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Table 2 Associations in HUNT2 between use of systemic MHT and prevalence of chronic LBP in cross-sectional analysis, among nonpregnant women aged 40–69 years

From: Menopausal hormone therapy, oral contraceptives and risk of chronic low back pain: the HUNT Study

 

Total number of womena

Number of women with chronic LBP (%)a

PR (95% CI) with adjustment for age only

PR (95% CI) with comprehensive adjustmentb

Use of systemic MHT

 Number of women included

  

12,974

11,072

 Never

9600

2682 (27.9)

1.00 (reference)

1.00 (reference)

 Former

997

425 (42.6)

1.47 (1.36–1.59)

1.46 (1.34–1.59)

 Current

2377

900 (37.9)

1.30 (1.22–1.38)

1.29 (1.20–1.38)

 P for categorical effect

  

 < 0.001

 < 0.001

Duration of use of systemic MHT (year)

 Number of women included

  

11,988

10,284

 Never used

9600

2682 (27.9)

1.00 (reference)

1.00 (reference)

 0-2c

1256

509 (40.5)

1.40 (1.30–1.51)

1.39 (1.28–1.50)

 3–5

682

250 (36.7)

1.25 (1.12–1.39)

1.27 (1.13–1.42)

 6–8

224

86 (38.4)

1.29 (1.09–1.53)

1.31 (1.10–1.56)

 ≥ 9

226

112 (49.6)

1.68 (1.47–1.93)

1.63 (1.40–1.89)

 P for categorical effect

  

 < 0.001

 < 0.001

 P for linear trendd

  

0.25

0.41

Use of systemic MHT by type in current users

 Number of women included

  

11,825

10,107

 Never used systemic

9600

2682 (27.9)

1.00 (reference)

1.00 (reference)

 Oestrogen only

554

238 (43.0)

1.46 (1.32–1.62)

1.45 (1.30–1.62)

 Combination

1671

604 (36.1)

1.24 (1.15–1.34)

1.23 (1.14–1.34)

 P for categorical effect

  

 < 0.001

 < 0.001

 P for difference between oestrogen only and combination

  

0.051

0.042

  1. HUNT Trøndelag Health Study, MHT menopausal hormone therapy, LBP low back pain, PR prevalence ratio, CI confidence interval, BMI body mass index, OC oral contraceptives
  2. aIn analysis adjusted for age only
  3. bAdjustment for age, BMI, physical activity, education, smoking, age at menarche, nulliparity, age at first childbirth, use of OC
  4. cMust have used systemic MHT for at least one month
  5. dAmong all women who had used systemic MHT for at least one month