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Straight intramedullary MultiLoc nails for displaced proximal humeral fractures: health status, radiographic results, clinical outcome, and complications

BMC Musculoskeletal Disorders volume 25, Article number: 531 (2024) Cite this article

Abstract

Background

The treatment of the displaced proximal humerus fractures (PHF) still facing a lot of unsolved problems. The aim of this study was to evaluate the clinical effect of MultiLoc nails for the treatment of PHF and present outcomes of patients with different Neer’s classification and reduction quality.

Methods

Adult patients with PHFs were recruited and treated with MultiLoc nail. Intraoperative data, radiographic and functional outcomes, as well as occurrence of postoperative complications were assessed.

Results

48 patients met inclusion and exclusion criteria and were included in this study. The DASH Score were 32.2 ± 3.1 points at 12 months, and 37.3 ± 2.5 points at the final follow-up. The mean ASES score at 12 months and final follow-up were 74.4 ± 6.2 and 78.8 ± 5.1, respectively. The mean CM Score in all 48 patients reached 68 ± 6.4 points at the final follow-up, relative side related CM Score 75.2 ± 7.7% of contralateral extremity. The incidence rate of complications was 20.8%. Patients with fracture mal-union, adhesive capsulitis were observed but no secondary surgeries were performed. There was no significantly difference of DASH Score 12 months after surgery and at the last follow-up among patients with different Neer’s classification or reduction quality. However, functional outcomes such as ASES score and CM score were significantly influenced by severity of fracture and the quality of fracture reduction.

Conclusions

Our study demonstrated that MultiLoc nails is well suited for proximal humeral fractures, with satisfactory health status recovery, good radiographic results, positive clinical outcomes and low rates of complications. The treatment for four part PHF still faces great challenges. Accurate fracture reduction was an important factor for good functional result.

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Introduction

Surgical treatment in proximal humerus fractures (PHF) is generally recommended for obvious displaced, unstable fracture patterns, but the ideal management of this fracture remains a topic of debate [1,2,3]. The goals of surgery are to obtain a better fracture reduction and a stable primary fixation to ensure rapid bone union and allow early postoperative mobilisation without prolonged immobilization [4, 5]. Frequently applied treatment options include locking plate fixation, intramedullary nailing and shoulder arthroplasty according to biological age and fracture patterns [6,7,8].

Among the many fixation methods available, intramedullary locking nails are commonly used, with several studies showing satisfactory clinical outcome results [6, 9]. The main drawbacks of the first and second generation of antegrade proximal humeral nailing include secondary dislocation of the fracture, screw loosening, chronic implant-related shoulder pain.

A higher risk of iatrogenic rotator cuff due to the entry point and a potential violation of the tendon of the long head of biceps brachii by the proximal anterior and posterior lateral locking-screws has also been reported in clinical cases [5,6,7, 10,11,12].

Recently, there are many studies comparing and evaluating the efficacy of intramedullary nails versus locking plates in the treatment of proximal humerus fractures. Interlocking Targon nail are more minimally invasive than locking plates and the intraoperative blood loss was much lower than that of the locking plate group [13]. Minghui Wang .et al found that TriGen straight nail has advantages over locking plates for OTA/AO type 11C1.1 and 11C3.1 proximal humerus anatomical neck fractures in terms of operation time and bleeding volume, with no significant difference in the number of complications [14]. A meta-analysis included 13 comparative studies with 958 patients indicates that locking plates and intramedullary nails have similar performance in terms of the functional scores and total complication rate [15].

As a third generation of intramedullary nail, straight MultiLoc Nail (DePuy Synthes, USA) could provide multi-planar distal fixation with angle-stable locking screws and an optional screw-in-screw concept. Further on, a calcar screw is introduced to increasing construct stability, which will play an important role in maintaining fracture reduction. Standard entry points in line with the humeral shaft axis could significantly reduce implant-related injuries to the adjacent anatomical structures in anatomical specimens [16]. Intramedullary nails demonstrated higher axial stiffness and smaller axial interfragmentary movements compared with locking plate designs in a biomechanical study [17]. Gomes GR .et al compared the proportions of complications and radiographic findings of Osteosynthesis of 2- and 3-part proximal humerus fractures with antegrade MultiLoc nail and locking plate. The nail group had less change in the postoperative cervicodiaphyseal angle [18]. MultiLoc nail with cement augmentation is a viable option for treating proximal humerus pathological fracture, providing less blood loss, rigid fixation and better pain relief [19]. However, superior clinical results have not been proven yet.

The purpose of the present study is to evaluate functional, radiological outcomes and potential complications of displaced PHFs using intramedullary MultiLocail nails.

We also analyse influence of Neer’s classification and the reduction quality on the functional outcome.

Patients and methods

Patients and interventions

This retrospective single-center study was conducted in a Level I trauma center at the Second People’s Hospital of Changzhou. Approval from the Ethics committee of the hospital was granted prior to initiation of the study(No.[2022]KY061-01).

Adult patients with displaced Neer proximal humerus fractures between August 2018 and December 2021 were recruited cumulatively and evaluated for eligibility. Patients with head-splitting fractures, bilateral fracture, pathological fractures, open fractures, posttraumatic nerve injury, associated fractures in the ipsilateral limb, previous surgery on the affected shoulder and comorbidities contraindicating surgery were excluded. Patients who were lost to follow-up or with new shoulder trauma on the ipsilateral side were excluded as well. Finally, 48 patients treated with an intramedullary MultiLoc Nail (DePuy Synthes, USA) were included in the study by a single senior surgeon(Fig. 1).

Fig. 1
figure 1

Flow diagram of patient enrolment and analysis. n, number; ORIF, Open reduction and internal fixation

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After X-ray with preliminary diagnose, 2D and 3D CT of injured proximal humerus with reconstructions was performed. Definitive decision about fracture type was made preoperatively. All fractures with technical possibility of reduction and fixation were indicated for reconstructive strategy. Operative treatment was exclusively performed by the study investigators, senior trauma surgeons experienced in the treatment of proximal humeral fractures.

Surgical techniques

Surgery was performed with the patient under general anesthesia in beach chair position through an anterolateral deltoid split approach with arm in retroversion. Reduction of head fragments was performed individually according to the fracture patterns, with K-wires used in joystick technique, bone hooks and sutures. As for the 3- and/or 4-part fractures, non-absorbable suture -retracting technique was used to reduct the greater and lesser tuberosities to the humeral head first. Having confirmed adequate reduction, 2–3 cm long longitudinal incision into the supraspinatus tendon was performed. The entry point is situated at the apex of the humeral head, about 1.5 cm away from the cuff insertion onto the greater tuberosity. The position of the guiding wire was adjusted under fluoroscopic guidance. The medullary cavity was then opened with a hollow reamers. After that, the MultiLoc nail was inserted. Depth of insertion was adapted to the ideal position of proximal locking screws regarding fracture fragments. The number of proximal interlocking screws used was based on the fracture configuration and bone quality. Routinely, we made an attempt to insert the medial calcar screw. Screw-in-screw technique is applied to increase angular stability when there was poor bone quality(Fig. 2d and e). Briefly, after 4.5 mm MultiLoc locking screws was inserted proximally, specialized positioning sleeve could further locked with the MultiLoc screw by assembling with a T25 star shaped screwdriver. Then, a 3.5 mm interlocking screw was implanted through the head of the 4.5 mm locking screws. Distal locking by 2 screws was performed in all cases. Finally, Length of all locking screws was checked.

Fig. 2
figure 2

Female, 52 years old, three-part PHF. (a) Preop AP radiographs and (b, c) CT 3D reconstruction. Initial post-op (d and e) and 20 months post-op (f and g) showing fracture union without complication. (h) range of shoulder motion 20 months post-op

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Whenever possible, the fragment control sutures were then inserted into the rotator cuff and tied to the suture holes on the interlocking screw heads to neutralize the pull of the rotator cuff and aid tuberosity fixation. After that, the rotator cuff was repaired. For patients with severe rotator cuff injury, we sutured the rotator cuff to the Multiloc screw hole. The deltoid fascia split was repaired. Finally, suture was closed by layers.

Postoperative rehabilitation protocol

All patients prospectively underwent same post-surgical rehabilitation protocol that emphasized early passive and active-assisted motion exercises. The duration of protective immobilization with a sling was 4 weeks. The exercises begun on day one after surgery, immediately after diminishing of major postoperative pain. Maximum passive range of motion exercises was continued within the first 6 weeks. Then active movements started, with the aim of regaining full range of motion and normal strength as early as possible.

Radiological assessment

Radiological evaluation took place immediately after surgery, after 3 months, and at the final follow up. Radiological outcomes were determined by two experienced surgeons.

The criteria for the quality of fracture reduction were adopted from previous studies, mainly depends on residual distance and angle between main fracture fragments. Under these considerations, patients were assigned in 3 groups according to Martin Kloub et al [20], rated as 1 = excellent, 2 = moderate and 3 = poor. Neck–shaft angle was also measured using the humeral shaft axis and line perpendicular to the articular segment or anatomic neck of the humerus.

Follow-up X-rays were used to identify union and all complications. Radiological union was defined as evidence of bridging external callous formation on radiographs, without shoulder pain or activity-related pain. If radiological union was not achieved 3 month after surgery, patients was asked to review every single month until the fracture healed. Complications assessed included mal-union, non-union, signs of avascular necrosis, resorption of the greater tuberosity and reduction/fixation failure.

Clinical assessment

The primary outcome parameter was the Disabilities of the Shoulder, Arm and Hand (DASH) Score after 12 months and last follow-up. The main part of the DASH is a 30-item disability/ symptom scale ranging from 0 (no disability) to 100 (severest disability), concerning about the patient’s health status during the preceding week. Lower scores indicated better health status. Functional outcomes were also determined by using American Shoulder and Elbow Surgeons (ASES) shoulder score, the Constant–Murley Score (absolute), Side related relative CM score (relative), and range of motion (ROM) of shoulder joint after 12 months and/or final follow-up.

Postoperative complications including axillary nerve injury, infection of incisional wound, clinical signs and symptoms of subacromial impingement and/or rotator cuff tendon tears were recorded as well.

Statistical analysis

Statistical analysis was performed with software Excel 2016, GraphPad Prism 7 and SPSS 22.0. The distributions of all numerical variables were evaluated for normality using the Shapiro-Wilk test. Data that satisfies normality were presented as the mean ± standard deviation. Those data that did not meet normality were presented as medians and quartiles.

Categorical data were represented by both a number and a percentage. Correlation between different Neer’s classification /reduction quality and DASH or functional scores(ASES score and CM score) were analyzed with one-way ANOVA or the Kruskal-Wallis test. P < 0.05 was regarded as statistical different.

Results

The mean follow-up to latest functional assessment was 18.6 ± 3.2 months (range 12–24 months). The mean age was 58.6 ± 10.6 (range 40–75 years), with a male to female ratio of 20:28. According to Neer’s classification, 48 patients sustained 13 a two-part, 25 a three-part, and 10 a four-part fracture. Demographic characteristics are shown in Table 1.

Table 1 Demographic and surgical characteristics of patient cohort
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Surgical data

The mean delay time from injury to surgery was 6.0 ± 2.1 days. Average length of the operation were 96.4 ± 26.4 min, and average intraoperative hemorrhage were 59.0 ± 24.7 mL, as summarized in Table 1.

Radiographic results

The mean intraoperative neck–shaft angle (NSA) was 129.9 ± 4.1º. In 19 cases was achieved excellent reduction, in 23 cases moderate, poor reduction was observed in 6 cases after osteosynthesis. All fractures achieved union.The mean radiographic fracture union time was 3.5 ± 0.7 months post-operation. The final NSA was 127.7 ± 5.1º.

Clinical results

The DASH Score were 32.2 ± 3.1 points at 12 months, and 37.3 ± 2.5 points at the final follow-up. The mean American Shoulder and Elbow Surgeons(ASES) score at 12 months and final follow-up were 74.4 ± 6.2 and 78.8 ± 5.1, respectively. Average absolute CM Score in all 48 patients reached 68 ± 6.4 points at the final follow-up; relative side related CM Score 75.2 ± 7.7% of contralateral extremity. At last review, mean range of motion was forward flexion 135.9 ± 16.2º, abduction 125.6 ± 15.8º, external rotation 53.6 ± 8.2º, and internal rotation 42.3 ± 6.8º. Data of radiographic results, clinical outcome, and complication was summarized in Table 2. Documentation of one patient with three-part PHF was shown in Fig. 2.

Table 2 Radiographic results, clinical outcome, and complication
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We further analyzed patient’s health status and functional outcomes according to Neer’s classification and quality of fracture reduction, as shown in Tables 3 and 4.

Table 3 Comparison of clinical results results according to Neer classifcations
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Table 4 Comparison of clinical results according to reduction quality
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We did not find any statistical relationship between DASH Score and Neer classifcations ( p = 0.946, at 12 months and p = 0.125, at the last follow-up) or reduction quality ( p = 0.278, at 12 months and p = 0.079, at the last follow-up). However, at 12 months, the mean ASES score in four-part PHF was much lower (67.2 ± 5.9) than these in two-part PHF (77.3 ± 4.4) and three-part (75.7 ± 5.0) ( p < 0.01). Moreover, worse functional outcomes were observed in the four-part (ASES score 67.2 ± 5.9 and absolute CM score 60.8 ± 4.9, relative CM score 67.1 ± 5.7%) compared to the two-part (ASES score 81.5 ± 3.6 and absolute CM score 72.3 ± 3.8, relative CM score 79.4 ± 5.7%) and three-part groups (ASES score 79.9 ± 4.7 and absolute CM score 68.6 ± 5.7, relative CM score 76.2 ± 7.0%) at the last follow-up. All p < 0.001.

ASES scores in the group of excellent reduction achieved 77.5 ± 5.8 at 12 months and 81.4 ± 4.8 at the last follow-up comparing with the group of moderate (74.3 ± 4.0, 78.6 ± 4.2) and poor reduction ( 64.5 ± 4.0, 72 ± 2.4) ( p < 0.001, p < 0.001). At the final follow-up, absolute/relative CM score in the group of poor reduction was 61.5 ± 3.4 / 67.4 ± 4.1% and significantly lower than these in the group of moderate and excellent reduction ( p = 0.003 and P = 0.002).

Complications

Surgical complications including axillary nerve injury, infection of incisional wound and rotator cuff tear were not found. No radiographic evidences of screw cut-out or backout, failure of fixation, nonunion or avascular necrosis of the humeral head was identified at the final follow-up. The incidence rate of complications was 20.8%. Fracture mal-union occurred in 4 cases (8.3%), adhesive capsulitis in 8 cases (16.7%), but no secondary surgeries were performed.

Discussion

The purpose of this retrospective study was to evaluate the efficacy and outcome after treatment of proximal humeral fractures with third-generation straight intramedullary Multiloc nails. The major findings of this study is that MultiLoc nail is well suited for the treatment of PHF with satisfactory recovering of health status, as well as good radiological and clinical outcomes, low rates of complications. Our study also yielded further results. First, four-part type PHF resulted in worse functional outcome. Second, if better reduction quality achieved, clinical outcome dramatically raised.

Owing to its biomechanical advantages, locked intramedullary nailing is emerging as a preferred technique in managing displaced proximal humerus fractures in appropriately selected patients in clinical practice [21, 22]. Several studies demonstrated good functional outcomes for intramedullary nails, similar to locking plates, in the treatment of displaced fractures [23,24,25].

As a third-generation straight intramedullary nails, the MultiLoc® humeral nail is an implant with locked properties that offers numerous modular proximal locking options, compared with previous generations of intramedullary nails [6], MultiLoc nail configurated with screw-in-screw and calcar screw could support the humeral head fragment in both axial and rotational direction to prevent varus collapse and reduce the risk of secondary redislocation in clinical use [26]. Additionally, MultiLoc nail with a appropriate endcap significantly reduced varus-displacing forces to the humeral head and provided increased stability [27]. All of these design of MultiLoc nail could be advantageous in case of poor fixation, due to osteoporosis or a complex fracture pattern, as shown in Table 5.

Table 5 Characteristics of different generations of antegrade humeral nail designs
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Recently, MultiLoc nail is already considered as a reliable technology for the treatment of more complex fractures of proximal humerus. Several clinical trials reported good clinical and radiographic outcomes for MultiLoc® nail, even in the elderly patients. Toon, et al. investigated the clinical data of 22 consecutive patients with PHF underwent MultiLoc nail treatment. Good early outcomes and low rates of complications demonstrated that MultiLoc nail is well suited for Neer’s two- and three-part proximal humeral fractures [28]. In elderly patients, osteoporosis makes internal fixation problematic and frequently contributes to failed fixation and poor clinical results. In a prospective randomized controlled clinical trial, MultiLoc nail as well as Locked plating with screw-tip-augmentation achieve satisfying functional outcomes in 2-part surgical neck type fractures of the proximal humerus in an elderly population at two years of follow-up [29]. Yaiza, et al. found proper operative technique with a MultiLoc nail result in good functional results and good HRQol with a low complication rate in elderly patients aged 80 y.o. or older presenting a two-part or three-part PHFs [30]. In our study, treatment of the PHF including three and four part by intramedullary MultiLoc nail provided good DASH score as high as 37.3 ± 2.5, representing a satisfactory health status after surgry. Positive radiographic and functional outcomes and low rates of postoperative complications were also achieved. There was no ununion, avascular necrosis and secondary surgeries at the final follow-up.

The treatment strategy of displaced 4-part proximal humeral fractures is still in the focus of the interest. Conservative management, locked PHILOS plate, hemi-arthroplasty, or reverse total shoulder arthroplasty, including intramedullary nails, were all chosen as possible therapies [31,32,33,34]. However, no intervention was considered as the most appropriate for their management currently. Greenberg, et al.evaluated the radiographic and clinical outcomes of 23 patients with low-energy, osteoporotic, 4-part proximal humeral fractures underwent fixation via Targon intramedullary nails [35]. They found intramedullary nails can successfully be used by experienced surgeons in fixation of 4-part PHFs with osteoporosis. Toon, et al. found the outcome for four-part fractures after MultiLoc nail treatment were inferior to two or three-part fractures in a single-institution prospective cohort study [28]. In another prospective monocentric cohort study, 40 patients with displaced four-part proximal humeral fractures were treated with MultiLoc nail. Complications like head necrosis and failure of fixation were not rare at the final follow-up [36]. In this study, we evaluated 10 patients with 4-part fracture in average age 55.9 ± 12.7, with average ASES score 72.9 ± 3.2, absolute CM score 60.8 ± 4.9 and relative CM score 67.1 ± 5.7% at the final follow-up, significantly lower than 2-part or 3-part fractures. These results were similar to previous researches.

In addition to the classification, appropriate reduction of fracture fragments also have a great impact on clinical result. Influence of reduction quality on the functional result was already observed and most studies report worsening of outcome in malreduced or malunited fractures [37,38,39]. Martin, et al. reassessed long term results of 137 patients with three or four-part fractures of the humeral head treated by intramedullary nailing. Long term results confirmed nailing as appropriate treatment strategy for all types of humeral head fractures with limitation of excellent reduction in every age group [20]. Similarly, better functional result and lower rates of complications in patient treated with MultiLoc nail depending on surgical technique, especially accurate reduction [29, 36]. We compared ASES score and CM score among patients with different reduction quality. Better quality of fracture reduction corresponds to higher ASES score while poor reduction led to lower CM score, indicating that functional outcome is strongly influenced by the grade of achieved reduction.

Outcomes after MultiLoc nail magement also involved complications after surgical operation. In 48 patients there were together 12 complications until final follow-up.

Implant related complications like screw cut-out or back-out, loss of reduction were not found in our study group, similar to previous studies [40]. Martin, et al. reported complete or partial head necrosis, resorption of the greater tuberosity in 40% in patients with displaced four-part proximal after intramedullary nails treatment [36]. However, these complications was not occurred in our study cohort. This may be explained by lower proportion of four-part fractures and higher reduction quality of fractures. Nevertheless, 4 cases (17.1%) of mal-union was happened, mainly found in patients with poor reduction quality. Adhesive capsulitis was found in eight cases, which might be attribute to primary or implant mal-position induced rotator cuff injury or negative rehabilitation.

There are several limitations in our study. The first limitation could be different length of follow-up time, which varies from 12 to 24 months, might influence clinical outcomes. Fortunately, we have got DASH score and ASES score 12months after surgical operation. Secondly, the results were based on patients treated by the same surgeon in our study. This may affect the further generalizability of the conclusion. On the other hand, data bias is reduced when we further investigate the outcome-related factors. Other limitations of this study were a retrospective design, small number of cases and only a short-term outcome.

The strength of this study is the use of multiple objective and subjective clinical-functional outcomes, especially DASH score concerning patient’s health status. Further studies with larger patient numbers, prospective randomized controlled clinical trial, even multicenter cohort study, are still needed to determine the role and efficiency of MultiLoc nail for proximal humeral fracture fractures.

Conclusions

In conclusion, MultiLoc nail resulted in a satisfactory clinical outcome for the treatment of proximal humeral fractures, with a reasonable low complication rate. The technique is suitable to help patient regain health status after operation. Optimum management choice of four-part fractures still facing a big challenge. Appropriate reduction of the fracture during the operation is a key for a good functional result.

Data availability

The datasets used and/or analyzed during the current study available from the corresponding author on reasonable request.

References

  1. Aaron D, Shatsky J, Paredes JC, Jiang C, Parsons BO, Flatow EL. Proximal humeral fractures: internal fixation. Instr Course Lect. 2013;62:143–54.

    PubMed  Google Scholar 

  2. Dilisio MF, Nowinski RJ, Hatzidakis AM, Fehringer EV. Intramedullary nailing of the proximal humerus: evolution, technique, and results. J Shoulder Elb Surg. 2016;25:e130–8.

    Article  Google Scholar 

  3. Resch H. Proximal humeral fractures: current controversies. J Shoulder Elb Surg. 2011;20:827–32.

    Article  Google Scholar 

  4. Gerber C, Werner CM, Vienne P. Internal fixation of complex fractures of the proximal humerus. J Bone Joint Surg Br Vol. 2004;86:848–55.

    Article  CAS  Google Scholar 

  5. Gradl G, Dietze A, Arndt D, Beck M, Gierer P, Börsch T, et al. Angular and sliding stable antegrade nailing (Targon PH) for the treatment of proximal humeral fractures. Arch Orthop Traum Su. 2007;127:937–44.

    Article  Google Scholar 

  6. Hessmann MH, Nijs S, Mittlmeier T, Kloub M, Segers MJ, Winkelbach V, et al. Internal fixation of fractures of the proximal humerus with the MultiLoc nail. Oper Orthop Traumato. 2012;24:418–31.

    Article  CAS  Google Scholar 

  7. Lopiz Y, Garcia-Coiradas J, Garcia-Fernandez C, Marco F. Proximal humerus nailing: a randomized clinical trial between curvilinear and straight nails. J Shoulder Elb Surg. 2014;23:369–76.

    Article  Google Scholar 

  8. Nho SJ, Brophy RH, Barker JU, Cornell CN, Macgillivray JD. Management of proximal humeral fractures based on current literature. J Bone Joint Surg Am Vol. 2007:44–58.

  9. Mittlmeier TW, Stedtfeld HW, Ewert A, Beck M, Frosch B, Gradl G. Stabilization of proximal humeral fractures with an angular and sliding stable antegrade locking nail (Targon PH). The Journal of bone and joint surgery. Am Volume. 2003:136–46.

  10. Gierer P, Scholz M, Beck M, Schaser KD, Vollmar B, Mittlmeier T, et al. Microcirculatory sequelae of the rotator cuff after antegrade nailing in proximal humerus fracture. Arch Orthop Traum Su. 2010;130:687–91.

    Article  Google Scholar 

  11. Murray IR, Amin AK, White TO, Robinson CM. Proximal humeral fractures: current concepts in classification, treatment and outcomes. J Bone Joint Surg Br Vol. 2011;93:1–11.

    CAS  Google Scholar 

  12. Nolan BM, Kippe MA, Wiater JM, Nowinski GP. Surgical treatment of displaced proximal humerus fractures with a short intramedullary nail. J Shoulder Elb Surg. 2011;20:1241–7.

    Article  Google Scholar 

  13. Guo Z, Sang L, Meng Q, Tian L, Yin Y. Comparison of surgical efficacy of locking plates and interlocking intramedullary nails in the treatment of proximal humerus fractures. J Orthop Surg Res. 2022;17(1):481.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Wang M, Wang X, Cai P, Guo S, Fu B. Locking plate fixation versus intramedullary nail fixation for the treatment of multifragmentary proximal humerus fractures (OTA/AO type 11 C): a preliminary comparison of clinical efficacy. BMC Musculoskelet Disord. 2023;24(1):461.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Sun Q, Ge W, Li G, Wu J, Lu G, Cai M, et al. Locking plates versus intramedullary nails in the management of displaced proximal humeral fractures: a systematic review and meta-analysis. Int Orthop. 2018;42(3):641–50.

    Article  PubMed  Google Scholar 

  16. Schwarz AM, Hohenberger GM, Euler S, Weiglein AH, Riedl R, Kuchling S, et al. Straight proximal humeral nailing: risk of iatrogenic tendon injuries with respect to different entry points in anatomical specimens. Injury. 2018;49:1750–7.

    Article  CAS  PubMed  Google Scholar 

  17. Pastor T, Zderic I, Pastor T, Drenchev L, Skulev HK, van Knegsel KP et al. Helical plating compared with straight plating and nailing for treatment of Proximal Third Humeral Shaft Fractures-A Biomechanical Study. Med (Kaunas Lithuania) 2023, 59(11).

  18. Gomes GR, Maciel RA, Almeida Neto JI, Toledo DC, Machado CJ, Bomfim LS. ANTEGRADE NAILING VERSUS LOCKING PLATE OF 2-AND 3-PART PROXIMAL HUMERUS FRACTURES. Acta Ortop Bras. 2022;30(5):e256113.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Wu K, Lin T, Lee CH. Intramedullary nailing versus cemented plate for treating metastatic pathological fracture of the proximal humerus: a comparison study and literature review. J Orthop Traumatology: Official J Italian Soc Orthop Traumatol. 2023;24(1):45.

    Article  Google Scholar 

  20. Kloub M, Holub K, Polakova S. Nailing of three- and four-part fractures of the humeral head -- long-term results. Injury. 2014:S29–37.

  21. Caforio M, Maniscalco P, Colombo M, Calori GM. Long endomedullary nail in proximal third humeral shaft fractures. Injury. 2016:S64–70.

  22. Gracitelli ME, Malavolta EA, Assunção JH, Kojima KE, Dos Reis PR, Silva JS, et al. Locking intramedullary nails compared with locking plates for two- and three-part proximal humeral surgical neck fractures: a randomized controlled trial. J Shoulder Elb Surg. 2016;25:695–703.

    Article  Google Scholar 

  23. Kazakos K, Lyras DN, Galanis V, Verettas D, Psillakis I, Chatzipappas C, et al. Internal fixation of proximal humerus fractures using the Polarus intramedullary nail. Arch Orthop Traum Su. 2007;127:503–8.

    Article  CAS  Google Scholar 

  24. Matziolis D, Kaeaeb M, Zandi SS, Perka C, Greiner S. Surgical treatment of two-part fractures of the proximal humerus: comparison of fixed-angle plate osteosynthesis and Zifko nails. Injury. 2010;41:1041–6.

    Article  PubMed  Google Scholar 

  25. Young AA, Hughes JS. Locked intramedullary nailing for treatment of displaced proximal humerus fractures. Qld Gov Min J. 2008;39:417–28.

    Google Scholar 

  26. Rothstock S, Plecko M, Kloub M, Schiuma D, Windolf M, Gueorguiev B. Biomechanical evaluation of two intramedullary nailing techniques with different locking options in a three-part fracture proximal humerus model. Clin Biomech (Bristol Avon). 2012;27:686–91.

    Article  PubMed  Google Scholar 

  27. Euler SA, Petri M, Venderley MB, Dornan GJ, Schmoelz W, Turnbull TL, et al. Biomechanical evaluation of straight antegrade nailing in proximal humeral fractures: the rationale of the proximal anchoring point. Int Orthop. 2017;41:1715–21.

    Article  PubMed  Google Scholar 

  28. Hao TD, Huat A. Surgical technique and early outcomes of intramedullary nailing of displaced proximal humeral fractures in an Asian population using a contemporary straight nail design. J Orthop Surg. 2017;25:613374222.

    Article  Google Scholar 

  29. Helfen T, Siebenbürger G, Fleischhacker E, Gleich J, Böcker W, Ockert B. Operative treatment of 2-part surgical neck type fractures of the proximal humerus in the elderly: cement augmented locking plate PHILOS™ vs. proximal humerus nail multiloc®. Injury. 2020;51:2245–52.

  30. Lopiz Y, Garríguez-Pérez D, Martínez-Illán M, García-Fernández C, Marco F. Third-generation intramedullary nailing for displaced proximal humeral fractures in the elderly: quality of life, clinical results, and complications. Arch Orthop Traum Su. 2022;142:227–38.

    Article  Google Scholar 

  31. Caliskan E, Doğan Ö. PHILOS plate versus nonoperative treatment in 2-, 3-, and 4-part proximal humeral fractures: comparison with healthy control subjects. J Orthop Surg. 2019;27:615535457.

    Article  Google Scholar 

  32. Jonsson EÖ, Ekholm C, Salomonsson B, Demir Y, Olerud P. Reverse total shoulder arthroplasty provides better shoulder function than hemiarthroplasty for displaced 3- and 4-part proximal humeral fractures in patients aged 70 years or older: a multicenter randomized controlled trial. J Shoulder Elb Surg. 2021;30:994–1006.

    Article  Google Scholar 

  33. Lopiz Y, Alcobía-Díaz B, Galán-Olleros M, García-Fernández C, Picado AL, Marco F. Reverse shoulder arthroplasty versus nonoperative treatment for 3- or 4-part proximal humeral fractures in elderly patients: a prospective randomized controlled trial. J Shoulder Elb Surg. 2019;28:2259–71.

    Article  Google Scholar 

  34. Soler-Peiro M, García-Martínez L, Aguilella L, Perez-Bermejo M. Conservative treatment of 3-part and 4-part proximal humeral fractures: a systematic review. J Orthop Surg Res. 2020;15:347.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Greenberg A, Rosinsky PJ, Gafni N, Kosashvili Y, Kaban A. Proximal humeral nail for treatment of 3- and 4-part proximal humerus fractures in the elderly population: effective and safe in experienced hands. Eur J Orthop Surg Traumatology: Orthopedie Traumatologie. 2021;31:769–77.

    Article  Google Scholar 

  36. Kloub M, Holub K, Urban J, Látal P, Peml M, Křivohlávek M. Intramedullary nailing of displaced four-part fractures of the proximal humerus. Injury. 2019;50:1978–85.

    Article  PubMed  Google Scholar 

  37. Habib N, Fornaciari P, Thuerig G, Maniglio M, Tannast M, Vial P. Hinge plate technique for osteosynthesis of comminuted proximal humeral fractures. Injury. 2021;52:2292–9.

    Article  PubMed  Google Scholar 

  38. Konrad G, Audigé L, Lambert S, Hertel R, Südkamp NP. Similar outcomes for nail versus plate fixation of three-part proximal humeral fractures. Clin Orthop Relat R. 2012;470:602–9.

    Article  Google Scholar 

  39. Micic ID, Kim KC, Shin DJ, Shin SJ, Kim PT, Park IH, Jeon IH. Analysis of early failure of the locking compression plate in osteoporotic proximal humerus fractures. J Orthop Science: Official J Japanese Orthop Association. 2009;14:596–601.

    Article  Google Scholar 

  40. Bu G, Sun W, Li J, Yang T, Li M, Wei W. MutiLoc nail versus philos plate in treating proximal humeral fractures: a retrospective study among the alderly. Geriatric Orthop Surg Rehabilitation. 2021;12:1781215111.

    Article  Google Scholar 

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Acknowledgements

Not applicable.

Funding

the National Science Foundation of China (81901247), the Changzhou Sci&Tech Program (CJ20230070,CJ20220010,CJ20220072), the Medical Research Project of Jiangsu Health Commission (Z2022045), and Open Project of Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University (No. XZSYSKF2020044).

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Author notes

  1. Wei Chen and Zhenhua Zhang contributed equally to this work.

Authors and Affiliations

  1. Trauma Center, The Second People’s Hospital of Changzhou, Nanjing Medical University, Changzhou, 213003, China

    Wei Chen & Chunhui Zhu

  2. Department of Anesthesiology, The People’s Hospital of Danyang, Affiliated DanYang Hospital of Nantong University, Danyang, 212300, China

    Zhenhua Zhang

  3. Department of Spinal Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China

    Zhiwen Song

  4. Department of Orthopedics, Wujin Hospital Affiliated with Jiangsu University, Changzhou, 213003, China

    Zhiyuan Liu

  5. Department of Orthopedics, The Wujin Clinical College of Xuzhou Medical University, Changzhou, 213003, China

    Zhiyuan Liu

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  1. Wei Chen
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  3. Chunhui Zhu
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  4. Zhiwen Song
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Contributions

Wei Chen, zhenhua Zhang and Zhiyuan Liu wrote the main manuscript text. Chunhui Zhu collected Data and prepared figures and tables. Zhiwen Song and Zhiyuan Liu: Project Administration, Writing-Review & Editing. All authors reviewed the manuscript.

Corresponding author

Correspondence to Zhiyuan Liu.

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Approval from the This study was approved by the local ethics committee (Ethics committee of the Second People’s Hospital of Changzhou, China). Informed consent to participate in the study was obtained by all participants.

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The authors declare no competing interests.

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Chen, W., Zhang, Z., Zhu, C. et al. Straight intramedullary MultiLoc nails for displaced proximal humeral fractures: health status, radiographic results, clinical outcome, and complications. BMC Musculoskelet Disord 25, 531 (2024). https://doi.org/10.1186/s12891-024-07656-y

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Keywords

BMC Musculoskeletal Disorders

ISSN: 1471-2474

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