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Clinical rheumatology and osteoporosis

This section concerns all aspects of research into osteoporosis and rheumatic diseases, where the primary focus relates specifically to a component(s) of the musculoskeletal system

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  1. It has been reported that miR-93-5p and long non-coding RNA (lncRNA) Cancer Susceptibility 2 (CASC2) play opposite roles in regulating chondrocyte apoptosis, indicating the possible interaction between them. T...

    Authors: Yun Sun, Simiao Kang, Shuyan Pei, Changmin Sang and Yijun Huang

    Citation: BMC Musculoskeletal Disorders 2020 21:26

    Content type: Research article

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  2. The aim of this systematic review was to identify principles of exercise interventions associated with improved physical function, weight management or musculoskeletal pain relief among young and middle-aged a...

    Authors: Dylan R. Barrow, Lauren M. Abbate, Max R. Paquette, Jeffrey B. Driban, Heather K. Vincent, Connie Newman, Stephen P. Messier, Kirsten R. Ambrose and Sarah P. Shultz

    Citation: BMC Musculoskeletal Disorders 2019 20:610

    Content type: Research article

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  4. To study the prevalence of chronic widespread pain (CWP) and chronic regional pain (CRP), and their association to quality of life, pain, physical function at a 20-year follow-up in a population based cohort w...

    Authors: Stefan Bergman, Carina Thorstensson and Maria L. E. Andersson

    Citation: BMC Musculoskeletal Disorders 2019 20:592

    Content type: Research article

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  5. To examine the correlation between dietary selenium (Se) intake and the prevalence of osteoporosis (OP) in the general middle-aged and older population in China.

    Authors: Yuqing Wang, Dongxing Xie, Jiatian Li, Huizhong Long, Jing Wu, Ziying Wu, Hongyi He, Haochen Wang, Tuo Yang and Yilun Wang

    Citation: BMC Musculoskeletal Disorders 2019 20:585

    Content type: Research article

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  6. This study is aimed to determine the efficacy of X-Ray Microtomography (micro-CT) in predicting oxytocin (OT) treatment response in rabbit osteoporosis(OP) model.

    Authors: Yuyou Qiu, Cuisong Tang, Mario Serrano-Sosa, Jian Hu, Jingqi Zhu, Guangyu Tang, Chuan Huang and Mingqian Huang

    Citation: BMC Musculoskeletal Disorders 2019 20:560

    Content type: Research article

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  7. Previous studies have found that bone mesenchymal stem cells (BMSCs) were capable of self-replication, multi-differentiation, and regeneration. The aim of this study was to carry out a systematic review and me...

    Authors: Zhenxiong Jin, Jinman Chen, Bing Shu, Yanhua Xiao and Dezhi Tang

    Citation: BMC Musculoskeletal Disorders 2019 20:556

    Content type: Research article

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  8. Circulatory osteocalcin (OC) has been widely used as a biomarker to indicate bone turnover status in postmenopausal osteoporosis (PMO). However, the change of serum OC (sOC) level in PMO cases compared to post...

    Authors: Zhongyu Liu, Ruiqiang Chen, Yutong Jiang, Yang Yang, Lei He, Chunxiao Luo, Jianwen Dong and Limin Rong

    Citation: BMC Musculoskeletal Disorders 2019 20:532

    Content type: Research article

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  9. Simultaneous bilateral femoral neck fracture is a very rare condition, even in osteoporotic elderly individuals. We report an atypical case of a young male adult who developed simultaneous bilateral femoral ne...

    Authors: Shinkichi Arisumi, Taro Mawatari, Satoshi Ikemura, Gen Matsui, Takahiro Iguchi and Hiroaki Mitsuyasu

    Citation: BMC Musculoskeletal Disorders 2019 20:449

    Content type: Case report

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  10. Vertebral fractures are common osteoporotic fractures, affecting 2–46% of the population, causing morbidity and increased risk of mortality. Physical activity has beneficial effects for bone health, including ...

    Authors: Saija Mikkilä, Giovanna Calogiuri, Nina Emaus and Bente Morseth

    Citation: BMC Musculoskeletal Disorders 2019 20:435

    Content type: Research article

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  12. Bone loss with aging and menopause increases the risk of fragile vertebral fracture, osteoporotic vertebral compression fracture (OVCF). The fracture causes severe pain, impedes respiratory function, lower the...

    Authors: Yuan-Zhe Jin, Jae Hyup Lee, Bin Xu and Minjoon Cho

    Citation: BMC Musculoskeletal Disorders 2019 20:399

    Content type: Research article

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  13. Female patients with systemic lupus erythematosus (SLE) are prone to have musculoskeletal system involvement, which could lead to joint damage. However, few studies have assessed the incidence of arthroplasty ...

    Authors: Chien-Han Chen, Chia-Wen Hsu and Ming-Chi Lu

    Citation: BMC Musculoskeletal Disorders 2019 20:314

    Content type: Research article

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  14. Transpedicular intracorporeal cement augmentation (TCA) with short segmental posterior instrumentation (SSPI), which provides an ideal immediate analgesic effect and long-term reconstructive stability, is thou...

    Authors: Hongli Deng, Yibing Li, Jinsong Zhou, Xiaodong Wang, Jinpeng Du, Wenjie Gao and Dingjun Hao

    Citation: BMC Musculoskeletal Disorders 2019 20:305

    Content type: Research article

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  15. For patients with painful knee osteoarthritis, long-term symptomatic relief may improve quality of life. Cooled radiofrequency ablation (CRFA) has demonstrated significant improvements in pain, physical functi...

    Authors: Mehul Desai, Anthony Bentley, William A. Keck, Thomas Haag, Rod S. Taylor and Helen Dakin

    Citation: BMC Musculoskeletal Disorders 2019 20:302

    Content type: Research article

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  16. The objective of this pilot study was to identify biological, clinical or structural biomarkers of an intra-articular hyaluronic acid injection efficacy (HYMOVIS®) for the design of a larger placebo-controlled...

    Authors: Yves Henrotin, Raveendhara Bannuru, Michel Malaise, Hang-korng Ea, Cyrille Confavreux, Jacques Bentin, Didier Urbin-Choffray, Thierry Conrozier, Jean-Pierre Brasseur, Philippe Thomas, Anne-Christine Hick, Alessandro Marinello, Nicola Giordan and Pascal Richette

    Citation: BMC Musculoskeletal Disorders 2019 20:293

    Content type: Research article

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  17. Active foot disease persists in a high proportion of people with psoriatic arthritis despite the availability of pharmacological and non-pharmacological interventions to modify the course of the disease. Limit...

    Authors: Kate Carter, Steven Walmsley, Keith Rome and Deborah E. Turner

    Citation: BMC Musculoskeletal Disorders 2019 20:191

    Content type: Research article

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  18. Osteoarthritis (OA) in the thumb carpometacarpal joint (CMCJ) is a prevalent disease which may lead to structural damage, severe pain and functional limitations. Evidence-based treatment recommendations state ...

    Authors: Else Marit Holen Gravås, Anne Therese Tveter, Randi Nossum, Ruth Else Mehl Eide, Åse Klokkeide, Karin Hoegh Matre, Monika Olsen, Øyvor Andreassen, Nina Østerås, Ida Kristin Haugen and Ingvild Kjeken

    Citation: BMC Musculoskeletal Disorders 2019 20:180

    Content type: Research article

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  19. The objectives of this study were to assess the maintenance of effect of duloxetine 60 mg once-daily (QD) in Chinese patients with chronic pain due to osteoarthritis (OA) of the knee or hip and to provide addi...

    Authors: Guochun Wang, Liqi Bi, Xiangpei Li, Zhijun Li, Dongbao Zhao, Jinwei Chen, Dongyi He, Chia-Ning Wang, Tao Wu, Héctor Dueñas, Vladimir Skljarevski and Li Yue

    Citation: BMC Musculoskeletal Disorders 2019 20:174

    Content type: Research article

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  20. There is no cure for knee osteoarthritis (KOA) and typically patients live approximately 30-years with the disease. Most common medical treatments result in short-term palliation of symptoms with little consid...

    Authors: Jonathon Charlesworth, Jane Fitzpatrick, Nirmala Kanthi Panagodage Perera and John Orchard

    Citation: BMC Musculoskeletal Disorders 2019 20:151

    Content type: Research article

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  21. This study compared clinical, laboratory and radiographic features of axial spondyloarthritis (axSpA) between ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nrAxSpA) of young male pa...

    Authors: Hong Ki Min, Hyonjoung Cho and Sung-Hwan Park

    Citation: BMC Musculoskeletal Disorders 2019 20:144

    Content type: Research article

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  22. To date, there have been little published data on surgical outcomes for patients with PD with thoracolumbar OVF. We conducted a retrospective multicenter study of registry data to investigate the outcomes of f...

    Authors: Kei Watanabe, Keiichi Katsumi, Masayuki Ohashi, Yohei Shibuya, Tomohiro Izumi, Toru Hirano, Naoto Endo, Takashi Kaito, Tomoya Yamashita, Hiroyasu Fujiwara, Yukitaka Nagamoto, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Hidetomi Terai, Koji Tamai…

    Citation: BMC Musculoskeletal Disorders 2019 20:103

    Content type: Research article

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  23. There is a pressing need to enhance osteoarthritis (OA) research to find ways of alleviating its enormous individual and societal impact due to the high prevalence, associated disability, and extensive costs.

    Authors: David J. Hunter, Philippa J. A. Nicolson, Christopher B. Little, Sarah R. Robbins, Xia Wang and Kim L. Bennell

    Citation: BMC Musculoskeletal Disorders 2019 20:74

    Content type: Research article

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  24. Previous studies suggest that RA activity is sensitive to seasonal changes. This study explored the influence of season on RA activity, particularly the distribution of affected joints, using a nationwide data...

    Authors: Hiroaki Mori, Tetsuji Sawada, Susumu Nishiyama, Kota Shimada, Koichiro Tahara, Haeru Hayashi, Eri Kato, Mayu Tago, Toshihiro Matsui and Shigeto Tohma

    Citation: BMC Musculoskeletal Disorders 2019 20:30

    Content type: Research article

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  25. This study examines the association of both pain severity and within-person pain variability with physical activity (PA) in older adults with osteoarthritis (OA).

    Authors: Erik J. Timmermans, Elisa J. de Koning, Natasja M. van Schoor, Suzan van der Pas, Michael D. Denkinger, Elaine M. Dennison, Stefania Maggi, Nancy L. Pedersen, Ángel Otero, Richard Peter, Cyrus Cooper, Paola Siviero, Maria Victoria Castell, Florian Herbolsheimer, Mark Edwards, Federica Limongi…

    Citation: BMC Musculoskeletal Disorders 2019 20:12

    Content type: Research article

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  26. Rheumatoid arthritis (RA) is a chronic and refractory autoimmune joint disease. Fibroblast-like synoviocytes (FLS) produce inflammatory cytokines and are involved in the migration and invasion of panuus tissue...

    Authors: Jing Wu, Yuan Qu, Yu-Ping Zhang, Jia-Xin Deng and Qing-Hong Yu

    Citation: BMC Musculoskeletal Disorders 2018 19:455

    Content type: Research article

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  27. The aetiology and pathogenesis of primary bone marrow oedema syndrome (BMES) remain unclear. This retrospective cross-sectional study in a large cohort of patients with BMES was performed to characterise the o...

    Authors: Nicola Oehler, Haider Mussawy, Tobias Schmidt, Tim Rolvien and Florian Barvencik

    Citation: BMC Musculoskeletal Disorders 2018 19:451

    Content type: Research article

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  28. It is generally believed that Thai people do not suffer from hypovitaminosis D because there is abundant sunlight throughout the year, and that taking vitamin D supplements could result in abnormally high leve...

    Authors: Thawee Songpatanasilp, Sattaya Rojanasthien, Pansak Sugkraroek, Boonsong Ongphiphadhanakul, Lamar Robert, Chongchit Sripun Robert, Sirichai Luevitoonvechkij and Arthur C. Santora

    Citation: BMC Musculoskeletal Disorders 2018 19:392

    Content type: Research article

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  30. Osteoarthritis (OA) is a highly debilitating joint disease that causes progressive, irreversible damage to articular cartilage. OA takes a massive toll on society that has grown in recent decades, but no thera...

    Authors: Ian A. Jones, Melissa Wilson, Ryan Togashi, Bo Han, Austin K. Mircheff and C. Thomas Vangsness JR

    Citation: BMC Musculoskeletal Disorders 2018 19:383

    Content type: Study protocol

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  31. Reconstructive joint surgery is an indicator of poor prognosis in rheumatoid arthritis (RA). Objectives of this study were to describe the incidence rate of orthopedic and hand surgery indication (OHSI) in an ...

    Authors: Irazú Contreras-Yáñez, G. Guaracha-Basáñez, E. Díaz-Borjón, M. Iglesias and V. Pascual-Ramos

    Citation: BMC Musculoskeletal Disorders 2018 19:378

    Content type: Research article

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  32. Knee bone shape differs between men and women and the incidence of knee osteoarthritis (OA) is higher in women than in men. Therefore, the purpose of the present study was to determine whether the observed dif...

    Authors: Barton L. Wise, Jingbo Niu, Yuqing Zhang, Felix Liu, Joyce Pang, John A. Lynch and Nancy E. Lane

    Citation: BMC Musculoskeletal Disorders 2018 19:331

    Content type: Research article

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  33. IDC in children, first reported by Baron in 1924, is very rare. OPLL of the cervical spine mainly affect people ages 50–70 years. The coexistence of IDC and OPLL in children is very rare, only six cases with 3...

    Authors: Jun-Jie Du, Yu-Fei Chen, Ye Peng, Xiao-jie Li and Wei Ma

    Citation: BMC Musculoskeletal Disorders 2018 19:316

    Content type: Case report

    Published on:

  34. Knee osteoarthritis (OA) causes substantial pain, physical dysfunction and impaired quality of life. There is no cure for knee OA, and for some people, the disease may involve progressive symptomatic and struc...

    Authors: Kade L. Paterson, David J. Hunter, Ben R. Metcalf, Jillian Eyles, Vicky Duong, Jessica Kazsa, Yuanyuan Wang, Rachelle Buchbinder, Flavia Cicuttini, Andrew Forbes, Anthony Harris, Shirley P. Yu, Bing Hui Wang, David Connell, James Linklater and Kim L. Bennell

    Citation: BMC Musculoskeletal Disorders 2018 19:272

    Content type: Study protocol

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  35. The wrist is often severely affected in rheumatoid arthritis (RA) patients; however, little is known about the potential risk factors of the reduced wrist range of motion. In this study, we explored a broad ra...

    Authors: Lijuan Zhang, Haixia Cao, Qiuxiang Zhang, Ting Fu, Rulan Yin, Yunfei Xia, Liren Li and Zhifeng Gu

    Citation: BMC Musculoskeletal Disorders 2018 19:270

    Content type: Research article

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  36. Evidence on the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis is limited and conflicting. The primary objective of the Hip Injection Trial (HIT) is to compare pain intensity ...

    Authors: Zoe Paskins, Gemma Hughes, Helen Myers, Emily Hughes, Susie Hennings, Andrea Cherrington, Amy Evans, Melanie Holden, Kay Stevenson, Ajit Menon, Kieran Bromley, Philip Roberts, Alison Hall, George Peat, Clare Jinks, Raymond Oppong…

    Citation: BMC Musculoskeletal Disorders 2018 19:218

    Content type: Study protocol

    Published on:

  37. Vitamin D (VD) insufficiency or deficiency is a frequent comorbidity in Chinese women with postmenopausal osteoporosis (PMO). The present study aimed to investigate 25-hydroxyvitamin D [25(OH) D] improvement a...

    Authors: Er-Yuan Liao, Zhen-Lin Zhang, Wei-Bo Xia, Hua Lin, Qun Cheng, Li Wang, Yong-Qiang Hao, De-Cai Chen, Hai Tang, Yong-De Peng, Li You, Liang He, Zhao-Heng Hu, Chun-Li Song, Fang Wei, Jue Wang…

    Citation: BMC Musculoskeletal Disorders 2018 19:210

    Content type: Research article

    Published on:

  38. Dutasteride is a potent inhibitor of 5-alpha reductase enzymes that reduces concentrations of dihydrotestosterone to a greater extent than finasteride. Whether this has adverse implications for bone health is ...

    Authors: Tony Antoniou, Erin M. Macdonald, Zhan Yao, Tara Gomes, Mina Tadrous, Joanne M.-W. Ho, Muhammad M. Mamdani and David N. Juurlink

    Citation: BMC Musculoskeletal Disorders 2018 19:160

    Content type: Research article

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  39. Osteoarthritis (OA) is the most common joint disorder worldwide and one of the leading causes of disability in the elderly. We have investigated the novel sodium hyaluronate derivative chemically linked with d...

    Authors: Keiji Yoshioka, Tomochika Kisukeda, Ryoji Zuinen, Yosuke Yasuda and Kenji Miyamoto

    Citation: BMC Musculoskeletal Disorders 2018 19:157

    Content type: Research article

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  40. Knowledge on prevalence of osteoporosis stratifying for socioeconomic background is insufficient in Germany. Little is known in Europe about other diseases that go along with it although these aspects are impo...

    Authors: Marie-Therese Puth, Manuela Klaschik, Matthias Schmid, Klaus Weckbecker and Eva Münster

    Citation: BMC Musculoskeletal Disorders 2018 19:144

    Content type: Research article

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  41. Several studies looking into the association between insulin-like growth factor-1 (IGF-1) gene polymorphisms and osteoporosis predisposition have been conducted among Chinese population with conflicting outcom...

    Authors: Shu-tao Gao, Zheng-tao Lv, Chuan-kun Zhou, Chao Mao and Wei-bin Sheng

    Citation: BMC Musculoskeletal Disorders 2018 19:141

    Content type: Research article

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  42. To increase the uptake of key clinical recommendations for non-surgical management of knee osteoarthritis (OA) and improve patient outcomes, we developed a new model of service delivery (PARTNER model) and an ...

    Authors: David J. Hunter, Rana S. Hinman, Jocelyn L. Bowden, Thorlene Egerton, Andrew M. Briggs, Stephen J. Bunker, Jessica Kasza, Andrew B. Forbes, Simon D. French, Marie Pirotta, Deborah J. Schofield, Nicholas A. Zwar and Kim L. Bennell

    Citation: BMC Musculoskeletal Disorders 2018 19:132

    Content type: Study protocol

    Published on:

    The Correction to this article has been published in BMC Musculoskeletal Disorders 2018 19:443

  43. Inflammatory back pain is a condition characterized by inflammation of the sacroiliac joints and lower spine. It is frequently seen in patients with spondyloarthropathies like ankylosing spondylitis, psoriatic...

    Authors: Safi Alqatari, Roberta Visevic, Nina Marshall, John Ryan and Grainne Murphy

    Citation: BMC Musculoskeletal Disorders 2018 19:126

    Content type: Case report

    Published on:

  44. Osteoporotic vertebral fractures are common, and are associated with reduced functioning and health related quality of life. The primary aims of this randomized controlled trial are to examine the immediate an...

    Authors: Brita Stanghelle, Hege Bentzen, Lora Giangregorio, Are Hugo Pripp and Astrid Bergland

    Citation: BMC Musculoskeletal Disorders 2018 19:100

    Content type: Study protocol

    Published on:

  45. The prevalence of hand osteoarthritis (HOA) has been reported to be higher amongst women over 50 years old (66%) compared to men of the same age (34%). Although exercise therapy has been shown effective in red...

    Authors: Paulette Guitard, Lucie Brosseau, George A. Wells, Nicole Paquet, Gail Paterson, Karine Toupin-April, Sabrina Cavallo, Sibel Z. Aydin, Guillaume Léonard and Gino De Angelis

    Citation: BMC Musculoskeletal Disorders 2018 19:56

    Content type: Study protocol

    Published on:

  46. Impaired bone quality is associated with poor outcome of spinal surgery. The aim of the study was to assess the bone mineral status of patients scheduled to undergo spinal surgery and to report frequencies of ...

    Authors: Tobias Schmidt, Katharina Ebert, Tim Rolvien, Nicola Oehler, Jens Lohmann, Luca Papavero, Ralph Kothe, Michael Amling, Florian Barvencik and Haider Mussawy

    Citation: BMC Musculoskeletal Disorders 2018 19:53

    Content type: Research article

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  47. Dupuytren’s disease (DD) is a common and progressive, fibroproliferative disorder of the palmar and digital fascia of the hand. Various treatments have been recommended for advanced disease or to retard progre...

    Authors: Melina Dritsaki, Oliver Rivero-Arias, Alastair Gray, Catherine Ball and Jagdeep Nanchahal

    Citation: BMC Musculoskeletal Disorders 2018 19:34

    Content type: Research article

    Published on:

  48. The roles of C-reactive protein (CRP) and cartilage oligomeric matrix protein (COMP) in knee osteoarthritis (KOA) remain controversial, thus the present study is aimed to explore the relationships between CRP,...

    Authors: Junfeng Zhang

    Citation: BMC Musculoskeletal Disorders 2018 19:22

    Content type: Research article

    Published on:

  49. Pain is the principal clinical symptom of osteoarthritis (OA), and development of safe and effective analgesics for OA pain is needed. Drug development of new analgesics for OA pain is impaired by substantial ...

    Authors: Asger Reinstrup Bihlet, Inger Byrjalsen, Anne-Christine Bay-Jensen, Jeppe Ragnar Andersen, Claus Christiansen, Bente Juel Riis, Ivo Valter, Morten A. Karsdal and Marc C. Hochberg

    Citation: BMC Musculoskeletal Disorders 2018 19:17

    Content type: Research article

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  50. Associations between adipokines and bone mineral density (BMD) in knee osteoarthritis (OA) remain indistinct. The aim of this study was to investigate the cross-sectional associations between serum levels of a...

    Authors: Juan Wu, Jianhua Xu, Kang Wang, Qicui Zhu, Jingyu Cai, Jiale Ren, Shuang Zheng and Changhai Ding

    Citation: BMC Musculoskeletal Disorders 2018 19:16

    Content type: Research article

    Published on:

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BMC Musculoskeletal Disorders

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