From: Menopausal hormone therapy, oral contraceptives and risk of chronic low back pain: the HUNT Study
 | Total number of womena | Number of women with chronic LBP (%)a | PR (95% CI) with adjustment for age only | PR (95% CI) with comprehensive adjustmentb |
---|---|---|---|---|
Use of systemic MHT | ||||
 Number of women included |  |  | 12,974 | 11,072 |
 Never | 9600 | 2682 (27.9) | 1.00 (reference) | 1.00 (reference) |
 Former | 997 | 425 (42.6) | 1.47 (1.36–1.59) | 1.46 (1.34–1.59) |
 Current | 2377 | 900 (37.9) | 1.30 (1.22–1.38) | 1.29 (1.20–1.38) |
 P for categorical effect |  |  |  < 0.001 |  < 0.001 |
Duration of use of systemic MHT (year) | ||||
 Number of women included |  |  | 11,988 | 10,284 |
 Never used | 9600 | 2682 (27.9) | 1.00 (reference) | 1.00 (reference) |
 0-2c | 1256 | 509 (40.5) | 1.40 (1.30–1.51) | 1.39 (1.28–1.50) |
 3–5 | 682 | 250 (36.7) | 1.25 (1.12–1.39) | 1.27 (1.13–1.42) |
 6–8 | 224 | 86 (38.4) | 1.29 (1.09–1.53) | 1.31 (1.10–1.56) |
 ≥ 9 | 226 | 112 (49.6) | 1.68 (1.47–1.93) | 1.63 (1.40–1.89) |
 P for categorical effect |  |  |  < 0.001 |  < 0.001 |
 P for linear trendd |  |  | 0.25 | 0.41 |
Use of systemic MHT by type in current users | ||||
 Number of women included |  |  | 11,825 | 10,107 |
 Never used systemic | 9600 | 2682 (27.9) | 1.00 (reference) | 1.00 (reference) |
 Oestrogen only | 554 | 238 (43.0) | 1.46 (1.32–1.62) | 1.45 (1.30–1.62) |
 Combination | 1671 | 604 (36.1) | 1.24 (1.15–1.34) | 1.23 (1.14–1.34) |
 P for categorical effect |  |  |  < 0.001 |  < 0.001 |
 P for difference between oestrogen only and combination |  |  | 0.051 | 0.042 |