Clinical rheumatology and osteoporosis

Section edited by Jasvinder Singh

This section concerns all aspects of research into osteoporosis and rheumatic diseases, where the primary focus relates specifically to a component(s) of the musculoskeletal system

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  2. Research article

    Effectiveness and tolerability of transdermal buprenorphine patches: a multicenter, prospective, open-label study in Asian patients with moderate to severe chronic musculoskeletal pain

    We examined the effectiveness and tolerability of transdermal buprenorphine (TDB) treatment in real-world setting in Asian patients with musculoskeletal pain.

    Do Heum Yoon, Seong-Il Bin, Simon Kin-Cheong Chan, Chun Kee Chung, Yong In, Hyoungmin Kim, Juan Javier Lichauco, Chi Chiu Mok, Young-Wan Moon, Tony Kwun-Tung Ng, Ester Gonzales Penserga, Dong Ah Shin, Dora You and Hanlim Moon

    BMC Musculoskeletal Disorders 2017 18:337

    Published on: 4 August 2017

  3. Research article

    Drug survival of second biological DMARD therapy in patients with rheumatoid arthritis: a retrospective non-interventional cohort analysis

    Since persistence to first biological disease modifying anti-rheumatic drugs (bDMARDs) is far from ideal in rheumatoid arthritis (RA) patients, many do receive a second and/or third bDMARD treatment. However, ...

    Thomas Wilke, Sabrina Mueller, Sze Chim Lee, Istvan Majer and Marieke Heisen

    BMC Musculoskeletal Disorders 2017 18:332

    Published on: 2 August 2017

  4. Research article

    The relationship between demographic- and disease-related variables and health-related quality of life in patients with axial spondyloarthritis

    Axial spondyloarthritis (ax-SpA) is a chronic inflammatory disease of the spine causing pain, stiffness, loss in physical function, and fatigue. Therefore, the physical and psychological burden of having this ...

    Gudrun Rohde, Kari Hansen Berg, Anne Prøven and Glenn Haugeberg

    BMC Musculoskeletal Disorders 2017 18:328

    Published on: 1 August 2017

  5. Research article

    Delayed anti-TNF therapy increases the risk of total knee replacement in patients with severe rheumatoid arthritis

    This study evaluated the effect of early anti-tumor necrosis factor (TNF) therapy in patients with severe rheumatoid arthritis (RA) on the subsequent risk of total knee replacement (TKR) surgery.

    Ying-Chou Chen, Wen-Chan Chiu, Tien-Tsai Cheng, Han-Ming Lai, Shan-Fu Yu, Ben Yu-Jih Su, Chung-Yuan Hsu, Chi-Hua Ko and Jia-Feng Chen

    BMC Musculoskeletal Disorders 2017 18:326

    Published on: 1 August 2017

  7. Research article

    Leflunomide is equally efficacious and safe compared to low dose rituximab in refractory rheumatoid arthritis given in combination with methotrexate: results from a randomized double blind controlled clinical trial

    The standard dose of rituximab used in rheumatoid arthritis (RA) is 1000 mg but recent studies have shown that low dose (500 mg) is also effective. Efficacy of low dose rituximab in rheumatoid arthritis (RA) r...

    Harindu Wijesinghe, Priyadharshini Galappatthy, Rajiva de Silva, Suranjith L. Seneviratne, Ushagowry Saravanamuttu, Preethi Udagama, Melanie Hart, Peter Kelleher, Upul Senerath, Rohini Fernandopulle, Lilani P. Weerasekera and Lalith S. Wijayaratne

    BMC Musculoskeletal Disorders 2017 18:310

    Published on: 19 July 2017

  8. Study protocol

    The GOLMePsA study protocol: an investigator-initiated, double-blind, parallel-group, randomised, controlled trial of GOLimumab and methotrexate versus methotrexate in early diagnosed psoriatic arthritis using clinical and whole body MRI outcomes

    Psoriatic arthritis (PsA) is a chronic inflammatory arthritis which impacts significantly on the quality of life and work capacity of affected individuals. Recent evidence has shown that early control of infla...

    Gabriele De Marco, Philip Helliwell, Dennis McGonagle, Paul Emery, Laura C. Coates, Elizabeth M. A. Hensor and Helena Marzo-Ortega

    BMC Musculoskeletal Disorders 2017 18:303

    Published on: 18 July 2017

  9. Research article

    Plantar plate pathology is associated with erosive disease in the painful forefoot of patients with rheumatoid arthritis

    Disease-related foot pathology is recognised to have a significant impact on mobility and functional capacity in the majority of patients with rheumatoid arthritis (RA). The forefoot is widely affected and the...

    Heidi J Siddle, Richard J Hodgson, Elizabeth M A Hensor, Andrew J Grainger, Anthony C Redmond, Richard J Wakefield and Philip S Helliwell

    BMC Musculoskeletal Disorders 2017 18:308

    Published on: 18 July 2017

  10. Research article

    Antiresorptive effect of a cathepsin K inhibitor ONO-5334 and its relationship to BMD increase in a phase II trial for postmenopausal osteoporosis

    ONO-5334 is a cathepsin K inhibitor that induced bone mineral density (BMD) gain in a phase II study in postmenopausal osteoporosis patients. Even though the antiresorptive effect could only be monitored in th...

    Makoto Tanaka, Yoshitaka Hashimoto, Chihiro Hasegawa, Steve Deacon and Richard Eastell

    BMC Musculoskeletal Disorders 2017 18:267

    Published on: 19 June 2017

  11. Research article

    The pathway to consultation for rheumatoid arthritis: exploring anticipated actions between the onset of symptoms and face-to-face encounter with a healthcare professional

    When people first experience symptoms of rheumatoid arthritis (RA) they often delay seeking medical attention resulting in delayed diagnosis and treatment. This research assesses behaviours people might engage...

    Gwenda Simons, Sophie Lumley, Marie Falahee, Kanta Kumar, Christian D. Mallen, Rebecca J. Stack and Karim Raza

    BMC Musculoskeletal Disorders 2017 18:258

    Published on: 14 June 2017

  12. Research article

    Validity of the Nurses’ health study physical activity questionnaire in estimating physical activity in adults with rheumatoid arthritis

    Patients with rheumatoid arthritis (RA) demonstrate reduced aerobic capacity, excess cardiovascular risk, mobility limitations and are less physically active than their healthy peers. Physical activity may dec...

    Thomas Quinn, Michelle Frits BS, Johan von Heideken, Christine Iannaccone, Nancy A. Shadick, Michael Weinblatt and Maura D. Iversen

    BMC Musculoskeletal Disorders 2017 18:234

    Published on: 31 May 2017

  13. Research article

    Patients’ views and needs about systemic sclerosis and its management: a qualitative interview study

    Systemic sclerosis (SSc) is a chronic connective-tissue disease responsible for reduced life expectancy, disability and a decreased quality of life. In order to optimize patients-physicians relationship and ca...

    Luc Mouthon, Sophie Alami, Anne-Sophie Boisard, Benjamin Chaigne, Eric Hachulla and Serge Poiraudeau

    BMC Musculoskeletal Disorders 2017 18:230

    Published on: 30 May 2017

  14. Research article

    Reduction of the Serum Levels of a Specific Biomarker of Cartilage Degradation (Coll2-1) by Hyaluronic Acid (KARTILAGE® CROSS) Compared to Placebo in Painful Knee Osteoarthritis Patients: the EPIKART Study, a Pilot Prospective Comparative Randomized Double Blind Trial

    Viscosupplementation is a symptomatic treatment of the knee osteoarthritis based on the intra-articular injection of hyaluronic acid (IAHA). Although many studies have investigated its effect on symptoms, few ...

    Yves Henrotin, Francis Berenbaum, Xavier Chevalier, Marc Marty, Pascal Richette and François Rannou

    BMC Musculoskeletal Disorders 2017 18:222

    Published on: 26 May 2017

  15. Research article

    Association between antibodies to carbamylated proteins and subclinical atherosclerosis in rheumatoid arthritis patients

    Rheumatoid arthritis (RA) patients carry a high risk of cardiovascular morbidity and mortality. The excess of cardiovascular disease cannot be entirely explained by traditional risk factors and the immune syst...

    Francesca Romana Spinelli, Arbi Pecani, Francesco Ciciarello, Tania Colasanti, Manuela Di Franco, Francesca Miranda, Fabrizio Conti, Guido Valesini and Cristiano Alessandri

    BMC Musculoskeletal Disorders 2017 18:214

    Published on: 25 May 2017

    The Erratum to this article has been published in BMC Musculoskeletal Disorders 2017 18:263

  16. Research article

    Factors associated with hand joint destruction in Chinese patients with rheumatoid arthritis

    There have been no previous report of hand joint destruction prevalence in Chinese rheumatoid arthritis (RA) patients. Therefore, the aim of this study was to investigate the prevalence and potential factors o...

    Lijuan Zhang, Jing Wang, Qiuxiang Zhang, Ting Fu, Rulan Yin, Ze Wang, Liren Li, Xianhua Wu and Zhifeng Gu

    BMC Musculoskeletal Disorders 2017 18:211

    Published on: 22 May 2017

    The Erratum to this article has been published in BMC Musculoskeletal Disorders 2017 18:231

  17. Research article

    Multidimensional daily diary of fatigue-fibromyalgia-17 items (MDF-fibro-17): part 2 psychometric evaluation in fibromyalgia patients

    The Multidimensional Daily Diary of Fatigue-Fibromyalgia-17 instrument (MDF-Fibro-17) has been developed for use in fibromyalgia (FM) clinical studies and includes 5 domains: Global Fatigue Experience, Cogniti...

    Y. Li, S. Morris, J. Cole, S. Dube’, J. A. M. Smith, C. Burbridge, T. Symonds, S. Hudgens and W. Wang

    BMC Musculoskeletal Disorders 2017 18:198

    Published on: 18 May 2017

  18. Research article

    Multidimensional daily diary of fatigue–fibromyalgia–17 items (MDF-fibro-17). part 1: development and content validity

    Fibromyalgia (FM), a disorder characterized by chronic widespread pain and tenderness, affects greater than five million individuals in the United States alone. Patients experience multiple symptoms in additio...

    S. Morris, Y. Li, J.A.M. Smith, S. Dube’, C. Burbridge and T. Symonds

    BMC Musculoskeletal Disorders 2017 18:195

    Published on: 16 May 2017

  19. Research article

    Persons with rheumatoid arthritis challenge the relevance of the health assessment questionnaire: a qualitative study of patient perception

    The Stanford Health Assessment Questionnaire-Disability Index (HAQ) is widely used to measure functional ability in persons with Rheumatoid Arthritis (RA). The instrument was developed with limited involvement...

    David Ebbevi, Anna Essén and Helena Hvitfeldt Forsberg

    BMC Musculoskeletal Disorders 2017 18:189

    Published on: 12 May 2017

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