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Clinical rheumatology and osteoporosis

This section concerns all aspects of research into osteoporosis and rheumatic diseases, where the primary focus relates specifically to a component(s) of the musculoskeletal system

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  1. Skeletal manifestations are predominant in psoriatic arthritis (PsA). The aim of this cross-sectional, case-control study is the complex assessment of areal and volumetric bone mineral density (BMD), fracture ...

    Authors: Zsófia Pethő, Edit Kalina, Zoltán Pap, Katalin Hodosi, Rebeka Falcsik, Ádám Balogh, Zoltán Szekanecz and Harjit Pal Bhattoa

    Citation: BMC Musculoskeletal Disorders 2021 22:70

    Content type: Research article

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  2. Primary hyperparathyroidism (PHPT) is a common endocrinopathy that may increase fracture risk and decrease bone mineral density (BMD). Some patients develop distal renal tubular acidification dysfunction under...

    Authors: Wangna Tang, Hongwei Jia, Baoping Wang, Yun Chai, Tong Liu, Hao Wang and Chenlin Dai

    Citation: BMC Musculoskeletal Disorders 2021 22:69

    Content type: Research article

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  3. Long non-coding RNA (lncRNA) has been implicated in the progression of osteoarthritis (OA). This study was aimed to explore the role and molecular mechanism of lncRNA HOXA terminal transcriptional RNA (HOTTIP)...

    Authors: Xianwei He, Kun Gao, Shuaihua Lu and Rongbo Wu

    Citation: BMC Musculoskeletal Disorders 2021 22:67

    Content type: Research article

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  4. Recent research has suggested that cardiotrophin-like cytokine factor 1 (CLCF1) may be an important regulator of bone homeostasis. Furthermore, a whole gene chip analysis suggested that the expression levels o...

    Authors: Xuan Chen, Jianyang Li, Yunjin Ye, Jingwen Huang, Lihua Xie, Juan Chen, Shengqiang Li, Sainan Chen and Jirong Ge

    Citation: BMC Musculoskeletal Disorders 2021 22:62

    Content type: Research article

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  5. Obstructive sleep apnea (OSA) is prevalent in individuals with Osteogenesis imperfecta (OI). To date, no study has investigated treatment of OSA in adult individuals with OI using positive airway pressure (PAP...

    Authors: Heidi Arponen, Adel Bachour, Leif Bäck, Helena Valta, Antti Mäkitie, Outi Mäkitie and Janna Waltimo-Sirén

    Citation: BMC Musculoskeletal Disorders 2021 22:61

    Content type: Research article

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  6. First metatarsophalangeal (MTP) joint osteoarthritis (OA) is a painful and debilitating condition affecting nearly one in 10 people aged over 50 years. Non-drug, non-surgical treatments are recommended by OA c...

    Authors: Kade L. Paterson, Rana S. Hinman, Ben R. Metcalf, Sarah E. Jones, Hylton B. Menz, Shannon E. Munteanu, Jessica Kasza and Kim L. Bennell

    Citation: BMC Musculoskeletal Disorders 2020 21:830

    Content type: Study protocol

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  7. It is mechanically plausible that osteoporosis leads to more severe peripheral fractures, but studies investigating associations between BMD and radiographically verified complexity of distal radius fractures ...

    Authors: Anja M. Hjelle, Jan-Erik Gjertsen, Ellen M. Apalset, Roy M. Nilsen, Anja Lober, Grethe S. Tell and Pawel Mielnik

    Citation: BMC Musculoskeletal Disorders 2020 21:811

    Content type: Research article

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  8. Bisphosphonate (BP) therapy has been associated with atypical femur fracture (AFF). However, the threshold of treatment duration leading to increased AFF risk is unclear. In a retrospective cohort of older wom...

    Authors: Joan C. Lo, Romain S. Neugebauer, Bruce Ettinger, Malini Chandra, Rita L. Hui, Susan M. Ott, Christopher D. Grimsrud and Monika A. Izano

    Citation: BMC Musculoskeletal Disorders 2020 21:801

    Content type: Research article

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  9. Several risk assessments have been developed to evaluate fall risk in older adults, but it has not been conclusively established which of these tools is most effective for assessing fall risk in this vulnerabl...

    Authors: Nitchanant Kitcharanant, Ekasame Vanitcharoenkul and Aasis Unnanuntana

    Citation: BMC Musculoskeletal Disorders 2020 21:757

    Content type: Research article

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  10. Sequential therapy from bone-forming medication to resorptive agents is reportedly effective for patients with severe osteoporosis. The objective of this study is to determine the impact of implementing short-...

    Authors: Chan Ho Park, Jun-Il Yoo, Chang Hyun Choi and You-Sung Suh

    Citation: BMC Musculoskeletal Disorders 2020 21:751

    Content type: Research article

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  11. Globally, osteoarthritis (OA) is the third condition associated with disability. There is still poor treatment in OA but science holds the key to finding better treatments and a cure. It is essential to learn ...

    Authors: Marianna Vitaloni, Angie Botto-van Bemden, Rosa Sciortino, Xavier Carné, Maritza Quintero, Pedro Santos-Moreno, Rolando Espinosa, Oscar Rillo, Jordi Monfort, Francisco de Abajo, Elizabeth Oswald, Marco Matucci, Patrick du Souich, Ingrid Möller, Montserrat Romera Baures, Arlene Vinci…

    Citation: BMC Musculoskeletal Disorders 2020 21:727

    Content type: Research article

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  12. The 2013 American Academy of Orthopaedic Surgeons (AAOS) guidelines made strong recommendations against intraarticular hyaluronic acid (IAHA) for patients with knee osteoarthritis (OA), as evidence supporting ...

    Authors: Charles D. Hummer, Felix Angst, Wilson Ngai, Craig Whittington, Sophie S. Yoon, Lionel Duarte, Colleen Manitt and Emil Schemitsch

    Citation: BMC Musculoskeletal Disorders 2020 21:702

    Content type: Research article

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  13. Low back pain is common and a significant number of patients experience chronic low back pain. Current treatment options offer small to moderate effects. Patients with vertebral bone marrow lesions visualized ...

    Authors: Elisabeth Gjefsen, Lars Christian Haugli Bråten, Guro Løvik Goll, Monica Wigemyr, Nils Bolstad, Morten Valberg, Elina Iordanova Schistad, Gunn Hege Marchand, Fredrik Granviken, Kaja Kristine Selmer, Anne Froholdt, Anne Julsrud Haugen, Magnhild Hammersland Dagestad, Nils Vetti, Gunnstein Bakland, Benedicte Alexandra Lie…

    Citation: BMC Musculoskeletal Disorders 2020 21:698

    Content type: Study protocol

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  14. Osteoporosis affects elderly patients of both sexes. It is characterized by an increased fracture risk due to defective remodeling of the bone microarchitecture. It affects in particular postmenopausal women d...

    Authors: K. Jäckle, J. P. Kolb, A. F. Schilling, C. Schlickewei, M. Amling, J. M. Rueger and W. Lehmann

    Citation: BMC Musculoskeletal Disorders 2020 21:693

    Content type: Research article

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  15. Inflammatory diseases are chronic autoimmune systemic autoimmune diseases, which may increase the risk of prosthetic joint infection (PJI) after total joint arthroplasty (TJA). However, to our best knowledge, ...

    Authors: Qiao Jiang, Jun Fu, Wei Chai, Li-Bo Hao, Yong-Gang Zhou, Chi Xu and Ji-Ying Chen

    Citation: BMC Musculoskeletal Disorders 2020 21:681

    Content type: Research article

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  16. To investigate the frequency of pain among subjects with advanced radiographic knee osteoarthritis (OA) defined as Kellgren–Lawrence (KL) grade 4 and clinical features associated with pain.

    Authors: Kyeong Min Son, Jeong Im Hong, Dong-Hyun Kim, Dae-Gyu Jang, Michel D. Crema and Hyun Ah Kim

    Citation: BMC Musculoskeletal Disorders 2020 21:640

    Content type: Research article

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  17. Chronic low back pain (cLBP) results in significant physical, psycho-social and socioeconomic burden. Identifying efficient and reliable patient reported outcome measures is critical for research and clinical pur...

    Authors: Rabih Nayfe, Matthieu Chansard, Linda S. Hynan, Eric M. Mortensen, Thiru Annaswamy, Liana Fraenkel and Una E. Makris

    Citation: BMC Musculoskeletal Disorders 2020 21:598

    Content type: Research article

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  18. Bone cement leakage causes severe complication following percutaneous vertebroplasty. This study probed the diffusion and leakage status of bone cement injected within diverged time duration, so as to find the...

    Authors: Meiyong Wang and Qunhua Jin

    Citation: BMC Musculoskeletal Disorders 2020 21:589

    Content type: Research article

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  19. Melanocortin receptor (MCR) agonists have anti-inflammatory and immunomodulatory properties mediated by receptors expressed on cells relevant to arthritis. Repository corticotropin injection (RCI; Acthar® Gel)...

    Authors: Dima A. Decker, Paul Higgins, Kyle Hayes, Chris Bollinger, Patrice Becker and Dale Wright

    Citation: BMC Musculoskeletal Disorders 2020 21:586

    Content type: Research article

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  20. Recently, an increasing number of studies have focused on the extra-gastrointestinal effects of Helicobacter pylori (H. pylori), including metabolic syndrome, fatty liver, and rheumatic and skin diseases. Oste...

    Authors: Jing-Wei Wang, Feng-Xiao Dong, Hui Su, Licun Zhu, Sujun Shao and Hong Liu

    Citation: BMC Musculoskeletal Disorders 2020 21:559

    Content type: Research article

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  22. Numerous comparative studies of surgical procedures have focused on clinical and radiographical outcomes, as well as the effect of bone fragility on the outcome of spinal surgery; however, insights concerning ...

    Authors: Tetsuro Ohba, Hiroshi Yokomichi, Kensuke Koyama, Nobuki Tanaka, Kotaro Oda and Hirotaka Haro

    Citation: BMC Musculoskeletal Disorders 2020 21:528

    Content type: Research article

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  23. Osteoporosis is a metabolic bone disorder characterized by deterioration in the quantity and quality of bone tissue, with a consequent increase susceptibility to fracture.

    Authors: Chin-Chean Wong, Jeng-Hao Liao, Shi-Yuan Sheu, Po-Yu Lin, Chih-Hwa Chen and Tzong-Fu Kuo

    Citation: BMC Musculoskeletal Disorders 2020 21:527

    Content type: Research article

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  24. Patients with rheumatoid arthritis (RA) who have undergone total knee arthroplasty are at increased risk of requiring a blood transfusion. This study is designed to compare the effects of preemptive antifibrin...

    Authors: Yiting Lei, Jiacheng Liu, Xi Liang, Ning Hu, Fuxing Pei and Wei Huang

    Citation: BMC Musculoskeletal Disorders 2020 21:465

    Content type: Study protocol

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  25. Osteoporosis (OP) is one of the commonly seen bone diseases with low bone mineral densities and trauma fractures. Accumulative studies have demonstrated that the occurrence of OP is closely related to osteocla...

    Authors: Yingfeng Yu, Peiquan Yao, Zhikun Wang and Wenwei Xie

    Citation: BMC Musculoskeletal Disorders 2020 21:456

    Content type: Research article

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  26. Open reduction and internal fixation is often used for the treatment of distal radius fracture. Opening the pronator quadratus muscle during the process of open reduction and internal fixation is necessary to ...

    Authors: Kaibin Fang, Xiaocong Lin, Xiaolin Liu, Qingfeng Ke, Shaoojian Shi and Zhangsheng Dai

    Citation: BMC Musculoskeletal Disorders 2020 21:453

    Content type: Research article

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  27. The prevalence of osteoporosis and risk of fractures is elevated in rheumatoid arthritis (RA), but we have limited information about the bone mineral density (BMD) and fracture risk in patients with inflammato...

    Authors: Anett Vincze, Levente Bodoki, Katalin Szabó, Melinda Nagy-Vincze, Orsolya Szalmás, József Varga, Katalin Dankó, János Gaál and Zoltán Griger

    Citation: BMC Musculoskeletal Disorders 2020 21:426

    Content type: Research article

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  29. Surgical site infections are more frequent among patients with rheumatic disease. To what extent this is related to immunosuppressive antirheumatic drugs is unclear, as is the value of discontinuing medication...

    Authors: Ylva Borgas, Anders Gülfe, Mikael Kindt and Anna Stefánsdóttir

    Citation: BMC Musculoskeletal Disorders 2020 21:410

    Content type: Research article

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  30. The Functional Index of Hand Osteoarthritis (FIHOA) is a clinically and methodologically validated score used to assess functional impact in patients with hand osteoarthritis (OA). The aim of the study was to ...

    Authors: Fatima Zahrae Taik, Latifa Tahiri, Hanan Rkain, Ilham Aachari, Emmanuel Maheu and Fadoua Allali

    Citation: BMC Musculoskeletal Disorders 2020 21:390

    Content type: Research article

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  31. Understanding the metabolic and lipidomic changes that accompany bone loss in osteoporosis might provide insights about the mechanisms behind molecular changes and facilitate developing new drugs or nutritiona...

    Authors: Diana Cabrera, Marlena Kruger, Frances M. Wolber, Nicole C. Roy and Karl Fraser

    Citation: BMC Musculoskeletal Disorders 2020 21:349

    Content type: Research article

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    The Correction to this article has been published in BMC Musculoskeletal Disorders 2020 21:501

  32. Postmenopausal osteoporosis (PMO) is the most common type of primary osteoporosis. ESR1 polymorphism rs2234693 and rs9340799 has been widely studied as a candidate gene associated with PMO, however, the findings ...

    Authors: Jin Shu, Junling Li, Yujuan Fu, Xuelian Hui, Yani Jin, Mengjie Chen, Xin Zheng and Yaowu Shi

    Citation: BMC Musculoskeletal Disorders 2020 21:346

    Content type: Research article

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  33. MicroRNAs (miRNAs) are critical regulators in osteogenesis and cartilage formation. This study was designed to investigate whether miR-532-5p plays a role in the regulation of osteoporosis.

    Authors: Xinyu Guo, Shijun Wei, Feng Xu, Xianhua Cai, Huasong Wang and Ran Ding

    Citation: BMC Musculoskeletal Disorders 2020 21:296

    Content type: Research article

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  34. The increase of augmented level and bone cement dose are accompanied by the rising incidence of cement leakage (CL) of cement-augmented pedicle screw instrumentation (CAPSI). But the effect and potential risks...

    Authors: Yong-chao Tang, Hui-zhi Guo, Dan-qing Guo, Pei-jie Luo, Yong-xian Li, Guo-ye Mo, Yan-huai Ma, Jian-cheng Peng, De Liang and Shun-cong Zhang

    Citation: BMC Musculoskeletal Disorders 2020 21:274

    Content type: Research article

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  35. Structural features of lateral tibiofemoral (TF) joint osteoarthritis (OA) occur in up to half of all people with knee OA, and co-existing lateral TF OA is associated with worse knee pain in people with mixed ...

    Authors: Kade L. Paterson, Kim L. Bennell, Ben R. Metcalf, Penny K. Campbell, Jessica Kasza, Tim V. Wrigley and Rana S. Hinman

    Citation: BMC Musculoskeletal Disorders 2020 21:247

    Content type: Study protocol

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  36. Total hip arthroplasty (THA) has been highlighted as the best treatment option for ankylosing spondylitis (AS) patients with advanced hip involvement. The huge blood loss associated with THA is a common concer...

    Authors: Yong Hu, Wei-Zhou Jiang, Cheng-Long Pan and Tao Wang

    Citation: BMC Musculoskeletal Disorders 2020 21:243

    Content type: Research article

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  37. Simultaneous bilateral femoral neck fractures are extremely rare without obvious injury. Herein, we report the case of a patient on dialysis presenting with bilateral femoral neck fractures, which is a conditi...

    Authors: Yunyun Zhu, Jingtao Hu, Wenlun Han, Jianwei Lu and Yuqing Zeng

    Citation: BMC Musculoskeletal Disorders 2020 21:242

    Content type: Case report

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  38. The knee is symptomatically the most frequent affected joint in osteoarthritis and, in the Netherlands and other Western countries, is mainly managed by general practitioners (GPs). An intra-articular glucocor...

    Authors: Marianne F. Mol, Jos Runhaar, P. Koen Bos, Desirée M. J. Dorleijn, Marijn Vis, Jacobijn Gussekloo, Patrick J. E. Bindels and Sita M. A. Bierma-Zeinstra

    Citation: BMC Musculoskeletal Disorders 2020 21:225

    Content type: Study protocol

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  39. Studies have shown that the combined application of hyaluronic acid (HA) and platelet-rich plasma (PRP) can repair degenerated cartilage and delay the progression of knee osteoarthritis (KOA). The purpose of t...

    Authors: Jinlong Zhao, Hetao Huang, Guihong Liang, Ling-feng Zeng, Weiyi Yang and Jun Liu

    Citation: BMC Musculoskeletal Disorders 2020 21:224

    Content type: Research article

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  40. Studies on osteoporosis awareness among the general population in China are still limited. We examined the level of osteoporosis awareness among residents in China, determined the risk factors associated with ...

    Authors: Kemal Sherefa Oumer, Yawen Liu, Qiong Yu, Fan Wu and Shuman Yang

    Citation: BMC Musculoskeletal Disorders 2020 21:197

    Content type: Research article

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  41. Several questionnaires have been used to assess the health status of patients with Kashin-Beck disease (KBD) in clinical trials, but the evidence regarding the responsiveness of these instruments in KBD patien...

    Authors: Lei Yang, Dimiao Wang, Xiuxia Li, Hangjing Yuan, Hua Fang and Xiong Guo

    Citation: BMC Musculoskeletal Disorders 2020 21:188

    Content type: Research article

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  42. Vitamin D deficiency has long been studied as a risk factor for osteoporosis. However, the association between serum vitamin D status, bone mineral density (BMD) and the incidence of vertebral fractures (OVFs)...

    Authors: Kishor chhantyal, Lei He, Jian Mo, Mingyu Yin, Tianwei He, Yuyong Chen, Yang Yang, Liangming Zhang and Limin Rong

    Citation: BMC Musculoskeletal Disorders 2020 21:164

    Content type: Research article

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  43. Rheumatoid arthritis is a long-term, progressive autoimmune disease. It is characterized by synovial hyperplasia leading to swelling, stiffness, and joint deformity in more than one joint. Fibroblast-like syno...

    Authors: Hong-Yan Meng, Li-Qing Chen and Li-Hui Chen

    Citation: BMC Musculoskeletal Disorders 2020 21:150

    Content type: Research article

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  44. The incidence of periprosthetic fractures after total knee arthroplasty (TKA) is rising due to the increasing number of TKAs performed annually and the growing elderly population. A periprosthetic fracture of ...

    Authors: Koji Nozaka, Naohisa Miyakoshi, Takeshi Sato and Yoichi Shimada

    Citation: BMC Musculoskeletal Disorders 2020 21:145

    Content type: Case report

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  45. Screening for osteoporosis with dual-energy X-ray absorptiometry (DXA) is recommended for male HIV-infected patients only above the age of 50. Recently, trabecular bone score (TBS) has been introduced as a nov...

    Authors: Youn Jeong Kim, Kwi Young Kang, Juyoung Shin, Yoonhee Jun, Sang Il Kim and Yang Ree Kim

    Citation: BMC Musculoskeletal Disorders 2020 21:94

    Content type: Research article

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  46. Osteoporosis is a highly prevalent disease identified by Dual Energy X-ray Absorptiometry (DEXA) that can be performed in an ambulatory (out-patient) or hospitalized population. We evaluated the use of baselin...

    Authors: Olivier Malaise, Marie Detroz, Mathieu Leroy, Lorenzo Leonori, Laurence Seidel and Michel G. Malaise

    Citation: BMC Musculoskeletal Disorders 2020 21:90

    Content type: Research article

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  47. It has been reported that miR-93-5p and long non-coding RNA (lncRNA) Cancer Susceptibility 2 (CASC2) play opposite roles in regulating chondrocyte apoptosis, indicating the possible interaction between them. T...

    Authors: Yun Sun, Simiao Kang, Shuyan Pei, Changmin Sang and Yijun Huang

    Citation: BMC Musculoskeletal Disorders 2020 21:26

    Content type: Research article

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  48. The aim of this systematic review was to identify principles of exercise interventions associated with improved physical function, weight management or musculoskeletal pain relief among young and middle-aged a...

    Authors: Dylan R. Barrow, Lauren M. Abbate, Max R. Paquette, Jeffrey B. Driban, Heather K. Vincent, Connie Newman, Stephen P. Messier, Kirsten R. Ambrose and Sarah P. Shultz

    Citation: BMC Musculoskeletal Disorders 2019 20:610

    Content type: Research article

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  50. To study the prevalence of chronic widespread pain (CWP) and chronic regional pain (CRP), and their association to quality of life, pain, physical function at a 20-year follow-up in a population based cohort w...

    Authors: Stefan Bergman, Carina Thorstensson and Maria L. E. Andersson

    Citation: BMC Musculoskeletal Disorders 2019 20:592

    Content type: Research article

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