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Clinical rheumatology and osteoporosis

This section concerns all aspects of research into osteoporosis and rheumatic diseases, where the primary focus relates specifically to a component(s) of the musculoskeletal system

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  1. MicroRNAs (miRNAs) are critical regulators in osteogenesis and cartilage formation. This study was designed to investigate whether miR-532-5p plays a role in the regulation of osteoporosis.

    Authors: Xinyu Guo, Shijun Wei, Feng Xu, Xianhua Cai, Huasong Wang and Ran Ding

    Citation: BMC Musculoskeletal Disorders 2020 21:296

    Content type: Research article

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  2. The increase of augmented level and bone cement dose are accompanied by the rising incidence of cement leakage (CL) of cement-augmented pedicle screw instrumentation (CAPSI). But the effect and potential risks...

    Authors: Yong-chao Tang, Hui-zhi Guo, Dan-qing Guo, Pei-jie Luo, Yong-xian Li, Guo-ye Mo, Yan-huai Ma, Jian-cheng Peng, De Liang and Shun-cong Zhang

    Citation: BMC Musculoskeletal Disorders 2020 21:274

    Content type: Research article

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  3. Structural features of lateral tibiofemoral (TF) joint osteoarthritis (OA) occur in up to half of all people with knee OA, and co-existing lateral TF OA is associated with worse knee pain in people with mixed ...

    Authors: Kade L. Paterson, Kim L. Bennell, Ben R. Metcalf, Penny K. Campbell, Jessica Kasza, Tim V. Wrigley and Rana S. Hinman

    Citation: BMC Musculoskeletal Disorders 2020 21:247

    Content type: Study protocol

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  4. Total hip arthroplasty (THA) has been highlighted as the best treatment option for ankylosing spondylitis (AS) patients with advanced hip involvement. The huge blood loss associated with THA is a common concer...

    Authors: Yong Hu, Wei-Zhou Jiang, Cheng-Long Pan and Tao Wang

    Citation: BMC Musculoskeletal Disorders 2020 21:243

    Content type: Research article

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  5. Simultaneous bilateral femoral neck fractures are extremely rare without obvious injury. Herein, we report the case of a patient on dialysis presenting with bilateral femoral neck fractures, which is a conditi...

    Authors: Yunyun Zhu, Jingtao Hu, Wenlun Han, Jianwei Lu and Yuqing Zeng

    Citation: BMC Musculoskeletal Disorders 2020 21:242

    Content type: Case report

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  6. The knee is symptomatically the most frequent affected joint in osteoarthritis and, in the Netherlands and other Western countries, is mainly managed by general practitioners (GPs). An intra-articular glucocor...

    Authors: Marianne F. Mol, Jos Runhaar, P. Koen Bos, Desirée M. J. Dorleijn, Marijn Vis, Jacobijn Gussekloo, Patrick J. E. Bindels and Sita M. A. Bierma-Zeinstra

    Citation: BMC Musculoskeletal Disorders 2020 21:225

    Content type: Study protocol

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  7. Studies have shown that the combined application of hyaluronic acid (HA) and platelet-rich plasma (PRP) can repair degenerated cartilage and delay the progression of knee osteoarthritis (KOA). The purpose of t...

    Authors: Jinlong Zhao, Hetao Huang, Guihong Liang, Ling-feng Zeng, Weiyi Yang and Jun Liu

    Citation: BMC Musculoskeletal Disorders 2020 21:224

    Content type: Research article

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  8. Studies on osteoporosis awareness among the general population in China are still limited. We examined the level of osteoporosis awareness among residents in China, determined the risk factors associated with ...

    Authors: Kemal Sherefa Oumer, Yawen Liu, Qiong Yu, Fan Wu and Shuman Yang

    Citation: BMC Musculoskeletal Disorders 2020 21:197

    Content type: Research article

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  9. Several questionnaires have been used to assess the health status of patients with Kashin-Beck disease (KBD) in clinical trials, but the evidence regarding the responsiveness of these instruments in KBD patien...

    Authors: Lei Yang, Dimiao Wang, Xiuxia Li, Hangjing Yuan, Hua Fang and Xiong Guo

    Citation: BMC Musculoskeletal Disorders 2020 21:188

    Content type: Research article

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  10. Vitamin D deficiency has long been studied as a risk factor for osteoporosis. However, the association between serum vitamin D status, bone mineral density (BMD) and the incidence of vertebral fractures (OVFs)...

    Authors: Kishor chhantyal, Lei He, Jian Mo, Mingyu Yin, Tianwei He, Yuyong Chen, Yang Yang, Liangming Zhang and Limin Rong

    Citation: BMC Musculoskeletal Disorders 2020 21:164

    Content type: Research article

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  11. Rheumatoid arthritis is a long-term, progressive autoimmune disease. It is characterized by synovial hyperplasia leading to swelling, stiffness, and joint deformity in more than one joint. Fibroblast-like syno...

    Authors: Hong-Yan Meng, Li-Qing Chen and Li-Hui Chen

    Citation: BMC Musculoskeletal Disorders 2020 21:150

    Content type: Research article

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  12. The incidence of periprosthetic fractures after total knee arthroplasty (TKA) is rising due to the increasing number of TKAs performed annually and the growing elderly population. A periprosthetic fracture of ...

    Authors: Koji Nozaka, Naohisa Miyakoshi, Takeshi Sato and Yoichi Shimada

    Citation: BMC Musculoskeletal Disorders 2020 21:145

    Content type: Case report

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  13. Screening for osteoporosis with dual-energy X-ray absorptiometry (DXA) is recommended for male HIV-infected patients only above the age of 50. Recently, trabecular bone score (TBS) has been introduced as a nov...

    Authors: Youn Jeong Kim, Kwi Young Kang, Juyoung Shin, Yoonhee Jun, Sang Il Kim and Yang Ree Kim

    Citation: BMC Musculoskeletal Disorders 2020 21:94

    Content type: Research article

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  14. Osteoporosis is a highly prevalent disease identified by Dual Energy X-ray Absorptiometry (DEXA) that can be performed in an ambulatory (out-patient) or hospitalized population. We evaluated the use of baselin...

    Authors: Olivier Malaise, Marie Detroz, Mathieu Leroy, Lorenzo Leonori, Laurence Seidel and Michel G. Malaise

    Citation: BMC Musculoskeletal Disorders 2020 21:90

    Content type: Research article

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  15. It has been reported that miR-93-5p and long non-coding RNA (lncRNA) Cancer Susceptibility 2 (CASC2) play opposite roles in regulating chondrocyte apoptosis, indicating the possible interaction between them. T...

    Authors: Yun Sun, Simiao Kang, Shuyan Pei, Changmin Sang and Yijun Huang

    Citation: BMC Musculoskeletal Disorders 2020 21:26

    Content type: Research article

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  16. The aim of this systematic review was to identify principles of exercise interventions associated with improved physical function, weight management or musculoskeletal pain relief among young and middle-aged a...

    Authors: Dylan R. Barrow, Lauren M. Abbate, Max R. Paquette, Jeffrey B. Driban, Heather K. Vincent, Connie Newman, Stephen P. Messier, Kirsten R. Ambrose and Sarah P. Shultz

    Citation: BMC Musculoskeletal Disorders 2019 20:610

    Content type: Research article

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  18. To study the prevalence of chronic widespread pain (CWP) and chronic regional pain (CRP), and their association to quality of life, pain, physical function at a 20-year follow-up in a population based cohort w...

    Authors: Stefan Bergman, Carina Thorstensson and Maria L. E. Andersson

    Citation: BMC Musculoskeletal Disorders 2019 20:592

    Content type: Research article

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  19. To examine the correlation between dietary selenium (Se) intake and the prevalence of osteoporosis (OP) in the general middle-aged and older population in China.

    Authors: Yuqing Wang, Dongxing Xie, Jiatian Li, Huizhong Long, Jing Wu, Ziying Wu, Hongyi He, Haochen Wang, Tuo Yang and Yilun Wang

    Citation: BMC Musculoskeletal Disorders 2019 20:585

    Content type: Research article

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  20. This study is aimed to determine the efficacy of X-Ray Microtomography (micro-CT) in predicting oxytocin (OT) treatment response in rabbit osteoporosis(OP) model.

    Authors: Yuyou Qiu, Cuisong Tang, Mario Serrano-Sosa, Jian Hu, Jingqi Zhu, Guangyu Tang, Chuan Huang and Mingqian Huang

    Citation: BMC Musculoskeletal Disorders 2019 20:560

    Content type: Research article

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  21. Previous studies have found that bone mesenchymal stem cells (BMSCs) were capable of self-replication, multi-differentiation, and regeneration. The aim of this study was to carry out a systematic review and me...

    Authors: Zhenxiong Jin, Jinman Chen, Bing Shu, Yanhua Xiao and Dezhi Tang

    Citation: BMC Musculoskeletal Disorders 2019 20:556

    Content type: Research article

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  22. Circulatory osteocalcin (OC) has been widely used as a biomarker to indicate bone turnover status in postmenopausal osteoporosis (PMO). However, the change of serum OC (sOC) level in PMO cases compared to post...

    Authors: Zhongyu Liu, Ruiqiang Chen, Yutong Jiang, Yang Yang, Lei He, Chunxiao Luo, Jianwen Dong and Limin Rong

    Citation: BMC Musculoskeletal Disorders 2019 20:532

    Content type: Research article

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  23. Simultaneous bilateral femoral neck fracture is a very rare condition, even in osteoporotic elderly individuals. We report an atypical case of a young male adult who developed simultaneous bilateral femoral ne...

    Authors: Shinkichi Arisumi, Taro Mawatari, Satoshi Ikemura, Gen Matsui, Takahiro Iguchi and Hiroaki Mitsuyasu

    Citation: BMC Musculoskeletal Disorders 2019 20:449

    Content type: Case report

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  24. Vertebral fractures are common osteoporotic fractures, affecting 2–46% of the population, causing morbidity and increased risk of mortality. Physical activity has beneficial effects for bone health, including ...

    Authors: Saija Mikkilä, Giovanna Calogiuri, Nina Emaus and Bente Morseth

    Citation: BMC Musculoskeletal Disorders 2019 20:435

    Content type: Research article

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  26. Bone loss with aging and menopause increases the risk of fragile vertebral fracture, osteoporotic vertebral compression fracture (OVCF). The fracture causes severe pain, impedes respiratory function, lower the...

    Authors: Yuan-Zhe Jin, Jae Hyup Lee, Bin Xu and Minjoon Cho

    Citation: BMC Musculoskeletal Disorders 2019 20:399

    Content type: Research article

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  27. Female patients with systemic lupus erythematosus (SLE) are prone to have musculoskeletal system involvement, which could lead to joint damage. However, few studies have assessed the incidence of arthroplasty ...

    Authors: Chien-Han Chen, Chia-Wen Hsu and Ming-Chi Lu

    Citation: BMC Musculoskeletal Disorders 2019 20:314

    Content type: Research article

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  28. Transpedicular intracorporeal cement augmentation (TCA) with short segmental posterior instrumentation (SSPI), which provides an ideal immediate analgesic effect and long-term reconstructive stability, is thou...

    Authors: Hongli Deng, Yibing Li, Jinsong Zhou, Xiaodong Wang, Jinpeng Du, Wenjie Gao and Dingjun Hao

    Citation: BMC Musculoskeletal Disorders 2019 20:305

    Content type: Research article

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  29. For patients with painful knee osteoarthritis, long-term symptomatic relief may improve quality of life. Cooled radiofrequency ablation (CRFA) has demonstrated significant improvements in pain, physical functi...

    Authors: Mehul Desai, Anthony Bentley, William A. Keck, Thomas Haag, Rod S. Taylor and Helen Dakin

    Citation: BMC Musculoskeletal Disorders 2019 20:302

    Content type: Research article

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  30. The objective of this pilot study was to identify biological, clinical or structural biomarkers of an intra-articular hyaluronic acid injection efficacy (HYMOVIS®) for the design of a larger placebo-controlled...

    Authors: Yves Henrotin, Raveendhara Bannuru, Michel Malaise, Hang-korng Ea, Cyrille Confavreux, Jacques Bentin, Didier Urbin-Choffray, Thierry Conrozier, Jean-Pierre Brasseur, Philippe Thomas, Anne-Christine Hick, Alessandro Marinello, Nicola Giordan and Pascal Richette

    Citation: BMC Musculoskeletal Disorders 2019 20:293

    Content type: Research article

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  31. Active foot disease persists in a high proportion of people with psoriatic arthritis despite the availability of pharmacological and non-pharmacological interventions to modify the course of the disease. Limit...

    Authors: Kate Carter, Steven Walmsley, Keith Rome and Deborah E. Turner

    Citation: BMC Musculoskeletal Disorders 2019 20:191

    Content type: Research article

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  32. Osteoarthritis (OA) in the thumb carpometacarpal joint (CMCJ) is a prevalent disease which may lead to structural damage, severe pain and functional limitations. Evidence-based treatment recommendations state ...

    Authors: Else Marit Holen Gravås, Anne Therese Tveter, Randi Nossum, Ruth Else Mehl Eide, Åse Klokkeide, Karin Hoegh Matre, Monika Olsen, Øyvor Andreassen, Nina Østerås, Ida Kristin Haugen and Ingvild Kjeken

    Citation: BMC Musculoskeletal Disorders 2019 20:180

    Content type: Research article

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  33. The objectives of this study were to assess the maintenance of effect of duloxetine 60 mg once-daily (QD) in Chinese patients with chronic pain due to osteoarthritis (OA) of the knee or hip and to provide addi...

    Authors: Guochun Wang, Liqi Bi, Xiangpei Li, Zhijun Li, Dongbao Zhao, Jinwei Chen, Dongyi He, Chia-Ning Wang, Tao Wu, Héctor Dueñas, Vladimir Skljarevski and Li Yue

    Citation: BMC Musculoskeletal Disorders 2019 20:174

    Content type: Research article

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  34. There is no cure for knee osteoarthritis (KOA) and typically patients live approximately 30-years with the disease. Most common medical treatments result in short-term palliation of symptoms with little consid...

    Authors: Jonathon Charlesworth, Jane Fitzpatrick, Nirmala Kanthi Panagodage Perera and John Orchard

    Citation: BMC Musculoskeletal Disorders 2019 20:151

    Content type: Research article

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  35. This study compared clinical, laboratory and radiographic features of axial spondyloarthritis (axSpA) between ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nrAxSpA) of young male pa...

    Authors: Hong Ki Min, Hyonjoung Cho and Sung-Hwan Park

    Citation: BMC Musculoskeletal Disorders 2019 20:144

    Content type: Research article

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  36. To date, there have been little published data on surgical outcomes for patients with PD with thoracolumbar OVF. We conducted a retrospective multicenter study of registry data to investigate the outcomes of f...

    Authors: Kei Watanabe, Keiichi Katsumi, Masayuki Ohashi, Yohei Shibuya, Tomohiro Izumi, Toru Hirano, Naoto Endo, Takashi Kaito, Tomoya Yamashita, Hiroyasu Fujiwara, Yukitaka Nagamoto, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Hidetomi Terai, Koji Tamai…

    Citation: BMC Musculoskeletal Disorders 2019 20:103

    Content type: Research article

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  37. There is a pressing need to enhance osteoarthritis (OA) research to find ways of alleviating its enormous individual and societal impact due to the high prevalence, associated disability, and extensive costs.

    Authors: David J. Hunter, Philippa J. A. Nicolson, Christopher B. Little, Sarah R. Robbins, Xia Wang and Kim L. Bennell

    Citation: BMC Musculoskeletal Disorders 2019 20:74

    Content type: Research article

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  38. Previous studies suggest that RA activity is sensitive to seasonal changes. This study explored the influence of season on RA activity, particularly the distribution of affected joints, using a nationwide data...

    Authors: Hiroaki Mori, Tetsuji Sawada, Susumu Nishiyama, Kota Shimada, Koichiro Tahara, Haeru Hayashi, Eri Kato, Mayu Tago, Toshihiro Matsui and Shigeto Tohma

    Citation: BMC Musculoskeletal Disorders 2019 20:30

    Content type: Research article

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  39. This study examines the association of both pain severity and within-person pain variability with physical activity (PA) in older adults with osteoarthritis (OA).

    Authors: Erik J. Timmermans, Elisa J. de Koning, Natasja M. van Schoor, Suzan van der Pas, Michael D. Denkinger, Elaine M. Dennison, Stefania Maggi, Nancy L. Pedersen, Ángel Otero, Richard Peter, Cyrus Cooper, Paola Siviero, Maria Victoria Castell, Florian Herbolsheimer, Mark Edwards, Federica Limongi…

    Citation: BMC Musculoskeletal Disorders 2019 20:12

    Content type: Research article

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  40. Rheumatoid arthritis (RA) is a chronic and refractory autoimmune joint disease. Fibroblast-like synoviocytes (FLS) produce inflammatory cytokines and are involved in the migration and invasion of panuus tissue...

    Authors: Jing Wu, Yuan Qu, Yu-Ping Zhang, Jia-Xin Deng and Qing-Hong Yu

    Citation: BMC Musculoskeletal Disorders 2018 19:455

    Content type: Research article

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  41. The aetiology and pathogenesis of primary bone marrow oedema syndrome (BMES) remain unclear. This retrospective cross-sectional study in a large cohort of patients with BMES was performed to characterise the o...

    Authors: Nicola Oehler, Haider Mussawy, Tobias Schmidt, Tim Rolvien and Florian Barvencik

    Citation: BMC Musculoskeletal Disorders 2018 19:451

    Content type: Research article

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  42. It is generally believed that Thai people do not suffer from hypovitaminosis D because there is abundant sunlight throughout the year, and that taking vitamin D supplements could result in abnormally high leve...

    Authors: Thawee Songpatanasilp, Sattaya Rojanasthien, Pansak Sugkraroek, Boonsong Ongphiphadhanakul, Lamar Robert, Chongchit Sripun Robert, Sirichai Luevitoonvechkij and Arthur C. Santora

    Citation: BMC Musculoskeletal Disorders 2018 19:392

    Content type: Research article

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  44. Osteoarthritis (OA) is a highly debilitating joint disease that causes progressive, irreversible damage to articular cartilage. OA takes a massive toll on society that has grown in recent decades, but no thera...

    Authors: Ian A. Jones, Melissa Wilson, Ryan Togashi, Bo Han, Austin K. Mircheff and C. Thomas Vangsness JR

    Citation: BMC Musculoskeletal Disorders 2018 19:383

    Content type: Study protocol

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  45. Reconstructive joint surgery is an indicator of poor prognosis in rheumatoid arthritis (RA). Objectives of this study were to describe the incidence rate of orthopedic and hand surgery indication (OHSI) in an ...

    Authors: Irazú Contreras-Yáñez, G. Guaracha-Basáñez, E. Díaz-Borjón, M. Iglesias and V. Pascual-Ramos

    Citation: BMC Musculoskeletal Disorders 2018 19:378

    Content type: Research article

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  46. Knee bone shape differs between men and women and the incidence of knee osteoarthritis (OA) is higher in women than in men. Therefore, the purpose of the present study was to determine whether the observed dif...

    Authors: Barton L. Wise, Jingbo Niu, Yuqing Zhang, Felix Liu, Joyce Pang, John A. Lynch and Nancy E. Lane

    Citation: BMC Musculoskeletal Disorders 2018 19:331

    Content type: Research article

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  47. IDC in children, first reported by Baron in 1924, is very rare. OPLL of the cervical spine mainly affect people ages 50–70 years. The coexistence of IDC and OPLL in children is very rare, only six cases with 3...

    Authors: Jun-Jie Du, Yu-Fei Chen, Ye Peng, Xiao-jie Li and Wei Ma

    Citation: BMC Musculoskeletal Disorders 2018 19:316

    Content type: Case report

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  48. Knee osteoarthritis (OA) causes substantial pain, physical dysfunction and impaired quality of life. There is no cure for knee OA, and for some people, the disease may involve progressive symptomatic and struc...

    Authors: Kade L. Paterson, David J. Hunter, Ben R. Metcalf, Jillian Eyles, Vicky Duong, Jessica Kazsa, Yuanyuan Wang, Rachelle Buchbinder, Flavia Cicuttini, Andrew Forbes, Anthony Harris, Shirley P. Yu, Bing Hui Wang, David Connell, James Linklater and Kim L. Bennell

    Citation: BMC Musculoskeletal Disorders 2018 19:272

    Content type: Study protocol

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  49. The wrist is often severely affected in rheumatoid arthritis (RA) patients; however, little is known about the potential risk factors of the reduced wrist range of motion. In this study, we explored a broad ra...

    Authors: Lijuan Zhang, Haixia Cao, Qiuxiang Zhang, Ting Fu, Rulan Yin, Yunfei Xia, Liren Li and Zhifeng Gu

    Citation: BMC Musculoskeletal Disorders 2018 19:270

    Content type: Research article

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  50. Evidence on the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis is limited and conflicting. The primary objective of the Hip Injection Trial (HIT) is to compare pain intensity ...

    Authors: Zoe Paskins, Gemma Hughes, Helen Myers, Emily Hughes, Susie Hennings, Andrea Cherrington, Amy Evans, Melanie Holden, Kay Stevenson, Ajit Menon, Kieran Bromley, Philip Roberts, Alison Hall, George Peat, Clare Jinks, Raymond Oppong…

    Citation: BMC Musculoskeletal Disorders 2018 19:218

    Content type: Study protocol

    Published on:

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BMC Musculoskeletal Disorders

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