Table 2 Influence of genetic factors on bone health in idiopathic scoliosis
Gene/signal pathway | Number of studies | The sample size of IS patients | Outcome measures relate to bone | Results | Research type |
|---|---|---|---|---|---|
4 | 717 | BMD (n = 4) | VDR BsmI rs1544410 polymorphism was susceptive to low BMD in Asians | Observational study (n = 2) Systematic review (n = 2) | |
RANK/RANKL signal pathway [30, 32, 36, 40, 42, 44, 48, 51, 52, 54] | 10 | 525 | Bone metabolism parameters (n = 3) BMD (n = 5) Bone development endocrine (n = 1) Bone morphology parameters (n = 1) | T single nucleotide polymorphism in Adiponectin gene site rs7639352 and G → C mutation in OPG gene site 1181 may be associated with low BMD | Observational study (n = 10) |
3 | 35 | BMD (n = 3) | The mechanisms underlying low BMD in AIS may be related to the dropped osteogenic differentiation ability | Observational study (n = 3) | |
3 | 78 | BMD (n = 2) | Low Runx2 expression may related to low BMD | Observational study (n = 3) | |
3 | 472 | Bone metabolism parameters (n = 1) BMD (n = 2) Bone morphology parameters (n = 1) | G-c polymorphism at the -174 and -572 sites of the IL-6 gene promoter was associated with low BMD Adiponectin may be a key factor in this pathway | Observational study (n = 3) | |
2 | 22 | Bone metabolism parameters (n = 2) | Knockdown or overexpression of miR-145/β-catenin inhibits osteocyte function | Observational study (n = 2) |