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Table 3 Influence of endocrine factors on bone health in idiopathic scoliosis

From: Risk factors associated with low bone mineral density in children with idiopathic scoliosis: a scoping review

Endocrine factors

Number of studies

Sample size

Other outcome measures

Results

Research type

Serum leptin [59]

1

120

Anthropometric data

Decrease in serum leptin Correlations between leptin and the BMI, and BMC/BMD

Observational study

SLR [57, 60,61,62]

4

486

HR-pQCT parameters(n = 3) Anthropometric parameters (n = 1)

Decrease in serum leptin Increase of SLR Correlations between leptin and bone-related measures

Observational study (n = 3) Systematic review (n = 1)

Serum sclerostin [58]

1

47

Anthropometric parameters DXA/HR-pQCT parameters

Increase the level of serum sclerostin Correlation between serum sclerostin and cortical volumetric BMD and thickness

Observational study

Serum ghrelin [62]

1

132

/

Increase of ghrelin

Systematic review

IL-6 [63]

1

36

Anthropometric parameters BMD

Correlation between IL-6 and BMD

Observational study

Nontargeted plasma metabolites [64]

1

16

Anthropometric parameters BMD

Correlation between oxoglutarate, L-arginine, arginine, N-acetylaspartate, citrate, and BMI/BMD

Observational study

  1. BMI body mass index, BMC bone mineral content, BMD bone mineral density, SLR soluble leptin receptor, HR-pQCT high-resolution peripheral quantitative computed tomography, DXA dual-energy X-ray absorptiometry, IL-6 Interleukin-6