoskeletal Disorders 2018 19:455

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  4. Content type: Research article

    The aetiology and pathogenesis of primary bone marrow oedema syndrome (BMES) remain unclear. This retrospective cross-sectional study in a large cohort of patients with BMES was performed to characterise the o...

    Authors: Nicola Oehler, Haider Mussawy, Tobias Schmidt, Tim Rolvien and Florian Barvencik

    Citation: BMC Musculoskeletal Disorders 2018 19:451

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  5. Content type: Research article

    It is generally believed that Thai people do not suffer from hypovitaminosis D because there is abundant sunlight throughout the year, and that taking vitamin D supplements could result in abnormally high leve...

    Authors: Thawee Songpatanasilp, Sattaya Rojanasthien, Pansak Sugkraroek, Boonsong Ongphiphadhanakul, Lamar Robert, Chongchit Sripun Robert, Sirichai Luevitoonvechkij and Arthur C. Santora

    Citation: BMC Musculoskeletal Disorders 2018 19:392

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  6. Content type: Study protocol

    Osteoarthritis (OA) is a highly debilitating joint disease that causes progressive, irreversible damage to articular cartilage. OA takes a massive toll on society that has grown in recent decades, but no thera...

    Authors: Ian A. Jones, Melissa Wilson, Ryan Togashi, Bo Han, Austin K. Mircheff and C. Thomas Vangsness JR

    Citation: BMC Musculoskeletal Disorders 2018 19:383

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  7. Content type: Research article

    Reconstructive joint surgery is an indicator of poor prognosis in rheumatoid arthritis (RA). Objectives of this study were to describe the incidence rate of orthopedic and hand surgery indication (OHSI) in an ...

    Authors: Irazú Contreras-Yáñez, G. Guaracha-Basáñez, E. Díaz-Borjón, M. Iglesias and V. Pascual-Ramos

    Citation: BMC Musculoskeletal Disorders 2018 19:378

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  8. Content type: Research article

    Knee bone shape differs between men and women and the incidence of knee osteoarthritis (OA) is higher in women than in men. Therefore, the purpose of the present study was to determine whether the observed dif...

    Authors: Barton L. Wise, Jingbo Niu, Yuqing Zhang, Felix Liu, Joyce Pang, John A. Lynch and Nancy E. Lane

    Citation: BMC Musculoskeletal Disorders 2018 19:331

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  9. Content type: Case report

    IDC in children, first reported by Baron in 1924, is very rare. OPLL of the cervical spine mainly affect people ages 50–70 years. The coexistence of IDC and OPLL in children is very rare, only six cases with 3...

    Authors: Jun-Jie Du, Yu-Fei Chen, Ye Peng, Xiao-jie Li and Wei Ma

    Citation: BMC Musculoskeletal Disorders 2018 19:316

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  10. Content type: Study protocol

    Knee osteoarthritis (OA) causes substantial pain, physical dysfunction and impaired quality of life. There is no cure for knee OA, and for some people, the disease may involve progressive symptomatic and struc...

    Authors: Kade L. Paterson, David J. Hunter, Ben R. Metcalf, Jillian Eyles, Vicky Duong, Jessica Kazsa, Yuanyuan Wang, Rachelle Buchbinder, Flavia Cicuttini, Andrew Forbes, Anthony Harris, Shirley P. Yu, Bing Hui Wang, David Connell, James Linklater and Kim L. Bennell

    Citation: BMC Musculoskeletal Disorders 2018 19:272

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  11. Content type: Research article

    The wrist is often severely affected in rheumatoid arthritis (RA) patients; however, little is known about the potential risk factors of the reduced wrist range of motion. In this study, we explored a broad ra...

    Authors: Lijuan Zhang, Haixia Cao, Qiuxiang Zhang, Ting Fu, Rulan Yin, Yunfei Xia, Liren Li and Zhifeng Gu

    Citation: BMC Musculoskeletal Disorders 2018 19:270

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  12. Content type: Study protocol

    Evidence on the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis is limited and conflicting. The primary objective of the Hip Injection Trial (HIT) is to compare pain intensity ...

    Authors: Zoe Paskins, Gemma Hughes, Helen Myers, Emily Hughes, Susie Hennings, Andrea Cherrington, Amy Evans, Melanie Holden, Kay Stevenson, Ajit Menon, Kieran Bromley, Philip Roberts, Alison Hall, George Peat, Clare Jinks, Raymond Oppong…

    Citation: BMC Musculoskeletal Disorders 2018 19:218

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  13. Content type: Research article

    Vitamin D (VD) insufficiency or deficiency is a frequent comorbidity in Chinese women with postmenopausal osteoporosis (PMO). The present study aimed to investigate 25-hydroxyvitamin D [25(OH) D] improvement a...

    Authors: Er-Yuan Liao, Zhen-Lin Zhang, Wei-Bo Xia, Hua Lin, Qun Cheng, Li Wang, Yong-Qiang Hao, De-Cai Chen, Hai Tang, Yong-De Peng, Li You, Liang He, Zhao-Heng Hu, Chun-Li Song, Fang Wei, Jue Wang…

    Citation: BMC Musculoskeletal Disorders 2018 19:210

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  14. Content type: Research article

    Osteoarthritis (OA) is the most common joint disorder worldwide and one of the leading causes of disability in the elderly. We have investigated the novel sodium hyaluronate derivative chemically linked with d...

    Authors: Keiji Yoshioka, Tomochika Kisukeda, Ryoji Zuinen, Yosuke Yasuda and Kenji Miyamoto

    Citation: BMC Musculoskeletal Disorders 2018 19:157

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  15. Content type: Research article

    Dutasteride is a potent inhibitor of 5-alpha reductase enzymes that reduces concentrations of dihydrotestosterone to a greater extent than finasteride. Whether this has adverse implications for bone health is ...

    Authors: Tony Antoniou, Erin M. Macdonald, Zhan Yao, Tara Gomes, Mina Tadrous, Joanne M.-W. Ho, Muhammad M. Mamdani and David N. Juurlink

    Citation: BMC Musculoskeletal Disorders 2018 19:160

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  16. Content type: Research article

    Knowledge on prevalence of osteoporosis stratifying for socioeconomic background is insufficient in Germany. Little is known in Europe about other diseases that go along with it although these aspects are impo...

    Authors: Marie-Therese Puth, Manuela Klaschik, Matthias Schmid, Klaus Weckbecker and Eva Münster

    Citation: BMC Musculoskeletal Disorders 2018 19:144

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  17. Content type: Research article

    Several studies looking into the association between insulin-like growth factor-1 (IGF-1) gene polymorphisms and osteoporosis predisposition have been conducted among Chinese population with conflicting outcom...

    Authors: Shu-tao Gao, Zheng-tao Lv, Chuan-kun Zhou, Chao Mao and Wei-bin Sheng

    Citation: BMC Musculoskeletal Disorders 2018 19:141

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  18. Content type: Study protocol

    To increase the uptake of key clinical recommendations for non-surgical management of knee osteoarthritis (OA) and improve patient outcomes, we developed a new model of service delivery (PARTNER model) and an ...

    Authors: David J. Hunter, Rana S. Hinman, Jocelyn L. Bowden, Thorlene Egerton, Andrew M. Briggs, Stephen J. Bunker, Jessica Kasza, Andrew B. Forbes, Simon D. French, Marie Pirotta, Deborah J. Schofield, Nicholas A. Zwar and Kim L. Bennell

    Citation: BMC Musculoskeletal Disorders 2018 19:132

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    The Correction to this article has been published in BMC Musculoskeletal Disorders 2018 19:443

  19. Content type: Case report

    Inflammatory back pain is a condition characterized by inflammation of the sacroiliac joints and lower spine. It is frequently seen in patients with spondyloarthropathies like ankylosing spondylitis, psoriatic...

    Authors: Safi Alqatari, Roberta Visevic, Nina Marshall, John Ryan and Grainne Murphy

    Citation: BMC Musculoskeletal Disorders 2018 19:126

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  20. Content type: Study protocol

    Osteoporotic vertebral fractures are common, and are associated with reduced functioning and health related quality of life. The primary aims of this randomized controlled trial are to examine the immediate an...

    Authors: Brita Stanghelle, Hege Bentzen, Lora Giangregorio, Are Hugo Pripp and Astrid Bergland

    Citation: BMC Musculoskeletal Disorders 2018 19:100

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  21. Content type: Study protocol

    The prevalence of hand osteoarthritis (HOA) has been reported to be higher amongst women over 50 years old (66%) compared to men of the same age (34%). Although exercise therapy has been shown effective in red...

    Authors: Paulette Guitard, Lucie Brosseau, George A. Wells, Nicole Paquet, Gail Paterson, Karine Toupin-April, Sabrina Cavallo, Sibel Z. Aydin, Guillaume Léonard and Gino De Angelis

    Citation: BMC Musculoskeletal Disorders 2018 19:56

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  22. Content type: Research article

    Impaired bone quality is associated with poor outcome of spinal surgery. The aim of the study was to assess the bone mineral status of patients scheduled to undergo spinal surgery and to report frequencies of ...

    Authors: Tobias Schmidt, Katharina Ebert, Tim Rolvien, Nicola Oehler, Jens Lohmann, Luca Papavero, Ralph Kothe, Michael Amling, Florian Barvencik and Haider Mussawy

    Citation: BMC Musculoskeletal Disorders 2018 19:53

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  23. Content type: Research article

    Dupuytren’s disease (DD) is a common and progressive, fibroproliferative disorder of the palmar and digital fascia of the hand. Various treatments have been recommended for advanced disease or to retard progre...

    Authors: Melina Dritsaki, Oliver Rivero-Arias, Alastair Gray, Catherine Ball and Jagdeep Nanchahal

    Citation: BMC Musculoskeletal Disorders 2018 19:34

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  24. Content type: Research article

    The roles of C-reactive protein (CRP) and cartilage oligomeric matrix protein (COMP) in knee osteoarthritis (KOA) remain controversial, thus the present study is aimed to explore the relationships between CRP,...

    Authors: Junfeng Zhang

    Citation: BMC Musculoskeletal Disorders 2018 19:22

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  25. Content type: Research article

    Pain is the principal clinical symptom of osteoarthritis (OA), and development of safe and effective analgesics for OA pain is needed. Drug development of new analgesics for OA pain is impaired by substantial ...

    Authors: Asger Reinstrup Bihlet, Inger Byrjalsen, Anne-Christine Bay-Jensen, Jeppe Ragnar Andersen, Claus Christiansen, Bente Juel Riis, Ivo Valter, Morten A. Karsdal and Marc C. Hochberg

    Citation: BMC Musculoskeletal Disorders 2018 19:17

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  26. Content type: Research article

    Associations between adipokines and bone mineral density (BMD) in knee osteoarthritis (OA) remain indistinct. The aim of this study was to investigate the cross-sectional associations between serum levels of a...

    Authors: Juan Wu, Jianhua Xu, Kang Wang, Qicui Zhu, Jingyu Cai, Jiale Ren, Shuang Zheng and Changhai Ding

    Citation: BMC Musculoskeletal Disorders 2018 19:16

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  27. Content type: Research article

    Intra-articular hyaluronic acid (IA-HA) is a common therapy used to treat knee pain and suppress knee inflammation in knee osteoarthritis (OA), typically prescribed in regimens ranging from a single injection ...

    Authors: Andrew Concoff, Parag Sancheti, Faizan Niazi, Peter Shaw and Jeffrey Rosen

    Citation: BMC Musculoskeletal Disorders 2017 18:542

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  28. Content type: Research article

    Despite the widely known benefits of exercise and physical activity, adherence rates to these activities are poor. Understanding exercise facilitators, barriers, and preferences may provide an opportunity to p...

    Authors: Isabel B. Rodrigues, Jonathan D. Adachi, Karen A. Beattie and Joy C. MacDermid

    Citation: BMC Musculoskeletal Disorders 2017 18:540

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  29. Content type: Research article

    We used High Resolution – peripheral Quantitative CT (HR-pQCT) imaging to examine peri-articular bone quality in early rheumatoid arthritis (RA) and explore whether bone quality improved over 12-months in indi...

    Authors: Lynne M. Feehan, Linda L. Li and Heather A. McKay

    Citation: BMC Musculoskeletal Disorders 2017 18:521

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  30. Content type: Research article

    The Lower Limb Assessment Score (LLAS) has only been validated in a paediatric population. The aim of this study was to validate the use of the LLAS in an adult population by: i) evaluating its ability to disc...

    Authors: Kaitlin J. Meyer, Cliffton Chan, Luke Hopper and Leslie L. Nicholson

    Citation: BMC Musculoskeletal Disorders 2017 18:514

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  31. Content type: Research article

    Oscarvit (OSC) is an in-house preparation consisting of calcium, magnesium, phosphorus, strontium, Vitamin D, and eggshell membrane hydrolysate containing naturally occurring glycosaminoglycans and sulfated gl...

    Authors: Tibor Görögh, Elgar S. Quabius, Alexander Georgitsis, Markus Hoffmann and Sebastian Lippross

    Citation: BMC Musculoskeletal Disorders 2017 18:500

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  32. Content type: Research article

    Social media is increasingly used by patients to source information for managing chronic disease. The aim of this study was to understand patient information needs about gout by a content analysis of questions...

    Authors: Christina Derksen, Anna Serlachius, Keith J. Petrie and Nicola Dalbeth

    Citation: BMC Musculoskeletal Disorders 2017 18:488

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  33. Content type: Research article

    Rheumatologists increasingly perform ultrasound (US) imaging to aid diagnosis and management decisions. There is a need to determine the role of US in facilitating early diagnosis of inflammatory arthritis. Th...

    Authors: Stephen Kelly, Brian Davidson, Sarah Keidel, Stephan Gadola, Claire Gorman, Gary Meenagh and Piero Reynolds

    Citation: BMC Musculoskeletal Disorders 2017 18:487

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  34. Content type: Research article

    Osteoarthritis (OA) of the trapeziometacarpal joint (TMJ) is a disabling condition with a significant impact on quality of life. The optimal management of hand OA requires a combination of non-pharmacological ...

    Authors: Sara Tenti, Nicola Antonio Pascarelli, Stefano Giannotti, Mauro Galeazzi, Nicola Giordano and Antonella Fioravanti

    Citation: BMC Musculoskeletal Disorders 2017 18:444

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  35. Content type: Study protocol

    Several drugs have become available for the treatment of osteoporosis. However, screening and treatment of patients with a high fracture risk is currently not recommended in the Netherlands, because the effect...

    Authors: P. J. M. Elders, T. Merlijn, K. M. A. Swart, W. van Hout, B. C. van der Zwaard, C. Niemeijer, M. W. Heymans, A. A. van der Heijden, F. Rutters, H. E. van der Horst, P. Lips, J. C. Netelenbos and N. M. van Schoor

    Citation: BMC Musculoskeletal Disorders 2017 18:424

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  36. Content type: Research article

    Use of conservative treatment modalities in osteoarthritis (OA) is suboptimal, which appears to be partly due to patients’ beliefs about treatments. The aim of this study was to develop a research instrument a...

    Authors: Ellen M. H. Selten, Johanna E. Vriezekolk, Henk J. Schers, Marc W. Nijhof, Willemijn H. van der Laan, Roelien G. van der Meulen-Dilling, Rinie Geenen and Cornelia H. M. van den Ende

    Citation: BMC Musculoskeletal Disorders 2017 18:402

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  37. Content type: Research article

    During the course of rheumatoid arthritis (RA), patients have profound negative effects on their patient-reported-outcomes (PRO); in addition, the impact of sustained remission (SR) on PROs may differ for each...

    Authors: Irazú Contreras-Yáñez, Guillermo Guaracha-Basañez, Daniel Ruiz-Domínguez and Virginia Pascual-Ramos

    Citation: BMC Musculoskeletal Disorders 2017 18:379

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  38. Content type: Research article

    Investigate the prevalence and risk factors of low bone mineral density (BMD) in patients with axial spondyloarthritis as well as investigating the prevalence of vertebral fractures.

    Authors: Sandrine Malochet-Guinamand, Bruno Pereira, Zuzana Tatar, Anne Tournadre, Anna Moltó, Maxime Dougados and Martin Soubrier

    Citation: BMC Musculoskeletal Disorders 2017 18:357

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  39. Content type: Research article

    To cross-culturally adapt and validate the Singapore Chinese and Singapore English versions of the Ankylosing Spondylitis Quality of Life (ASQoL) scales.

    Authors: Ying Ying Leung, Weixian Lee, Nai Lee Lui, Matthew Rouse, Stephen P. McKenna and Julian Thumboo

    Citation: BMC Musculoskeletal Disorders 2017 18:353

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  40. Content type: Research article

    We examined the effectiveness and tolerability of transdermal buprenorphine (TDB) treatment in real-world setting in Asian patients with musculoskeletal pain.

    Authors: Do Heum Yoon, Seong-Il Bin, Simon Kin-Cheong Chan, Chun Kee Chung, Yong In, Hyoungmin Kim, Juan Javier Lichauco, Chi Chiu Mok, Young-Wan Moon, Tony Kwun-Tung Ng, Ester Gonzales Penserga, Dong Ah Shin, Dora You and Hanlim Moon

    Citation: BMC Musculoskeletal Disorders 2017 18:337

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  41. Content type: Research article

    Since persistence to first biological disease modifying anti-rheumatic drugs (bDMARDs) is far from ideal in rheumatoid arthritis (RA) patients, many do receive a second and/or third bDMARD treatment. However, ...

    Authors: Thomas Wilke, Sabrina Mueller, Sze Chim Lee, Istvan Majer and Marieke Heisen

    Citation: BMC Musculoskeletal Disorders 2017 18:332

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  42. Content type: Research article

    Axial spondyloarthritis (ax-SpA) is a chronic inflammatory disease of the spine causing pain, stiffness, loss in physical function, and fatigue. Therefore, the physical and psychological burden of having this ...

    Authors: Gudrun Rohde, Kari Hansen Berg, Anne Prøven and Glenn Haugeberg

    Citation: BMC Musculoskeletal Disorders 2017 18:328

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  43. Content type: Research article

    This study evaluated the effect of early anti-tumor necrosis factor (TNF) therapy in patients with severe rheumatoid arthritis (RA) on the subsequent risk of total knee replacement (TKR) surgery.

    Authors: Ying-Chou Chen, Wen-Chan Chiu, Tien-Tsai Cheng, Han-Ming Lai, Shan-Fu Yu, Ben Yu-Jih Su, Chung-Yuan Hsu, Chi-Hua Ko and Jia-Feng Chen

    Citation: BMC Musculoskeletal Disorders 2017 18:326

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  44. Content type: Research article

    RA patients who eventually dropped out of treatment and out of the health care system had potentially disastrous consequences for their health-related quality-of-life outcomes. Objectives of the study were to ...

    Authors: Irazú Contreras-Yáñez and Virginia Pascual-Ramos

    Citation: BMC Musculoskeletal Disorders 2017 18:321

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  45. Content type: Research article

    The standard dose of rituximab used in rheumatoid arthritis (RA) is 1000 mg but recent studies have shown that low dose (500 mg) is also effective. Efficacy of low dose rituximab in rheumatoid arthritis (RA) r...

    Authors: Harindu Wijesinghe, Priyadharshini Galappatthy, Rajiva de Silva, Suranjith L. Seneviratne, Ushagowry Saravanamuttu, Preethi Udagama, Melanie Hart, Peter Kelleher, Upul Senerath, Rohini Fernandopulle, Lilani P. Weerasekera and Lalith S. Wijayaratne

    Citation: BMC Musculoskeletal Disorders 2017 18:310

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  46. Content type: Study protocol

    Psoriatic arthritis (PsA) is a chronic inflammatory arthritis which impacts significantly on the quality of life and work capacity of affected individuals. Recent evidence has shown that early control of infla...

    Authors: Gabriele De Marco, Philip Helliwell, Dennis McGonagle, Paul Emery, Laura C. Coates, Elizabeth M. A. Hensor and Helena Marzo-Ortega

    Citation: BMC Musculoskeletal Disorders 2017 18:303

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  47. Content type: Research article

    Disease-related foot pathology is recognised to have a significant impact on mobility and functional capacity in the majority of patients with rheumatoid arthritis (RA). The forefoot is widely affected and the...

    Authors: Heidi J Siddle, Richard J Hodgson, Elizabeth M A Hensor, Andrew J Grainger, Anthony C Redmond, Richard J Wakefield and Philip S Helliwell

    Citation: BMC Musculoskeletal Disorders 2017 18:308

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  48. Content type: Research article

    ONO-5334 is a cathepsin K inhibitor that induced bone mineral density (BMD) gain in a phase II study in postmenopausal osteoporosis patients. Even though the antiresorptive effect could only be monitored in th...

    Authors: Makoto Tanaka, Yoshitaka Hashimoto, Chihiro Hasegawa, Steve Deacon and Richard Eastell

    Citation: BMC Musculoskeletal Disorders 2017 18:267

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  49. Content type: Research article

    When people first experience symptoms of rheumatoid arthritis (RA) they often delay seeking medical attention resulting in delayed diagnosis and treatment. This research assesses behaviours people might engage...

    Authors: Gwenda Simons, Sophie Lumley, Marie Falahee, Kanta Kumar, Christian D. Mallen, Rebecca J. Stack and Karim Raza

    Citation: BMC Musculoskeletal Disorders 2017 18:258

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