Table 3 Included review articles’ characteristics and results
N | Author | Study design | Reviewed articles (N) | Study question | Sample size (PI + Non PI) | Odds ratio | 95% CI | P value | Conclusion |
|---|---|---|---|---|---|---|---|---|---|
1 | Kobayashi et al. (2021) | SR and MA | 8 | Efficacy of diluted PI lavage for preventing PJI in primary and revision surgery | 10,390 + 22,623 | NS control : 0.33 CHG control: 2.17 Overall: 0.83 | NS control : 0.16–0.71 CHG control: 0.97–4.87 Overall: 0.45–1.51 | NS control : 0.004 CHG control: 0.06 Overall: 0.54 | Diluted PI lavage is significantly better than saline solution lavage for preventing PJI. |
2 | Kim et al. (2020) | SR and MA | 7 | Does the performance of PI lavage before wound closure in TJA reduce the postoperative infection rate? | 8,861 + 22,352 | 0.67 | 0.38–1.19 | 0.17 | No differences in the overall postoperative infection rates between the PI and non-PI lavage groups before wound closure in TJA |
3 | Zlotnicki et al. (2021) | Review | 4 | The role of irrigants for prevention of PJIs | Although a role for further cocktails may have utility, dilute betadine solution remains a possible option | ||||
4 | Chundamala et al. (2007) | Review | 15 | Determine the efficacy and risks of using povidone-iodine irrigation to prevent surgical site infection | Povidone-iodine irrigation is a simple and inexpensive solution with the potential to prevent surgical site infection | ||||
6 | Cacciola et al. (2020) | SR | 7 | Current literature on the efficacy of dilute betadine in reducing PJI | Some studies found that using DPI reduces the risk of infective consequences, whereas others found no changes when DPI was utilized. More research is needed to determine the efficacy of DPI irrigation. |